193results about How to "Effective therapeutic" patented technology

The invention discloses a porcine pseudorabies virus virulent strain, and a gene deletion vaccine strain thereof and applications thereof. The porcine pseudorabies virus virulent strain is named as HeN1, the microbial preservation number of the porcine pseudorabies virus virulent strain is CGMCC NO.6656, the deleted gE gene obtaines the gene deletion vaccine strain rPRV-gE-EGFP+ on the basis of the virulent strain HeN1, and the microbial preservation number is CGMCC NO.6657. The virulent strain can be prepared into inactivated vaccine (single vaccine or combined vaccine), the gene deletion vaccine strain rPRV-gE-EGFP+ can be prepared into activated vaccine or inactivated vaccine (single vaccine or combined vaccine) and the like, so that porcine pseudorabies can be effectively prevented or cured, or the gene deletion vaccine strain rPRV-gE-EGFP+ can be prepared into a diagnosis reagent for diagnosing the porcine pseudorabies. The gene deletion vaccine strain rPRV-gE-EGFP+ has the advantages of being good in safety, high in protection efficiency, beneficial to differential diagnosis.

The invention relates to a preparation method of a xylitol liver-protecting tablet, belonging to the technical field of medical health care. The formula of the xylitol liver-protecting tablet comprises the following raw materials in proportion: 15-45 parts of kudzu root extract, 2-20 parts of glycyrrhizic acid, 5-35 parts of propolis powder, 20-60 parts of xylitol, 1-10 parts of low-substituted hydroxypropyl cellulose, 1-10 parts of cross-linked sodium carboxymethyl cellulose and 0.5-5 parts of magnesium stearate; and a coating agent comprises 0.5-40 parts of hydroxypropyl methylcellulose, 1-30 parts of polyethylene glycol 6000, 0.5-40 parts of talcum powder, 0.5-30 parts of titanium pigment, 0.5-30 parts of iron oxide brown and 10-75 parts of maltitol. The finished product of the xylitol liver-protecting tablet is prepared by the processing steps of crushing, mixing, tabletting, coating and the like. In the invention, by using the xylitol as a main raw material and adding partial auxiliary materials, the xylitol liver-protecting tablet which is a health food and has auxiliary protection effect on chemical liver injury is prepared. The xylitol liver-protecting tablet can effectively prevent and treat fatty liver; and after patients suffering from the fatty liver take the xylitol liver-protecting tablet, severe fatty liver can be relieved into moderate fatty liver, and moderate fatty liver can be relieved into mild fatty liver. Thus, the xylitol liver-protecting tablet has obvious benefit to improve liver functions of human bodies and has wide market prospects.

The invention belongs to the field of biotechnology and particularly relates to Bacillus subtilis and application thereof. The Bacillus subtilis is Bacillus subtilis HS5B5. The strain is preserved in China General Microbiological Culture Collection Center, with the preservation number of CGMCC No. 6088. The Bacillus subtilis HS5B5 provided by the invention has a very strong restraining effect on the pathogen Cladosporiwm paeoniae of brown spot of peony, and can effectively prevent and cure brown spot of peony. The Bacillus subtilis HS5B5 is harmless to the ecological environment and cannot cause the resistance of the pathogen. The Bacillus subtilis HS5B5 is cultured under simple conditions, is easy to preserve, facilitates industrial production and has a favorable development and application prospect.

A system and method for assessing the performance of a system for delivering a pharmaceutical agent to a portion of a body. A pair of electrodes are applied to the portion of the body. A pharmaceutical agent is infused into the portion of the body and the electrodes are energized by a signal generator, electrically stimulating the portion of the body. The voltage and current delivered to the portion of the body are measured using a data acquisition system thereby generating electrical parameter data. An immune response, gene expression level or other biological response to the pharmaceutical agent is measured and the electrical test data is correlated with the biological response to assess the performance of the system.

