Method for detecting irritation of cosmetic raw material and method for detecting anti-irritation of anti-irritation product

A detection method and cosmetic technology, applied in the direction of measuring devices, analyzing materials, and analyzing materials through optical means, can solve the problems of less research, achieve accurate research results, avoid human subjective influence, and have good repeatability

Active Publication Date: 2019-07-16
三立慧评(北京)检测技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, in order to improve the accuracy of the patch detection results, the uniformity, repeatability, and stability of the patch matrix to the erythema are studied to ensure the accuracy of the anti-irritation test results, and the patch test interpretation method is improved to obtain There are few studies on accurate and dose-effective test results

Method used

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  • Method for detecting irritation of cosmetic raw material and method for detecting anti-irritation of anti-irritation product
  • Method for detecting irritation of cosmetic raw material and method for detecting anti-irritation of anti-irritation product
  • Method for detecting irritation of cosmetic raw material and method for detecting anti-irritation of anti-irritation product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] The product (see Table 1) obtained by the formula of Example 1 is added one by one in the small chamber of the spot tester, and after the back is closed and applied for 24 hours, the result is observed 24 hours after the connection. figure 1 Show, the erythema that embodiment 1 causes is very uniform, and erythema all occurs in 10 small chambers, and sees erythema evenly in small chamber and small chamber, inventor has carried out same patch test with the product prepared in embodiment 2-6, compared with The proportions have good repeatability and uniformity.

[0054] Example 1 erythema pictures and erythema value analysis results see Figure 5 , 6 .

[0055] Table 1 Embodiment 1 formula detailed list

[0056]

[0057]

[0058] Preparation Process:

[0059] 1. Phase A is stirred and dissolved evenly;

[0060] 2. After the water of phase B and acrylic acid (ester) / C10-30 alkanol acrylate crosslinked polymer (U20) are soaked and swelled completely, stir and dis...

Embodiment 2

[0063] Table 2 Embodiment 2 formula detailed list

[0064]

[0065] Preparation Process:

[0066] 1. Phase A is stirred and dissolved evenly;

[0067] 2. After the water of phase B and acrylic acid (ester) / C10-30 alkanol acrylate crosslinked polymer (U20) are soaked and swelled completely, stir and disperse evenly, add 1,2-pentanediol and stir evenly, add 10% Adjust the pH to 5.5-6 with NaOH, add polyurethane-35 (C1004), stir evenly, add phase A, stir evenly;

[0068] 3. Add the phase C raw materials, stir well and then discharge.

Embodiment 3

[0070] Table 3 Embodiment 3 formula detailed list

[0071]

[0072] Preparation Process:

[0073] 1. Phase A is stirred and dissolved evenly;

[0074] 2. After the water of phase B and acrylic acid (ester) / C10-30 alkanol acrylate crosslinked polymer (U20) are soaked and swelled completely, stir and disperse evenly, add 1,2-pentanediol and stir evenly, add 10% Adjust the pH to 5.5-6 with NaOH, add polyurethane-35 (C1004), stir evenly, add phase A, stir evenly;

[0075] 3. Add the phase C raw materials, stir well and then discharge.

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PUM

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Abstract

The invention discloses a method for detecting anti-irritation of an anti-irritation product. The method for detecting the anti-irritation of the anti-irritation product comprises the following stepsof 1) obtaining an image of skin or a skin mimic obtained after patch treatment, wherein a patch is coated with a gel composition comprising the anti-irritation product and an irritant; and 2) measuring an erythema feature value of the skin or the skin mimic in the image. The invention also discloses a method for detecting the irritation of a cosmetic raw material, the gel composition and the patch. The detection method provided by the invention not only has good repeatability, but also can more accurately score the results of irritation antagonism; meanwhile, the subjective influence of people is avoided; and therefore, the irritation antagonism effect of the anti-irritation product is more accurately and objectively evaluated.

Description

technical field [0001] The invention belongs to the field of cosmetics, and specifically relates to a method for detecting the irritation of cosmetic raw materials and an anti-irritation product for anti-irritation products. The invention also relates to a gel composition and a patch. Background technique [0002] The patch test is greatly affected by factors such as the patch substrate, individual differences, and interpretation methods. The choice of patch substrate for product irritation or antagonistic stimulation test is very important. The erythema carried by a good substrate is relatively uniform and has high repeatability, and can produce a stable dose-effect relationship and accurate test results after adding inhibitors. play a decisive role. [0003] Due to the unreasonable selection of the matrix, the uneven erythema and the poor repeatability of the concentration gradient make it difficult to accurately judge the irritation or antagonistic irritation detection. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/84
CPCG01N21/84
Inventor 董银卯李静刘宇红秦哲
Owner 三立慧评(北京)检测技术有限公司
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