Externally applied plaster for treating arthralgia and arthritis, and preparation method of externally applied plaster

A technology for joint pain and joints, which is applied in the field of external plaster for the treatment of joint pain and arthritis and its preparation. It can solve the problems of difficult to achieve air permeability, short drug effect time, and no long-term onset of effect, so as to achieve drug onset The effect of long time, simple preparation method and good sustained release effect

Active Publication Date: 2017-12-01
杭州仁德药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Existing plasters usually use natural rubber matrix. A serious disadvantage of natural rubber-based plasters is their extremely poor air permeability. , but in order to improve the air permeability of plaster paste, the effect of such improvement is extremely limited, and it is difficult to achieve good air permeability requirements
In addition, there is another shortcoming, which is also the problem of the existing natural rubber matrix plaster, that is, its drug effect time is short, and it does not have the characteristics of long-acting onset, which also causes patients to frequently replace the plaster when using it. , which brings great inconvenience to patients, especially for plasters that need to be applied on special parts, and the replacement brings great inconvenience; existing sustained-release drugs only exist in oral and other drugs, for There are almost no sustained-release treatment methods for external-use drugs, which can achieve a feasible and effective drug sustained-release treatment method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] An external plaster for treating joint pain and arthritis, prepared from the following raw materials in parts by weight:

[0037]250 parts of pepper, 25 parts of menthol, 25 parts of borneol, 200 parts of rubber, 80 parts of lanolin, 240 parts of zinc oxide, 240 parts of rosin, 70 parts of beeswax, 7 parts of coating agent, 500 parts of gasoline; Acetyl chitin;

[0038] Wherein, zinc oxide is a mixture of zinc oxide powder and zinc oxide fiber, wherein the weight percentage of zinc oxide fiber is 45%; the length of zinc oxide fiber is 50 μm, the aspect ratio is 5, and the particle size of zinc oxide powder is 200 mesh;

[0039] Zinc oxide is processed through the following steps before use:

[0040] Add zinc oxide to water twice the weight of zinc oxide, then add carboxymethyl cellulose with 20% weight of zinc oxide, and stir magnetically at a speed of 41rpm for 10 minutes, then magnetically stir at a speed of 11rpm for 1 minute, then vacuum The liquid is removed by f...

Embodiment 2

[0051] An external plaster for treating joint pain and arthritis, prepared from the following raw materials in parts by weight:

[0052] 250 parts of pepper, 30 parts of menthol, 30 parts of borneol, 250 parts of rubber, 90 parts of lanolin, 250 parts of zinc oxide, 255 parts of rosin, 80 parts of beeswax, 9 parts of coating agent, 560 parts of gasoline; Acetyl chitin and dimethylaminoethyl methacrylate-methacrylate copolymer are composed at a weight ratio of 5:4;

[0053] Wherein, zinc oxide is a mixture of zinc oxide powder and zinc oxide fiber, wherein the weight percentage of zinc oxide fiber is 50%; the length of zinc oxide fiber is 200 μm, the aspect ratio is 7, and the particle size of zinc oxide powder is 300 mesh;

[0054] Zinc oxide is processed through the following steps before use:

[0055] Add zinc oxide to water that is 4 times the weight of zinc oxide, then add carboxymethyl cellulose with 30% weight of zinc oxide, and magnetically stir at a speed of 45rpm for...

Embodiment 3

[0066] An external plaster for treating joint pain and arthritis, prepared from the following raw materials in parts by weight:

[0067] 250 parts of pepper, 30 parts of menthol, 30 parts of borneol, 250 parts of rubber, 90 parts of lanolin, 250 parts of zinc oxide, 255 parts of rosin, 80 parts of beeswax, 9 parts of coating agent, 560 parts of gasoline; Acetyl chitin and dimethylaminoethyl methacrylate-methacrylate copolymer are composed at a weight ratio of 5:12;

[0068] Wherein, zinc oxide is a mixture of zinc oxide powder and zinc oxide fiber, wherein the weight percentage of zinc oxide fiber is 50%; the length of zinc oxide fiber is 200 μm, the aspect ratio is 7, and the particle size of zinc oxide powder is 300 mesh;

[0069] Zinc oxide is processed through the following steps before use:

[0070] Add zinc oxide to water that is 4 times the weight of zinc oxide, then add carboxymethyl cellulose with 30% weight of zinc oxide, and magnetically stir at a speed of 45rpm fo...

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Abstract

The invention belongs to the technical fields of plasters and preparation thereof. The invention discloses an externally applied plaster for treating arthralgia and arthritis, and a preparation method of the externally applied plaster. The plaster is prepared from the following raw materials: capsicum annuum, menthol, borneol, rubber, lanolin, zinc oxide, rosin, beeswax, a coating agent, gasoline, and the like. The preparation method comprises the steps of preparing the raw materials, carrying out medicine preparation, refining rubber, coating, mashing, gluing, drying, carrying out aftertreatment, and the like. The externally applied plaster for treating the arthralgia and the arthritis has the effects of expelling wind and removing cold, relaxing tendons and activating collaterals, relieving swelling and pain, and the like, can be used for treating the arthralgia, backache and sprain bruise as well as diseases such as chronic arthritis and chilblain being not broken; furthermore, the externally applied plaster has good air permeability and is long in drug onset time; the externally applied plaster for treating the arthralgia and the arthritis is simple in preparation method and can be easily realized on the existing equipment.

Description

technical field [0001] The invention relates to the technical field of plaster and its preparation, in particular to an external plaster for treating joint pain and arthritis and a preparation method thereof. Background technique [0002] Existing plasters usually use natural rubber matrix. A serious disadvantage of natural rubber-based plasters is their extremely poor air permeability. , but due to improving the air permeability of plaster paste, such improvement has extremely limited effect, and it is difficult to realize the requirement of good air permeability. In addition, there is another shortcoming, which is also the problem of the existing natural rubber matrix plaster, that is, its drug effect time is short, and it does not have the characteristics of long-acting onset, which also causes patients to frequently replace the plaster when using it. , which brings great inconvenience to patients, especially for plasters that need to be applied on special parts, and the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81A61K9/70A61K47/36A61K47/44A61K47/32A61K47/02A61P29/00A61P19/02A61K31/045
CPCA61K9/0002A61K9/7076A61K31/045A61K36/81A61K47/02A61K47/32A61K47/36A61K2300/00
Inventor 俞帮和徐明蒋志刚汪海涛
Owner 杭州仁德药业股份有限公司
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