Traditional Chinese medicine composition, traditional Chinese medicine preparation, traditional Chinese medicine patch for reducing swelling, resolving masses, unblocking nose and opening orifice, preparation method and application

Abstract

The application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for eliminating swelling and resolving nodes, a traditional Chinese medicine preparation, a traditional Chinese medicine patch, a preparation method and application, and the traditional Chinese medicine composition for eliminating swelling and resolving nodes, which is characterized by comprising the following components by weight: asarum 0.5-1.2 parts; white radish seed 0.5-1.2 parts; baizhi 0.5-1.2 parts; turtle 1.5-3.6 parts; and Sichuan fuzi 0.5-1.2 parts. The application can effectively prevent and / or treat adenoid hypertrophy in children, and has simple drug components, low side effects and high safety and reliability.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine technology, and in particular relates to a traditional Chinese medicine composition, preparation, patch, preparation method and application for reducing swelling and dissipating nodules and clearing the nasal passages. Background Technology

[0002] Adenoid hypertrophy typically manifests as nasal congestion, a muffled nasal voice, snoring during sleep, and, in severe cases, sleep apnea. It often leads to secretory otitis media, resulting in tinnitus and hearing loss. If left untreated for a long time, it can develop into adenoid facies. The occurrence of adenoid hypertrophy is related to repeated inflammatory stimulation, such as repeated episodes of acute and chronic rhinitis, tonsillitis, and influenza, which cause pathological hyperplasia of the adenoids. In addition, allergic reactions, endocrine disorders, and malnutrition can also lead to adenoid hypertrophy.

[0003] Currently, treatments for adenoid hypertrophy typically include general treatment, Western medicine treatment, surgical treatment, radiation therapy, and traditional Chinese medicine treatment. Among these:

[0004] In terms of general treatment, if patients with adenoid hypertrophy do not experience obvious discomfort symptoms and the condition is relatively mild, special treatment is usually not required. They should pay attention to a light diet and eat more fruits and vegetables rich in dietary fiber, such as apples and spinach, to supplement the nutrients needed by the body.

[0005] In terms of Western medicine treatment, if a patient experiences nasal congestion, they can use medications such as oxymetazoline hydrochloride nasal drops or xylometazoline hydrochloride nasal drops under the guidance of a doctor to effectively control the disease. If an infection occurs, antibiotics such as cefixime granules or amoxicillin granules can be used as prescribed by a doctor.

[0006] In terms of surgical treatment, if the patient's condition is more serious and there is adenoid hypertrophy, accompanied by symptoms such as sore throat and difficulty swallowing, adenoidectomy and other related surgeries can be performed to effectively control the disease.

[0007] In terms of radiotherapy, it is suitable for patients who are unwilling or unsuitable for surgery. High-temperature rays can be used to kill adenoid tissue, thereby achieving the purpose of treatment.

[0008] In Traditional Chinese Medicine (TCM) treatment, adenoid hypertrophy is considered to be caused by insufficient vital energy (Qi) and weakened defensive Qi, allowing pathogenic factors to invade and cause lung Qi to rise abnormally, leading to nasal congestion and mouth breathing. Patients can undergo acupuncture treatment under the guidance of a doctor, selecting acupoints such as Tian Tu (CV22), Da Zhui (GV14), and Qu Chi (LI11), which can dispel wind, release the exterior, and clear the nasal passages. Oral herbal decoctions, based on syndrome differentiation and treatment, employ formulas to dispel wind, invigorate blood circulation, clear the nasal passages, reduce swelling, and dissipate nodules. Examples include Yin Qiao San (Honeysuckle and Forsythia Powder) for wind-evil invading the lungs, Er Chen Tang (Two-Ingredient Decoction) for phlegm obstructing the nasal passages, and Tong Qiao Huo Xue Tang (Blood Stasis and Nourishing Blood Decoction) for blood stasis obstructing the nasal passages.

