105 results about "Lactobacillus helveticus" patented technology

The invention provides composite probiotic powder capable of nourishing the stomach and tonifying the spleen and a preparation method of the composite probiotic powder. The composite probiotic powder comprises the following components in parts by weight: 6-12 parts of freeze-dried bacterial powder, 40-50 parts of prebiotics, 20-25 parts of fruit and vegetable powder, 14-19 parts of enzymolysis plant powder, 12-15 parts of fermented plant powder and 46-61 parts of sugar alcohol. The freeze-dried bacterial powder is prepared by mixing lactobacillus acidophilus, bifidobacterium animalis, lactobacillus plantarum, lactobacillus helveticus and lactobacillus bulgaricus; the prebiotics are prepared by mixing inulin, galactooligosaccharide, isomaltooligosaccharide and fructo-oligosaccharide in a weight ratio of 10: (8-12): (4-6): (13-16). The prepared compound probiotic powder has the effects of nourishing the stomach and tonifying the spleen.

The present invention belongs to the technical fields of biological bacterium agents and functional food processing. Specifically, it relates to a bacterium agent for soybean milk fermentation and its application, a soy cheese stick and a preparation method thereof. The bacterium agent for soybean milk fermentation provided by the present invention uses Lactobacillus helveticus HL88 and Lactobacillus casei BL25 in combination. It can not only quickly acidify the soy milk, shortening the coagulation time of soy cheese, but also more fully hydrolyze soy proteins, releasing more short peptides and amino acids. In particular, it can highly produce γ-aminobutyric acid (GABA), enhancing the fermentation effect and nutritional value of soybean milk. Further, the soy cheese food prepared by fermenting with the above bacterium agent not only has a strong soy milk fragrance and a smooth texture, but is also easily digested and absorbed, improving the digestibility and reducing the soybean allergenicity, especially helping to improve exercise fatigue and enhance sleep quality. Therefore, the above bacterium agent provided by the present invention has excellent application prospects in the field of preparing functional foods for anti-fatigue and promoting sleep.

The invention discloses a preparation method of high-stability beta-glucan yoghourt. Mixing the sterilized fresh milk with a composite strain consisting of lactobacillus delbrueckii subsp. Bulgaricus, streptococcus salivarius subsp. Thermophilus, bifidobacterium animalis subsp. Lactis, plant lactobacillus, bifidobacterium breve, lactobacillus paracasei, lactobacillus helveticus, lactobacillus rhamnosus and bifidobacterium longum subsp. Longum, and fermenting; and adding beta-glucan into the fermented yoghourt to obtain the high-stability beta-glucan yoghourt. Before beta-glucan is added, the compound bacterial strain is added into the milk, protein in the milk can be gathered under the action of the compound bacterial strain to form a three-dimensional curd network, so that the flowability of a system is reduced, then glucan is added, and the glucan can be uniformly dispersed in curd gaps, so that the glucan is prevented from being excessively combined with the protein in the milk; the stability of a yoghourt system is improved.

The invention belongs to the technical field of probiotic particles, and particularly relates to probiotic particles for improving intestinal functions as well as a preparation method and application of the probiotic particles. The probiotic particles capable of improving the intestinal function comprise a probiotic core, a first embedding layer, a second embedding layer and a third embedding layer, the probiotic inner core is prepared from plant lactobacillus, bifidobacterium animalis, lactobacillus acidophilus, bifidobacterium longum, lactobacillus paracasei, lactobacillus rhamnosus, lactobacillus fermentum, lactobacillus helveticus, streptococcus thermophilus, plant lactobacillus, lactobacillus helveticus and lactobacillus rhamnosus. According to the present invention, the twelve probiotics are contained, and the latest three-layer embedding technology is adopted so as to enhance the storage property and the digestive tract tolerance, such that the product can maintain the beneficial bacterium activity for a long time without refrigeration, and the product is suitable for the crowd with the alteration of the intestinal flora.

The invention provides zero-fat low-sugar yoghourt and a preparation method thereof, the zero-fat low-sugar yoghourt comprises the following raw materials: skimmed milk, a fermentation inoculant, a sweetening agent and a protein product, the fat content of the skimmed milk is less than or equal to 0.3 g / 100mL, the protein content of the skimmed milk is greater than or equal to 6.0 g / 100mL, and the lactose content of the skimmed milk is less than or equal to 4.0 g / 100mL; the fermentation inoculant is composed of pichia kudriavzevii, lactobacillus helveticus and streptococcus thermophilus, and the ratio of the three strains is 2: 1: 5. According to the zero-fat low-sugar yoghourt disclosed by the invention, through selection of specific strains, good stability can be realized under the condition that a thickening agent and a stabilizing agent are not added, the product can be endowed with better oxidation resistance, human body metabolism improving efficacy and immunity regulating efficacy, and a green, clean and healthy yoghourt product is really obtained.

