Probiotics and prebiotics for preventing and treating foetid faeces and foetid faeces poisoning syndrome and the composition preparations thereof

A technology of probiotics and prebiotics, which can be used in drug combinations, non-central analgesics, carbohydrate active ingredients, etc., can solve problems such as not many and insufficient awareness of harm

Active Publication Date: 2008-01-02
QINGDAO EASTSEA PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But because people are not enough to the hazard understanding of fecal odor and fecal odor poisoning syndrome, scientific worker is also few to this aspect research, for this reason, the purpose of the present inventor will be exactly in micro-ecological innovative drug research, develops Probiotics, prebiotics, or a combination of probiotics and prebiotics for the prevention or treatment of fecal odor and fecal odor poisoning syndrome, this patent is hereby applied for

Method used

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  • Probiotics and prebiotics for preventing and treating foetid faeces and foetid faeces poisoning syndrome and the composition preparations thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1 Bacillus coagulans and Clostridium butyricum live bacteria are on the impact of ammonia and amine content in mouse feces

[0033] Method: 50 ICR purebred mice were divided into 5 groups, 10 mice in each group, and 10 live bacteria of Bacillus coagulans and Clostridium butyricum were used respectively. 9 cfu, 10 8 cfu / ml and physiological sodium chloride solution, 0.5ml / only, ig, once a day for a total of 21 days. The day before the end of the experiment, divide the mice into cages, one in each cage, take an equal amount of feces from each mouse, soak them in normal saline, then centrifuge to get the supernatant, and measure the amine value (μg / g) in the feces by titration . After the mice were sacrificed, the cecum was weighed, cut open in saline, and the contents were mixed well, then centrifuged to obtain the supernatant, and the ammonia value (μg / g) in the contents was determined with a corresponding kit.

[0034] Results Both Bacillus coagulans and C...

Embodiment 2

[0041] Example 2 Effects of Bacillus coagulans Live Bacteria Tablets and Clostridium Butyricum Capsules on Indole and Skatole Content in Human Feces

[0042] Methods HP-6890 gas chromatograph was used to determine the content of indole and skatole in the feces of 16 volunteers with informed consent. That is, take 0.5g of fresh feces and accurately weigh it, put it in a 50ml Erlenmeyer flask, add 20ml of ethanol for ultrasonic extraction for 20 minutes, filter, add 3ml of internal standard solution (0.1% p-Isopropylphenol), dilute to a 25ml measuring bottle, and measure 4 μl of the solution was injected into a chromatographic column (HP-INNO WAX glass capillary column, 30m×0.53mm, filled with 17% Silicone SE-30) for analysis. The measurement conditions are: column temperature: 200°C; inlet temperature: 230°C, detector temperature: 260°C, carrier gas flow rate N 2 90m1 / min; H2 Flow: 58ml / min; air flow: 60ml / min.

[0043] 16 volunteers, 6 males and 10 females, aged 25-55 years,...

Embodiment 3

[0048] Example 3 Effects of Bacillus coagulans Live Bacteria Tablets on the Odor and Shape of Human Feces, etc.

[0049] Methods In the case of informed consent, 42 volunteers, 20 males and 22 females, aged 20-30 years old, maintained a normal diet and took live Bacillus coagulans tablets after meals, 3 tablets each time, 3 times a day, for 7 days in a row. sky. During the period of taking the medicine, observe the shape of the stool (normal-banana shape, strip shape, abnormal-chestnut shape, lumpy shape, muddy shape), hardness (normal-soft, abnormal-slightly hard, dry, hard), color ( Normal-yellow, light yellow-brown, yellow-colored, abnormal-dark brown, black, gray) and smell of stool (normal-smelling, abnormal-smell, very smelly, foul smell) and other conditions, Then count the test results.

[0050] Results The odor, shape, hardness, color and certain symptoms of the gastrointestinal tract of the volunteers after taking the medicine were significantly improved compared w...

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Abstract

The invention discloses the syndrome of diarrhea with loose and fetid stools caused by harmful bacteria in intestine, especially relates to a kind of probiotics and prebiotics used for treating said syndrome and the compound product. Said probiotics comprises bacillus coagulans, butanoic acid clostridial vaccine, infant bifidobacteria, young bifidobacteria, long bifidobacteria, Bifidobacterium bifidum and bacillus subtilis, and etc. The prebiotics can be soybean oligosaccharide and other oligosaccharides. The probiotics and prebiotics and their compound can be taken orally, and they can remove indole, scatal, sulfur, amino and amine from intestinal canal.

Description

technical field [0001] The present invention relates to stool odor and fecal odor poisoning syndrome caused by intestinal harmful bacteria producing fecal odor toxin, including its related symptoms and related diseases, especially the method also includes administering an effective amount of the present invention to the selected object. Defined probiotics, prebiotics for preventing and treating fecal odor and fecal odor toxic syndrome and composition preparation thereof. Background technique [0002] Smelly stool and toxic stool syndrome There are 6.5 billion people in the world, everyone eats every day, and the food they eat is digested in the stomach and small intestine, mainly due to the action of various digestive enzymes, which convert food into what the human body needs Nutrition. The colon does not produce digestive enzymes, and the remaining food that enters the colon is digested by bacteria. There are a variety of bacteria in the colon, both beneficial and harmful...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/74A61P1/00A61P3/06A61P3/10A61P9/12A61P25/20A61P25/00A61P11/00A61P13/00A61P15/02A61P15/12A61P17/00A61P29/00A61K35/742A61K35/745
CPCA61K35/745A61K35/742A61K35/74A61K31/70A61P1/00A61P3/06A61P3/10A61P9/12A61P11/00A61P13/00A61P15/02A61P15/12A61P17/00A61P25/00A61P25/20A61P29/00Y02A50/30A61K2300/00
Inventor 崔云龙
Owner QINGDAO EASTSEA PHARMA
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