[0009] The above-mentioned general treatment methods are not very effective and are prone to further development of the disease. Western medicine and radiotherapy have significant toxic side effects, and surgical treatment causes great damage to the patient's body. Among the traditional Chinese medicine treatments, acupuncture and oral decoction are not easily accepted by children, resulting in poor efficacy.

[0010] In view of this, the present invention is hereby proposed. Summary of the Invention

[0011] In order to overcome the shortcomings of the existing technology, the present invention proposes a traditional Chinese medicine composition, preparation, patch, preparation method and application for reducing swelling and dissipating nodules and clearing the nasal passages.

[0012] The first aspect of this invention provides a traditional Chinese medicine composition for reducing swelling and lumps, and clearing nasal passages, the composition comprising the following traditional Chinese medicinal materials in parts by weight:

[0013]

[0014]

[0015] The detailed pharmacological effects of each of the above components are as follows:

[0016] Asarum: pungent and warm in nature, it enters the heart, lung, and kidney meridians. It relieves exterior syndromes and dispels cold, eliminates wind and relieves pain, clears the orifices, warms the lungs and resolves phlegm. It is used for common cold due to wind-cold, headache, toothache, rheumatic pain, sinusitis, and cough due to lung cold.

[0017] Angelica dahurica: It has a pungent taste and warm nature, and enters the lung, spleen, and stomach meridians. It relieves exterior syndromes and dispels cold, dispels wind and relieves pain, clears nasal passages, dries dampness and stops leukorrhea, reduces swelling and drains pus, dispels wind and relieves itching. It is used for colds due to wind-cold, headaches, toothaches, rheumatic pain, sinusitis, leukorrhea, carbuncles and boils.

[0018] Chuanxiong (Ligusticum striatum): pungent and warm in nature, it enters the liver and gallbladder meridians. It promotes qi circulation, relieves stagnation, dispels wind and dampness, invigorates blood, and relieves pain. It treats wind-cold headaches and dizziness, hypochondriac pain and abdominal pain, cold-induced muscle spasms, amenorrhea, dystocia, postpartum blood stasis and pain, carbuncles and sores. It is also used for irregular menstruation, amenorrhea and dysmenorrhea, abdominal masses and pain, chest and hypochondriac pain, traumatic swelling and pain, headache, and rheumatic pain.

[0019] White mustard seed: It has a pungent taste and warm properties, and enters the lung meridian. It can resolve phlegm, promote qi circulation, disperse nodules, and reduce swelling. It is used for symptoms such as phlegm stagnation due to cold, chest fullness and hypochondriac pain, cough with shortness of breath and excessive phlegm.

[0020] Ao Jia: Salty in taste, slightly cold in nature, and enters the liver and kidney meridians. It nourishes yin and subdues yang, reduces fever and eliminates steaming heat, softens hardness and dissipates nodules. It is used for yin deficiency fever, bone steaming fever, yin deficiency with yang hyperactivity, dizziness, internal wind, amenorrhea, abdominal masses, chronic malaria, and malarial fever.

[0021] In summary, it can be seen that the traditional Chinese medicine composition of the present invention has sufficient theoretical support at the level of modern pharmacological research, and the traditional Chinese medicine composition of the present invention can have good therapeutic and / or preventive effects on pediatric adenoid hypertrophy.

[0022] The formula of the traditional Chinese medicine composition of the present invention is as follows:

[0023] Traditional Chinese medicine believes that adenoid hypertrophy typically manifests as nasal congestion, a muffled nasal voice, snoring during sleep, and, in severe cases, sleep apnea. It often leads to secretory otitis media, resulting in tinnitus and hearing loss. If left untreated for a long time, it can lead to adenoid facies. The occurrence of adenoid hypertrophy is related to repeated inflammatory stimulation, such as repeated episodes of acute and chronic rhinitis, tonsillitis, and influenza, causing pathological hyperplasia of the adenoids. In addition, allergic reactions, endocrine disorders, and malnutrition can also contribute to adenoid hypertrophy.