The invention belongs to the field of functional composite microbial preparations, and particularly discloses a microbial agent and GABA compounded composition and application thereof in promoting growth and development of children. The composition is prepared from a freeze-dried bacterial agent and a GABA (gamma-aminobutyric acid) compound, wherein the freeze-dried bacterial agent comprises lactobacillus johnsonii YH1136 and lactobacillus helveticus Helveticus; the GABA compound is prepared by loading GABA with the purity of greater than or equal to 98% on a nano cellulose carrier, and the loading rate is 20-35%. The composition realizes high survival rate of the microbial inoculum and targeted slow release of GABA through a freeze-drying process and enteric coating. Experiments show that the composition can significantly improve the serum GH / IGF-1 level, the bone mineral density and the body growth rate, and has a synergistic effect when combined with the vitamin D3. According to the invention, the problems of single strain function, low GABA utilization rate and gastric acid damage in the prior art are solved, and an efficient and safe solution is provided for children growth and development intervention.

The invention relates to the technical field of feed additives, and particularly discloses a synbiotic feed additive as well as a preparation method and application thereof. The synbiotic feed additive provided by the invention is prepared from the following components in parts by weight: 50 to 100 parts of prebiotics, 10 to 20 parts of probiotics and 5 to 15 parts of plant extract, the prebiotics comprise pachymaran and pullulan in a weight ratio of 1: (0.2-0.5); the probiotics comprise lactobacillus helveticus, acetobacter ollani and streptomyces virginiae; the probiotics comprise lactobacillus helveticus, acetobacter ollani and streptomyces virginiae; wherein the plant extract is selected from a Chinese yam extract, a soybean extract, astragalus polysaccharide and allicin; the invention also provides a preparation method of the synbiotic feed additive. The synbiotic feed additive provided by the invention can regulate the balance of intestinal microorganisms of animals and improve the digestion and absorption functions of the animals, so that the growth performance of the animals and the feed conversion rate are improved.

The invention discloses lactobacillus helveticus for producing DPP-IV (dipeptidyl peptidase-IV) inhibitory peptide and hypoglycemic goat milk and a preparation method thereof, goat milk is used as a raw material, and lactobacillus helveticus KD12 for producing the DPP-IV inhibitory peptide is used for fermenting the goat milk to obtain hypoglycemic lactobacillus fermented goat milk containing the DPP-IV inhibitory peptide. And drying the fermented goat milk to obtain the hypoglycemic lactic acid bacteria fermented goat milk powder containing the DPP-IV inhibitory peptide. Lactic acid bacteria of the hypoglycemic lactic acid bacteria fermented goat milk are inactivated to obtain hypoglycemic post-prebiotics goat milk, and the hypoglycemic post-prebiotics goat milk powder is obtained after the hypoglycemic post-prebiotics goat milk is concentrated and dried. The hypoglycemic goat dairy product provided by the invention has a relatively high DPP-IV inhibition rate, and can be used for inhibiting DPP-IV activity after consumers eat the hypoglycemic goat dairy product so as to reduce blood sugar and reduce the dosage of hypoglycemic drugs, so that side effects caused by the hypoglycemic drugs are reduced.

The invention relates to a multi-enzyme synergistic skin care composition suitable for sensitive skin and application thereof, the skin care composition comprises the following components: crithmum maritimum extract, pomegranate peel extract, lysozyme and coenzyme Q10, the crithmum maritimum extract is obtained by anaerobic fermentation of crithmum maritimum through leuconostoc mesenteroides and lactobacillus plantarum and is rich in SOD enzyme; the pomegranate peel extract is obtained by performing anaerobic fermentation on pomegranate fruits through lactobacillus helveticus and is rich in protease and lipase. The crithmum maritimum extract, the pomegranate peel extract, the lysozyme and the coenzyme Q10 are compounded for use, a multi-dimensional synergistic skin care system is constructed, and repairing, anti-inflammatory and anti-aging integrated efficient improvement is achieved.

