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Composite probiotic liquid for preventing diabetes and controlling body weight and preparation method thereof

A technology for compounding probiotics and weight control, which can be used in metabolic diseases, drug combinations, pharmaceutical formulations, etc., and can solve problems such as restricting the use of metformin

Inactive Publication Date: 2016-12-07
北京鸿保康微生物技术发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The effect of treating obese diabetes is very good. Because of its wide clinical application, the common adverse reactions of metformin are gastrointestinal discomfort, such as nausea, vomiting, diarrhea, abdominal pain, constipation, abdominal distension, indigestion, and heartburn. Response up to 30%, this adverse reaction limits the use of metformin

Method used

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  • Composite probiotic liquid for preventing diabetes and controlling body weight and preparation method thereof
  • Composite probiotic liquid for preventing diabetes and controlling body weight and preparation method thereof
  • Composite probiotic liquid for preventing diabetes and controlling body weight and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] A compound probiotic liquid for preventing and treating diabetes and controlling body weight, characterized in that the composition and weight ratio of the compound probiotic are: 15 parts of Clostridium butyricum seed liquid, 15 parts of defatted soybean powder, Brassica 30 parts of yeast seed liquid, 10 parts of Lactobacillus plantarum seed liquid, 8 parts of Acetobacter xylinum seed liquid, 15 parts of Bifidobacterium adolescent seed liquid, 15 parts of Bacillus licheniformis seed liquid, 40 parts of brown sugar, 15 parts of skimmed milk powder, honey 15 parts, 3 parts of sodium chloride, 15 parts of arabinose, 8 parts of xylooligosaccharides and 800 parts of purified water. The preparation process includes: (1). Add 40 parts of brown sugar and 15 parts of defatted soybean powder into 1000L fermenter A 2 parts of sodium chloride, 400 parts of purified water, mix well and then keep warm at 115°C for 30 minutes, then cool down to 30°C; then add 30 parts of Saccharomyces...

Embodiment 2

[0093] The test was conducted on 240 obese patients with type 2 diabetes mellitus, all of which met the WHO diagnostic criteria and met the following conditions: first diagnosis or no treatment for more than half a year after diagnosis and fasting blood glucose ≥ 10.9mmol / L; no serious acute or chronic complications.

[0094] treatment method:

[0095] 240 eligible patients were divided into two groups according to the degree of obesity and the severity of diabetes.

[0096] Control group: combined with metformin on the basis of diabetes health knowledge education and diet therapy, metformin 0.5g each time, twice a day.

[0097] Experimental group: On the basis of diabetes health knowledge education and diet therapy, combined application of compound probiotic liquid, three times a day, before meals, one bottle a day. There was no significant difference in gender, age, body mass index, glycosylated hemoglobin, fasting blood sugar, and approximate onset time distribution betwee...

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Abstract

The invention discloses a composite probiotic liquid for preventing diabetes and controlling body weight and a preparation method thereof. The composite probiotic liquid contains saccharomyces boulardii, acetobacter xylinum, lactobacillus plantarum, bifidobacterium adolescentis, bacillus licheniformis, clostridium butyricum, arabinose, xylooligosaccharide and bacterial cellulose and the like. After probiotics and prebiotics of the composite probiotic liquid enter the human body, the absorption of glycogens such as glucose by the intestinal tract can be quickly reduced, and thus the body weight is controlled and blood glucose is reduced. Clinical test results indicate that for a patient who orally administers the composite probiotic liquid, it is determined preliminarily that the composite probiotic liquid is more excellent than pure application of metformin in the aspects of time for blood glucose to meet the standard, sugar tolerance improvement, insulin improvement and c-peptide release, and has a remarkable weight loss effect. In addition, the composite probiotic liquid indeed has curative effects in the aspects of functions of improving insulin resistance and protecting islet cells and has no side effect.

Description

technical field [0001] The invention belongs to the technical field of probiotic biomedicine and health care products, and in particular relates to a compound probiotic liquid for preventing and controlling diabetes and controlling body weight and a preparation method thereof. Background technique [0002] Diabetes is a general term for a series of metabolic disorders that result in a decrease in the amount of insulin in the body or insufficient utilization of insulin, resulting in high blood sugar. Simply put, there is too much sugar in the blood, but the blood cannot use that sugar properly. [0003] There are two types of diabetes. Type 1 diabetes (or insulin-dependent diabetes), in which the body makes little or no insulin, is considered an autoimmune disease. This type of diabetes is often diagnosed very early, so it is sometimes called juvenile diabetes. [0004] In type 2 diabetes (or non-insulin-dependent diabetes), the body's ability to control blood sugar decrea...

Claims

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Application Information

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IPC IPC(8): A61K36/076A61P3/10A61P3/04A23L33/135A61K35/741A61K35/742A61K35/745A61K35/747
CPCA61K35/742A23V2002/00A61K35/741A61K35/745A61K35/747A61K36/076A61K2236/19A23V2200/328A23V2200/332A61K2300/00
Inventor 蒋常德胡艳晖
Owner 北京鸿保康微生物技术发展有限公司
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