The invention provides a Chinese herbal tea for preventing and treating flu and for preventing and treating cold and upper respiratory infection. The Chinese herbal tea is prepared by processing 13 herbal medicines including honeysuckle, fructus forsythia, chrysanthemum, folium mori, scutellaria baicalensis, folium isatidis, dandelion, houttuynia cordata, isatis root, cyrtomium fortune, astragalus mongholicus, poria cocos and liquorice. The formula of the Chinese herbal tea for preventing and treating the flu is formulated on the basis of traditional Chinese medicine, traditional Chinese internal medicine, traditional Chinese medicine and pharmacology, traditional tea art and clinical experience of traditional Chinese folk medicine recipes for clearing summer heat, relieving exterior syndrome and resolving dampness, treating fever and aversion to cold, headache and body fatigue, bad appetite, choking sensation in chest and sicchasia, dispelling the wind and relieving pain, dispelling mild wind and opening the inhibited lung-energy. The Chinese herbal tea has the functions of enhancing immunity, resisting microbes and bacteria and preventing flu, can be used for effectively preventing and treating rhinitis, sphagitis, pneumonia and other diseases caused by cold and upper respiratory infection. The Chinese herbal tea is convenient to take and good in prevention and treatment effect.

The invention belongs to the technical field of food and health care products, and particularly relates to a quintuplet probiotic composition for improving intestinal tracts. The quintuplet probioticcomposition comprises the following components in parts by weight: 60-65 parts of polyisomaltose, 25-30 parts of maltodextrin, 15-20 parts of erythritol, 10-12 parts of galactooligosaccharide and 11-25 parts of probiotic, wherein the probiotic comprises lactobacillus rhamnosus R0011, lactobacillus helveticus R0052, lactobacillus rhamnosus GG, animal bifidobacterium B94 and bifidobacterium longum R0175. At the same time, the invention provides a composite solid beverage prepared from the quintuplet probiotic composition. Through a scientific strain ratio, gastrointestinal tracts are promoted toabsorb an effective quantity of viable bacteria; intestinal florae are adjusted; uncomfortable symptoms of the gastrointestinal tracts, such as various uncomfortable symptoms of the gastrointestinaltracts after flora disequilibrium due to bacterial infection and antibiotic related diarrhea, are improved; an intestinal environment is adjusted, so that the immunity is boosted; an immunoreaction ofan allergic disease is adjusted fundamentally; a constitution environment of females can also be improved; and bacterial vaginitis is effectively prevented and treated.

The invention provides acne treatment water with acne treatment efficacy and a preparation method of the water. The acne treatment water is prepared by taking traditional Chinese medicine theory of China as a basis, taking skin health as a purpose, taking a composite traditional Chinese medicine extract as a main efficacy additive and taking common substrate components in makeup as assistance. The acne treatment water provided by the invention has bacteriostasis efficacy, and also has the efficacies of removing pathogenic heat from blood, promoting blood, reducing the stagnation, relieving itching, diminishing inflammation and the like. The composite traditional Chinese medicine extract is naturally green, healthy and safe, and can be widely applied to acne treatment cosmetics.

The invention relates to a primer pair based on cervical cancer specificity methylation detection. The primer pair comprises a PAX1 forward primer, a reverse primer and a detection probe as well as an ACTB forward primer, a reverse primer and a detection probe. The invention also relates to a kit based on cervical cancer specificity methylation detection. The kit comprises PCR reaction liquid containing the primers and the probes, including the PAX1 forward primer, the PAX1 reverse primer, the PAX1 detection probe, the ACTB forward primer, the ACTB reverse primer, the ACTB detection probe, 10*PCR buffer, dNTP, nuclease-free water and Ex Taq enzyme. The invention also relates to a method based on cervical cancer specificity methylation detection. The kit and the detection method thereof provided by the invention have the advantages of accurate detection result, high detection throughput, good specificity and sensitivity, fast detection and convenience in use and can effectively meet clinical requirements.

