29 results about "Eye irritation" patented technology

The disclosure relates to formulations and methods for the in vitro testing of ocular irritants. It was discovered that adding an antioxidant formulation to in vitro ocular irritation tests, including for example, a biochemical ocular irritation test, a reconstituted human corneal epithelium (RhCE) ocular irritation test and an excised eye depth of injury (Dol) test, substantially reduces the rate of false positives without diminishing test sensitivity, resulting in more accurately predicting ocular irritancy of test substances. More particularly, the disclosed method employs relatively high physiologic concentrations of one or more antioxidants that are normally present in tears. In a variation, much higher concentrations of one or more antioxidants may provide protection against in vivo exposure to ocular irritants.

The invention discloses difunctional nano drug-loaded eye drops for xerophthalmia and a preparation method of the difunctional nano drug-loaded eye drops, and belongs to the field of pharmaceutical preparation technologies and ophthalmology pharmacy. The core of the invention is to construct a composite nanoparticle which has a core-shell structure and has long-acting adhesion lubrication and targeted control drug release functions. The preparation method comprises the following steps: firstly, encapsulating a hydrophobic immunosuppressant such as cyclosporine A in a biodegradable pad polymer matrix such as polylactic acid-glycolic acid copolymer (PLGA) by an emulsification-solvent evaporation method to form a drug-loaded polymer nano core; through the exquisite integrated design of the structure and the function, collaborative targeted therapy of two core pathological links of'tear film instability 'and'immune inflammation' of xerophthalmia is achieved, the bioavailability of the medicine is remarkably improved, the medication frequency and eye irritation are reduced, and the curative effect of xerophthalmia is improved. A more efficient and safer administration scheme with better patient compliance is provided for clinical treatment of xerophthalmia.

The present application relates to the technical field of cosmetic safety evaluation, and specifically to a method for evaluating the eye irritation of cosmetic raw materials, which is executed by a processor and includes: obtaining data of in vitro surrogate test results and in vivo test results of target cosmetic raw materials to form a data set; executing an input fusion model on the data set; judging whether there is the same result data based on the data set, and if so, outputting the evaluation result; if not, executing integrated learning and similarity judgment; and outputting the evaluation result. The present application solves the technical problem that the prior art cannot provide a method with a high accuracy rate for predicting and evaluating the eye irritation of cosmetic raw materials.

The utility model discloses a cosmetic eye irritation detection and analysis device which comprises a base, and the right side of the top of the base is fixedly connected with an analysis device main body. Through the arrangement of the groove, the analysis device is started, the start button is pressed down to start the automatic sample dropping pipettor, after the automatic sample dropping pipettor drips a sample to a chick embryo chorioallantoic membrane in the groove under the automatic sample dropping pipettor, the stepping motor is automatically started and drives the rotating base plate to rotate by 36 degrees, and the chick embryo chorioallantoic membrane is automatically dropped into the chick embryo chorioallantoic membrane in the groove under the automatic sample dropping pipettor. The chick embryo chorioallantoic membrane in the next groove is moved to the position under the automatic sample dropwise adding pipettor for dropwise adding the sample, and a pause button is controllably pressed until the ten chick embryo chorioallantoic membranes are dropwise added completely, so that the stepping motor and the automatic sample dropwise adding pipettor stop working, and then the chick embryo chorioallantoic membranes can be covered with a preservative film for constant-temperature culture; the dripping process is automatically and quickly completed, so that the analysis efficiency is improved, the use of a user is facilitated, and the practicability of the analysis device is improved.

The invention designs a new application of grape seed procyanidine in prevention and treatment of cataract. The method comprises the following steps: constructing a cataract injury model by inducing rabbit crystalline lens oxidative injury with hydrogen peroxide, culturing by adopting a domestic rabbit crystalline lens, detecting the activity of total superoxide dismutase, glutathione peroxidase and catalase and the content of malondialdehyde by observing the opacity and structural form of the crystalline lens, and detecting the expression of apoptosis regulation proteins BCL-2 and BAX in combination with immunohistochemistry. And the protective effect and molecular mechanism of the grape seed procyanidine on crystalline lens injury are researched. Researches show that the grape seed procyanidine has a protective effect on hydrogen peroxide induced rabbit crystalline lens injury, and the mechanism of the grape seed procyanidine is related to an antioxidant effect and adjustment of BCL-2 / BAX apoptotic protein; rabbit eye stimulation experiments prove that the grape seed procyanidine has no stimulation or only slight stimulation to rabbit eyes. Therefore, the grape seed procyanidine can prevent cataract, is a potential cataract treatment medicine, provides a new way for development of related medical products such as eye drops, and has good clinical application value.

