94 results about "Micro nanoparticles" patented technology

The invention belongs to the technical field of brazing materials, and particularly relates to micro-nano particle reinforced nickel-based ultralow-melting-point wear-resistant brazing filler metal and a preparation method and application thereof. The invention provides micro-nano particle reinforced nickel-based ultralow-melting-point wear-resistant brazing filler metal. The micro-nano particle reinforced nickel-based ultralow-melting-point wear-resistant brazing filler metal comprises 94-99 parts of ultralow-melting-point nickel-based brazing filler metal and 1-6 parts of micro-nano particles. The ultralow-melting-point nickel-based brazing filler metal contains B, Si, In, Sn and Cu elements at the same time, and the melting temperature of the brazing filler metal can be cooperatively reduced; and meanwhile, the micro-nano particles are added, so that the strengthening and abrasion increasing effects on the nickel-based brazing filler metal can be effectively guaranteed, and meanwhile the flowability of the brazing filler metal is not affected. Therefore, through component design of the nickel-based brazing filler metal and synergistic cooperation of the micro-nano particles, the melting point of the brazing filler metal can be remarkably reduced, the brazing filler metal can be endowed with excellent hardness and wear resistance, and the technical bottlenecks that traditional nickel-based brazing filler metal is high in melting temperature and poor in wear resistance and brazed diamond is subjected to thermal damage are solved; and the method has a wide application prospect in brazing of diamond tools.

The invention relates to a preparation method and application of a composite piezoelectric catalytic material NaNbO3-coated BiFeO3 for rapidly degrading antibiotics, NaNbO3 is flaky crystal grains with [001] crystallographic orientation prepared by a two-step molten salt method, and BiFeO3 is micro-nano particles prepared by a coprecipitation method. Composite micro-nano BiFeO3 powder and [001] oriented NaNbO3 flaky grains form a heterojunction, conversion of mechanical energy and electric energy of the material is achieved under the ultrasonic vibration condition, inductive charges are generated on the surface of the material, and photon-generated carriers move reversely under driving of a built-in electric field. According to the invention, the piezoelectric catalytic degradation capability of the BiFeO3 and NaNbO3 composite piezoelectric catalytic materials with different proportions on four antibiotics, namely oxytetracycline, levofloxacin, carbamazepine and paracetamol in different time periods is researched. When the mass ratio of the BiFeO3 to the NaNbO3 composite material is 1: 3, the oxytetracycline degradation rate within 30 min can reach 78.2%, the oxytetracycline degradation rate within 120 min can reach 91.8%, and the piezoelectric electro-catalysis characteristic is rapid and efficient. The method disclosed by the invention has important significance in developing a high-efficiency piezoelectric catalyst for degrading antibiotics.

The invention relates to the technical field of sewage treatment, in particular to a metal sulfide nanoparticle slow-release activator for sewage treatment and a preparation method of the metal sulfide nanoparticle slow-release activator for sewage treatment. The surface of the core layer is coated with the porous silicon dioxide membrane shell layer; the citric acid modifier is loaded on a core-shell interface; according to the invention, metal sulfide (such as FeS, MoS2, WS2 and the like) micro-nano particles are used as a solid-phase slow-release activator, so that the core problem of a traditional homogeneous activation system is radically solved. Firstly, the metal sulfide exists in the form of a solid phase and can directly contact and react with permanganate without an additional dissolving step, so that the problem of complicated process operation caused by poor solubility of activating agents such as sulfite is thoroughly avoided, and the process of reclaimed water treatment is simplified. The problem of poor continuous oxidation effect of a traditional homogeneous system is thoroughly solved.

The invention discloses a dispersion distribution method for a micro-nano multi-scale mixed SiC particle reinforced phase in an aluminum-based composite material and the composite material, and relates to the technical field of metal-based composite material preparation. The method comprises the following steps: firstly, carrying out ultrasonic cleaning, ultrasonication and two-stage high-temperature oxidation treatment on SiC particles, and generating an oxidation film on the surfaces of the particles; ball-milling and mixing the treated micron and nano SiC particles and micron pure magnesium particles according to a specific proportion, and pressing into a precast block; then preparing an aluminum alloy melt, cooling to a solid-liquid two-phase region, carrying out semi-solid stirring, and adding the preheated precast block; and finally, raising the temperature to be above a liquidus, rewarming, stirring and molding by casting. Through the synergistic effect of ultrasonic physical dispersion, high-temperature oxidation surface modification and magnesium-induced semi-solid stirring, the problems that micro-nano particles are prone to agglomeration, wettability is poor and interface reaction is difficult to control are effectively solved, multi-scale uniform dispersion distribution of a reinforced phase in an aluminum matrix is achieved, and the comprehensive performance of the composite material is remarkably improved.