[0024] The main causes of adenoid hypertrophy in children include the following: (1) External wind-cold: refers to the influence of cold weather on the human body, which causes lung qi stagnation and leads to difficulty breathing; (2) Improper diet: such as eating too much raw, cold, or greasy food, which may lead to spleen and stomach dysfunction, accumulation of damp-heat evil that invades the head and face, and obstructs the clear orifices; (3) Spleen and lung qi deficiency: leads to poor blood circulation, and deficiency will cause the nine orifices to be obstructed; (4) Phlegm stagnation: due to long-term uncontrolled diet, damage to the spleen and stomach, leading to spleen dysfunction, water and dampness stagnation and phlegm stagnation, phlegm stagnation on the surface of the adenoids and obstructing the airway; (5) Intestinal food accumulation: Traditional Chinese medicine believes that most cases of adenoid hypertrophy in children are due to intestinal food accumulation. "Children's spleen is often deficient", the lung and large intestine are internally and externally related, and problems in the transmission of the large intestine can accumulate to the lungs, resulting in lung meridian stagnation and heat. The basic pathogenesis of the above-mentioned causes, including poor blood and qi circulation, water metabolism disorders, and phlegm stagnation, ultimately leads to proliferative changes in the adenoid tissue.

[0025] It is evident that the pathogenesis of adenoid hypertrophy is closely related to its etiology. The traditional Chinese medicine composition of this invention comprehensively and dialectically addresses adenoid hypertrophy. Through the rational combination of principal, assistant, adjuvant, and guide herbs, and based on the treatment principles of dispelling wind and releasing the exterior, resolving phlegm and dissipating nodules, and clearing the nasal passages, it achieves the effects of reducing swelling and dissipating nodules, clearing the nasal passages, and improving nasal ventilation.

[0026] This invention's treatment strategy for adenoid hypertrophy primarily focuses on resolving phlegm, clearing the orifices, promoting blood circulation, reducing swelling, and dissipating nodules to improve respiratory tract function. Asarum and white mustard seed are the principal herbs. Asarum, warming and invigorating, clears the nine orifices and resolves phlegm, while white mustard seed enhances its phlegm-resolving and nasal discharge-eliminating effects, reducing deposits on the glandular mucosa and increasing nasal airflow. Angelica dahurica is the assistant herb, effective in treating headaches and known as a plant-like musk; its aromatic and orifice-opening properties are rapid, guiding other herbs directly to the affected area. Turtle shell is the adjuvant herb, effectively reducing swelling and dissipating nodules, treating all types of masses and accumulations. Ligusticum chuanxiong is the guiding herb, a qi-regulating herb in the blood, assisting Angelica dahurica in relieving pain, promoting blood circulation, and regulating qi. Its significant blood-activating and swelling-reducing effects provide rapid relief for acute swelling of the glands. The above medications work synergistically to clear deposits on the gland surface, promote blood circulation to eliminate acute inflammation, and use aromatic substances to open the nasal passages, reduce swelling and dissipate nodules, and break down glandular tissue to improve nasal ventilation and resolve symptoms such as snoring, nasal congestion, sleep apnea, hypoxia, and headache.