The invention discloses a traditional Chinese medicine composition for relieving eye discomfort, a preparation and a preparation and use method, and belongs to the technical field of Chinese herbal medicines. The composition is prepared by mixing flos chrysanthemi indici, semen cassiae, flos carthami, pearl powder, myrrh, frankincense, fructus lycii, folium mori, flos buddlejae, flos lonicerae and radix salviae miltiorrhizae. When the traditional Chinese medicine composition is used as an external liquid preparation, mint is added, so that the traditional Chinese medicine composition not only can effectively relieve eye fatigue, dry eyes, eye astringency, blurred eyes, impaired vision, relieved vision and heavy couperose skin, but also can further relieve dry skin around eyes and the like due to the addition of propolis. According to the preparation method of the traditional Chinese medicine preparation, the raw materials are soaked with edible alcohol and then decocted with a water extraction method to obtain a stock solution, separation of effective components in the raw materials can be effectively improved, the alcohol is completely volatilized through the water extraction method, it is guaranteed that eye irritation and discomfort of a user cannot be caused in the using process, and the use effect is good. The use safety is realized.

The invention provides a method for evaluating eye irritation of cosmetics, and relates to the technical field of detection. The method comprises the following steps: firstly, acquiring a first image of a chick embryo chorioallantoic membrane before contacting a to-be-detected sample; removing the to-be-detected sample contact film after a preset time to obtain a second image; performing color channel separation on the two images, and selecting a green channel image to perform gray value analysis to obtain a first gray value and a second gray value; and finally evaluating the eye irritation level of the sample to be detected according to the gray value difference. According to the method disclosed by the invention, quantitative evaluation on eye irritation is realized by utilizing the optical characteristic of chick embryo blood vessels to green light, the subjective defect that a traditional chick embryo chorioallantoic membrane test depends on visual inspection is overcome, the objectivity, accuracy and repeatability of a detection result are remarkably improved, the operation is simple and convenient, and animal ethical dispute is avoided.

The application discloses a kind of zinc sulfide nanometer eye drops and its preparation method and application, the zinc sulfide nanometer eye drops includes zinc sulfide nanoparticles and sterile water, the zinc sulfide nanoparticles are spherical nanoparticles with pseudo-virus-like spike structure, and particle size is 150-250nm, and the zinc sulfide nanoparticles can release hydrogen sulfide gas under eye acidic inflammatory microenvironment.The application can realize the stable, slow, controllable release of hydrogen sulfide gas under eye acidic inflammatory microenvironment, utilize the anti-inflammatory, antioxidant, promote mucosa repair and improve tear film stability and other biological functions of gas signal molecule hydrogen sulfide, realize the effective treatment of dry eye, relieve eye dryness, inflammation, injury and other symptoms;The formula of the application is mild, has no obvious cytotoxicity and eye irritation, has good biological safety, can meet the needs of long-term, safe and comfortable use in clinic, provides a new, efficient and safe gas treatment approach for dry eye.

The invention discloses eye-soothing herbal liquid medicine and a preparation method thereof, and particularly relates to the technical field of traditional Chinese medicine preparations, and the eye-soothing herbal liquid medicine is prepared from the following raw material medicines in parts by weight: 5-15 parts of American ginseng, 5-15 parts of lucid ganoderma, 5-15 parts of honeysuckle, 5-15 parts of schizonepeta, 5-15 parts of semen cassiae, 5-15 parts of gastrodia elata and 5-15 parts of pseudo-ginseng. And at least one auxiliary material selected from the following groups: 5-15 parts of Chinese wolfberry, 5-15 parts of chrysanthemum, 5-15 parts of butterflybush flower, 3-10 parts of coptis chinensis, 5-15 parts of salvia miltiorrhiza and 1-5 parts of menthol. By optimizing the formula combination and the extraction process, the extraction rate of effective components and the clarity of liquid medicine are remarkably improved, the product stability is good, eye irritation is avoided, antioxidant activity tests show that the optimized formula has a synergistic effect, can be used for relieving eyestrain, resisting inflammation and improving eyesight, and is suitable for being used as a daily eye care product.