The invention discloses a high-performance super-hydrophobic coating, and relates to the technical field of coating preparation. The high-performance super-hydrophobic coating comprises a composite resin matrix composed of polyurethane and polyethersulfone, and zinc selenide nanoparticles and hydrophobic modified inorganic micro-nanoparticles used for constructing a super-hydrophobic surface are dispersed in the composite resin matrix. Polyether sulfone has good tolerance, can significantly improve the thermal stability and structural strength of the coating in a high-temperature environment, and can be blended and crosslinked with a polyurethane network to form a more stable multiphase composite system, enhance the crack resistance and peel strength of the coating, and effectively improve the adhesive force; the zinc selenide nanoparticles can effectively absorb ultraviolet rays and protect the organic resin matrix from being damaged by ultraviolet radiation. The high-performance super-hydrophobic coating provided by the invention is suitable for outdoor severe environments with high temperature, strong ultraviolet radiation and chemical corrosion risk, and long-term stable protection can be provided for outdoor equipment by coating the surface of the outdoor equipment with the high-performance super-hydrophobic coating to form a protective coating.

Disclosed is a zinc zoledronate micro-nanoparticle adjuvant, which contains zinc and zoledronic acid and optionally contains a phosphate and aluminum. The preparation method therefor comprises performing mixed precipitation on a soluble salt solution containing zinc ions, zoledronic acid, and sodium hydroxide. The adjuvant can be used to prepare vaccines, etc.

The invention provides a double-barrier self-lubricating anti-coking composite coating and a preparation method thereof, and belongs to the technical field of boiler anti-coking coatings. The composite coating comprises a bottom layer and a surface layer, the bottom layer is of a porous structure, and the bottom layer is made of an alloy material; the surface layer comprises a coating layer located on the bottom layer and an embedded layer embedded in the porous structure of the bottom layer, and the surface layer is made of a micro-nano ceramic composite material. The porous bottom layer coating provides implantation for the surface layer ceramic particles, the micro-nano particles of the surface layer can be physically embedded into pores of the bottom layer porous material, the binding force between the surface layer ceramic particles and a base body is increased, the service life of the coating is prolonged, and a microcosmic composite material coating interface is formed by the multi-element corrosion-resistant alloy and the micro-nano ceramic material.

The embodiment of the invention provides a mask preparation method and a patterning method. The mask preparation method comprises the following steps: providing a substrate, a template and micro-nano particles; assembling micro-nano particles on the first surface or the second surface to form a micro-nano particle layer; the template and the substrate are stacked, so that the micro-nano particle layer is located between the first surface and the second surface; pressing the template and the substrate; the template is separated from the substrate, so that a patterned micro-nano particle array located on the substrate is obtained, and the pattern of the micro-nano particle array is consistent with the preset transfer printing pattern; and modifying the micro-nano particle array to obtain a mask layer which is tightly combined with the substrate. According to the mask preparation method and the patterning method disclosed by the invention, the mask is prepared by adopting the micro-nano particles, and the patterning transfer printing is carried out by adopting the template, so that the mask preparation method and the patterning method do not depend on complicated light paths and equipment, have the advantages of low cost, high preparation speed and low equipment requirement, and can replace a traditional photoresist mask to a certain extent.

The invention discloses an in-situ doped ZnO paper-based insulating material and a preparation method thereof, and belongs to the technical field of paper-based special materials in paper industry. The method disclosed by the invention comprises the following steps: mixing and stirring zinc chloride and water to obtain a zinc chloride hydrated eutectic solvent; then soaking the porous base paper in a zinc chloride hydrated deep-eutectic solvent for swelling treatment to obtain gelatinized base paper; immersing the gelatinized raw paper into an ethanol / water anti-solvent system for regeneration treatment to obtain regenerated raw paper; then dipping the regenerated raw paper in alkali liquor for in-situ deposition treatment to obtain raw paper with ZnO micro-nano particles loaded and doped on the surface; and performing post-treatment on the body paper with the surface loaded and doped with the ZnO micro-nano particles to obtain the in-situ doped ZnO paper-based insulating material. According to the method disclosed by the invention, in-situ doping of the ZnO micro-nano particles is successfully realized in the densified base paper, and the dielectric property is further remarkably improved by cooperating with the densification effect.

