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Poly-d-lactic acid micro-nano particle as cosmetic and plastic filler and preparation method thereof

A D-polylactic acid, micro-nano particle technology, applied in the field of biomedicine, can solve the problem that it is not long enough, generally 10-13 months, etc., to achieve the perfect self-filling effect, prolong the degradation time, and promote the secretion effect.

Inactive Publication Date: 2014-11-19
吴学森
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the degradation time of poly-L-lactic acid itself is not long enough, usually 10-13 months

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Take 50 g of dextrorotatory polylactic acid polymer resin, dissolve it in an appropriate amount of ethyl acetate, and keep stirring to obtain a polymer solution. 10 g of amino acid was added to the polymer solution, and the resulting suspension was ground with a mortar until a uniform suspension was obtained. The above system was dried at room temperature under low vacuum conditions for 24 hours, then under high vacuum conditions for 24 hours, and the solvent in the mixture was removed to obtain a polymer-amino acid mixture. Scrape this mixture from the mortar and granulate. The pellets were extruded into thin strands using a small single-screw extruder. The extrusion temperature is 60-80°C. The extruded bars were cut into pellets. Put the above-mentioned resin granules in the ball tank of the ball machine, add the balls, and seal the cap. Place the pellet jar with resin pellets in liquid nitrogen and freeze for 20 minutes. Place the frozen pellet jars on the pelle...

Embodiment 2

[0019] 1g of amino acid was dissolved in 2ml of distilled water to prepare an aqueous solution, and a total weight of 10g of D-polylactic acid polymer resin was dissolved in 20ml of dichloromethane to form a polymer solution. The aqueous solution containing amino acid is added to the organic solvent containing polymer, and the water-in-oil nanoemulsion is made by ultrasonic wave. Then add the nanoemulsion into 150 ml of an aqueous solution with a concentration of 0.5% polyvinyl alcohol, and form a double emulsion liquid by mechanical stirring. When the outer emulsion reached below 50 microns, the obtained double emulsion liquid was added to 2 liters of distilled water, and the solvent dichloromethane was extracted at 4° C. to solidify the microparticles. The resulting suspension was then filtered using 0.45 micron filter paper to collect the solidified particles. The resulting microparticles were vacuum dried.

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PUM

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Abstract

The invention discloses a micron and nanoscale cosmetic and plastic filling particle made of poly-d-lactic acid macromolecule resin and a preparation method thereof. The size of the particle is 50-0.45micron. The freeze-dried powder of the particle is suspended in water, and then is injected into a loose or wrinkled facial tissue by an injector so as to achieve the purpose of plastic surgery. The particle contains compound amino acid and is prepared by a mechanical method or an emulsification method. The mechanical method comprises the following steps: suspending the amino acid into a polymer solution, removing a mixture of the dried solvent, extruding into strips, and smashing at low temperature into micro-nano particles; and the emulsification method comprises the following steps: emulsifying an amino acid water solution into a polymer organic solution to form a first emulsion, then emulsifying the emulsion into another water solution so as to obtain a multiple emulsion, and removing the organic solvent to obtain micro-nano particles. The micro-nano particle containing compound amino acid prepared by the two methods is sieved and then suspended in the water solution with a frozen support again, and after freeze drying is finished, the product is obtained.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and mainly relates to D-polylactic acid particles used as fillers for cosmetic plastic surgery and a preparation method thereof. Background technique [0002] Plastic surgery has become an emerging industry in the world market. The proportion of plastic surgery in the United States, Japan, and South Korea is about twice that of China. With the continuous deepening of China's reform and opening up and the continuous improvement of people's living standards, cosmetic surgery has mushroomed like mushrooms. In 2010, the output value of China's plastic surgery market reached about 300 billion yuan, and the number of employees in the industry exceeded 20 million. The average annual growth rate of the industry is more than 40%, and the sales of plastic beauty products of upstream companies are growing rapidly at an annual growth rate of 60%. China's huge 1.3 billion service groups have established...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/50A61L27/54
Inventor 吴学森
Owner 吴学森
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