15 results about "Eye irritation" patented technology

The disclosure relates to formulations and methods for the in vitro testing of ocular irritants. It was discovered that adding an antioxidant formulation to in vitro ocular irritation tests, including for example, a biochemical ocular irritation test, a reconstituted human corneal epithelium (RhCE) ocular irritation test and an excised eye depth of injury (Dol) test, substantially reduces the rate of false positives without diminishing test sensitivity, resulting in more accurately predicting ocular irritancy of test substances. More particularly, the disclosed method employs relatively high physiologic concentrations of one or more antioxidants that are normally present in tears. In a variation, much higher concentrations of one or more antioxidants may provide protection against in vivo exposure to ocular irritants.

The invention discloses difunctional nano drug-loaded eye drops for xerophthalmia and a preparation method of the difunctional nano drug-loaded eye drops, and belongs to the field of pharmaceutical preparation technologies and ophthalmology pharmacy. The core of the invention is to construct a composite nanoparticle which has a core-shell structure and has long-acting adhesion lubrication and targeted control drug release functions. The preparation method comprises the following steps: firstly, encapsulating a hydrophobic immunosuppressant such as cyclosporine A in a biodegradable pad polymer matrix such as polylactic acid-glycolic acid copolymer (PLGA) by an emulsification-solvent evaporation method to form a drug-loaded polymer nano core; through the exquisite integrated design of the structure and the function, collaborative targeted therapy of two core pathological links of'tear film instability 'and'immune inflammation' of xerophthalmia is achieved, the bioavailability of the medicine is remarkably improved, the medication frequency and eye irritation are reduced, and the curative effect of xerophthalmia is improved. A more efficient and safer administration scheme with better patient compliance is provided for clinical treatment of xerophthalmia.

The invention designs a new application of grape seed procyanidine in prevention and treatment of cataract. The method comprises the following steps: constructing a cataract injury model by inducing rabbit crystalline lens oxidative injury with hydrogen peroxide, culturing by adopting a domestic rabbit crystalline lens, detecting the activity of total superoxide dismutase, glutathione peroxidase and catalase and the content of malondialdehyde by observing the opacity and structural form of the crystalline lens, and detecting the expression of apoptosis regulation proteins BCL-2 and BAX in combination with immunohistochemistry. And the protective effect and molecular mechanism of the grape seed procyanidine on crystalline lens injury are researched. Researches show that the grape seed procyanidine has a protective effect on hydrogen peroxide induced rabbit crystalline lens injury, and the mechanism of the grape seed procyanidine is related to an antioxidant effect and adjustment of BCL-2 / BAX apoptotic protein; rabbit eye stimulation experiments prove that the grape seed procyanidine has no stimulation or only slight stimulation to rabbit eyes. Therefore, the grape seed procyanidine can prevent cataract, is a potential cataract treatment medicine, provides a new way for development of related medical products such as eye drops, and has good clinical application value.

The invention provides a method for evaluating eye irritation of cosmetics, and relates to the technical field of detection. The method comprises the following steps: firstly, acquiring a first image of a chick embryo chorioallantoic membrane before contacting a to-be-detected sample; removing the to-be-detected sample contact film after a preset time to obtain a second image; performing color channel separation on the two images, and selecting a green channel image to perform gray value analysis to obtain a first gray value and a second gray value; and finally evaluating the eye irritation level of the sample to be detected according to the gray value difference. According to the method disclosed by the invention, quantitative evaluation on eye irritation is realized by utilizing the optical characteristic of chick embryo blood vessels to green light, the subjective defect that a traditional chick embryo chorioallantoic membrane test depends on visual inspection is overcome, the objectivity, accuracy and repeatability of a detection result are remarkably improved, the operation is simple and convenient, and animal ethical dispute is avoided.

The application discloses a kind of zinc sulfide nanometer eye drops and its preparation method and application, the zinc sulfide nanometer eye drops includes zinc sulfide nanoparticles and sterile water, the zinc sulfide nanoparticles are spherical nanoparticles with pseudo-virus-like spike structure, and particle size is 150-250nm, and the zinc sulfide nanoparticles can release hydrogen sulfide gas under eye acidic inflammatory microenvironment.The application can realize the stable, slow, controllable release of hydrogen sulfide gas under eye acidic inflammatory microenvironment, utilize the anti-inflammatory, antioxidant, promote mucosa repair and improve tear film stability and other biological functions of gas signal molecule hydrogen sulfide, realize the effective treatment of dry eye, relieve eye dryness, inflammation, injury and other symptoms;The formula of the application is mild, has no obvious cytotoxicity and eye irritation, has good biological safety, can meet the needs of long-term, safe and comfortable use in clinic, provides a new, efficient and safe gas treatment approach for dry eye.

