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Andrographolide soft capsule formulation and preparation method

A technology of andrographolide and soft capsules, applied in the field of medicine, can solve the problems of inconvenient medication for patients, slow dissolution of active ingredients, and poor patient compliance

Inactive Publication Date: 2008-02-13
山东希尔康泰药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the clinical preparations of andrographolide include injections and tablets, etc., while the curative effect of injections can be sure, there is a shortcoming of inconvenience for patients
Due to the poor solubility of andrographolide in tablets, the active ingredients dissolve slowly and the onset of action is slow
Simultaneously, andrographolide has a bitter taste, and the patient's medical compliance is poor.

Method used

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  • Andrographolide soft capsule formulation and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Component Quantity (g / grain)

[0031] Andrographolide 0.025

[0032] Polyethylene glycol 0.225

[0033] Gelatin 0.16

[0034] Glycerin 0.09

[0035] Hydroxyethylcellulose 0.007

[0036] Citric acid 0.008

[0037] Methyl sorbate 0.001

[0038] Beeswax 0.01

[0039] water 0.25

Embodiment 2

[0041] Component Quantity (g / grain)

[0042] Andrographolide 0.05

[0043] Peanut oil 0.39

[0044] Gelatin 0.12

[0045] Glycerin 0.05

[0046] Ethyl cellulose 0.008

[0047] Ethylenediaminetetraacetic acid 0.001

[0048] Benzoic acid 0.002

[0049] Beeswax 0.02

[0050] water 0.25

Embodiment 3

[0052] Component Quantity (g / grain)

[0053] Andrographolide 0.01

[0054] soybean oil 0.08

[0055] Gelatin 0.18

[0056] Glycerin 0.08

[0057] Chitosan 0.006

[0058] Ascorbic acid 0.007

[0059] Propyl p-hydroxybenzoate 0.002

[0060] Beeswax 0.006

[0061] water 0.25

[0062] The preparation technology of above embodiment andrographolide soft capsule is:

[0063] Weigh the gelatin and add it to a 100L gelatin reaction tank, add an appropriate amount of water while stirring, and seal it tightly. After the gelatin is completely dissolved, add glycerin and an appropriate amount of coloring agent, stir evenly, vacuumize and degas for 2 hours, and put it in a gelatin insulation bucket. Keep warm overnight and set aside.

[0064] Add the suspending agent to the diluent, mix well, weigh andrographolide, pulverize, sieve, mix the andrographolide with the diluent, add antioxidants and preservatives after being completely mixed, stir evenly, and leave to rest at room tempe...

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PUM

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Abstract

The present invention is one kind of soft andrographolide capsule preparation and its preparation process. The capsule medicine liquid contains enough andrographolide as its effective component, and proper amount of medicinal supplementary material is added, including diluent, suspension assistant, antioxidant, preservative, etc. The capsule shell consists of mainly gelatin, glycerine and water. The capsule of the present invention has stable quality, convenient administration, fast leaching out of the effective component and timely acting.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a pharmaceutical preparation of andrographolide, more specifically to a soft capsule of andrographolide, and simultaneously the invention also relates to a preparation method of the preparation. Background technique [0002] Andrographolide has the functions of clearing away heat and detoxification, antibacterial and anti-inflammatory, and is clinically used for upper respiratory tract infection and bacillary dysentery. [0003] At present, the clinical preparations of andrographolide include injections and tablets, etc., and the injections have the disadvantage of inconvenient medication for patients while the curative effect can be affirmed. Due to the poor solubility of andrographolide in the tablet, the active ingredient dissolves slowly and the onset of action is slow. Simultaneously, andrographolide tastes bitter, and patient's medical compliance is relatively poor. Andr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/365A61K9/48A61P31/00A61P31/04A61P11/00
Inventor 张川张卫东苏娟周耘
Owner 山东希尔康泰药业有限公司
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