Traditional Chinese medicine probiotics compound for conditioning insomnia and depression

A technology of probiotics and complexes, applied in the direction of drug combinations, medical formulas, plant raw materials, etc., can solve the problems of drug side effects, psychological pressure of patients, etc., achieve excellent drug efficacy, improve sleep and insomnia, and enrich the effect of application

Active Publication Date: 2018-10-19
山东神农医院管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term use of traditional Chinese medicine will cause psychological stress and side effects of the drug, and the taste of traditional Chin

Method used

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  • Traditional Chinese medicine probiotics compound for conditioning insomnia and depression
  • Traditional Chinese medicine probiotics compound for conditioning insomnia and depression
  • Traditional Chinese medicine probiotics compound for conditioning insomnia and depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1: Preparation of a probiotic composition for regulating insomnia and depression

[0038] (1) Preparation of active probiotic dry powder

[0039] 1) Inoculate Bifidobacterium lactis, Bifidobacterium adolescentis, Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus casei and Lactobacillus plantarum into the fermentation medium after being activated in the culture medium, and shake culture to make the bacteria The body concentration reaches the logarithmic growth phase of 0.5-2×10 9 CFU / mL.

[0040] Fermentation of bifidobacteria: Take out the strain preservation tube, scratch the plate with bifidobacteria solid medium for recovery, and culture anaerobically at 37°C for 48-72 hours. Pick a single colony under the plate to inoculate 50 ml of bifidobacterium medium, and cultivate it in an anaerobic incubator for 48 hours. The seeds are inoculated into a 3L large triangular flask (filling volume is 2.5L) with an inoculum amount of 3%, oil-sealed with...

Embodiment 2

[0050] Example 2: Preparation of a probiotic composition for regulating insomnia and depression

[0051] The difference with Example 1 is that Bifidobacterium lactis, Bifidobacterium adolescentis, Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus casei and Lactobacillus plantarum are by viable count 100:100:150:50:80: 200 for batching, in which the number of live bacteria of each probiotic is 1×10 respectively 9 CFU / g, 1×10 9 CFU / g, 1.5×10 9 CFU / g, 5×10 8 CFU / g, 8×10 8 CFU / g and 2×10 9 CFU / g; Others are similar to Example 1, named as Product 2.

Embodiment 3

[0052] Example 3: Preparation of a probiotic composition for regulating insomnia and depression

[0053] The difference with Example 1 is that Bifidobacterium lactis, Bifidobacterium adolescentis, Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus casei and Lactobacillus plantarum are by viable count 1:1:5:1:3: 1 for batching, wherein the number of live bacteria of each probiotic is 1×10 respectively 7 CFU / g, 1×10 7 CFU / g, 5×10 7 CFU / g, 1×10 7 CFU / g, 3×10 7 CFU / g and 1×10 7 CFU / g; Others are similar to Example 1, named as Product 3.

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Abstract

The invention belongs to the field of health foods and drugs, and specifically relates to a traditional Chinese medicine probiotics compound for conditioning insomnia and depression. The probiotics compound comprises bifidobacterium lactis, bifidobacterium adolescentis, lactobacillus acidophilus, lactobacillus rhamnosus, lactobacillus casei and lactobacillus plantarum based on viable count ratio of 1-100: 1-100: 5-150: 1-50: 3-80: 1-200. According to the traditional Chinese medicine probiotics compound for conditioning insomnia and depression, medicinal and edible traditional Chinese medicineextracts and the probiotics compound are used as raw materials; the traditional Chinese medicines and probiotics are in reasonable compatibility and play coordination and promotion functions; the testverifies that the traditional Chinese medicines and probiotics are coordinated with each other, and the medicines are superior to that of a traditional Chinese medicine composition; the shortages oflong use time and side effect of independent use are overcome; and the application of probiotics in traditional Chinese medicine is further improved.

Description

technical field [0001] The invention belongs to the fields of health food and medicine, and in particular relates to a traditional Chinese medicine probiotic compound for regulating insomnia and depression. Background technique [0002] Insomnia is the most common type of sleep disorder clinically, and it usually refers to a subjective experience that patients are not satisfied with sleep time and (or) quality and affect daytime social function. Insomnia is characterized by difficulty falling asleep (time to fall asleep for more than 30 minutes), sleep maintenance disturbance (wakes ≥ 2 times throughout the night), early awakening, decreased sleep quality, and decreased total sleep time (usually less than 6 hours), accompanied by daytime dysfunction . [0003] Epidemiological survey results show that the prevalence of chronic insomnia is between 6% and 30%. According to the survey results released by the Chinese Sleep Research Association, the incidence of insomnia among C...

Claims

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Application Information

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IPC IPC(8): A61K36/8967A61P25/20A61P25/24A61K35/747A61K35/745
CPCA61K35/745A61K35/747A61K36/076A61K36/484A61K36/725A61K36/736A61K36/744A61K36/752A61K36/77A61K36/8967A61K2236/19A61K2236/331A61K2236/39A61K2236/51A61P25/20A61P25/24A61K2300/00
Inventor 单宝龙张建梅樊梅娜程秀芳陈甜甜党兰庆刘红孙尹双白冬红
Owner 山东神农医院管理有限公司
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