The application discloses a kind of semi-fluorocarbon for removing emulsified silicone oil filling and its preparation method and application, comprising, olefin and perfluoroalkyl iodine are dissolved in acetonitrile, initiator is added and reacted under light source, to obtain fluorine-containing iodoalkane;Fluorine-containing iodoalkane is dissolved in isopropyl alcohol, and after adding reducing agent and heating reaction, it is washed to obtain semi-fluorocarbon with the structure of CF3 (CF2) 3 (CH2) 4CH3, named semi-fluorinated nonafluorononane;Wherein, the molar ratio of the olefin and perfluoroalkyl iodine is 1:1-1.4, and the initiator is cuprous chloride.The application controls the proportion of raw materials, carries out reaction under the condition of suitable initiator, simultaneously preferably zinc powder is used as reducing agent, effectively improves product purity and product yield, and operation process is simple, safe, and CF3 (CF2) 3 (CH2) 4CH3 prepared has not only good stability, but also good biocompatibility, no cytotoxicity, no skin sensitization, no acute eye irritation, can dissolve or wrap emulsified silicone oil droplets, and play a great role in the removal of emulsified silicone oil.

The application provides a collagen moisturizing soft hydrophilic contact lens and a preparation method thereof, and belongs to the technical field of soft hydrophilic contact lenses. The contact lens is prepared from HEMA, DMAA and MA as main base materials, and four types of functional components, namely, polydeoxyribonucleotide (PDRN), PEG400, sodium hyaluronate and chitosan derivative, are compounded. An initiator of azobisdimethylvaleronitrile and benzoyl peroxide and a crosslinking agent of ethylene glycol dimethacrylate and pentaerythritol tetraacrylate are compounded. The contact lens is prepared through segmented constant temperature polymerization and sufficient post-treatment and refining. The application simulates the moisturizing mechanism of collagen by constructing a three-dimensional deep water locking network through natural moisturizing components, and long-acting water locking and soothing eye dryness. The application greatly improves the ocular surface biocompatibility of the lens by relying on the biological activity components and low-toxicity mild formula, reduces the residual monomer toxicity, and has no eye irritation.

The invention discloses an oral antibacterial liquid for an oral antibacterial mucoprotective film, which has an excellent inhibition effect on escherichia coli, porphyromonas gingivalis, staphylococcus aureus, streptococcus mutans and candida albicans through the synergistic effect of lysozyme, lysostaphin, angelia and plant extract. The bacteriostasis rate can reach 99.99% or above after 5 minutes of action; through a specific ratio and a specific process, after the active ingredients in the product are subjected to an accelerated test at 37 DEG C for 90 days, the activity decline rate of lysozyme and lysostaphin is lower than 10%, the color and precipitation are not changed, the validity period of the product can stably reach 2 years, and the efficacy in the shelf life is ensured; an acute eye stimulation test verifies that the product has no stimulation to New Zealand rabbit eyes, which indicates that the product is safe and mild when being used for oral mucosa, and stimulation and side effects possibly brought by a chemical bacteriostatic agent are avoided.

To provide a ceiling light with a night light function. The present invention includes a socket 3, a drive assembly 2, a light source assembly 4, a lens assembly 5, and a lampshade 1, the drive assembly being attached to the socket, the light source assembly including a light source plate 401, a main light source 403 mounted on the light source plate, and a night-light light source 402, the light source plate being attached to the socket and electrically connected to the drive assembly, the lens assembly including a main lighting lens 501 connected to the light source plate and a night-light lens 502 mounted on the light output side of the night-light light source, the main lighting lens having a light-transmitting portion corresponding to the main light source, an escape hole in the main lighting lens, the night-light lens being inserted into the escape hole, and the lampshade being connected to the socket. The present invention aims to solve the technical problem that the light beam from the night-light in the prior art is directly projected outward, irritating to the eyes, and that the use of a backlight method can reduce the eye irritation caused by the light beam from the night-light, but results in increased production costs and is detrimental to the development of businesses.