The invention discloses eye-soothing herbal liquid medicine and a preparation method thereof, and particularly relates to the technical field of traditional Chinese medicine preparations, and the eye-soothing herbal liquid medicine is prepared from the following raw material medicines in parts by weight: 5-15 parts of American ginseng, 5-15 parts of lucid ganoderma, 5-15 parts of honeysuckle, 5-15 parts of schizonepeta, 5-15 parts of semen cassiae, 5-15 parts of gastrodia elata and 5-15 parts of pseudo-ginseng. And at least one auxiliary material selected from the following groups: 5-15 parts of Chinese wolfberry, 5-15 parts of chrysanthemum, 5-15 parts of butterflybush flower, 3-10 parts of coptis chinensis, 5-15 parts of salvia miltiorrhiza and 1-5 parts of menthol. By optimizing the formula combination and the extraction process, the extraction rate of effective components and the clarity of liquid medicine are remarkably improved, the product stability is good, eye irritation is avoided, antioxidant activity tests show that the optimized formula has a synergistic effect, can be used for relieving eyestrain, resisting inflammation and improving eyesight, and is suitable for being used as a daily eye care product.

The invention discloses an oral antibacterial liquid for an oral antibacterial mucoprotective film, which has an excellent inhibition effect on escherichia coli, porphyromonas gingivalis, staphylococcus aureus, streptococcus mutans and candida albicans through the synergistic effect of lysozyme, lysostaphin, angelia and plant extract. The bacteriostasis rate can reach 99.99% or above after 5 minutes of action; through a specific ratio and a specific process, after the active ingredients in the product are subjected to an accelerated test at 37 DEG C for 90 days, the activity decline rate of lysozyme and lysostaphin is lower than 10%, the color and precipitation are not changed, the validity period of the product can stably reach 2 years, and the efficacy in the shelf life is ensured; an acute eye stimulation test verifies that the product has no stimulation to New Zealand rabbit eyes, which indicates that the product is safe and mild when being used for oral mucosa, and stimulation and side effects possibly brought by a chemical bacteriostatic agent are avoided.

An emulsion containing a nitrogenous heterocyclic compound and a preparation method therefor. The emulsion comprises an active ingredient, vegetable oil, an emulsifier, hydroxypropyl cellulose, and water. The emulsion not only exhibits good efficacy in alleviating xerophthalmia, but also has relatively good homogeneity and stability, which helps ensure the effectiveness and safety of the drug during storage and use. Moreover, the ophthalmic emulsion composition can increase the retention time of the active ingredient in the eyes, improve the bioavailability of the drug, and reduce cytotoxicity and eye irritation.

A method for preparing a highly biocompatible phakic posterior chamber intraocular lens (ICL) material, belonging to the field of polymer materials, includes the following steps: Hydroxyethyl methacrylate, ethylene glycol, bovine serum albumin solution, and initiator solution are stirred and mixed until the solution is clear, obtaining a mixture. The mixture is then degassed by ultrasonication. The degassed mixture is injected into a mold and transferred to an incubator for polymerization. After the reaction, the mold is removed and the sample is taken out. The obtained sample is dialyzed in a buffer solution to obtain the ICL material. This process has simple reaction steps, controllable reaction rate, and low energy consumption, reducing the production cost of ICL. The copolymer exhibits excellent optical and mechanical properties while demonstrating good biocompatibility, providing good visual effects and reducing eye irritation after implantation.

