23 results about "Bifidobacterium infantis" patented technology

The invention discloses bifidobacterium longum subsp.infantis capable of promoting bone growth and a metagen thereof, and belongs to the technical field of biology. The bifidobacterium longum subsp. Infantis CCFM1445 provided by the invention can promote the increase of bone volume fraction, femoral bone trabecula thickness and far-end growth plate thickness of mammals in a growth period, reduce the levels of serum bone resorption markers I-type collagen amino-terminal peptide and tartrate-resistant acid phosphatase, improve the levels of serum bone alkaline phosphatase and parathyroid hormone, and improve the clinical application value of the bifidobacterium longum subsp. Infantis CCFM1445. And the relative abundance of the other bacteria in the intestinal flora and the levels of creatine and indole-3-lactic acid are increased. The thermally inactivated bifidobacterium longum subsp. Infantis CCFM1445 can promote the increase of the volume fraction of femoral bones and the number of bone trabecula of malnourished mice and improve the N-terminal propeptide level of serum I-type procollagen. Therefore, the medicine or health care product prepared from the bifidobacterium longum subsp. Infantis CCFM1445 can be used for assisting in regulating bone metabolism and bone mass, and has a wide market prospect.

The invention discloses a novel bifidobacterium infantis strain and application of extracellular products of the novel bifidobacterium infantis strain in delaying skin aging and regulating skin micro-ecology, and bifidobacterium infantis is bifidobacterium infantis BSJM24L007 which is preserved in the China General Microbiological Culture Collection Center (CGMCC for short) and has the preservation number of CGMCC No.33258. The invention further discloses a preparation method of the novel bifidobacterium infantis strain and the application of the extracellular products of the novel bifidobacterium infantis strain. The bifidobacterium infantis extracellular product prepared by the invention has an ideal effect of delaying skin aging, enables the skin to be more compact and elastic, reduces the generation of wrinkles and maintains normal metabolism of the skin, has relatively high safety, can effectively reduce the skin infection problem caused by staphylococcus aureus and propionibacterium acnes, and has a good application prospect. Skin infection and inflammation are reduced, skin health is promoted, and skin micro-ecological balance is maintained. The requirements of a modern skin external preparation on functionality and safety are met.

The present invention provides a composition for use in the prevention and / or treatment of a viral infection in an individual wherein the composition comprises Bifidobacterium longum subsp. Infantis and a mixture of HMO consisting of 2 '-fucosyllactose (2FL), difucosyllactose (DFL), lactose-N-tetraose (LNT), 6'-sialyllactose (6SL), 3 '-sialyllactose (3SL), and 3-fucosyllactose (3FL). The present invention also provides compositions for use in preventing and / or reducing the risk of allergen sensitization, preventing and / or reducing the risk of developing respiratory disorders in an individual, and / or preventing and / or reducing the risk of developing asthma in an individual.

A method of treating, preventing or ameliorating at least one symptom of obsessive compulsive disorder (OCD) in a subject is disclosed. The method comprises a step in which a multistrain probiotic formulation is administered to the subject. The multistrain probiotic formulation includes the bacterial strains Bacillus coagulans, Lactobacillus rhamnosus, Bifidobacterium lactis, Lactobacillus plantarum, Bifidobacterium breve and Bifidobacterium infantis and Glutamine in a concentration range of 100-500 mg.

The current disclosure provides compositions comprisingBifidobacterium longum subspecies infantis (B. infantis) strains with enhanced ability to uptake or utilize N-glycan and plant-based polysaccharides, and methods of using these compositions.

A novel Bifidobacterium longum subsp. infantis DS2696 strain according to the present invention and a composition comprising same can be usefully employed for preventing or treating liver diseases.

The invention provides a post-medical repair application of fermented artemisia apiacea oil. The fermented artemisia apiacea oil is prepared by the following steps: (a) carrying out supercritical CO2 extraction on artemisia apiacea medicinal materials; (b) fermenting, namely fermenting by adopting bifidus yeast; (c) separating to obtain fermented artemisia apiacea oil; wherein the bifidobacterium is selected from bifidobacterium adolescentis, bifidobacterium animalis subspecies, bifidobacterium animalis subspecies lactis, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium longum subspecies longum or bifidobacterium longum subspecies infantis. The medical art is caused by dot matrix laser. The invention also relates to an application of the fermented artemisia apiacea oil in preparation of an external skin preparation with a post-medical repair effect.