An emulsion containing a nitrogenous heterocyclic compound and a preparation method therefor. The emulsion comprises an active ingredient, vegetable oil, an emulsifier, hydroxypropyl cellulose, and water. The emulsion not only exhibits good efficacy in alleviating xerophthalmia, but also has relatively good homogeneity and stability, which helps ensure the effectiveness and safety of the drug during storage and use. Moreover, the ophthalmic emulsion composition can increase the retention time of the active ingredient in the eyes, improve the bioavailability of the drug, and reduce cytotoxicity and eye irritation.

To provide a therapeutic tool capable of bringing hot spring water into direct contact with eyes for a long time without immersing the face in hot spring water.SOLUTION: An upper edge part of a goggle type therapeutic tool is provided with a pad tool abutting on the forehead. A space for supplying hot spring water into the therapeutic tool is formed between the pad tool and the upper edge part of the therapeutic tool. and a cushion for preventing the hot spring water stored in the therapeutic tool from falling off is attached to the side edge part and the lower edge part of the therapeutic tool. The space for supplying the hot spring water into the treatment tool may be provided with a guide for directly applying the hot spring water flowing into the space to the eye to stimulate the meridian point.SELECTED DRAWING: Figure 1

A method for preparing a highly biocompatible phakic posterior chamber intraocular lens (ICL) material, belonging to the field of polymer materials, includes the following steps: Hydroxyethyl methacrylate, ethylene glycol, bovine serum albumin solution, and initiator solution are stirred and mixed until the solution is clear, obtaining a mixture. The mixture is then degassed by ultrasonication. The degassed mixture is injected into a mold and transferred to an incubator for polymerization. After the reaction, the mold is removed and the sample is taken out. The obtained sample is dialyzed in a buffer solution to obtain the ICL material. This process has simple reaction steps, controllable reaction rate, and low energy consumption, reducing the production cost of ICL. The copolymer exhibits excellent optical and mechanical properties while demonstrating good biocompatibility, providing good visual effects and reducing eye irritation after implantation.

The invention relates to the technical field of contact lens disinfectants, and particularly discloses a deproteinization care solution for contact lenses as well as a preparation method and application of the deproteinization care solution aiming at the problems of poor sterilization timeliness, low efficiency and poor disinfection and sterilization effects of a currently common deproteinization AB solution for disinfecting the contact lenses. The deproteinization care solution for the contact lenses comprises a solution A and a solution B. The solution A is prepared from, by mass, 0.5%-0.8% of sodium hypochlorite, 1.0%-1.5% of anhydrous sodium carbonate, 0.2%-0.4% of sodium hydroxide, 0.01%-0.03% of PHMB nanoparticles, 0.03%-0.07% of EDTA-2Na and the balance water for injection; and the liquid B comprises the following components in percentage by mass: 0.5-1.0% of potassium bromide, 0.4-0.6% of anhydrous sodium carbonate, 0.05-0.15% of sodium silicate and the balance of water for injection. According to the deproteinization care solution for the contact lenses, through the synergistic effect of multiple components in the solution A and the solution B, the dynamic and stable disinfection and sterilization efficiency is achieved, and damage to the lenses and eye stimulation caused by too high alkalinity can be reduced.

The invention provides a fragrant glasses cleaning solution and a preparation method thereof, and relates to the technical field of glasses cleaning solutions. The invention relates to an antibacterial perfume, which is prepared from the following ingredients in parts by weight: 0.8 to 2 parts of fragrant microcapsules, 0.3 to 1 part of polyether modified silicone oil, 0.05 to 0.1 part of modified nano silicon dioxide, 1.5 to 3 parts of glycerinum, 0.5 to 2 parts of compound antibacterial agents, 0.3 to 0.5 part of ethylene diamine tetraacetic acid disodium salt, 8 to 12 parts of alcohols and 78 to 88 parts of deionized water. Wherein the fragrant microcapsules are prepared by wrapping essence in beta-cyclodextrin-chitosan composite microspheres, the composite antibacterial agent comprises benzalkonium chloride and polyhexamethylene biguanide in a weight ratio of (2.5-3.5): 1, and the pH value of the cleaning solution is 6-8. Through microcapsule slow release and pH control, the irritation of the cleaning liquid to eyes is reduced, and the fragrance can last for 8-10 hours; glycerin and polyether modified silicone oil have a synergistic effect, so that the antifogging time of the lens is prolonged to 72 hours, the antibacterial rate within 5 minutes can reach 99.9%, and the wear rate of 100-time coating is less than 0.1%.