[0027] Considering the pharmacopoeia's maximum dosage requirements for Asarum and the safety of medication in children, controlling the dosage of Asarum within the range of 0.5-1.2 parts by weight can maximize its effect of clearing the orifices within the safe dosage range for children. According to the experience of traditional "Sanfu Patch" formulation, a large dosage of white mustard seed can cause skin blistering. Therefore, the dosage of white mustard seed is controlled within the safe range of 0.5-1.2 parts by weight. In combination with the warming nature of Asarum, it is necessary to warm and transform cold phlegm while preventing excessive heat and signs of internal heat. Turtle shell is salty and cold, softening and dispersing hardness, while restraining the principal drug from being too drying. Therefore, the dosage of turtle shell is slightly higher than that of the principal drug. The chief herb, Angelica dahurica, is aromatic and has a strong effect in clearing the nasal passages, assisting the principal herb in strengthening its ability to clear the nasal passages and stop runny nose. However, its strong aroma can easily damage the Qi. The adjuvant herb, Ligusticum chuanxiong, is known as a Qi-regulating herb in the blood. Excessive dosage can prevent blood stasis and nosebleeds. A small amount can act as a boat to guide the medicine upward to the head and face, directly reaching the affected area. Based on the overall dosage control of the medicine pack and the inventor's many years of experience, the above-mentioned Chinese medicinal materials have been rationally formulated.

[0028] Furthermore, the traditional Chinese medicine composition comprises the following parts by weight of traditional Chinese medicinal materials:

[0029]

[0030] Furthermore, the traditional Chinese medicine composition comprises the following parts by weight of traditional Chinese medicinal materials:

[0031]

[0032]

[0033] Furthermore, the traditional Chinese medicine composition comprises the following parts by weight of traditional Chinese medicinal materials:

[0034]

[0035] The second aspect of this invention provides a traditional Chinese medicine preparation, which includes the traditional Chinese medicine composition for reducing swelling and dissipating nodules and clearing the nasal passages proposed in the first aspect of this invention, and the traditional Chinese medicine preparation is for external use.

[0036] Furthermore, the dosage form of the traditional Chinese medicine preparation is either a paste or a powder. During use, the paste can be applied directly to the Dazhui (GV14) and Feishu (BL13) acupoints, or the powder can be made into a medicated pack and applied to the Dazhui and Feishu acupoints. In practical applications, the dosage form of the traditional Chinese medicine can be flexibly selected based on a comprehensive consideration of the method of administration, application location, and efficacy.

[0037] The third aspect of the present invention provides a traditional Chinese medicine patch, which includes a carrier and the traditional Chinese medicine composition for reducing swelling and dissipating nodules and clearing nasal passages proposed in the first aspect of the present invention.

[0038] Furthermore, the herbal patch also includes rice wine, and the ratio of the herbal composition to the rice wine is 1:1 to 2.

[0039] Optionally, the carrier may include nonwoven fabric, gauze, adhesive tape, adhesive plaster, or medical rubber.

[0040] The fourth aspect of this invention provides a method for preparing a traditional Chinese medicine patch, wherein the preparation method is applied to the traditional Chinese medicine patch proposed in the third aspect of this invention, and the preparation method includes:

[0041] Weigh out each Chinese medicinal herb according to its weight and mix them together;

[0042] The mixed Chinese medicinal materials are pulverized and passed through a 40-100 mesh sieve, preferably through an 80 mesh sieve, to obtain a powdered Chinese medicinal mixture;

[0043] Add excipients to a mixture of powdered Chinese medicine to prepare a dressing.

[0044] The dressing is placed on a carrier to obtain a patch. In practical applications, the dressing can be prepared into a medicated ball, then pressed into a cake shape, and finally the cake-shaped dressing is placed on a carrier to obtain a patch.

[0045] An optional method of using the herbal patch of the present invention is as follows:

[0046] Treatment course: Apply the patch continuously for two weeks, one patch per day, for two hours each time;

[0047] Administration method: External application to acupoints, applied to the Dazhui (GV14) and Feishu (BL13) acupoints.

[0048] The fifth aspect of this invention provides the application of the traditional Chinese medicine composition for reducing swelling and dissipating nodules and clearing nasal passages proposed in the first aspect of this invention, or the traditional Chinese medicine preparation proposed in the second aspect of this invention, or the traditional Chinese medicine patch proposed in the third aspect of this invention, in the preparation of a drug, wherein the drug is used to prevent and / or treat adenoid hypertrophy in children.

