45results about How to "Long onset time" patented technology

The invention relates to Lactobacillus helveticus H9 and application of the Lactobacillus helveticus H9 to the resistance of hypertension and the prevention of cardiovascular disease. A preparation method comprises the following steps of: isolating strains, identifying the strains, preserving the strains, culturing the strains, preparing a bacterial liquid, preparing fermented milk, and screening a strain with angiotensin-converting enzyme (ACE) inhibitory activity; and further evaluating the influence of Lactobacillus helveticus H9 fermented milk on hypertension (SHR, spontaneously hypertensive rats) and normal blood pressure (WHY rats, Wistar-Kyoto rats). The research shows that strain fermented milk has a better in-vivo antihypertensive effect, has the advantages of long onset time and the like, does not affect blood circulation, and has no adverse effects on the normal blood pressure.

The invention relates to a novel procedure for the production of a high yield of small crystalline particles of a narrow size distribution.

The invention relates to the technical field of biological medicines, and particularly discloses a modified sodium alginate self-developing embolization microsphere and a preparation method and application thereof. The modified sodium alginate self-developing embolization microsphere comprises modified sodium alginate and a developing agent, wherein the modified sodium alginate is sodium alginatewhich is firstly subjected to branching modification to introduce a plurality of hydroxyl groups and then subjected to hydrophobic modification and sulfonation modification, and the branching substitution rate of branching modification is 22-81%; the hydrophobic substitution rate of the hydrophobic modification is 5-32%; and the sulfonation substitution rate of sulfonation modification is 57-266%.When the embolization microsphere disclosed by the invention is used as a drug carrier, the drug loading capacity and the drug loading rate of a negatively charged drug can be remarkably improved, the drug release time can be delayed, and the burst release of the drug is reduced.

The invention discloses a tadalafil compound. The tadalafil is a crystalline compound of which the molecule is combined with 2.5 water molecules; by detecting with an X-ray powder diffraction pattern, when 2theta DEG is 10.2+/-0.1 DEG, 11.6+/-0.1 DEG, 15.9+/-0.1 DEG, 18.0+/-0.1 DEG, 19.4+/-0.1 DEG, 21.0+/-0.1 DEG, 24.2+/-0.1 DEG and 27.2+/-0.1 DEG, characteristic peaks are shown. Further, the tadalafil hydrate is a crystalline compound, and the solubleness is improved to some extent. Common tablets, disintegrating tablets and chewable tablets, which are prepared from the tadalafil crystalline compound, are dissolved out within a short time, and the onset time of the tablets is shortened.

The invention discloses a compound crystal, and a preparation method and application thereof, belonging to the technical field of chemical medicines. The compound crystal is a eutectic crystal of favipiravir and p-aminobenzoic acid, the unit cell of the eutectic crystal belongs to a monoclinic system and a P21/c space group, and the unit cell parameters are as follows: alpha = gamma = 90 degrees and beta = 92.578 (3) degrees. The equivalent solubility of the favipiravir in the compound crystal provided by the invention is reduced by about 50%, so that the dissolution rate of the favipiravir is favorably reduced, the onset time of the favipiravir is prolonged, and the toxic and side effects of the favipiravir are reduced.

The invention provides a nerve-soothing type auxiliary smoking-cessation atomized inhalation beverage and a preparation method thereof. According to the beverage, spina date seeds with the functions of soothing the nerve, stabilizing the mind, calming the heart and relieving restlessness serve as a main raw material, with ginseng with the functions of consolidating the basis and nourishing vital energy, radix polygonati officinalis with the functions of clearing heat and nourishing Yin and rhizoma polygonati with the functions of nourishing Yin and tonifying the vital energy, assisted by poriacocos, dried tangerine peel, emblic leafflower fruits and herba menthae with the functions of clearing away the lung dryness, relieving asthma, dispelling the wind, relieving a cough, clearing heat and strengthening the spleen, theanine which is internationally recognized as safe and effective is further added so as to induce and improve the nerve-soothing function of the beverage, and various effective components can act together to relieve smoking-cessation discomfort syndromes such as cough, excessive phlegm, anxiety and sleep disorders of a smoking-cessation person; and meanwhile, the beverage is used in an ultrasonic atomized inhalation mode, so that the medicine incense of a product and the aromatic seasoning components can be integrated, and the dual requirements for relaxation andfragrance enjoyment of a user can be met.