The invention relates to the technical field of daily chemical cleaning and nursing, and discloses a silicone oil-free sulfate-free weak cation system shampoo and a preparation method thereof.According to the formula of the shampoo, lauramide propyl betaine, sodium lauroyl sarcosinate and other multi-element surfactants are compounded; a weak cation conditioning system cooperatively constructed by matching phytosterols, cationic cellulose and cationic guar gum does not contain silicone oil and sulfate components; gradient temperature change and segmented pH regulation and control processes are adopted for preparation. The product has a pH value of 5.0-6.0, conforms to the scalp environment, does not have harmful residues such as D4 and dioxane, has acute eye irritation of slight irritation, has a cleaning rate of 91-97%, is fine and smooth in foam and easy to wash, can significantly improve the smoothness of wet and dry hair and reduce frizz, has stable performance after being placed at 60 DEG C for 4 months, has mild property, cleaning power, repairing effect and use experience, and is suitable for various hair qualities.

The invention relates to diquafosol sodium eye drops. Specifically, the invention provides the diquafosol sodium eye drops, and the diquafosol sodium eye drops comprise diquafosol sodium, propylene glycol, sorbitol, hydroxypropyl methylcellulose, glycine, sodium chloride, sodium dihydrogen phosphate and water. The diquafosol sodium eye drops disclosed by the invention have excellent illumination and high-temperature stability, so that excellent stability can be maintained in the transportation and storage processes, the transportation and storage cost is reduced, the quality safety of the diquafosol sodium eye drops is improved, and the diquafosol sodium eye drops are free of eye irritation and can be used for preparing eye drops. Therefore, the composition has excellent medication safety, and the eye administration compliance of a patient is high.

The invention provides a method for evaluating irritation of a compound to eyes and application of the method, and belongs to the field of in-vitro detection. According to the method, an irritation screening test based on a TRPV1 ion channel is adopted, the final concentration of a fluorescent probe is 1.0-5.0 [mu] M during detection, the final concentration of cells is 0.8 * 10 < 5 >-1.5 * 10 < 5 > cells / mL, the incubation temperature is 30-40 DEG C, the incubation time is 25-35 min, the accuracy of the detection method is improved, and the method can be used for screening potential eye irritation substances.

The application discloses a kind of composite plant extract eye drops for relieving eye fatigue and a preparation method thereof, and relates to the technical field of ophthalmic preparations.The eye drops of the present application use lutein, zeaxanthin, blueberry extract, peppermint essential oil and borneol as fat-soluble active ingredients, and use phospholipid and poloxamer 188 as a composite nanocarrier, in combination with sodium hyaluronate, sodium chloride and a buffer system, a bacteriostatic system to form the eye drops.The present application uses a film hydration combined with high-pressure homogenization process to produce clear and transparent, thermodynamically stable eye drops, which solves the problems of low solubility, easy oxidative degradation and poor bioavailability of fat-soluble ingredients, improves the concentration and retention time of active ingredients in the eye, and the synergistic effect of various plant extracts can effectively relieve the symptoms of eye fatigue caused by long-term eye use, such as dryness, acid swelling, blurred vision and ciliary spasm, without eye irritation and with high stability.

The present invention concerns an in vitro test for detecting the irritant potential of chemicals combining a corneal cell model with a selection of predictive and qualitative molecular markers to classify compounds into 3 categories, namely irreversible eye damage 21 days after application (category 1), reversible eye damage 21 days after application (category 2) and no irritation (no category). The inventors have thus demonstrated that the response following the action of an irritant substance occurs directly on an in vitro reconstructed corneal epithelium, and that the degree of irritation and the qualification of this irritation of a molecule may be determined by the use of specific biomarkers of eye irritation.