Provided in the present application are a composite Bifidobacterium preparation and the use thereof in yogurt fermentation. The strains in the composite Bifidobacterium preparation consist of Bifidobacterium animalis subsp. lactis strain BLa36, Bifidobacterium longum strain BL21, Bifidobacterium breve strain BBr60, Bifidobacterium adolescentis strain BAC30, and Bifidobacterium infantis strain Bl45. In the present application, the five specific types of different Bifidobacterium strains are compounded. There are potential interactions between the five strains, enabling the strains to cooperate with each other and produce synergistic effects in terms of enhancing the gastric juice tolerance of the strains and improving the overall survival rate of fermentation strains. When used in combination with a basic fermentation strain for yogurt fermentation, the composite Bifidobacterium preparation can significantly improve the acid tolerance of lactic acid bacteria in yogurt, thereby leading to a substantial increase in the number of live bacteria that enter the human intestinal tract and exert functions therein. Furthermore, the composite Bifidobacterium preparation can significantly promote intestinal peristalsis and gastric motility, ameliorate imbalances in intestinal flora, and promote intestinal health.

The present invention provides a composition for use in the prevention and / or treatment of a viral infection in an individual wherein the composition comprises a mixture of Bifidobacterium longum subsp. Infantis and HMO, the HMO mixture consists of 2 '-fucosyllactose (2FL), difucosyllactose (DFL), lactose-N-tetraose (LNT), 6'-sialyllactose (6SL), 3 '-sialyllactose (3SL), and lactose-N-neotetraose (LNnT), and optionally, 3-fucosyllactose (3FL). The present invention also provides compositions for use in preventing and / or reducing the risk of allergen sensitization, preventing and / or reducing the risk of developing respiratory disorders in an individual, and / or preventing and / or reducing the risk of developing asthma in an individual.

The application discloses a kind of 7 kinds of composition containing probiotic and its preparation method of drinkable yoghurt, belong to microbial fermentation technical field.Composition includes the combination of 2 kinds of lactic acid bacteria and 7 kinds of probiotic, lactic acid bacteria is the combination of lactococcus lactis subsp cremoris and lactococcus lactis subsp lactis;Probiotic is the combination of lactobacillus bulgaricus, streptococcus thermophilus, bifidobacterium lactis, lactobacillus acidophilus, paracasei, lactobacillus rhamnosus and bifidobacterium infantis.The composition can provide the required probiotic for children, young people, old people respectively, and in the new preparation method developed additionally, through the combination of lactic acid bacteria and probiotic, lactase pretreatment and two-step inoculation fermentation process in fermentation stage, twice post-ripening process can effectively guarantee the acidity of composition fermentation moderate, improve the stability of composition system and taste.The overall additive of the obtained product is zero addition and the flavor is excellent and high stability.

The present invention relates to a combination and nutritional composition comprising fucosylated human milk oligosaccharides, i.e., lactose-N-fucopentasaccharide-I (LNFP-I), as the most abundant human milk oligosaccharide in the combination or the nutritional composition, and Bifidobacterium longum subsp. Infantis (Bifidobacterium infantis). The combination and the nutritional composition are useful for treating, preventing and / or inhibiting the growth of intestinal pathogens, in particular in infants.

The invention relates to a new composite formed with Prebiotic xylooligosaccharide, Probiotic Bifidobacterium Infantis and Postbiotic Sodium Alginate and Chitre, Bicarbonate, Glycerol, a powder form composite with unique properties and applications, after the production of probiotic bacteria-based food packaging, the extracellular membrane vesicles of the bacteria in the biofilm in solid form turning into live probiotic bacteria after the biofilm is dissolved in water.

