7results about How to "Good tissue compatibility" patented technology

The invention belongs to the technical field of polymer biomedical materials, and particularly relates to an eyeball sclera external implantation hydrogel as well as a preparation method and application thereof. The invention provides a self-expandable hydrogel which is prepared by using methyl methacrylate, N-vinyl pyrrolidone and methacryloyloxyethyl trimethyl ammonium chloride as monomer raw materials through cross-linking of N, N-bis (acryloyl) cystamine, and the hydrogel is used for a rabbit pore-derived retinal detachment model. According to the material, the operation time is greatly shortened, the operation difficulty is reduced, meanwhile, the purposes of minimally invasive implantation, self-expansion, no need of suture and retina restoration are achieved, the material has good histocompatibility, and the material fills the technical blank of sclera buckle belt materials in hole-derived retina detachment treatment and has good application prospects. A novel diagnosis and treatment material which is safe, reliable and high in adaptability is provided for clinic, and a new solution is injected for precise treatment of related diseases.

This invention discloses a cefoperazone sodium and sulbactam sodium composition and its preparation method, comprising the following steps: preparing a chitosan-β-glycerophosphate sodium colloidal solution; mixing dry ice and sorbitol evenly, then adding the mixture to the colloidal solution, freezing, heating, and drying under reduced pressure to obtain chitosan-β-glycerophosphate sodium nanospheres; slowly adding cefoperazone sodium, sulbactam sodium, and chitosan-β-glycerophosphate sodium nanospheres to water for injection, stirring to dissolve; adjusting the pH to 7.1-7.5, adding an adsorbent for adsorption and filtration, adding dry ice; freeze-drying to obtain a cefoperazone sodium and sulbactam sodium mixed powder. The nanospheres of this invention, with a certain size gradient, are beneficial for the uniformity of the mixed powder of cefoperazone sodium and sulbactam sodium, resulting in a longer-lasting efficacy, better stability, lower hygroscopicity, and also playing an antibacterial role.

This invention provides a wireless bladder volume monitoring system based on inductive coupling, comprising a passive LC sensor unit attached close to the bladder, an external reading coil integrated into clothing or a belt, and a portable impedance measurement unit located in a clothing pocket. This system utilizes the strong penetrating power of low-to-medium frequency scanning signals to wirelessly monitor the state of the bladder through electromagnetic coupling between the passive LC sensor unit and the external reading coil, effectively overcoming the influence of relative pose changes between the passive LC sensor unit and the external reading coil on the measurement results. This invention obtains the system resonant frequency of the passive LC resonant unit by continuously detecting the impedance at the input terminal of the external reading coil, thereby realizing a wearable, wireless, passive, real-time bladder volume monitoring system. It features a simple structure, high reliability, and portability, making it suitable for long-term monitoring scenarios.

The invention relates to the technical field of biomedical engineering and implantable medical instruments, in particular to a biodegradable flexible wireless implantable intracerebral heating device and a preparation method thereof. The device is of a layered structure and sequentially comprises a porous bioprotein substrate layer and a silk protein nanofiber membrane prepared by adopting an electrostatic spinning process from bottom to top, and the crystallinity and degradation rate of the silk protein nanofiber membrane are adjusted through ethanol annealing treatment. And the lower hydrophobic encapsulation layer is positioned on the substrate layer, is made of a biodegradable hydrophobic polymer, preferably polylactic acid (PLA), and is used for isolating biological fluid. And the wireless heating layer is positioned on the lower hydrophobic packaging layer and is formed by depositing a biodegradable metal material, preferably zinc (Zn). And the upper hydrophobic packaging layer covers the wireless heating layer and forms a sealed package for the heating layer together with the lower layer, so that the metal layer is prevented from being corroded by the body fluid too early. The device aims at solving the problems that an existing intracerebral implantation device needs to be taken out through a secondary operation and mechanical mismatch is caused.

The application belongs to the technical field of medical materials and relates to a bacteriostatic suture for surgical suturing and a preparation method thereof. The preparation method comprises the following steps: 2-amino-5-acetylpyridine is dissolved in a hydrobromic acid glacial acetic acid solution, an acetic acid solution containing bromine is added, and an intermediate 1 is obtained through reaction; the intermediate 1 is added to tetrahydrofuran, triethylamine and acetic anhydride are added, and an intermediate 2 is obtained through reaction; the intermediate 2 and thiourea are added to anhydrous ethanol, and an intermediate 3 is obtained through reaction; the intermediate 3 and p-nitrobenzaldehyde are added to anhydrous methanol, and an intermediate 4 is obtained through reaction; phosphorus oxychloride is added to N,N-dimethylformamide, and the intermediate 4 is added to obtain an intermediate 5 through reaction; the intermediate 5 is dissolved in a mixed solvent, and cystamine is added to obtain an antibacterial agent; and the medical silk suture is immersed in dimethyl sulfoxide containing the antibacterial agent, and is subjected to ultrasonic treatment, soaking, rinsing and drying to obtain the bacteriostatic suture. The bacteriostatic suture has the advantages of multi-mechanism synergistic enhanced bacteriostatic performance, an environment-responsive active release mechanism and excellent interface affinity.

The present application relates to the technical field of pulling apparatus, in particular to a tissue adsorption type pulling apparatus for thoracoscope surgery. The apparatus comprises a main rod body, the bottom of the main rod body is connected with a mounting rod through welding, the diameter of the mounting rod is smaller than that of the main rod body, the mounting rod is used for mounting an adsorption sleeve, the bottom of the mounting rod is fixedly connected with an auxiliary support hook through integral forming, the end of the auxiliary support hook is in arc structure, and the outer wall is polished, the top of the main rod body is fixedly connected with a handle, the outer wall of the handle is provided with anti-skid lines to increase the friction between the hand and the handle, which is convenient for doctors to stably hold during surgery, through the setting of the adsorption sleeve and the control assembly, the stable pulling of soft tissue is realized, the uniform adsorption force of the plane suction cup can be realized, the pulling pressure of the auxiliary support hook is dispersed, the adsorption sleeve can be individually or synchronously controlled to rotate through the control assembly, and the soft tissue in the target area is removed, thereby solving the problem that the traditional hook type pulling apparatus is easy to damage soft tissue.

The application discloses a self-derived protein anticoagulant coating and a preparation method and application thereof. The coating utilizes the oxidation of hydrogen peroxide generated by the reaction of an oxidizing agent or a reducing agent with oxygen in the air, is based on the endogenous active center (such as hematin) removal mechanism of self-extracted proteins (such as hemoglobin), induces the oxidative self-assembly of the proteins, and loads an anticoagulant in the assembly process to form a protein-anticoagulant composite nanofilm. The application utilizes the self-proteins to avoid the transmission risk of pathogens such as HIV, PERVs and prions from the source; the preparation method is simple and rapid, and the obtained coating has excellent adhesion stability, good biocompatibility and anti-biofouling capacity on the surface of various substrates. In-vitro and in-vivo experiments prove that the coating has superior anticoagulant performance, reduces the risk of bleeding and liver and kidney toxicity, and can be used for the surface modification of blood-contacting medical devices such as a heart stent, an artificial blood vessel, a central venous catheter and an extracorporeal oxygenator.