The application provides a foamed alkali-activated cementitious material, which is composed of an intermediate layer and surface layers covering the upper and lower surfaces of the intermediate layer, and the intermediate layer and the surface layers comprise the following raw materials: 30-50 parts by mass of blast furnace slag, 12-18 parts by mass of low-calcium fly ash, 9-15 parts by mass of alkaline magnesium slag, 10-15 parts by mass of alkali activator, 6-8 parts by mass of foaming agent and 3-5 parts by mass of foam stabilizer; the surface layer further comprises 1.5-5 parts by mass of functional catalyst, and the functional catalyst is gel-like micro-nano TiO2 particles. The application utilizes fly ash, magnesium slag and slag and other types of solid waste to prepare building materials with the ability to degrade formaldehyde. Compared with traditional porous foamed materials, the foamed alkali-activated cementitious material prepared by using aluminum powder as a foaming agent has the advantage of utilizing industrial by-products, and the excess aluminum powder not only produces a dense and uniform pore structure, but also is conducive to the adsorption of formaldehyde gas and the improvement of mechanical strength.

The invention discloses a silicon carbide / molybdenum alloy gap filling and low-temperature connection process based on metal slurry, and belongs to the field of material connection. The nickel-based micro-nano slurry is composed of nickel-based micro-nano particles and an organic auxiliary agent, and is formed after vacuum stirring and defoaming. The nickel-based micro-nano particles comprise Ni nano particles, NiCr micro particles and Si nano particles. The method comprises the following steps: firstly, uniformly coating nickel-based micro-nano slurry on a silicon carbide / molybdenum alloy connecting surface; secondly, vacuum sintering is conducted in a tubular furnace, the silicon carbide / molybdenum alloy connector is obtained, and the connector has high strength and heat conductivity. The Si nanoparticles are added, so that the wettability of the nickel-based micro-nano slurry and a silicon carbide base material is enhanced, a connection joint obtained after sintering has higher strength and thermal conductivity, the brush coating process can be adopted to cope with various special-shaped structures, connection gaps of the special-shaped structures are filled compactly, and the connection joint with excellent mechanical property and thermal property is obtained.

The invention belongs to the technical field of super-hydrophobic gel, and particularly relates to super-hydrophobic composite hydrogel as well as a gradient assembly preparation method and application thereof. The method comprises the following steps: (1) copolymerizing isopropyl acrylamide, acrylamide, methyl methacrylate and hydroxypropyl methyl cellulose to prepare a hydrogel substrate, and then immersing the substrate into a solution containing poly (4-bromomethyl styrene) to carry out n-alkylation surface modification; (2), SiO2 (at) PDA micro-nano particle powder and perfluorosilane modified halloysite nanotube powder are prepared respectively; and (3) stretching the modified hydrogel substrate, sequentially coating the SiO2 (at) PDA micro-nano particles on the surface of the hydrogel substrate to form a middle layer, then coating the perfluorosilane modified halloysite nanotube powder, and carrying out rolling treatment to form an outer surface layer, thereby finally obtaining the super-hydrophobic composite hydrogel.

The present application belongs to the technical field of agricultural bio-based slow-release carriers and pesticide formulations, and relates to a kind of lignin-based pesticide controlled-release micro-nanoparticles with multiple stimuli response and a preparation method thereof, lignin and hydrochloric acid dopamine are dissolved in buffer solution in proportion, an oxidizing agent is added thereto, stirred and reacted to obtain a lignin-polydopamine composite solution, which is purified by dialysis in water, dried to obtain a lignin-polydopamine solid powder; the lignin-polydopamine solid powder and abamectin are mixed in an organic solvent in a mass ratio of 1-5:1, then water is added in portions while stirring, the polarity of the system is changed, and the lignin-polydopamine micro-nanoparticle drug-loaded particles loaded with abamectin are precipitated, which are dried to obtain the present application. The abamectin delivery system has multiple environmental responsiveness, long-acting leaf adhesion function and controllable release characteristics.

The invention discloses a catalytic membrane capable of repeatedly self-growing an active layer. A flaky solid of a layered double hydroxide micro / nano active layer is self-grown in situ on a geopolymer inorganic membrane; the invention also discloses a preparation method and application of the catalytic membrane. According to the catalytic membrane, the layered double hydroxide active layer with the micro / nano structure is subjected to in-situ hydro-thermal synthesis, the multifunctional catalytic membrane with the repeatable self-growing active layer is obtained, the repeatable and self-growing active layer can be achieved for multiple times, and micro / nano particles are not prone to falling off from a carrier in the using process.