The invention relates to a synbiotics for improving growth performance of weaned piglets and application thereof. The synbiotics comprise the following components: a) a probiotic component: bacterial powder of Bifidobacterium infantis B.infantis-zju (the preservation number is CCTCC NO: 20251039), the bacterial powder is prepared by culturing the bacterial strain in a TPY culture medium under anaerobic conditions, concentrating, freeze-drying and adding maltodextrin; and b) a prebiotic component: 3 '-sialylated milk oligosaccharide (3'-SL) with the purity of more than 95%, and the addition amount of the prebiotic component in the daily ration is 5g / kg. The synbiotics provided by the invention can significantly reduce the diarrhea rate of piglets after weaning, significantly improve the average daily gain of pigs in the nursing period, and reduce the feed-to-weight ratio. In addition, the synbiotics can also significantly reduce the level of proinflammatory factors in the serum of the weaned piglets and significantly improve the level of anti-inflammatory factors in the serum of the weaned piglets, which prompts that the synbiotics can reduce the level of intestinal inflammation and improve intestinal health, and has a great application prospect in healthy breeding of live pigs.

The invention belongs to the technical field of microorganisms, and particularly discloses a composition for promoting proliferation of bifidobacterium longum subsp. Infantis i18 and application of the composition. Compared with bifidobacteria such as bifidobacterium breve, bifidobacterium animalis or bifidobacterium longum, the bifidobacterium bifidum i771 has the advantages that the bifidobacterium bifidum i771 is found to be capable of remarkably promoting the proliferation of bifidobacterium infantis i18, so that the composition containing the bifidobacterium bifidum i771 for promoting the proliferation of the bifidobacterium longum subsp.infantis i18 is provided on the basis of the bifidobacterium bifidum i771. Through optimization of the carbon source, the composition with the function of regulating intestinal flora is provided. In the composition, the target strain, the symbiotic strain and the specific carbon source have a remarkable synergistic effect, rapid starting, continuous proliferation and stable maintenance of the target strain can be achieved, the relative abundance of bifidobacterium flora in intestinal tracts is obviously improved, and the intestinal flora structure is promoted to develop towards the healthy direction. The product is suitable for regulating intestinal micro-ecology, and is especially suitable for infants.

The invention belongs to the technical field of microorganisms and nutriology, and discloses bifidobacterium longum subsp.infantis CICC 6069 for promoting calcium absorption and application of a composition of the bifidobacterium longum subsp.infantis CICC 6069 and vitamin D in improvement of bone health. Cytology experiments and animal models verify that the strain can significantly promote absorption of intestinal epithelial cells to calcium ions and improve the serum calcium level and the calcium apparent absorption rate of calcium-deficient model animals; when the strain is combined with vitamin D, skeletal development (such as increasing bone length and improving bone mineral density) can be further remarkably promoted, and the synergistic effect is remarkably superior to that of single use of the strain. The invention provides an application of bifidobacterium longum infant subCICC 6069 in preparation of related products for promoting calcium absorption, and also provides a composition for promoting calcium absorption and / or improving bone health, and the composition comprises the strain and vitamin D. The invention further provides a preparation method of the bifidobacterium longum infant subCICC 6069 and a preparation method of the bifidobacterium longum infant subCICC 6069. The strain and the composition are suitable for preparing food, health food or medicine for promoting calcium absorption and improving bone health.

The present disclosure provides an integrated culture-freeze drying method for Bifidobacterium longum subsp. infantis B8762, which belongs to the field of biotechnology. The method includes: activating a strain in a carbon-source-free modified MRS culture medium and inoculating the activated strain into a fresh culture medium; adding one of D-lactose, D-sucrose or D-maltose; monitoring a growth curve, and building kinetic models in combination with metabolite analysis; collecting bacterial sludge after culture to a stationary phase, preparing a bacterial suspension, and testing a bacterial cell size, the number of growth generations, colony activity and a freeze-drying survival rate; and finally, performing vacuum freeze drying, and monitoring enzyme activity during storage. The method provided by the present disclosure can significantly improve the freeze-drying survival rate, delay attenuation of enzyme activity in a storage phase, and optimize growth and cell activity.

