The invention relates to a
citric acid-based
particle injection material as well as a preparation method and application thereof. The preparation method comprises the following steps: melting and heating
citric acid and 1, 8-octylene glycol to form a POC
prepolymer, dissolving the POC
prepolymer with an
organic solvent to obtain a dissolved solution, and slowly pouring the dissolved solution into
ultrapure water for multiple times for purification to obtain a purified POC degradable
prepolymer; and dissolving the POC degradable prepolymer with a
solvent, adding inorganic salt particles, and carrying out a cross-linking reaction to obtain the POC injectable
particle material. Medicines, active molecules, various
metal ions and the like are loaded on POC in a physical compounding or chemical crosslinking mode, and the
citric acid-based
particle injection material is obtained. The citric acid-based biological material provided by the invention, as a novel medical beauty
raw material and a related
particle injection filler thereof, can effectively promote regeneration, proliferation, migration and
chemotaxis of
skin cells, promote the production of collagen and achieve a medical beauty effect. Meanwhile, the immune response of the
organism can be activated,
inflammation is reduced, the product after degradation is citric acid which can be metabolized randomly, and obvious
immunogenicity and toxic and side effects are avoided.