A traditional Chinese medicine probiotic compound for regulating insomnia and depression

A technology of probiotics and complexes, which is applied in the field of medicines and health food, can solve problems such as drug side effects and psychological pressure of patients, achieve excellent drug efficacy, improve sleep and insomnia, and overcome the effects of long medication time

Active Publication Date: 2021-06-08
山东神农医院管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term use of traditional Chinese medicine will cause psychological stress and side effects of the drug, and the taste of traditional Chinese medicine is unacceptable to many people. Therefore, it is necessary to provide an edible product that can regulate insomnia and depression

Method used

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  • A traditional Chinese medicine probiotic compound for regulating insomnia and depression
  • A traditional Chinese medicine probiotic compound for regulating insomnia and depression
  • A traditional Chinese medicine probiotic compound for regulating insomnia and depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1: Preparation of a probiotic composition for regulating insomnia and depression

[0038] (1) Preparation of active probiotic dry powder

[0039] 1) Inoculate Bifidobacterium lactis, Bifidobacterium adolescentis, Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus casei and Lactobacillus plantarum into the fermentation medium after being activated in the culture medium, and shake culture to make the bacteria The body concentration reaches the logarithmic growth phase of 0.5-2×10 9 CFU / mL.

[0040] Fermentation of bifidobacteria: Take out the strain preservation tube, scratch the plate with bifidobacteria solid medium for recovery, and culture anaerobically at 37°C for 48-72 hours. Pick a single colony under the plate to inoculate 50 ml of bifidobacterium medium, and cultivate it in an anaerobic incubator for 48 hours. The seeds are inoculated into a 3L large triangular flask (filling volume is 2.5L) with an inoculum amount of 3%, oil-sealed with...

Embodiment 2

[0050] Example 2: Preparation of a probiotic composition for regulating insomnia and depression

[0051] The difference with Example 1 is that Bifidobacterium lactis, Bifidobacterium adolescentis, Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus casei and Lactobacillus plantarum are by viable count 100:100:150:50:80: 200 for batching, in which the number of live bacteria of each probiotic is 1×10 respectively 9 CFU / g, 1×10 9 CFU / g, 1.5×10 9 CFU / g, 5×10 8 CFU / g, 8×10 8 CFU / g and 2×10 9 CFU / g; Others are similar to Example 1, named as Product 2.

Embodiment 3

[0052] Example 3: Preparation of a probiotic composition for regulating insomnia and depression

[0053] The difference with Example 1 is that Bifidobacterium lactis, Bifidobacterium adolescentis, Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus casei and Lactobacillus plantarum are by viable count 1:1:5:1:3: 1 for batching, wherein the number of live bacteria of each probiotic is 1×10 respectively 7 CFU / g, 1×10 7 CFU / g, 5×10 7 CFU / g, 1×10 7 CFU / g, 3×10 7 CFU / g and 1×10 7 CFU / g; Others are similar to Example 1, named as Product 3.

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PUM

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Abstract

The invention belongs to the fields of health food and medicine, and in particular relates to a traditional Chinese medicine probiotic compound for regulating insomnia and depression. The probiotic composition is composed of Bifidobacterium lactis, Bifidobacterium adolescentis, Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus casei and Lactobacillus plantarum according to the number of live bacteria 1-100:1-100:5-150 :1‑50:3‑80:1‑200. The traditional Chinese medicine probiotic compound preparation with the functions of regulating insomnia and antidepressant provided by the present invention uses Chinese medicine extract and probiotic composition of the same medicine and food as raw materials, and through reasonable compatibility of Chinese medicine and probiotics, the two play a synergistic promotion effect . It is verified by experiments that the combination of the two has synergistic effect, and the drug effect is better than that of the traditional Chinese medicine composition used alone, which overcomes the shortcomings of long medication time and side effects of the traditional Chinese medicine alone; the invention further enriches the application of probiotics in traditional Chinese medicine.

Description

technical field [0001] The invention belongs to the fields of health food and medicine, and in particular relates to a traditional Chinese medicine probiotic compound for regulating insomnia and depression. Background technique [0002] Insomnia is the most common type of sleep disorder clinically, and it usually refers to a subjective experience that patients are not satisfied with sleep time and (or) quality and affect daytime social function. Insomnia is characterized by difficulty falling asleep (time to fall asleep for more than 30 minutes), sleep maintenance disturbance (wakes ≥ 2 times throughout the night), early awakening, decreased sleep quality, and decreased total sleep time (usually less than 6 hours), accompanied by daytime dysfunction . [0003] Epidemiological survey results show that the prevalence of chronic insomnia is between 6% and 30%. According to the survey results released by the Chinese Sleep Research Association, the incidence of insomnia among C...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8967A61P25/20A61P25/24A61K35/747A61K35/745
CPCA61K35/745A61K35/747A61K36/076A61K36/484A61K36/725A61K36/736A61K36/744A61K36/752A61K36/77A61K36/8967A61K2236/19A61K2236/331A61K2236/39A61K2236/51A61P25/20A61P25/24A61K2300/00
Inventor 单宝龙张建梅樊梅娜程秀芳陈甜甜党兰庆刘红孙尹双白冬红
Owner 山东神农医院管理有限公司
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