The invention provides application of manuka honey in skin antibiosis and anti-inflammation, and belongs to the technical field of cosmetics, the application comprises the following steps: (1) mixing rose petals, perilla roots, grape seeds and manuka honey, and adding the mixture into water to obtain an enzymolysis substrate; (2) sequentially adding pectinase, neutral protease and beta-glucanase into the enzymolysis substrate, and performing enzymolysis to obtain an enzymolysis product; (3) adding lactobacillus brevis, lactobacillus helveticus and bifidobacterium lactis into the enzymolysis product, and fermenting to obtain a fermentation product; (4) adding an ethanol aqueous solution into the fermentation product, stirring, filtering by using a filter membrane to obtain a supernatant, and concentrating the supernatant to obtain a mixed extract; and (5) preparing skin antibacterial and anti-inflammatory products from the mixed extract. The mixed extract disclosed by the invention is good in batch stability, relatively good in antibacterial and anti-inflammatory effects and low in irritation.

Disclosed are a strain of Lactobacillus helveticus capable of removing multiple heavy metals and an application thereof in milk powder, where the strain is Lactobacillus helveticus KD-3, which is deposited in the China Center for Type Culture Collection on Apr. 6, 2023, with a deposit number of CCTCC NO: M2023479. The Lactobacillus helveticus KD-3 has a cadmium resistant gene czcD, a chromium resistant gene chrA and a lead resistant gene pbrT, and is capable of tolerating single and compound heavy metals (cadmium, chromium and lead). The Lactobacillus helveticus KD-3 of the present disclosure is used to prepare lyophilized bacterial powder.

The invention provides ginseng freeze-dried powder capable of resisting oxidation, improving immunity and inhibiting cancer cell diffusion and a preparation method of the ginseng freeze-dried powder, and belongs to the technical field of ginseng processing. According to the ginseng freeze-dried powder researched and developed by the invention, three traditional Chinese medicinal materials including ginseng, lucid ganoderma and radix ophiopogonis are selected, the performance is improved through synergistic fermentation of bifidobacterium bifidum CICC-6168 and lactobacillus helveticus CICC-6273, then the ginseng freeze-dried powder is prepared by utilizing a vacuum freeze-drying technology, and the prepared product has the effects of resisting oxidation, improving immunity, inhibiting cancer cell diffusion and reducing uric acid.

Compositions for use in oral hygiene contain a Lactobacillus helveticus strain. Compositions further containing a Lactobacillus plantarum strain, especially Lactobacillus plantarum SD5870, are particularly effective. The combination of Lactobacillus helveticus LAFTI L10 and Lactobacillus plantarum SD5870 synergistically improves oral hygiene. The compositions are particularly useful against dental caries.

This invention discloses a method for enhancing the color and aroma of whole-component fruit juice through synergistic fermentation with lactic acid bacteria, belonging to the field of food processing technology. The method uses ripe mangoes / pineapples as raw materials. After washing, pitting (peeling), and low-temperature jet milling to retain all components, the juice undergoes compound enzymatic hydrolysis and optimization of its uniformity. A compound strain composed of *Lactobacillus plantarum*, *Lactobacillus fermentum*, and *Lactobacillus helveticus* is then inoculated. The mixture undergoes constant-temperature anaerobic fermentation. The process is optimized using fuzzy mathematical sensory evaluation and response surface methodology, resulting in a sensory score of 91.67 for mango juice and 90.83 for pineapple juice. The retention rate of carotenoids is increased by 25%-30%, the lactic acid content reaches 2.97-26.45 mg / g, and the relative content of esters in volatile aroma components increases to over 35%. Simultaneously, the total sugar content decreases by 3.7%-24.0%. This method solves the problems of dull color, weak aroma, and nutrient loss in traditional whole-component fruit juices. The product combines natural functionality with a unique fermented flavor, making it suitable for industrial production.

The application discloses a fermented fruit juice with the effect of reducing high uric acid and a preparation method thereof, and comprises the following steps: step one, obtaining fruit wine after fruit juice fermentation, and obtaining de-alcohol fruit juice by removing alcohol from the fruit wine; step two, inoculating lactic acid bacteria into the de-alcohol fruit juice to perform lactic acid fermentation, and obtaining the fermented fruit juice; the lactic acid bacteria comprises lactobacillus helveticus CICC6064 and / or lactobacillus paracasei CICC20292. The fruit juice prepared by the fermentation process disclosed in the application not only retains the metabolic products of the yeast fermentation except for alcohol, but also increases the biomass and improves the content of apple polyphenol monomers through lactic acid bacteria fermentation, so that the fermented apple juice has the effects of rich taste and nutrition and reducing high uric acid, and has the innovation in the field of functional development of ordinary fruit juice.