The invention discloses valnemulin hydrochloride emulsion for animals. Each 100ml of emulsion mainly comprises the following components by weight: 5 to 10g of valnemulin hydrochloride, 1 to 5g of emulsifier, 20 to 40g of oil for injection, 5 to 15g of ethanol and the balance of water for injection. The valnemulin hydrochloride emulsion for animals has the advantages of quick in vivo distribution and good target, can reduce the medicament residue in vivo and the toxic or side effect on the animals, and also can mask the unpleasant odor of the medicament, and improve the stability of the medicament. The valnemulin hydrochloride emulsion for animals can effectively treat gram-positive bacteria and mycoplasma infection, particularly swine dysentery and porcine enzootic pneumonia, and can reduce the using amount of the medicament and avoid medicament tolerance.

The invention discloses a multifunctional anti-thrombus foot-drop exercise rehabilitation apparatus. The apparatus comprises a base plate, a fixing base, a motor, a first rotating shaft, a gear, a lifting plate, a gear rack, a counter, a timing alarm clock, a fixing shaft, a rotating plate, a slide rail, a back plate, a first electric push rod, a fixing cover, a stepping motor, a second rotating shaft, a cam, a limit block, a cushion, a bandage, a vibrator, a second electric push rod, a first switch, a second switch and a third switch. The multifunctional anti-thrombus foot-drop exercise rehabilitation apparatus is ingenious in structure and powerful in function, by the adoption of the multifunctional anti-thrombus foot-drop exercise rehabilitation apparatus, not only can effective massage be conducted on the lower limbs of a patient, and therefore the blood circulation is promoted, and the purpose of preventing thrombosis formation is achieved, but also dorsal flexure is conducted on the feet of the patient, and therefore the purpose of preventing and curing foot drop is effectively achieved. In addition, through simple operation, the lower limbs of the patient can move within a certain range, and therefore the apparatus can assist in exercise of the lower limbs of the patient, and finally the patient's rehabilitation effect is effectively improved.

The invention provides a healthy antibiotic-free broiler chicken feeding method. The method mainly comprises the steps of conducting chicken house sterilization and drinking pipeline sterilization before chicken enter a chicken house; conducting vaccination periodically so that broiler chicken can have the immune antibody; adding immune traditional Chinese medicine to drank water to improve the habitus and immunity of the chicken, adding microecologics to drank water to restrain breeding of harmful bacteria and enable intestinal florae to be balanced, and adding respiratory tract traditional Chinese medicine to drank water so that respiratory mucosa recovery can be facilitated, respiratory mucosa inflammation can be avoided and respiratory diseases can be prevented and treated. By the adoption of the method, disease resistance of broiler chicken can be effectively improved, the health of chicken is guaranteed, the ideal feeding effect is realized, the quality of chicken can be improved, antibiotic residues in broiler products are effectively controlled, and feeding cost is effectively reduced.

The invention provides a Pseudorabies virus resisting monoclonal antibody, a vaccine composition containing the monoclonal antibody and an application of the vaccine composition. The monoclonal antibody has very high neutralizing potency and can be used for effectively neutralizing swine classical and variant strains of Pseudorabies virus; and the vaccine composition containing the monoclonal antibody has the characteristic of broad spectrum, application objects are free from limitations to animal species, and the preventing and treating efficacy (effect) of display of swine and canine animal experiments is excellent.

The invention discloses powder for treatment of chicken colibacillosis and a preparation method thereof. The powder is mainly composed of the following components by weight: 40 parts of pulsatilla chinensis, 30 parts of dandelion, 20 parts of scutellaria baicalensis, 25 parts of honeysuckle, 10 parts of phellodendron, 30 parts of sophora flavescens, 15 parts of gentian, 15 parts of bighead atractylodes rhizome, and 10 parts of licorice. The Chinese veterinary medicinal composition for prevention and treatment of chicken colibacillosis provided by the invention has a significant curative effect on pullorum disease and a remarkable prevention effect, has good popularization and application prospects, and can promote the sound development of pollution-free cultivation and no residual green meat food processing industry.