The invention relates to the technical field of daily chemical cleaning and nursing, and discloses a silicone oil-free sulfate-free weak cation system shampoo and a preparation method thereof.According to the formula of the shampoo, lauramide propyl betaine, sodium lauroyl sarcosinate and other multi-element surfactants are compounded; a weak cation conditioning system cooperatively constructed by matching phytosterols, cationic cellulose and cationic guar gum does not contain silicone oil and sulfate components; gradient temperature change and segmented pH regulation and control processes are adopted for preparation. The product has a pH value of 5.0-6.0, conforms to the scalp environment, does not have harmful residues such as D4 and dioxane, has acute eye irritation of slight irritation, has a cleaning rate of 91-97%, is fine and smooth in foam and easy to wash, can significantly improve the smoothness of wet and dry hair and reduce frizz, has stable performance after being placed at 60 DEG C for 4 months, has mild property, cleaning power, repairing effect and use experience, and is suitable for various hair qualities.

The application discloses a kind of composite plant extract eye drops for relieving eye fatigue and a preparation method thereof, and relates to the technical field of ophthalmic preparations.The eye drops of the present application use lutein, zeaxanthin, blueberry extract, peppermint essential oil and borneol as fat-soluble active ingredients, and use phospholipid and poloxamer 188 as a composite nanocarrier, in combination with sodium hyaluronate, sodium chloride and a buffer system, a bacteriostatic system to form the eye drops.The present application uses a film hydration combined with high-pressure homogenization process to produce clear and transparent, thermodynamically stable eye drops, which solves the problems of low solubility, easy oxidative degradation and poor bioavailability of fat-soluble ingredients, improves the concentration and retention time of active ingredients in the eye, and the synergistic effect of various plant extracts can effectively relieve the symptoms of eye fatigue caused by long-term eye use, such as dryness, acid swelling, blurred vision and ciliary spasm, without eye irritation and with high stability.

This invention discloses a liquid composition containing carotenoids, belonging to the field of eye care. The liquid composition comprises: carotenoids; and a mixed solvent; said mixed solvent comprises: perfluorocarbon as a first solvent; and semi-fluorinated alkane as a second solvent. In particular, liquid compositions containing carotenoids, represented by lutein, do not require the addition of pH adjusters, surfactants, or preservatives, thus avoiding eye irritation and damage, and exhibit excellent carotenoid stability.

A personal care composition, comprising a mono-rhamno-mono-lipid, a di-rhamno-mono-lipid, a co-surfactant and a carrier. The combination of rhamno-mono-lipids and co-surfactants in a personal cleansing composition reduces the eye irritation potential during application.

This invention relates to the field of medical solution preparation technology. Addressing the problems of incomplete and slow neutralization processes in traditional hydrogen peroxide contact lens solutions, which lead to eye irritation risks and low care efficacy, this invention specifically discloses a neutralized hydrogen peroxide contact lens solution, its preparation method, and its usage method. The solution comprises: 2.0-4.0% (w / v) hydrogen peroxide, 0.01-0.5% (w / v) poloxamer, 0.01-0.1% (w / v) diethylenetriaminepentamethylphosphonic acid, and 0.001-0.01% (w / v) UCNP@TiO2 nanomaterials, with the remainder being a buffer system, an osmotic pressure regulator, and purified water. The UCNP@TiO2 nanomaterials are a core-shell composite material with a lanthanide-doped upconversion nanomaterial core and a titanium dioxide shell. This invention introduces UCNP@TiO2 nanomaterials into the nursing solution. Under near-infrared light irradiation, this material can instantly generate a significant killing effect on microorganisms and can also rapidly and completely decompose hydrogen peroxide into water and oxygen, achieving a nursing effect of active light-controlled triggering for disinfection and sterilization.

The invention belongs to the technical field of intelligent glasses with intelligent perception, and particularly relates to intelligent glasses with intelligent perception, which comprise a glasses frame, a camera slot, two glasses support arms, two touch glasses legs and an intelligent control module. A high-definition lens, a display lens, a holographic AR information display lens and a protective cover are arranged in the glasses frame; a high-definition CMOS (Complementary Metal Oxide Semiconductor) camera is arranged in the camera slot, and low-light induction intensifiers are arranged in the induction slots on the two sides of the A lithium battery and a microphone are arranged in the glasses support arm, and the touch glasses leg is hinged to the tail end of the glasses support arm; the intelligent control module can project digital information to the display lens and the holographic AR information display lens to be superposed with reality. According to the glasses, through cooperation of all parts, a user can normally see objects in dark, smog, haze and other environments, light brightness is automatically adapted, eye stimulation is avoided, night vision full-color imaging is achieved, and the glasses are portable and easy to operate.