The present invention discloses a method for preparing milk-derived angiotensin-converting enzyme inhibitory peptides by fermentation with composite strains, which belongs to the fields of microbial technology and fermentation. The ratio of whey protein hydrolysate with a molecular weight below 1000 Da and the angiotensin-converting enzyme inhibition rate in the milk-based fermentation broth are used as evaluation indicators. The composite strain Lactobacillus helveticus ( Lactobacillus helveticus , CICC: 20289), composite strain Pediococcus dilactici ( Pediococcus acidilactici , CICC:20719) were rescreened to obtain strains with excellent whey protein hydrolysis performance and high angiotensin-converting enzyme inhibitory peptide production capacity. The two composite strains obtained from the rescreening were enriched and cultured separately, and then inoculated into skim milk powder culture medium at a specific compound ratio. Through composite fermentation, the angiotensin-converting enzyme inhibitory peptide content in the milk-based fermentation product was increased. The process of this invention is rationally designed and highly operable. It provides a reference for further increasing the content of small molecule functional peptides in fermented dairy products, efficiently preparing milk-derived angiotensin-converting enzyme inhibitory peptides, and improving the nutritional value of dairy products, and has great application prospects.

This invention discloses a composition that helps improve sleep and its application in infant formula. The composition comprises plant fermentation products, theanine, magnesium oxide, milk mineral salts, ferric pyrophosphate, vitamin B6, vitamin C, and vitamin D3. The plant fermentation products are obtained by fermenting licorice powder, jujube seed powder, poria cocos powder, angelica powder, and hawthorn powder with *Lactobacillus helveticus* and *Lactobacillus rhamnosus*, followed by sterilization, filtration, concentration, and freeze-drying. This invention employs multi-strain mixed fermentation, and the synergistic effect between different microorganisms can effectively increase the concentration of natural active substances in the extract. The resulting plant fermentation products can effectively enhance the sleep-improving effect of the composition.

The present invention relates to the field of nutritional supplements, and discloses a composition for preventing Parkinson's disease and its application, wherein the composition comprises 30 to 44 parts of probiotics, 5 to 7 parts of plant extracts, and 0 to 1 part of nutritional supplements. The probiotics include Lactobacillus helveticus R0052 and Bifidobacterium longum R0175, and the total viable bacterial concentration of the probiotics is not less than 8×10 8 CFU / g. The plant extracts include cranberry extract, ashwagandha extract, and saffron extract. The anthocyanin content of the cranberry extract is 30-50 mg / g, and the proanthocyanidin content is 23-35 mg / g. The composition for preventing Parkinson's disease of the present invention can improve the ability of the intestine to resist oxidative stress, improve anxiety, depression and sleep conditions in the prodromal stage of PD, alleviate constipation and anosmia symptoms in the prodromal stage of PD, and can prevent and delay the continuous development of symptoms in the prodromal stage before Parkinson's disease is diagnosed.

The application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition and a preparation method and application thereof, active ingredients of the traditional Chinese medicine composition including a fermentation product prepared by subjecting traditional Chinese medicine raw materials to anaerobic solid-state fermentation in combination with Lactobacillus helveticus and enzyme preparation; the traditional Chinese medicine raw materials include ginseng, poria cocos, Chinese yam, white lentil, lotus seed, yiyi seed, amomum villosum, platycodon grandiflorum, licorice and dried tangerine or orange peel; and the enzyme preparation includes cellulase and / or cellobiase. The application effectively promotes dissolution of effective ingredients of Shenlingbaizhu powder, significantly enriches antioxidant active ingredients in the fermentation product, relieves inhibition of oxidative stress on immune cells, and greatly improves survival rate and phagocytic efficacy of macrophages, so that the application shows a significant antibacterial pneumonia effect and has an excellent application prospect.