The hypertension treating Chinese medicine preparation is prepared with kendir, earthworm, wild chrysanthemum flower, selfheal, eucommia bark and other ten kinds of Chinese medicinal materials. It has the functions of clearing away heat, purging fire, calming liver and wind, nourishing Yin, benefiting kidney, promoting urination and lowering blood pressure. It is used in treating hypertension, and has determined curative effect, no toxic side effect, taking convenience and low cost.

The purpose of the present invention is to provide a traditional Chinese medicine for treatment of myopia with good effects. The technical solution is that: the traditional Chinese medicine for treatment of myopia includes the components of: Chinese foxglove root, glossy privet fruit, mulberry, medlar, dogwood, concha haliotidis, motherwort fruit, dodder seed, plantago seeds, schisandra chinensis, processed fleece flower root, codonopsis root, poria cocos, rhizoma acori graminei, polygala tenuifolia, astragalus mongholicus, angelica, radix ophiopogonis, and asparagus cochinchinensis. The above medicines are added into water of 2-3 times of total weight of the medicines, then soaked, boiled by big fire, decocted for 20-30 minutes by small fire, and filtered to remove residues to get a soup. The residues are then boiled and decocted for a second time, and then filtered to remove the residues to get a soup. The soups are mixed and the preparation is complete. The present invention is low in production costs, quick in effects, has a good effect on treatment of myopia, has a wide use crowd, and can effectively relieve and treat myopia symptoms.

The Chinese medicine consists of nine kinds of Chinese medicinal materials, including capillary artemisia, skullcap root, cape jasmine, parasitic loranthus, dodder seed, etc. It may be used in preventing and treating habitual abortion and dead fetus caused by ABO blood group incompatibility and RH blood group incompatibility between pregnant woman and fetus, and preventing and treating hyperbilirubinaemia encephalopathy of newborn baby caused by newborn baby hemolysis.

The invention provides skincare lotion with an anti-acne effect and a preparation method of the skincare lotion. Being based on the traditional theory of traditional Chinese medicine, and aiming at the health of the skin, the skincare lotion provided by the invention is prepared by taking extracts of traditional Chinese medicine in the composition as the main effect additive and additionally utilizing conventional matrix elements in the cosmetic. The anti-acne lotion provided by the invention has the antimicrobial effect and also has the effects of removing heat and cooling blood, invigorating the circulation of blood and eliminating stagnation, relieving itching, diminishing inflammation and the like; and the extracts of traditional Chinese medicine in the composition are natural, green, healthy and safe, and can be widely applied to anti-acne cosmetics.

The invention relates to a technology for predicting clinical complications after radiotherapy of tumor patients, in particular to a method for predicting complications of normal tissue organs after tumor radiotherapy based on the multimodal image omics characteristics and the radiotherapy dosimetry characteristics. The method mainly comprises the steps: S1, a multimodal image database is established; S2, image data of endangered organs near a tumor target area are extracted; S3, the image omics characteristics of the endangered organs are extracted, and the characteristics of normal organ image data are extracted; S4, parameters of the image phenotypic characteristics of the endangered organs are extracted according to image segmentation results; S5, the image omics characteristics are analyzed; S6, parameters of the exposure doses of the endangered organs are extracted; and S7, the characteristics are collected and extracted. The complications after radiotherapy and chemotherapy of the tumor patients are predicted through the image omics data, effective treatment and intervention can be provided for the patients in time through the reliable, safe and high-precision prediction method, the complications are reduced, and thus the treatment effect on the patients and the later life quality of the patients are improved.

The invention relates to nutritional stomach-strengthening fermented pig feed. The nutritional stomach-strengthening fermented pig feed comprises the following raw materials by weight percentage: 60-65 percent of corn meal, 10-13 percent of wheat bran, 18-20 percent of soybean meal, 2-5 percent of fish meal, 0.5-1 percent of Chinese medicine adding powder, 1-5 percent of trace element and a trace of probiotics. The probiotics are added into pig feed to form fermented feed, so that the nutritional stomach-strengthening fermented pig feed has a relatively strong appetizing effect, thus improving the appetite of a live pig, strengthening the strongness and health of the live pig and improving the disease resistance of the live pig.

