Preparation method of composite probiotic agent for preventing and treating diabetes and controlling body weight

A compound probiotics, weight control technology, applied in the direction of biochemical equipment and methods, microorganism-based methods, bacteria, etc., can solve problems such as restricting the use of metformin

Inactive Publication Date: 2016-11-23
FOSHAN YANHUI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The effect of treating obese diabetes is very good. Because of its wide clinical application, the common adverse reactions of metformin are gastrointestinal discomfort, such as

Method used

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  • Preparation method of composite probiotic agent for preventing and treating diabetes and controlling body weight
  • Preparation method of composite probiotic agent for preventing and treating diabetes and controlling body weight
  • Preparation method of composite probiotic agent for preventing and treating diabetes and controlling body weight

Examples

Experimental program
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Effect test

Embodiment 1

[0043]A compound probiotic preparation for preventing and treating diabetes and controlling body weight, characterized in that: the compound probiotic components and the proportions by weight are: 15 parts of 1 billion CFU / g Clostridium butyricum, 1 billion CFU / g cloth 20 parts of Saccharomyces lazii, 10 parts of Lactobacillus reuteri 5 billion CFU / g, 15 parts of Bifidobacterium infantis 1 billion CFU / g, 15 parts of Bacillus licheniformis 10 billion CFU / g, 10 parts of metformin, 15 parts of arabinose 10 parts, 10 parts of xylo-oligosaccharide, 15 parts of soluble starch; the preparation process includes: sequentially adding 15 parts of 1 billion CFU / g Clostridium butyricum and 20 parts of 1 billion CFU / g Saccharomyces boulardii in a sterile stirring tank 10 parts of 5 billion CFU / g Lactobacillus reuteri, 15 parts of 1 billion CFU / g Bifidobacterium infantis, 15 parts of 10 billion CFU / g Bacillus licheniformis, 15 parts of soluble starch and stir for 30 minutes; then add 10 part...

Embodiment 2

[0058] The test was carried out on 120 cases of type 2 obese diabetic patients, all of which met the WHO diagnostic criteria and met the following conditions: first diagnosis or no treatment for less than half a year after diagnosis and fasting blood glucose ≥ 11.1mmol / L; no serious acute or chronic complications.

[0059] treatment method

[0060] 120 eligible patients were divided into two groups according to the degree of obesity and the severity of diabetes.

[0061] Control group: combined with metformin on the basis of diabetes health knowledge education and diet therapy, metformin 0.5g each time, twice a day.

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Abstract

The invention discloses a preparation method of a composite probiotic agent for preventing and treating diabetes and controlling body weight, in particular to a composite probiotic agent formed by compounding probiotics, prebiotics and metformin and used for preventing and treating diabetes and controlling body weight and a preparation method of the composite probiotic agent. Beneficial bacteria such as clostridium butyricum, saccharomyces boulardii, lactobacillus reuteri, bifidobacterium infantis, bacillus licheniformis and the like, the prebiotics such as arabinose and xylooligosaccharide, and metformin are combined to avoid symptoms such as nausea, emesis, diarrhea, abdominal pain, constipation, abdominal distention, dyspepsia, heartburn and the irritable bowel syndrome which are caused by the metformin, the curative effect is good, glucose metabolism is accelerated by directly absorbing and utilizing glucose, and effects of controlling body weight and treating the diabetes are improved. In the aspect of improving adverse effects of the metformin drug to a gastrointestinal tract, the effect of the composite probiotic agent is higher than that of the metformin which is applied purely.

Description

technical field [0001] The invention belongs to the technical field of probiotic biomedicine and health care products, and in particular relates to a preparation method of a compound probiotic preparation for preventing and treating diabetes and controlling body weight. Background technique [0002] Diabetes is the second killer of modern diseases, and its harm to the human body is second only to cancer. In fact, diabetes itself is not terrible, what is terrible is the complications of diabetes, almost all the harm caused by diabetes comes from its complications. Among the diabetic patients in our country, there are as many as 12 million with high blood pressure, 5 million with stroke, 6 million with coronary heart disease, 450,000 with blindness, and 500,000 with uremia. [0003] Diabetes mellitus is a complex disease of multiple etiology. It is a syndrome of glucose, protein and lipid metabolism disorders caused by the lack of insulin in the body or the increase of hormon...

Claims

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Application Information

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IPC IPC(8): A61K36/064A61K47/26A61K47/36A61P3/10A61P3/04A61P1/16A61P37/04C12N1/16C12N1/20A61K35/742A61K35/747A61K35/745A61K31/155C12R1/645C12R1/145C12R1/10C12R1/01
CPCA61K36/064A61K31/155A61K35/742A61K35/745A61K35/747A61K47/26A61K47/36C12N1/16C12N1/20A61K2300/00
Inventor 蒋常德胡艳晖
Owner FOSHAN YANHUI BIOTECH CO LTD
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