The present disclosure provides a double-barrier self-lubricating anti-coking composite coating and a preparation method thereof, and belongs to the technical field of boiler anti-coking coating. The composite coating comprises a bottom layer and a surface layer. The bottom layer is of a porous structure and is formed of an alloy material. The surface layer comprises a cladding layer on the bottom layer and an embedded layer embedded in the porous structure of the bottom layer, and the surface layer is formed of a micro-nano ceramic composite material. The porous bottom layer coating provides a "bedding" for the surface layer ceramic particles. The micro-nano particles of the surface layer can be physically embedded in the pores of the porous material of the bottom layer, thereby increasing the bonding force between the surface layer ceramic particles and the substrate, prolonging the service life of the coating, and forming a micro composite material coating interface by the multi-element corrosion-resistant alloy and the micro-nano ceramic material.

The present application relates to the technical field of medicine, in particular to a functional nanomaterial based on choline phosphate-cell membrane interaction and application thereof.The present application modifies manganese mineralized black phosphorus nanomaterial by bio-inspired polymer pGluCP adsorption, which retains the excellent biocompatibility and photothermal performance of BP, and at the same time, pGluCP enhances the 'chassis' effect of the material, captures tumor-related antigens, and can simultaneously capture water-soluble antigens and water-insoluble membrane antigens and form pathogen-like micro-nanoparticles, which is helpful for antigen delivery and APC presentation, and provides a feasible tool for capturing non-water-soluble membrane antigens, which is a major challenge.MnBP and pGluCP synergistically act, and can realize the personalized conversion of autologous tumors to vaccine production and delivery.

The invention belongs to the technical field of oil-gas field development and recovery efficiency improvement, and particularly relates to a resistance-increasing type in-situ gel deep profile control agent and a preparation method thereof. The resistance-increasing type in-situ gel deep profile control agent is prepared from the following raw materials in percentage by weight: 3 to 8 percent of water-soluble functional monomer, 0.5 to 2 percent of functional micro-nano particles, 0.3 to 1 percent of gelling control agent and the balance of water. The profile control agent reacts in a stratum to form three-dimensional network structure gel with functional micro-nano particles as crosslinking nodes, so that the temperature resistance is greatly improved, the dehydration rate at the constant temperature of 120 DEG C for 90 days is lower than 10%, and the profile control agent can be used for deep profile control of oil reservoirs at the high temperature of 120 DEG C.

This invention discloses a method for determining the surface charge density of micro / nano particles. The method first uses light scattering technology to determine the critical agglomeration concentration of micro / nano particles at a given electrolyte type and temperature. Then, under this concentration condition, the resultant force of electrostatic repulsion and long-range molecular attraction between particles is calculated, and the particle surface potential under this condition is determined. Finally, the surface charge density of the particles is obtained based on the obtained surface potential. This invention can accurately calculate the surface charge density of micro / nano particles by determining the critical agglomeration concentration using a laser scattering instrument, eliminating the need to separately measure the outer surface area of ​​the particles in a gaseous medium and the number of surface charges in a liquid medium before calculating the surface charge density.

The invention provides a multi-dynamic-bond cross-linked organic silicon resin, a multifunctional low-surface-energy anti-icing and deicing coating composition and a preparation method of the multi-dynamic-bond cross-linked organic silicon resin and the multifunctional low-surface-energy anti-icing and deicing coating composition. The finishing paint is also prepared by mixing the organic silicon resin serving as a resin matrix with the modified photo-thermal micro-nano particles. The coating composition can endow a base material with excellent photo-thermal conversion performance and super-hydrophobic performance, does not influence the original mechanical property and use performance of the base material, and can effectively solve the problems of insufficient mechanical stability and poor environmental adaptability of a super-hydrophobic coating in the prior art. And the requirements of fluoride-free environmental protection, stable anti-icing / deicing and long-term service on the coating material are met.

The invention relates to serum containing encapsulated niaouli essential oil. In the preparation of said serum, firstly niaouli essential oil is encapsulated and then the obtained micro / nanoparticles are loaded into the serum carrier system. The serum containing encapsulated niaouli essential oil, which is the subject of the invention, contains olive oil, caprylic / capric triglyceride, cyclopentasiloxane, isopropyl myristate and encapsulated niaoulii essential oil. The serum containing encapsulated niaouli essential oil is used as a new alternative treatment method for eczema treatment.