[0049] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0050] This invention provides a traditional Chinese medicine composition consisting of 0.5-1.2 parts by weight of Asarum, 0.5-1.2 parts by weight of Sinapis alba, 0.5-1.2 parts by weight of Angelica dahurica, 1.5-3.6 parts by weight of Scutellaria baicalensis and 0.5-1.2 parts by weight of Ligusticum chuanxiong. This traditional Chinese medicine composition can achieve significant efficacy in treating adenoid hypertrophy in children, and the drug components are simple, with low toxicity and side effects, and is safe and reliable. Detailed Implementation

[0051] The present invention will be further described below through specific embodiments, but this is not a limitation of the present invention. Those skilled in the art can make various modifications or improvements based on the basic idea of ​​the present invention, but as long as they do not depart from the basic idea of ​​the present invention, they are all within the scope of the present invention.

[0052] Example

[0053] Example 1

[0054] Select Chinese medicinal materials that meet quality standards, such as Asarum, white mustard seed, angelica, turtle shell, and chuanxiong, and mix them according to the formula of 1 part by weight of Asarum, 1 part by weight of white mustard seed, 1 part by weight of angelica, 3 parts by weight of turtle shell, and 1 part by weight of chuanxiong. Use a pulverizer to pulverize the mixed Chinese medicinal materials, and pass the pulverized Chinese medicinal mixture through an 80-mesh sieve to obtain a powder.

[0055] Example 2

[0056] Select Chinese medicinal materials that meet quality standards, such as Asarum, white mustard seed, angelica, turtle shell, and chuanxiong, and mix them according to the formula of 0.5 parts by weight of Asarum, 0.6 parts by weight of white mustard seed, 0.6 parts by weight of angelica, 1.5 parts by weight of turtle shell, and 0.5 parts by weight of chuanxiong. Use a pulverizer to pulverize the mixed Chinese medicinal materials, and pass the pulverized Chinese medicinal mixture through a 100-mesh sieve to obtain a powder.

[0057] Example 3

[0058] Select Chinese medicinal materials that meet quality standards, such as Asarum, white mustard seed, Angelica dahurica, turtle shell, and Ligusticum chuanxiong, and mix them according to the formula of 0.9 parts by weight of Asarum, 1.2 parts by weight of white mustard seed, 0.5 parts by weight of Angelica dahurica, 1.8 parts by weight of turtle shell, and 0.9 parts by weight of Ligusticum chuanxiong. Use a pulverizer to pulverize the mixed Chinese medicinal materials, and pass the pulverized Chinese medicinal mixture through an 80-mesh sieve to obtain a powder.

[0059] Example 4

[0060] Select the following Chinese medicinal materials that meet the quality standards: Asarum, white mustard seed, angelica, turtle shell, and chuanxiong. Mix them according to the formula: 0.8 parts by weight of Asarum, 0.5 parts by weight of white mustard seed, 0.9 parts by weight of angelica, 2.7 parts by weight of turtle shell, and 1.2 parts by weight of chuanxiong. Use a pulverizer to pulverize the mixed Chinese medicinal materials. Pass the pulverized Chinese medicinal mixture through an 80-mesh sieve to obtain a powder.

[0061] Example 5

[0062] Select Chinese medicinal materials that meet the quality standards, such as Asarum, white mustard seed, angelica, turtle shell and chuanxiong, and mix them according to the formula of 1.2 parts by weight of Asarum, 0.9 parts by weight of white mustard seed, 1.2 parts by weight of angelica, 2.4 parts by weight of turtle shell and 0.8 parts by weight of chuanxiong. Use a pulverizer to pulverize the mixed Chinese medicinal materials and pass the pulverized Chinese medicinal mixture through a 100-mesh sieve.

[0063] Take an appropriate amount of petroleum jelly, heat it to melt it into a liquid state, add the sieved Chinese medicine powder to the liquid petroleum jelly, stir repeatedly to form a paste, let it stand, and let it solidify into an ointment to obtain the ointment.

