10results about How to "Effective therapeutic" patented technology

The present invention relates to a triazole compound having a novel ring structure, a preparation method therefor, and a use thereof. The triazole compound having a novel ring structure according to the present invention exhibits excellent ASK1 inhibiting ability and inhibits apoptosis of neurons, and thus can be used for the prevention or treatment of ASK1-related diseases, including neurodegenerative diseases, cardiovascular diseases, autoimmune diseases, and liver diseases.

The invention discloses a 2-acetylglucosamine potassium sulfate salt compound as well as a preparation method and application thereof. The compound has a structure as shown in a formula I. The compound shown in the formula I has biological activity for preventing and / or treating tumors. I

The application discloses application of a CDK4 / 6 inhibitor combined with oxaliplatin in preparation of a treatment drug for chemotherapy-resistant colorectal cancer. The combined use of the CDK4 / 6 inhibitor combined with oxaliplatin has excellent therapeutic effect on locally advanced rectal cancer which is resistant to a first-line chemotherapy scheme, can overcome the drug resistance of the rectal cancer patient to the chemotherapy drug, so that the tumor proliferation is inhibited, and the apoptosis of the cancer cell is promoted. The application provides a combined drug treatment scheme for neoadjuvant therapy of locally advanced rectal cancer chemotherapy resistance, can achieve the purpose of effectively treating or assisting in treating the rectal cancer, and provides a new way for treating, diagnosing or predicting the rectal cancer patient.

This invention provides an activatable semiconductor polymer, its preparation method, and its applications. The activatable semiconductor polymer of this invention can efficiently accumulate at tumor sites. Due to the presence of electron-withdrawing groups on its side chains, the polymer's fluorescence is quenched. Upon response to tumor markers—biothiols, reactive oxygen species, and cathepsin B—the polymer's fluorescence recovers, enabling precise imaging and sonodynamic therapy at the tumor site. Simultaneously, the activatable semiconductor polymer of this invention can label immune cells (such as dendritic cells and macrophages) and track their metastasis from the tumor to the draining lymph nodes.

The invention discloses a magnetic therapy rod capable of generating a static magnetic field for killing bacteria, tumor cells and viruses, the magnetic therapy rod comprises a shell and a magnetic therapy rod body, a containing cavity is formed in the shell, the magnetic therapy rod body is located in the containing cavity, the magnetic therapy rod body is formed by connecting a plurality of magnetic rods end to end, and the magnetic poles of the magnetic rods are alternately arranged in a heteropole mode. The magnetic bar comprises the following raw materials in percentage by weight: 97%-98.4% of strontium iron oxide, 0.20%-0.50% of aluminum oxide, 0.20%-0.50% of silicon dioxide, 0.04%-0.07% of phosphorus pentoxide, 0.04%-0.5% of sulfur oxide, 0.3%-0.7% of calcium oxide, 0.03%-0.06% of titanium oxide, 0.5%-0.70% of manganese oxide and 0.04%-0.06% of nickel oxide. According to the magnetic therapy rod capable of generating the static magnetic field for killing bacteria, tumor cells and viruses, the static magnetic field can be generated, the bacteria, the tumor cells and the viruses are killed through the static magnetic field, and effective treatment on cervical cancer, vaginitis and HPV is achieved.

The invention discloses a traditional Chinese medicine oral prescription for preventing and treating influenza A and improving digestive tract diseases, and belongs to the technical field of traditional Chinese medicines. The prescription is prepared from kudzuvine root, radix bupleuri, moutan bark, peach kernel, scutellaria baicalensis, raw rhubarb, pinellia ternate, fructus forsythiae, mirabilite, mangnolia officinalis, immature bitter orange, poria cocos, bighead atractylodes rhizome, rhizoma alismatis, white paeony root, Chinese date and ginger which are strictly matched according to a specific weight ratio and are prepared by a specific water decoction process. The traditional Chinese medicine oral prescription can effectively prevent and treat influenza A through the synergistic effect of the components, has a remarkable improvement effect on most of digestive tract diseases, is simple in preparation process, convenient to take and high in safety, avoids the problems of poor curative effect, obvious side effect or narrow application range and the like of related medicines in the prior art, and has a wide application prospect. And a new effective choice is provided for prevention and treatment of influenza A and improvement of digestive tract diseases.

The present invention relates to a composition for ameliorating, preventing or treating vaginitis or vulvitis, comprising Lactobacillus salivarius HHuMin-U, the composition of the present invention exhibiting an excellent antibacterial power against pathogenic bacteria inducing vaginitis and vulvitis, and being very effective in ameliorating and treating vaginitis and vulvitis.

The application discloses a compound shown in formula I, or a pharmaceutically acceptable salt, isomer, metabolite, prodrug, solvate or hydrate thereof, a pharmaceutical composition and use. The deuterated isoquinoline-amino pyrimidine compound shown in formula I provided by the application has obvious effects on blocking VISTA and PD-1 / PD-L1 signal pathways, can effectively treat and relieve diseases such as cancers, and is simple in preparation as a small molecule inhibitor and convenient for industrial production.

This invention provides the application of active peptides in the preparation of products for the prevention and treatment of ALD. The amino acid sequence of the active peptides of this invention is shown in SEQ ID NO:1. These peptides not only activate ADH and ALDH enzymes to promote ethanol metabolism, but also significantly scavenge DPPH and ABTS free radicals, exerting antioxidant effects, thereby effectively preventing and / or treating ALD. Therefore, they are highly suitable for the preparation of products for the prevention and treatment of ALD.

This application relates to the technical field of disease prevention and control in aquaculture, specifically to a nanobody against white spot syndrome virus (WSSV) VP19 in shrimp and its application. The nanobody comprises CDR1, CDR2, and CDR3; wherein the amino acid sequences of CDR1, CDR2, and CDR3 are shown in SEQ ID NO. 1-3, respectively; or, the amino acid sequences of CDR1, CDR2, and CDR3 are shown in SEQ ID NO. 8-10, respectively. The nanobody provided in this application can be administered orally by mixing with feed and exhibits high specificity and affinity. Furthermore, this nanobody can cross the tissue barrier and bind to WSSV epitope proteins, blocking the binding of WSSV to host cells, thereby achieving the purpose of preventing and treating WSSV.