Spray for extraocular use

A technology for sprays and ophthalmic preparations, applied in the field of sprays for external application, can solve problems such as mucosal damage and irritation, and achieve the effects of promoting absorption, improving comfort, and prolonging onset time.

Inactive Publication Date: 2018-09-18
BEIJING LANDAN PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these chemical accelerators can increase the drug penetration rate, most of the chemical accelerators can cause damage or irritation to the skin and mucous membranes

Method used

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  • Spray for extraocular use
  • Spray for extraocular use
  • Spray for extraocular use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055]

[0056] Preparation:

[0057] (1) Add trehalose and sodium chloride into purified water and shear at high speed;

[0058] (2) adding egg yolk lecithin while step (1) high-speed shearing;

[0059] (3) high-pressure homogenization of the mixture obtained in step (2);

[0060] (4) Filtration and filling.

Embodiment 2

[0062]

[0063] Preparation:

[0064] (1) Add trehalose and sodium chloride into purified water and shear at high speed;

[0065] (2) adding egg yolk lecithin while step (1) high-speed shearing;

[0066] (3) high-pressure homogenization of the mixture obtained in step (2);

[0067](4) Filtration and filling.

Embodiment 3

[0069]

[0070]

[0071] Preparation:

[0072] (1) Add trehalose and sodium chloride into purified water and shear at high speed;

[0073] (2) adding egg yolk lecithin while step (1) high-speed shearing;

[0074] (3) high-pressure homogenization of the mixture obtained in step (2);

[0075] (4) Filtration and filling.

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Abstract

The invention provides a spray containing phospholipid and mycose for extraocular use, wherein the phospholipid content is 1 to 100mg/ml, and the mycose content is 1 to 100mg/ml; preferably, the phospholipid content is 1 to 20mg/ml, and the mycose content is 1 to 50mg/ml; further preferably, the phospholipid content is 5 to 15mg/ml, and the mycose content is 10 to 30mg/ml. The spray for extraocular use provided by the invention has the advantages that the spray can penetrate the eye skin barrier; the xerophthalmia is safely and effectively treated; the effect taking time can be prolonged; thecomfort of a patient is improved. In addition, when the spray for extraocular use is used as a carrier with pharmacological or cosmetic active substances, the permeable membrane absorption quantity ofthe active substances can be improved; the bioavailability is improved; meanwhile, no irritation is generated on the eyes.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a spray for extraocular administration. Background technique [0002] Dry eye syndrome is a common ophthalmic disease. It is a general term for a group of diseases characterized by decreased tear secretion or excessive evaporation, decreased tear film stability, and ocular surface damage caused by various reasons. Common symptoms of dry eye are local eye irritation, photophobia, pain, blurred vision, and fatigue. If dry eye is not treated effectively, corneal and conjunctival keratinization and ulcers may form, resulting in severe loss of vision. With the widespread penetration of video display terminals such as computers, TVs, and mobile phones in people's lives and the widespread use of contact lenses, there are more and more people with dry eye syndrome due to the decrease in the frequency of long-term blinking and the increase in exposure of ocular surface tissues. . At ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K47/26A61K47/24A61K45/00A61P27/02
CPCA61K9/0048A61K9/12A61K45/00A61K47/24A61K47/26A61P27/02
Inventor 林静文其他发明人请求不公开姓名
Owner BEIJING LANDAN PHARMA TECH
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