[0064] Example 6

[0065] Select Chinese medicinal materials that meet the quality standards, such as Asarum, white mustard seed, angelica, turtle shell, and chuanxiong, and mix them according to the formula of 0.6 parts by weight of Asarum, 0.8 parts by weight of white mustard seed, 0.7 parts by weight of angelica, 3.6 parts by weight of turtle shell, and 0.6 parts by weight of chuanxiong. Use a pulverizer to pulverize the mixed Chinese medicinal materials and pass the pulverized Chinese medicinal mixture through an 80-mesh sieve.

[0066] Take an appropriate amount of petroleum jelly, heat it to melt it into a liquid state, add the sieved Chinese medicine powder to the liquid petroleum jelly, stir repeatedly to form a paste, let it stand, and let it solidify into an ointment to obtain the ointment.

[0067] Example 7

[0068] Select Chinese medicinal materials that meet the quality standards, such as Asarum, white mustard seed, angelica, turtle shell and chuanxiong, and mix them according to the following ratios: Asarum 0.7 parts by weight, white mustard seed 0.8 parts by weight, angelica 0.8 parts by weight, turtle shell 3 parts by weight and chuanxiong 0.7 parts by weight. Use a pulverizer to pulverize the mixed Chinese medicinal materials and pass the pulverized Chinese medicinal mixture through a 40-mesh sieve.

[0069] Add rice wine to the sieved mixture of Chinese herbs to prepare a dressing, wherein the ratio of the Chinese herbal composition to the rice wine is 1:1. Place the dressing on gauze to obtain a patch.

[0070] Example 8

[0071] Select Chinese medicinal materials that meet the quality standards, such as Asarum, white mustard seed, angelica, turtle shell and chuanxiong, and mix them according to the formula of 1.1 parts by weight of Asarum, 0.7 parts by weight of white mustard seed, 1.1 parts by weight of angelica, 3.3 parts by weight of turtle shell and 1.1 parts by weight of chuanxiong. Use a pulverizer to pulverize the mixed Chinese medicinal materials and pass the pulverized Chinese medicinal mixture through a 100-mesh sieve.

[0072] Add rice wine to the sieved mixture of Chinese herbs to prepare a dressing, wherein the ratio of the Chinese herbal composition to the rice wine is 1:2. Place the dressing on adhesive tape to obtain a patch.

[0073] Test case

[0074] This experimental case is a clinical study of the traditional Chinese medicine patch of Example 1 in the treatment of pediatric adenoid hypertrophy.

[0075] Case selection: Sixty children with adenoid hypertrophy were randomly selected from Beijing Huimin Traditional Chinese Medicine Children's Hospital. The average age of the children was 6 years and 3 months, and the male-to-female ratio was 1:1.

[0076] 1. The diagnostic criteria are as follows:

[0077] (1) Clinical symptoms: Patients with adenoid hypertrophy usually experience symptoms such as nasal congestion, runny nose, ear fullness, ear pain, hearing loss, throat discomfort, and paroxysmal cough. If the condition is more severe, symptoms such as sleep apnea, snoring, slurred speech, and loss of appetite may occur.

[0078] (2) Nasal endoscopy: Adenoid tissue can be seen protruding from the posterior nasal aperture to the anterior nasal aperture. It can be hemispherical or conical in shape, with a smooth surface. There is a lot of secretion in the posterior part of the nasal cavity, and it is generally not easy to push the adenoids to the nasopharynx.

[0079] (3) Lateral nasopharyngeal radiograph: This is a commonly used imaging technique. The degree of hypertrophy is judged by measuring the ratio (A / N) of adenoid thickness (A value) to nasopharyngeal width (N value): the normal range is 0.5-0.6, 0.61-0.70 is mild hypertrophy, 0.71-0.80 is moderate hypertrophy, and ≥0.80 is severe hypertrophy.