The invention discloses composition containing kudzuvine roots. The composition comprises components in parts by weight as follows: 1-30 parts of kudzuvine roots, 4.5-4.8 parts of potassium citrate and 3.8-4.1 parts of sodium citrate. According to a preparation method, a kudzuvine root extract and a Pu'er tea extract are prepared, potassium citrate, sodium citrate, the kudzuvine root extract, tea polyphenol, the Pu'er tea extract and matcha powder are uniformly mixed and subjected to ultramicro crushing, the granularity of solid materials is smaller than or equal to 0.5 mu m, and the composition containing the kudzuvine roots is prepared. The composition has the functions of reducing uric acid, reducing blood pressure, reducing blood sugar and the like.

The invention belongs to the technical fields of plasters and preparation thereof. The invention discloses an externally applied plaster for treating arthralgia and arthritis, and a preparation method of the externally applied plaster. The plaster is prepared from the following raw materials: capsicum annuum, menthol, borneol, rubber, lanolin, zinc oxide, rosin, beeswax, a coating agent, gasoline, and the like. The preparation method comprises the steps of preparing the raw materials, carrying out medicine preparation, refining rubber, coating, mashing, gluing, drying, carrying out aftertreatment, and the like. The externally applied plaster for treating the arthralgia and the arthritis has the effects of expelling wind and removing cold, relaxing tendons and activating collaterals, relieving swelling and pain, and the like, can be used for treating the arthralgia, backache and sprain bruise as well as diseases such as chronic arthritis and chilblain being not broken; furthermore, the externally applied plaster has good air permeability and is long in drug onset time; the externally applied plaster for treating the arthralgia and the arthritis is simple in preparation method and can be easily realized on the existing equipment.

The invention provides a surgical device for curing glaucoma by femtosecond laser transmitted by an energy transmission optical fiber. The surgical device comprises a femtosecond laser (1), a femtosecond laser output tail fiber (2) and an energy transmission optical fiber (4). One end of the energy transmission optical fiber (4) is fused with the femtosecond laser output tail fiber (2) so as to transmit laser, and the other end of the energy transmission optical fiber (4) is connected with a convex lens (5) through a lens seat (6), or the end face of the other end of the energy transmission optical fiber (4) is of a spherical structure (7) so as to realize the spherical refraction effect to focus laser light. The surgical device can be operated more finely in the water environment, can perform filtration surgery by substituting a scalpel, and has the advantages that hurts to surrounding tissues from the surgery and postoperation fibrosis effect can be effectively reduced, postoperation scarring is alleviated, and effect time is long and the like.

The invention provides a spray containing phospholipid and mycose for extraocular use, wherein the phospholipid content is 1 to 100mg/ml, and the mycose content is 1 to 100mg/ml; preferably, the phospholipid content is 1 to 20mg/ml, and the mycose content is 1 to 50mg/ml; further preferably, the phospholipid content is 5 to 15mg/ml, and the mycose content is 10 to 30mg/ml. The spray for extraocular use provided by the invention has the advantages that the spray can penetrate the eye skin barrier; the xerophthalmia is safely and effectively treated; the effect taking time can be prolonged; thecomfort of a patient is improved. In addition, when the spray for extraocular use is used as a carrier with pharmacological or cosmetic active substances, the permeable membrane absorption quantity ofthe active substances can be improved; the bioavailability is improved; meanwhile, no irritation is generated on the eyes.

The invention provides low-sudden-release-rate semaglutide microspheres and a preparation method thereof. The preparation is a long-acting injection prepared from the active ingredient semaglutide with the weight being 1-20% of the weight of the microspheres, a biocompatible polymer substrate with the weight being 60-99% of the weight of the microspheres, and other pharmaceutically acceptable auxiliary materials with the weight being 0-20% of the weight of the microspheres. The semaglutide microspheres prepared by using the method are high in encapsulation efficiency, low in sudden release rate and capable of being slowly continuously released, the slow-release effect can last for 20-60 days, the effect on reducing blood sugar can last for at least 2-4 weeks, it only takes two weeks to onemonth or longer to conduct injection administration one time, the bioavailability of the polypeptide drug semaglutide is obviously improved, the metabolic half-life of the semaglutide is prolonged, the semaglutide administration frequency is further reduced, and the drug application compliance of a patient is further improved; because there are few drugs on the surface and the superficial layer of the preparation, the preparation is little released in the incipient administration stage, and therefore, the adverse drug sudden release effect is avoided.

The invention discloses an N-acetylcysteine oral compound emulsion. The compound emulsion is prepared according to the following steps: 1), dissolving N-acetylcysteine and Arabic gum into warm water to obtain the inner water phase; 2), dissolving a lipophilic emulsifier into liquid paraffin to obtain the oil phase; 3), dropwise adding the oil phrase into the inner water phrase, and stirring to obtain a water-in-oil preliminary emulsion; 4), dissolving a hydrophilic emulsifier and polyvinylpyrrolidone into warm water to obtain the external water phrase; 5), mixing the water-in-oil preliminary emulsion with the external water phrase in proportion, and stirring to obtain the N-acetylcysteine embedded water-in-oil compound emulsion. The compound emulsion can improve the stability of N-acetylcysteine in the body, so that the initial effect time of the drug can be prolonged, and the frequency for taking the drug can be reduced; moreover, the compound emulsion can further cover the irritation of N-acetylcysteine, so that the burning sensation and the adverse reactions, such as choking, nausea, vomiting and ozostomia, during oral administration can be reduced, and the medication compliance can be improved.

