Natamycin-loaded alginic acid gel medicine membrane and a preparation method thereof

A technology of natamycin and alginic acid, applied in the field of medical materials, can solve the problems of poor solubility, large particle size of natamycin and many kinds of raw materials, etc.

Active Publication Date: 2021-06-04
THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically used natamycin suspension can be used to treat fungal keratitis, but natamycin has a large particle size, poor solubility, and is affected by tear secretion, so it is difficult to achieve sustained release effect
Researchers have been working on improving the administration effect of natamycin. For example, Chinese patent CN200810140337.7 discloses a cation-adhesive natamycin nano eye drop, including natamycin. agent and pH regulator, also including chitosan, Pluronic F-68 and phospholipids, wherein the mass percent concentration of phospholipids in eye drops is 0.01%-2%, the concentration of Pluronic F-68 in eye drops The mass percent concentration is 0.1%-20%, the mass percent concentration of chitosan in eye drops is 0.01-4%, the molecular weight of chitosan is 5000-300000, and the degree of deacetylation is >85%; Natamycin is usually suspended Suspension granules with a diameter of 10-1000nm are prepared from the preparation to increase the solubility of the drug, improve safety and effectiveness, and modify the natamycin drug particles of the common suspension wit

Method used

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  • Natamycin-loaded alginic acid gel medicine membrane and a preparation method thereof
  • Natamycin-loaded alginic acid gel medicine membrane and a preparation method thereof
  • Natamycin-loaded alginic acid gel medicine membrane and a preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0029] This embodiment relates to the alginic acid gel film loaded with natamycin, and its composition and content are: every 1mL volume of the film contains 0.01-0.03g of sodium alginate, 0.0025-0.00755g of polyethylene oxide and 0.005 The natamycin of -0.015g; Concrete preparation process is as follows:

[0030] (1) Dissolve 0.256-0.768g of sodium alginate powder and 0.065-0.195g of polyethylene oxide powder into 20mL and 5mL of deionized water respectively to ensure that sodium alginate and polyethylene oxide are not attached to the bottom and side walls of the beaker, and then The two solutions are mixed and stirred gently;

[0031] (2) Place the above solution on a magnetic stirrer, stir at room temperature for 3 to 5 hours to obtain a uniform gel, add natamycin to the uniform gel, and the mass volume ratio of natamycin to gel is 0.005 ~0.015g: 1mL, then stir for 30 minutes at 50°C in a dark environment until uniform without precipitation;

[0032] (3) Take 3-10 g of th...

Embodiment 2

[0037] This embodiment relates to the preparation process of the alginic acid gel film loaded with natamycin, and the specific steps are as follows:

[0038] (1) Dissolve 0.512g of sodium alginate powder and 0.127g of polyethylene oxide powder into 20mL and 5mL of deionized water respectively to ensure that sodium alginate and polyethylene oxide are not attached to the bottom and side walls of the beaker, and then mix the two solutions then stir gently;

[0039] (2) Place the above solution on a magnetic stirrer at room temperature and stir for 3 hours to obtain a uniform gel, add natamycin to the uniform gel, the mass volume ratio of natamycin to gel is 0.01g: 1mL , Stir for 30 minutes at 50°C in a dark environment until uniform and without precipitation;

[0040] (3) Spread 5 g of hydrogel containing natamycin on a petri dish with a diameter of 10 cm, and place it in the dark for defoaming;

[0041] (4) Mix 6 mL of absolute ethanol with 3 mL of deionized water to make an e...

Embodiment 3

[0045] This embodiment relates to the alginic acid gel film loaded with natamycin, and its specific preparation process is as follows:

[0046] (1) Dissolve 0.256g of sodium alginate powder and 0.065g of polyethylene oxide powder into 20mL and 5mL of deionized water respectively to ensure that sodium alginate and polyethylene oxide are not attached to the bottom and side walls of the beaker, and then mix the two solutions then stir gently;

[0047] (2) Place the above solution on a magnetic stirrer, stir at room temperature for 5 hours to obtain a uniform gel, add natamycin to the uniform gel, the mass volume ratio of natamycin to gel is 0.005g: 1mL, then stirred at 50°C for 30 minutes in a dark environment until uniform and without precipitation;

[0048] (3) Take 3 g of the hydrogel containing natamycin in step (2) and spread it on a petri dish with a diameter of 10 cm, and place it in the dark for defoaming;

[0049] (4) Get deionized water 9mL, then add calcium chloride ...

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Abstract

The invention relates to the technical field of medical materials, in particular to a natamycin-loaded alginic acid gel medicine membrane and a preparation method thereof. The natamycin-loaded alginic acid gel medicine membrane comprises the following components and contents: every 1mL of the medicine membrane contains 0.01-0.03 g of sodium alginate, 0.0025-0.0075 g of polyoxyethylene and 0.005-0.015 g of natamycin. Alginic acid gel is used as a carrier, natamycin is loaded, and an ethanol solution containing calcium ions is used for crosslinking, so that the spatial structure of the material is more cohesive, the medicine-loaded gel is more stable after membrane formation, the size of pores in a medicine membrane is reduced, membrane release is delayed, and the action time of natamycin is prolonged; alginic acid is good in histocompatibility, and eye irritation and discomfort of natamycin are reduced; the medicine membrane can be better attached to the cornea ulcer surface, and has long medicine action time, good effects, no irritation and discomfort and high acceptability of patients; and the medicine membrane is a novel ophthalmic medicine membrane which is simple in preparation method, low in cost and wide in market prospects.

Description

Technical field: [0001] The invention relates to the technical field of medical materials, and relates to a natamycin-loaded alginic acid gel film and a preparation method thereof. The alginic acid gel is used as a carrier and the natamycin is loaded into a therapeutic ophthalmic film. [0002] technical background: [0003] Fungal keratitis (FK) is a serious corneal disease. Common pathogenic fungi include Aspergillus and Fusarium. FK is one of the main causes of blindness in my country. The treatment effect of the disease is poor, and most of the patients are young adults working in the front line, which has a great impact on life and production. [0004] As an avascular organ, the cornea has unique defense mechanisms and anatomical and physiological barriers. Most topical antifungal eye drops have poor corneal penetration, and most of them are washed out by tears, blinking and drainage through the nasolacrimal duct after dripping, with little local absorption, which makes...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K9/06A61K31/7048A61K47/36A61K47/10A61P27/02A61P31/10
CPCA61K9/7007A61K9/06A61K9/0048A61K31/7048A61K47/36A61K47/10A61P27/02A61P31/10Y02A50/30
Inventor 李翠赵桂秋李道浩彭旭东尹晓妮贾文妍张晓萍张乐园
Owner THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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