[0080] 2. Symptom classification criteria

[0081] (1) Clinically, adenoid hypertrophy is classified into three grades: mild, moderate, and severe based on snoring:

[0082] Mild: Snoring is soft and even, with occasional apnea, having little impact on sleep quality, and no significant daytime sleepiness. Polysomnography (PSG): AHI (apnea-hypopnea index) 5 ≤ AHI < 15 times / hour.

[0083] Moderate: Loud snoring with intermittent apnea; patients experience varying degrees of daytime sleepiness. Polysomnography (PSG): AHI (apnea-hypopnea index) ≤ 15 < AHI < 30 times / hour.

[0084] Severe: Loud, irregular snoring with frequent sleep apnea. Patients experience significant daytime sleepiness, fatigue, and difficulty concentrating, and may even experience cognitive impairment and personality changes. Polysomnography (PSG): Assay based on the AHI (apnea-hypopnea index) of ≥30 times / hour.

[0085] (2) Adenoid hypertrophy is classified into three grades: mild, moderate, and severe, based on the nasopharyngeal lateral radiograph (A / N) standard:

[0086] Normal: A / N is 0.5-0.6.

[0087] Mild: A / N ratio is 0.61-0.70;

[0088] Moderate: A / N ratio is 0.71-0.8;

[0089] Severe: A / N≥0.80

[0090] 3. Experimental process

[0091] (1) Based on the clinical snoring symptom classification criteria, 12 children with severe snoring, 38 children with moderate snoring, and 10 children with mild snoring were enrolled in the experimental group. Based on the nasopharyngeal lateral radiograph (A / N) criteria, 16 children with severe snoring, 34 children with moderate snoring, and 10 children with mild snoring were enrolled in the experimental group.

[0092] (2) Medication process: The traditional Chinese medicine patch made from the traditional Chinese medicine composition of Example 1 was applied to the Dazhui and Feishu acupoints of all enrolled children in the trial. The patch was applied continuously for 2 weeks, one patch per day, for 2 hours each time.

[0093] (3) Efficacy judgment criteria: Clinically, the treatment effect is judged by comparing the severity of snoring before and after treatment of the same child and the changes in the values ​​of nasopharyngeal lateral radiographs. Finally, the total effective rate is used as the clinical efficacy judgment criterion.

[0094] 4. Test Results

[0095] (1) Comparison of data of children in the trial before and after treatment with different symptom levels. Table 1 shows the data of children enrolled according to the clinical snoring symptom classification criteria before and after treatment with different symptom levels. Table 2 shows the data of children enrolled according to the nasopharyngeal lateral radiograph (A / N) criteria before and after treatment with different symptom levels.

[0096] Table 1:

[0097]

[0098] Table 2:

[0099]

[0100]

[0101] It can be seen from the above results that no matter what symptom classification standard is adopted, children with different symptom grades can all obtain good curative effects after being treated with the patch prepared from the traditional Chinese medicine composition of the present embodiment, with an effective rate of more than 67%. It can be seen that the traditional Chinese medicine composition of the present embodiment has a significant therapeutic effect on pediatric adenoid hypertrophy.

[0102] 5. Case Analysis:

[0103] The patient is a 3-year-old male child. One week ago, he developed symptoms such as runny nose, cough and sore throat due to external infection. After treatment, he still had stuffy nose and snoring during sleep at night. Nasal endoscopy showed that the adenoid was enlarged to about 2 / 3 of the nasal cavity. The parents refused western medicine treatment with montelukast and sought traditional Chinese medicine treatment. Current examination: grade II hyperemia and swelling of nasal mucosa, red pharynx, lymphoid follicle hyperplasia on the posterior pharyngeal wall, red tongue with thick and greasy coating, and slippery pulse. The syndrome differentiation is phlegm-heat stagnation and blockage, and the therapeutic principle is clearing heat, resolving phlegm and unblocking orifices. The Xiaopian Patch (adenoid-reducing patch) was selected for external treatment. After one week, the patient returned for a follow-up visit. The snoring during sleep at night basically stopped, and there was no nasal discomfort during the day, which basically achieved the purpose of clinical cure. The external application was continued for another week to consolidate the curative effect.