The present invention discloses a preparation method and application of fermented milk rich in osteogenic growth peptide FPPQSVL, and belongs to the technical field of dairy product processing. The present invention prepares Lactobacillus helveticus fermented milk rich in osteogenic growth peptide FPPQSVL by inoculating Lactobacillus helveticus CCFM1263 into skimmed milk for fermentation. The fermented milk has the functions of significantly enhancing bone density, significantly increasing the number and thickness of trabeculae, significantly increasing bone volume fraction, significantly enhancing the bone biomechanics of rats, and significantly reducing the content of bone turnover biomarkers TRAP, CTX-1, and DPD in serum, while significantly increasing the content of BALP. The Lactobacillus helveticus fermented milk rich in osteogenic growth peptide FPPQSVL provided by the present invention can effectively prevent or treat osteoporosis, promote bone health, and is of great significance to the development of health products and medicines that promote bone health.

The present invention discloses a walnut oligopeptide powder with the functions of promoting peripheral nerve regeneration and repairing peripheral nerve injuries and a preparation method thereof, belonging to the technical field of walnut oligopeptide production. The walnut oligopeptide powder uses walnut cake as a raw material, is enzymatically hydrolyzed by an enzyme preparation, and is prepared by fermentation with Kluyveromyces marxianus and Lactobacillus helveticus. The enzyme preparation is trypsin and ficin. Compared with the prior art, the yield of the walnut oligopeptide powder of the present invention is higher. Moreover, it has been proven by experiments that the walnut oligopeptide powder prepared by the present invention can effectively extend the length of peripheral motor nerves and has a good effect on nerve repair.

The invention discloses six probiotics for preventing severe heatstroke and application of the six probiotics. A probiotic composition is prepared from bacillus coagulans XY2, lactobacillus plantarum KL100, lactobacillus rhamnosus TR08, lactobacillus helveticus TR05, lactobacillus casei TR01 and bifidobacterium longum TR17. The invention discloses novel application of the probiotic composition in prevention of severe heatstroke, heatstroke combined with liver injury, enhancement of intestinal mucosal barrier function, heatstroke combined with lung injury and heatstroke combined with myocardial injury. The sextuple probiotic preparation can effectively protect the state of an organism, enhance the resistance of the organism to high temperature, maintain the balance of a body temperature regulation mechanism, and prevent or relieve the phenomenon of severe heatstroke of the organism, and has the effects of preventing severe heatstroke and relieving heatstroke combined liver injury, lung injury and myocardial injury. Meanwhile, the six probiotic preparations can effectively enhance the intestinal mucosal barrier, and a new method and thought are provided for preventing the adverse outcome of extreme high temperature and complications thereof.

A probiotic composition for treating or preventing metabolic dysfunction-associated steatotic liver disease-associated hepatocellular carcinoma(MASLD-HCC) or colorectal cancer, comprises one or more microbiota selected from a group consisting of Lactobacillus helveticus, Lactobacillus plantarum, Lactobacillus rhamnosus GG, Lactobacillus paracasei, Lactobacillus acidophilus, Bifidobacterium breve, Bifidobacterium animalis subsp. Lactis, Streptococcus thermophilus or any combination thereof. The probiotic composition demonstrates improved therapeutic effects when combined with low-dose Sorafenib for MASLD-HCC and outperforms 5-Fluorouracil in colorectal cancer models.

The invention belongs to the field of medicine, and particularly relates to a montmorillonite-containing medicine compound and a preparation method thereof.The preparation method comprises the steps that cultured bifidobacterium bifidum bacterial liquid and cultured lactobacillus helveticus bacterial liquid are subjected to high-speed centrifugation, bacterial sludge is collected, the bifidobacterium bifidum bacterial sludge, the lactobacillus helveticus bacterial sludge, montmorillonite and trehalose are weighed, water is added, the materials are mixed to be uniform, and the montmorillonite-containing medicine compound is prepared. Adding 1%-2% of a sodium alginate solution, and uniformly stirring and mixing to prepare a suspension; the preparation method comprises the following steps: adding a chitosan-acetic acid solution with the pH value of 3.5 into a chitosan-acetic acid solution in an extruding and dropwise adding manner, filtering, adding into a carboxymethyl chitosan solution, assembling pellets for 4-6 times, and drying in a fluidized bed at 50-70 DEG C, thereby obtaining the product. The montmorillonite and the probiotics are combined for use, the montmorillonite can adsorb harmful substances which are not beneficial to the growth of the probiotics in the intestinal inflammation environment, the staying time of the probiotics in the intestinal tract is prolonged, the colonization rate is increased, and the probiotics relieve the adverse reactions such as constipation and intestinal flora imbalance occurring in the process of taking the montmorillonite.