The invention relates to a micro-nano particle for composite electroplating and a preparation method of the micro-nano particle. The micro-nano particle sequentially comprises a microsphere, a gel layer and a nanowire from inside to outside, the nanowires are distributed on the surface of the gel layer; the gel layer comprises pH sensitive gel and / or temperature sensitive gel. According to the method, the gel component is introduced during preparation of the micro-nano particles, and the property of gel is changed by adjusting local environment conditions in the electroplating process on the basis of the sensitive characteristic of the gel material to external environment change, so that the deposition behavior of the micro-nano particles is regulated in real time, and a plating layer is endowed with complex performance; and a new solution is provided for preparation of the high-performance composite electroplated layer.

The utility model belongs to the field of biomass material processing, for a kind of lignin micro-nano particle preparation device based on micro-flow atomization technology, it include: reaction kettle and install the pneumatic atomization spray head in reaction kettle top, the high-speed stirring paddle is installed in the bottom of reaction kettle, the bottom edge in reaction kettle is equipped with pH sensor;Reaction kettle side is equipped with feed inlet, feed inlet and metering feed pump one are connected by pipeline one, and the bottom of reaction kettle is equipped with discharge outlet with side wall junction;Pneumatic atomization spray head is connected with high-pressure gas transmission pump by pipeline two, and pneumatic atomization spray head is connected with metering feed pump two by pipeline three;Pneumatic atomization spray head, metering feed pump one, metering feed pump two, high-speed stirring paddle, pH sensor, high-pressure gas transmission pump are electrically connected with electric control system module.The technology can achieve lignin dissolution, atomization and particle forming continuous operation, and the obtained micro-nano particle has good monodispersity, high surface activity, low color and other characteristics, which provides an efficient preparation means for the development of bio-based functional materials.

The application discloses a kind of high tensile high conductive hydrogel with layered structure and its preparation method and application.The method mixes PVA, PEDOT:PSS with EGaIn microparticles, and is prepared by the way of gravity settlement and electrostatic adsorption auxiliary settlement, and the hydrogel with layered structure is obtained.By controlling the proportion of PVA, PEDOT:PSS solution and EGaIn microparticles, the conductive hydrogel with layered structure prepared shows good conductive capacity and mechanical behavior, and can work normally under larger strain and stress conditions, and has wide application prospect in the field of flexible stretchable electronic devices.

The invention provides a preparation method of a particle-self-supporting coupling oxygen evolution electrode for local phase change of an electrooxidation induced material, which comprises the following steps: firstly, constructing a flaky cobalt structure on the surface of foamed nickel by using an electrochemical deposition technology to form a three-dimensional conductive skeleton with a high specific surface area so as to provide more adsorption sites for subsequent particle loading; meanwhile, hydroxyl generated by surface hydrolysis is used for participating in subsequent reaction; secondly, carboxyl on the surface of the micro-nano particle material and hydroxyl on the surface of the substrate are subjected to a bonding reaction through ultrasonic induction, interaction between the carboxyl and the hydroxyl is enhanced, and loading of the particles on the substrate is achieved; and finally, long-time electrooxidation treatment is carried out on the particle-loaded electrode, the synergistic effect between the particles and the cobalt electroplated layer is excited, interface reaction between the particles and the cobalt electroplated layer is promoted, the microstructure of the material is obviously changed, and a firmer new phase is formed between the particles and the substrate.

The present application relates to a kind of methods for regulating the morphology of nitrogen-rich metal organic framework material using organic template agent, belong to the technical field of micro-nano material synthesis.The purpose of the present application is to solve the problems of single morphology, uneven particle size distribution and other problems of nitrogen-rich MOFs micro-nano particles obtained by the prior art, and to provide a method for regulating the morphology of nitrogen-rich metal organic framework material using organic template agent;By using organic template agent, the reaction solvent, reaction temperature and reaction time are controlled, the ratio of organic ligand, metal salt and organic template agent is controlled, so that the morphology and size of MOFs micro-nano particles are effectively controlled, and spherical, flower-like, snowflake-like, interpenetrating, cubic or sheet-like morphology can be obtained, with high yield, high repeatability, and morphology transformation of MOFs material is simultaneously controlled.