The invention belongs to the technical field of microbial fermentation, and discloses a method for fermenting a traditional Chinese medicine composition by polypeptide-induced bifidobacterium infantis, which comprises the following specific steps: step 1, preparing raw materials: selecting healthy and disease-free fructus alpiniae oxyphyllae, rhizoma acori graminei, uncaria rhynchophylla and pericarpium citri reticulatae, weighing 45g of fructus alpiniae oxyphyllae, 25g of rhizoma acori graminei, 15g of uncaria rhynchophylla and 15g of pericarpium citri reticulatae by using an electronic scale, after the weighing is finished, adding a proper amount of water, and uniformly mixing; putting the fructus alpiniae oxyphyllae, the rhizoma acori graminei, the uncaria rhynchophylla and the The activity of the probiotics is enhanced through polypeptide induction, metabolite is newly added in a fermentation product, the pathogenesis of phlegm stasis blocking orifices, heart-spleen deficiency and the like can be improved in a targeted mode, and it is clinically shown that the core symptoms of sick children are obviously improved; traditional Chinese medicine macromolecular components are degraded in the fermentation process, the effective component absorption efficiency is improved, and the problem that traditional Chinese medicine takes effect slowly is solved; the infant homologous probiotics and the medicine and food homologous traditional Chinese medicines are adopted, the intestinal administration route conforms to the physiological characteristics of children, and no side effect exists; compared with long-term rehabilitation treatment, the fermentation preparation is low in preparation cost.

The invention relates to the technical field of medicine preparation, in particular to a traditional Chinese medicine fermentation preparation for resisting porcine epidemic diarrhea virus and a preparation method thereof. The traditional Chinese medicine fermentation preparation for resisting the porcine epidemic diarrhea virus comprises traditional Chinese medicine raw materials and flora raw materials, the traditional Chinese medicine raw materials comprise liquorice, radix bupleuri, rhizoma atractylodis, radix puerariae, dandelion, purslane, semen armeniacae amarae, poria cocos, ligusticum wallichii and houttuynia cordata; the flora raw materials comprise bifidobacterium longum, lactobacillus acidophilus, bifidobacterium infantis and lactobacillus rhamnosus. The traditional Chinese medicine fermentation preparation for resisting the porcine epidemic diarrhea virus provided by the invention can effectively control the replication of the porcine epidemic diarrhea virus, protect effective microbial communities in the intestinal tract of a pig and repair the intestinal environment, so that the symptoms such as diarrhea, vomiting or dehydration of the pig are relieved. Moreover, the traditional Chinese medicine fermentation preparation for resisting the porcine epidemic diarrhea virus, provided by the invention, can weaken the transmission of the porcine epidemic diarrhea virus among pigs and reduce the overall disease risk of a swinery.

In particular, this invention refers to a composition comprising a probiotic combination comprising: a) at least one strain of the genus Lactobacillus selected from the species Lactobacillus plantarum; and c) at least one strain belonging to the genus Bifidobacterium selected from the species Bifidobacterium lactis, Bifidobacterium longum, Bifidobacterium infantis; wherein said composition is for use in a method for the prevention and / or treatment of chronic inflammatory bowel disease (Inflammatory Bowel Disease IBD).

We disclose a biochemical compound comprising CpG moieties derived from human commensal bacteria that exhibit the ability to suppress immune system responses in patients that suffer from autoimmune and allergic diseases arising from overactive immune systems. We outline several methods for use of the compound in the treatment of individuals suffering from various types of auto-immune and related diseases.

To provide a novel bacterium belonging to Bifidobacterium longum subsp. infantis. Provided is a bacterium belonging to Bifidobacterium longum subsp. infantis, which has an ability to assimilate human breast milk oligosaccharides and xylooligosaccharides and does not have a drug resistance gene.

Provided are a Bifidobacterium longum subsp. infantis for alleviating Parkinson's disease and a use thereof, and the Bifidobacterium longum subsp. infantis for alleviating Parkinson's disease is named as Bifidobacterium longum subsp. infantis BI03 strain, with a deposit number of CGMCC No. 24473 and deposit date of Mar. 7, 2022. The strain can significantly alleviate the symptoms of Parkinson's disease, specifically manifested in: alleviating Parkinson's disease-related dyskinesia and corticosterone elevation; weakening the neuroinflammation associated with Parkinson's disease; promoting glutathione and weakening brain oxidative stress damage.