The invention discloses a preparation method for a compound 3 alpha-Akebonolic acid and the application of the compound in the preparation of a glycosidase inhibitor drug. According to the invention, an alpha-glucosaccharase inhibitor is extracted and separated from akebia plants; the source of the plant material is abundant, the extraction and preparation method is easy to operate, and the plants can be utilized for a long term without being damaged through adopting fruits for extraction, so that the economic benefit can be improved, and the monomeric compound is environmentally friendly, stable, and easy to store. Pharmacology experiments show that the activity of the alpha-glucosaccharase inhibitor of the compound 3 alpha-Akebonolic acid is higher than that of the first-line diabetes drug acarbose, so that the compound 3 alpha-Akebonolic acid is expected to be developed into a drug for preventing and treating type 2 diabetes mellitus, and has excellent application and development prospects.

The invention relates to the field of genetic engineering products, more particularly, discloses a high-affinity anti-EGFR (epidermal growth factor receptor) monoclonal antibody and an application in preparing drugs for treating tumors, wherein the amino acid sequence of a heavy chain variable region (VH) of the antibody is SEQ ID NO:14, and the amino acid sequence of a light chain variable region (VL) of the antibody is SEQ ID NO:6 or SEQ ID NO:12. The affinity of the antibody to the EGFR is improved by at least ten times more than the affinity of Cetuximab to EGFR.

The invention discloses an immunoglobulin (IgY) antibody oral spray for preventing decayed teeth. The spray comprises the following components in percentage by weight: 0.1 to 0.5 percent of IgY, 5 to 15 percent of bacteriostat, 3 to 6 percent of preservative, 5 to 20 percent of glycerin, 5 to 10 percent of ethanol, 0.1 to 1 percent of edible essence and 50 to 75 percent of distilled water. The IgY antibody oral spray for preventing the decayed teeth is convenient to manufacture and use, can effectively prevent the decayed teeth and treat gingivitis, periodontitis and canker sore, and has high safety, the bacteriostatic ratio to streptococcus mutans c is over 80 percent, and the bacteriostatic ratio to streptococcus mutans d is over 85 percent. In addition, the IgY antibody oral spray for preventing the decayed teeth can be stably preserved at normal temperature for at least three years.

The invention belongs to the technical field of microorganisms and more particularly relates to a compound probiotic for raising poultries, particularly chicken. The compound probiotic is applied in manners of feed fermentation, feed stirring and feeding, feed drinking, atomization deodorization, fecal treatment and the like.

The invention relates to a medicament for the effective prevention and treatment of aquatic animal liver diseases which comprises the following raw materials (by weight portion): bupleurum root 200-400 parts, dyers woad leaf 300-400 parts, rheum officinale 100-200 parts, motherwort 20-70 parts. The preparing process consists of carrying out ultramicro disintegration to the herbs, then passing through 100-300 mesh sieves.

An application of arteannuin and its derivatives (dihydroarteannuin, artemether, arteether and artesunate) in preparing the medicines for preventing and treating the sepsis caused by CpG-ODN and bacteria is disclosed.

The invention provides feed for improving productivity of a sow and a feeding management method of the sow, and relates to the technical field of cultivation. The sow feed comprises an estrous sow feed, a pregnant sow feed and a nursing sow feed. The feeding management method of the sow comprises the steps of feeding management and disease control. According to the feed, a ratio of the three feed is reasonable; the feed is green and safe; a preparation process is simple; differential feeding is specifically performed in stages in a cultivation process; different nutritional requirements of the sow in the different stages are met; the health of the sow is ensured; a conception rate of the estrous sow is high; a piglet survival rate of the pregnant sow is high; the probability of abortion, stillbirth and fetal mummification is reduced; qi and blood of the nursing sow normally circulate; skin and hair are healthy; milk secretion is smooth. According to the feeding management method, the sow is specifically fed, and an attention is paid to the disease control of the sow, so that a cultivation benefit is maximized; purposes of saving the cost and increasing a utilization ratio of the feed are achieved; popularization is worthy.