[0104] Finally, it should be noted that the above description is only preferred embodiments of the present invention, and is not used to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, it is still possible for those skilled in the art to modify the technical solutions described in the foregoing embodiments, or equivalently replace some of the technical features thereof. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A topical traditional Chinese medicine composition for reducing swelling and lumps, and clearing nasal passages, characterized in that, The traditional Chinese medicine composition consists of the following parts by weight of traditional Chinese medicinal materials: Asarum 0.5-1.2 parts by weight; White mustard seeds: 0.5-1.2 parts by weight; Angelica dahurica 0.5-1.2 parts by weight; Carapace 1.5-3.6 parts by weight; Ligusticum chuanxiong 0.5-1.2 parts by weight; The traditional Chinese medicine composition is used for the prevention and / or treatment of adenoid hypertrophy in children.

2. The topical Chinese medicine composition for reducing swelling and dissipating nodules, clearing the nasal passages and opening the orifices according to claim 1, characterized in that, The traditional Chinese medicine composition consists of the following parts by weight of traditional Chinese medicinal materials: Asarum 0.6-0.9 parts by weight; White mustard seeds, 0.6-0.9 parts by weight; Angelica dahurica 0.6-0.9 parts by weight; Carapace 1.8-2.7 parts by weight; Chuanxiong (Ligusticum striatum) 0.6-0.9 parts by weight.

3. The topical Chinese medicine composition for reducing swelling and dissipating nodules, clearing the nasal passages and opening the orifices according to claim 1, characterized in that, The traditional Chinese medicine composition consists of the following parts by weight of traditional Chinese medicinal materials: Asarum 0.8-1 part by weight; 0.8-1 parts by weight of white mustard seeds; Angelica dahurica 0.8-1 parts by weight; Carapace 2.4-3 parts by weight; Chuanxiong (Ligusticum striatum) 0.8-1 parts by weight.

4. The topical Chinese medicine composition for reducing swelling and dissipating nodules, clearing the nasal passages and opening the orifices according to claim 1, characterized in that, The traditional Chinese medicine composition consists of the following parts by weight of traditional Chinese medicinal materials. composition: Asarum 1 part by weight; One part by weight of white mustard seeds; Angelica dahurica 1 part by weight; Three parts by weight of carapace; One part by weight of Ligusticum chuanxiong.

5. A topical traditional Chinese medicine preparation, characterized in that, The traditional Chinese medicine preparation is made from the external traditional Chinese medicine composition for reducing swelling and dissipating nodules and clearing the nasal passages as described in any one of claims 1-4.

6. The external application traditional Chinese medicine preparation according to claim 5, characterized in that, The dosage form of the external Chinese medicine preparation is ointment or powder.

7. A traditional Chinese medicine patch, characterized in that, The herbal patch is made from a carrier and the external herbal composition for reducing swelling and dissipating nodules and clearing nasal passages as described in any one of claims 1-4.

8. A method for preparing the traditional Chinese medicine patch according to claim 7, characterized in that, The preparation method includes: Weigh out each Chinese medicinal herb according to its weight and mix them together; The mixed Chinese medicinal materials are pulverized and passed through a 40-100 mesh sieve to obtain a powdered Chinese medicinal mixture; Add excipients to a mixture of powdered Chinese medicine to prepare a dressing. The dressing is placed on a carrier to form a patch.

9. The application of the external Chinese medicine composition for reducing swelling and dissipating nodules and clearing nasal passages according to any one of claims 1-4, or the external Chinese medicine preparation according to claim 5 or 6, or the Chinese medicine patch according to claim 7, in the preparation of a drug, characterized in that, The drug is used to prevent and / or treat adenoid hypertrophy in children.

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