The invention discloses a processing method for improving drug effect of tendril-leaved fritillary bulb powder and a product and use, and belongs to the field of medicinal material processing. The processing method for improving the drug effect of the tendril-leaved fritillary bulb powder in preventing and treating of bronchial diseases such as cough and asthma is disclosed based on innovation ofmodern traditional Chinese medicine processing method starting from the theory and practice of the traditional Chinese medicine. The processing method comprises the following steps in turn: taking fresh tendril-leaved fritillary bulb, washing, chopping, adding of Vc, Vc sodium, Vc phosphate and tea polyphenols as protective agents, coarse crushing, enzymatic hydrolysis, ultrafine crushing, low temperature microwave vacuum drying, fine crushing and the like. The method is easy to operate and has a short production cycle. The dissolution of active substances is increased, the loss of active ingredients is reduced, bioavailability is improved, and the tendril-leaved fritillary bulb powder has better drug and treatment effect for the bronchial diseases such as cough and asthma. At the same time, the tendril-leaved fritillary bulb powder is uniform in color, good in smell, and aseptic, and the method has a broad application prospect in the processing area of the tendril-leaved fritillary bulb powder.

The invention relates to the field of pharmaceuticals, and particularly relates to a supercritical anti-solvent fluidized coating nanoparticle and a preparation method of the supercritical anti-solvent fluidized coating nanoparticle. The preparation method of the supercritical anti-solvent fluidized coating nanoparticle comprises the following steps: enabling a breviscapine solution and a supercritical carbon dioxide fluid to contact, and then reacting with a coating agent to prepare the nanoparticle. The coating nanoparticle has the advantages of stable quality, even distribution of particlesize and good stability, can be directly packaged into a capsule, is high in dissolving-out speed, and obviously improves the bioavailability of the medicine.

The invention discloses a sanitary napkin medicinal additive with cooling and bacteriostasis functions and a preparation method of the additive. The medicinal additive comprises the following components in parts by weight: 0.10-0.15 part of wild chrysanthemum extract, 0.08-0.2 part of menthol, 0.25-0.53 part of dextrin, 0.26-0.5 part of distilled water. The wild chrysanthemum extract, menthol, dextrin and distilled water are included by using a specific preparation method to form the powdered additive which is stable and cannot be easily oxidized or deteriorated, and a sanitary napkin production material is coated with the powdered additive. When used, the sanitary napkin has remarkable and durable cooling effect, can be used for inhibiting generation of bacteria to play a role in relieving itching and diminishing inflammation, is mild, and cannot generate side effects on a human body.

The invention provides a medicine for treating bradycardia. The medicine comprises, by weight, 8-12 parts of radix astragali, 3-5 parts of monkshood, 8-15 parts of red sage root, 6-12 parts of ligusticum wallichii, 2-4 parts of asarum, 6-15 parts of radix astragali, 8-15 parts of Chinese angelica, 3-5 parts of safflower, 8-12 parts of licorice and 8-12 parts of ephedra. The medicine has the advantages of obvious treatment effects, long action time and small side-effect.

The invention discloses a depolymerization treatment method for hydrophobic associated polymer-containing oil sludge. The method comprises the following steps: mixing water and hydrophobic associatedpolymer-containing oil sludge at the temperature of 40-80 DEG C, wherein the mass ratio of the water to the hydrophobic associated polymer-containing oil sludge is (0.5-5):1; adding a depolymerizing agent A into the mixed oil sludge, uniformly stirring, adding a depolymerizing agent B, stirring for 30-180 s, pumping the oil sludge mixture into a horizontal screw centrifuge, carrying out three-phase separation for 2-6 min, and centrifuging to obtain bottom mud having crude oil on an upper layer, water on a middle layer and solid on a lower layer. The method has the beneficial effects that the polymer is degraded by adopting the inorganic chemical agent which is simple in structure and low in cost, the degradation effect of the agent on the polymer is brought into full play by adjusting theprocess, the viscosity of the oil sludge is reduced, and the phenomenon of expansion and gelatinization in subsequent treatment is avoided. The depolymerization treatment method provided by the invention is suitable for the pretreatment process of the hydrophobic associated polymer-containing oil sludge before reduction, recycling and harmless treatment.