The invention provides piglet feed and a piglet feeding method, and relates to the culture technical field. The piglet feed comprises breast milk, transitional period feed and weaning period feed. The invention further provides the piglet feeding method comprising feeding management, disease control and piglet management. According to spleen and stomach function features of piglets, the piglet feed provided by the invention provides three groups of feed reasonable in matching according to formulas, the feed is green and safe, and the preparation process is simple; in a culture process, feeding is specially and separately performed by stages, so as to meet different nutritional requirements of the piglets at different stages, ensure the health of the piglets and reduce the irritability of the piglets; the piglets are specially fed, and attention is paid to the control of piglet diseases, so that culture benefits are maximized, nutrient metabolism and absorption of the piglets are promoted, the piglet immunity is enhanced, the sick rate is reduced, the survival rate is improved, and market benefits are increased.

The invention discloses a brace with a function of cleaning teeth by the aid of hydrogen-rich water and ozone water. The brace comprises a brace body. An upper groove and a lower groove are formed inthe brace body, an ultrasonic vibration module is arranged in the middle of the brace body, an electrolysis device is arranged at an end of the brace body, an ozone groove is formed in the end of thebrace body, a plurality of bristles which are uniformly distributed are arranged inside the upper groove and the lower groove, ventilation and water flowing grooves are formed in the peripheral edge of the upper groove and the peripheral edge of the lower groove, ventilation and water flowing pipelines are arranged inside the bristles, the ventilation and water flowing grooves are connected with the upper groove and the lower groove by the ventilation and water flowing pipelines, a water inlet which is perforated towards the outside of the brace body is formed in a side of each ventilation andwater flowing groove, a control switch is arranged at the bottom of the electrolysis device, clear water is arranged in the electrolysis device, the inside of the electrolysis device is divided intoa hydrogen cavity and an ozone cavity by a negative electrode, a proton membrane and a positive electrode, the hydrogen cavity is connected with the ventilation and water flowing grooves via a gas outlet and a guide pipe, and the ozone cavity is connected with each ventilation and water flowing groove by the ozone groove. The brace has the advantages that the teeth can be automatically brushed without dead spaces, and good effects can be realized.

The invention relates to the biotechnical field, and concretely relates to an HSV1-H129-BAC and a mutant thereof. The above virus and the mutant thereof carry a bacterial artificial chromosome (BAC), can keep low-copy number self-replication in specific bacteria, and solve the disadvantages of unable long-term preservation, unable self-replication and inconvenient molecular biologic mutation reconstruction due to too large herpes virus genomes. The virus and the mutant thereof also carry a GFP reporter gene, and substantially develop the application prospect of the herpes virus as a tool virus. The invention also provides a construction method of the H129-BAC and the mutant thereof. The method allows H129 to be reconstructed in order to obtain H129-BAC and endows the H129-BAC with more mutant types; and the construction method, the H129 and the mutant thereof form a genetic modification platform with high application possibility.

The invention discloses an anti-human carcino-embryonic antigen antibody as well as a coding gene and application thereof. The anti-human carcino-embryonic antigen antibody comprises a heavy chain variable region and a light chain variable region, wherein the amino acid sequences of three hypervariable regions CDRLH1, CDRH2 and CDRH3 of the heavy chain variable region are GFAVSSN, HRSGN and VPGFSRGQYEESWYFDL respectively; the amino acid sequences of three hypervariable regions CDRL1, CDRL2 and CDRL3 of the light chain variable region are RASQSIDSYLN, GASNLRN and HQAYSPFT respectively. The anti-human carcino-embryonic antigen antibody disclosed by the invention is a fully humanized anti-human carcino-embryonic antigen antibody, has high affinity with a human carcino-embryonic antigen and can be used for detecting and treating the cancer disease of a human body.