This invention provides a method for preparing a particle-self-supported oxygen evolution electrode with localized phase transition induced by electro-oxidation. First, an electrochemical deposition technique is used to construct a sheet-like cobalt structure on the surface of nickel foam, forming a three-dimensional conductive framework with a high specific surface area, providing more adsorption sites for subsequent particle loading. Simultaneously, the hydroxyl groups generated from surface hydrolysis participate in subsequent reactions. Second, ultrasonic induction is used to induce a bonding reaction between the carboxyl groups on the surface of the micro / nano particle material and the hydroxyl groups on the substrate surface, strengthening the interaction between them and achieving particle loading on the substrate. Finally, a prolonged electro-oxidation treatment of the particle-loaded electrode stimulates the synergistic effect between the particles and the cobalt electroplated layer, promoting an interfacial reaction that significantly changes the material's microstructure, forming a more robust new phase between the particles and the substrate.

The invention discloses a method for preparing a high-protein solution from hydrophobin through membrane treatment and ultrasonic assistance, and belongs to the technical field of food protein modification and membrane separation. The preparation method comprises the following steps: dispersing hydrophobic protein in an alkaline solution, adding maltodextrin into the alkaline solution, carrying out multiple times of concentration and dilution operation through membrane treatment to remove salt ions and macromolecular aggregates, and then adjusting the pH value of a solution system to be neutral by adopting an acidic solution; the preparation method comprises the following steps: firstly, preparing a solution, then treating the solution under the ultrasonic action to form a micro-nano particle structure with good colloidal stability, and finally, concentrating and drying to obtain powdery protein with high solubility. The soluble protein powder obtained by the invention can be widely applied to vegetable protein drinks, nutritional formula foods and functional foods.

The invention discloses a degradable macroporous composite tissue engineering scaffold, a structural performance regulation and control method and application, and belongs to the technical field of biomedical materials. Induced phase separation is realized through design of gel molecules and a solvent, so that a macroporous structure is formed; the pore structure is adjusted by controlling the proportion of the polyvinyl alcohol aqueous solution, the glycerol and the hydrophilic degradable biomacromolecule aqueous solution; the mechanical property of the stent is regulated and controlled by adding the degradable inorganic micro-nano particles; meanwhile, a pore structure and a scaffold material with spatial heterogeneity in mechanical property are constructed through hot melt interface integration. The problems that an existing tissue engineering scaffold is insufficient in controllability of a pore structure and mechanical properties and the like are solved, and the degradable macroporous composite tissue engineering scaffold material is suitable for being used as a degradable macroporous composite tissue engineering scaffold material for promoting collaborative injury repair of soft and hard tissues such as osteochondral tissues, muscular bones and tendon bones.

The utility model relates to supercritical micro-nano particle preparation equipment which is applied to the technical field of polymer composite material production, and realizes that a material receiving barrel is firstly placed under a screening device, then an electromagnetic valve is controlled to be opened, so that micro-nano particles in a granulator fall on a coarse filter frame in the screening device through a blanking hopper, and the micro-nano particles in the granulator fall on the coarse filter frame in the screening device. At the moment, a micro servo motor is started to drive a rotating shaft to rotate left and right in a small range, a coarse filtering frame slightly swings and shakes, meanwhile, a connecting shaft and the rotating shaft are fixedly connected through a threaded rod by a fine filtering frame, and therefore the coarse filtering frame drives the fine filtering frame to synchronously shake for layered screening; in the shaking process, the rough filtering frame and the fine filtering frame can be prevented from impacting and damaging the inner wall of the screening device through the protective pad, so that micro-nano particles falling on the rough filtering frame can be shaken and filtered at the same time, stone balls in the rough filtering frame and the fine filtering frame are driven to roll and roll the micro-nano particles in the shaking process, and the situation that large aggregates are formed due to aggregation is avoided; therefore, screening cannot be performed.

This invention discloses a method for scalable preparation of 5-fluorouracil-loaded lyophilized nanoparticles. The method first involves self-assembling 5-fluorouracil into a polymer carrier to form core-shell nanoparticles. Then, the hydrophobic core-shell nanoparticles undergo a double emulsification-isothermal evaporation process to form hydrophilic micro / nanoparticles. Finally, D-mannose is assembled onto the surface of the micro / nanoparticles, followed by gradient freeze-drying to prepare PLGA / 5-FU-loaded lyophilized nanoparticles. This method offers advantages such as simple operation, scalability, and good reproducibility. The 5-FU drug in the prepared lyophilized nanoparticles exhibits good crystallinity. During the inhibition of pancreatic cancer cell growth, it effectively improves the bioavailability, biocompatibility, and physical stability of 5-fluorouracil, significantly inhibiting pancreatic cancer cell growth and demonstrating high anti-tumor immunomodulatory properties.