This invention discloses a liquid composition containing carotenoids, belonging to the field of eye care. The liquid composition comprises: carotenoids; and a mixed solvent; said mixed solvent comprises: perfluorocarbon as a first solvent; and semi-fluorinated alkane as a second solvent. In particular, liquid compositions containing carotenoids, represented by lutein, do not require the addition of pH adjusters, surfactants, or preservatives, thus avoiding eye irritation and damage, and exhibit excellent carotenoid stability.

The disclosure relates to formulations and methods for the in vitro testing of ocular irritants. It was discovered that adding an antioxidant formulation to in vitro ocular irritation tests, including for example, a biochemical ocular irritation test, a reconstituted human corneal epithelium (RhCE) ocular irritation test and an excised eye depth of injury (DoI) test, substantially reduces the rate of false positives without diminishing test sensitivity, resulting in more accurately predicting ocular irritancy of test substances. More particularly, the disclosed method employs relatively high physiologic concentrations of one or more antioxidants that are normally present in tears. In a variation, much higher concentrations of one or more antioxidants may provide protection against in vivo exposure to ocular irritants.

A personal care composition, comprising a mono-rhamno-mono-lipid, a di-rhamno-mono-lipid, a co-surfactant and a carrier. The combination of rhamno-mono-lipids and co-surfactants in a personal cleansing composition reduces the eye irritation potential during application.

This invention relates to the field of medical solution preparation technology. Addressing the problems of incomplete and slow neutralization processes in traditional hydrogen peroxide contact lens solutions, which lead to eye irritation risks and low care efficacy, this invention specifically discloses a neutralized hydrogen peroxide contact lens solution, its preparation method, and its usage method. The solution comprises: 2.0-4.0% (w / v) hydrogen peroxide, 0.01-0.5% (w / v) poloxamer, 0.01-0.1% (w / v) diethylenetriaminepentamethylphosphonic acid, and 0.001-0.01% (w / v) UCNP@TiO2 nanomaterials, with the remainder being a buffer system, an osmotic pressure regulator, and purified water. The UCNP@TiO2 nanomaterials are a core-shell composite material with a lanthanide-doped upconversion nanomaterial core and a titanium dioxide shell. This invention introduces UCNP@TiO2 nanomaterials into the nursing solution. Under near-infrared light irradiation, this material can instantly generate a significant killing effect on microorganisms and can also rapidly and completely decompose hydrogen peroxide into water and oxygen, achieving a nursing effect of active light-controlled triggering for disinfection and sterilization.

The invention provides a rose essential oil dew composition for treating xerophthalmia as well as a preparation method and application of the rose essential oil dew composition. The rose essential oil dew composition is prepared from the following raw materials: rose essential oil dew, vitamin A microcapsules, sodium hyaluronate, a chamomile extract, menthol, propylene glycol, phenoxyethanol and deionized water. According to the rose essential oil dew composition, through the synergistic effect of various effective components, the symptoms of xerophthalmia can be effectively relieved from multiple aspects, eye tissue repair and inflammatory factor reduction are promoted, and the curative effect is remarkable. Besides, the rose essential oil lotion composition adopts natural components and safe auxiliary materials, has small irritation to eyes, and is proved to have no obvious adverse reaction through strict acute toxicity tests, long-term toxicity tests and eye irritation tests, and is suitable for long-term use.

The invention belongs to the technical field of intelligent glasses with intelligent perception, and particularly relates to intelligent glasses with intelligent perception, which comprise a glasses frame, a camera slot, two glasses support arms, two touch glasses legs and an intelligent control module. A high-definition lens, a display lens, a holographic AR information display lens and a protective cover are arranged in the glasses frame; a high-definition CMOS (Complementary Metal Oxide Semiconductor) camera is arranged in the camera slot, and low-light induction intensifiers are arranged in the induction slots on the two sides of the A lithium battery and a microphone are arranged in the glasses support arm, and the touch glasses leg is hinged to the tail end of the glasses support arm; the intelligent control module can project digital information to the display lens and the holographic AR information display lens to be superposed with reality. According to the glasses, through cooperation of all parts, a user can normally see objects in dark, smog, haze and other environments, light brightness is automatically adapted, eye stimulation is avoided, night vision full-color imaging is achieved, and the glasses are portable and easy to operate.