The present invention relates to probiotic compositions comprising at least one Lactobacillus helveticus, at least one Bifidobacterium longum, and at least one Bifidobacterium animalis. The present invention further relates to methods of using said compositions for preventing muscle loss, improving or maintaining muscle strength, and maintaining intestinal barrier integrity.

This invention provides a method for screening highly specific nucleic acid aptamers and specific *Lactobacillus helveticus* aptamers, belonging to the field of nucleic acid aptamers. Specifically, the method for screening highly specific nucleic acid aptamers provided by this invention includes the following steps: S1: A second library is obtained after N rounds of forward screening of a first library; S2: A third library is obtained after M rounds of reverse screening of the second library; S3: The third library is obtained after X rounds of forward screening of the third library to obtain selected random single-stranded oligonucleotides, which are then subjected to PCR amplification, purification, cloning, and sequencing; S4: The sequences cloned and sequenced in step S3 are used for affinity and specificity assays to select sequences with high affinity and specificity, thereby obtaining highly specific nucleic acid aptamers. The aptamers provided by this invention have the advantages of high specificity and strong affinity, and the construction method of the aptamers provided by this invention has the advantage of short screening time.

The invention discloses a preparation method of a sodium hyaluronate Ectoine fermentation product, which comprises the following steps: lactic acid bacteria are inoculated into a fermentation substrate, and fermentation culture and sterilization are performed to obtain the sodium hyaluronate Ectoine fermentation product, the fermentation substrate is composed of sodium hyaluronate, Ectoine and water; the lactic acid bacteria consist of lactobacillus mucus fermentation and lactobacillus helveticus. Sodium hyaluronate and Ectoine are fermented through lactic acid bacteria, a synergistic effect can be achieved, and the prepared product can be directly used as a cosmetic and can also be added into a basic formula of the cosmetic for use, has good tightening and relieving effects, is basically free of irritation and has a good application prospect in the field of cosmetics.

The invention discloses a composition helpful for improving sleep and an application thereof in formula milk powder, the composition helpful for improving sleep comprises a plant fermentation product, theanine, magnesium oxide, milk mineral salt, ferric pyrophosphate, vitamin B6, vitamin C and vitamin D3, the plant fermentation product is prepared by taking licorice powder, spina date seed powder, poria cocos powder, angelica sinensis powder and hawthorn powder as raw materials, fermenting with lactobacillus helveticus and lactobacillus rhamnosus, and then sterilizing, filtering, concentrating and freeze-drying. Multi-strain mixed fermentation is adopted, the concentration of natural active substances in the extract can be effectively improved through the synergistic effect of different microorganisms, and the prepared plant fermentation product can effectively improve the sleep improvement effect of the composition.

The present invention relates to the technical field of cosmetics, and in particular to a composition prepared based on plant cell culture and its application in anti-photoaging, whitening, firming and anti-wrinkle cosmetics. The present invention uses raw materials (Schisandra chinensis, Borage, Polygonum cuspidatum, Bellis Perennis, Cryptomeria japonica, Kava pepper and Agave) with anti-photoaging, whitening, firming and anti-wrinkle effects, optimizes the dosage ratio of the raw materials, and uses plant cell culture technology to perform callus culture on the plant raw materials to obtain cell culture, and then uses Candida utilis CICC 31170 and Lactobacillus helveticus CICC 22818 for joint fermentation, and further adds ethanol to adjust the concentration to extract active ingredients, and then ultrafiltration is performed through an ultrafiltration membrane with a molecular weight cutoff of less than 3000Da, and finally after post-treatment, a composition is obtained. The composition prepared by the present invention has low irritation, excellent skin whitening effect, can give skin elasticity, and also has anti-wrinkle and anti-photoaging effects.

The present invention relates to the Lactobacillus helveticus strain VF45A, registered with the CNCM under the order number CNCM-I-5300, its mutants and variants exhibiting at least 80% identity, preferably at least 90% identity, preferably at least 95% identity with the genome of said strain VF45A, and capable of producing at least one peptide corresponding to the sequences SEQ ID 1 to SEQ ID NO 43 and / or capable of reducing, by anaerobic fermentation, the pH of milk, particularly cow's milk and especially skimmed cow's milk, to a value substantially equal to or less than 3.36, particularly equal to 3.32 after 48 hours of fermentation at 37°C. The present invention also relates to isolated peptides obtainable by fermentation of milk, particularly cow's milk, with the aforementioned strain.