19results about How to "Good tissue compatibility" patented technology

The invention belongs to the technical field of biological materials, and particularly discloses a blood vessel biological patch and preparation thereof, the blood vessel biological patch has the maximum tensile elongation of 20.1-35.1%, the elastic deformation rate of 15.1-29.4%, the value of the elastic deformation rate accounting for the maximum tensile elongation is 54-90%, and the bursting strength is 38-55N. The blood vessel biological patch provided by the invention can effectively reduce bleeding at the suture after carotid endarterectomy and prevent the problem of unstable performance of the biological patch.

The invention discloses a preparation method and application of a BG (at) ZIF-8 organic-inorganic nanofiber membrane, and belongs to the field of biomedical composite materials. The method comprises the following steps: preparing BG through high-temperature calcination, wrapping the BG in ZIF-8 by using a wrapping technology to form BG-coated ZIF-8, and then carrying out microfluidic electrostatic spinning on the BG-coated ZIF-8, PCL and PVA to obtain a nanofiber membrane containing Zn < 2 + >, Ca < 2 + > and Si < 4 + > for diabetes wound healing. The ions can be slowly released to promote growth factor expression and revascularization. Experiments prove that BG (at) ZIF-8 / PCL-PVA can inhibit diabetes mellitus wound inflammation and accelerate healing. The composite fiber membrane using the micro-fluidic electrostatic spinning technology provides a new view angle for wound healing of diabetes, and is a potential efficient treatment strategy.

The invention discloses a long-section peripheral vascular stent which is used for treating diseases such as peripheral vascular stenosis below knees and the like and solves the problems that an existing stent is difficult to introduce into peripheral blood vessels and lacks effective support. The stent has two states of a pressing and holding state and an expansion state with different section radiuses, is implanted into a peripheral vascular affected part in the pressing and holding state, and supports a blood vessel at the affected part in the expansion state. Sufficient radial yield strength is provided through a plurality of supporting rings so as to adapt to the characteristics that the peripheral blood vessel is large in elasticity and thick in outer base layer. And the stent is prepared from a degradable material, so that mechanical support required in the early stage of fusion is met, the stent also has relatively high strength and toughness, and the stent can be degraded in vivo, so that the use safety is greatly improved. Moreover, the pattern of the stent is optimized, so that the circumferential rotation phenomenon of the longer intravascular stent in the expansion process is improved, and the damage to the vascular wall in the implantation process is reduced to the greatest extent.

The invention discloses cross-linked hyaluronic acid or salt thereof and a preparation method and application thereof, the cross-linked hyaluronic acid or salt thereof is prepared by the following steps: preparing gels with different cross-linking degrees by adopting high and low molecular weights, respectively carrying out partial cross-linking under the conditions of large and small amount of an alkaline solution, and using mixed hyaluronic acid or salt thereof with high and low molecular weights under the condition of large amount of the alkaline solution, the preparation method comprises the following steps: under the condition that the amount of an alkali solution is small, hyaluronic acid with small molecular weight or a salt thereof is used to form a compact network structure to obtain micron gel particles, and a product with the loose structure is diluted and then mixed with the micron gel particles and the hyaluronic acid or the salt thereof for a cross-linking reaction, so that the compact structure penetrates into the loose structure, and the micro gel particles are obtained. The cross-linked hyaluronic acid or salt gel of a soft elastic embedded structure with loose pores wrapping elastic hard balls is formed, and the gel or a composition thereof has excellent supporting / extension / deformation resistance / water absorption / water retention performance and good histocompatibility and is more suitable for tiled injection filling of the inner surface and the outer surface of a cavity.

The present invention discloses an antibacterial and procoagulant pneumothorax sealing patch and a preparation method thereof. The antibacterial and procoagulant pneumothorax sealing patch comprises, from top to bottom, an outer protective layer, a dressing layer and a sealing adhesive layer; the dressing layer is prepared from a composite of dialdehyde carboxymethyl chitosan and tannic acid, and then the dialdehyde carboxymethyl chitosan in the composite is grafted with acrylic acid, and then cross-linked to form a hydrogel. The pneumothorax sealing patch provided by the present invention can improve the antibacterial and procoagulant abilities of the pneumothorax sealing patch by adding tannic acid, and enhance the hemostatic ability and overall performance of the pneumothorax sealing patch according to the structure of the hydrogel.

The invention belongs to the technical field of polymer biomedical materials, and particularly relates to an eyeball sclera external implantation hydrogel as well as a preparation method and application thereof. The invention provides a self-expandable hydrogel which is prepared by using methyl methacrylate, N-vinyl pyrrolidone and methacryloyloxyethyl trimethyl ammonium chloride as monomer raw materials through cross-linking of N, N-bis (acryloyl) cystamine, and the hydrogel is used for a rabbit pore-derived retinal detachment model. According to the material, the operation time is greatly shortened, the operation difficulty is reduced, meanwhile, the purposes of minimally invasive implantation, self-expansion, no need of suture and retina restoration are achieved, the material has good histocompatibility, and the material fills the technical blank of sclera buckle belt materials in hole-derived retina detachment treatment and has good application prospects. A novel diagnosis and treatment material which is safe, reliable and high in adaptability is provided for clinic, and a new solution is injected for precise treatment of related diseases.

This invention discloses a cefoperazone sodium and sulbactam sodium composition and its preparation method, comprising the following steps: preparing a chitosan-β-glycerophosphate sodium colloidal solution; mixing dry ice and sorbitol evenly, then adding the mixture to the colloidal solution, freezing, heating, and drying under reduced pressure to obtain chitosan-β-glycerophosphate sodium nanospheres; slowly adding cefoperazone sodium, sulbactam sodium, and chitosan-β-glycerophosphate sodium nanospheres to water for injection, stirring to dissolve; adjusting the pH to 7.1-7.5, adding an adsorbent for adsorption and filtration, adding dry ice; freeze-drying to obtain a cefoperazone sodium and sulbactam sodium mixed powder. The nanospheres of this invention, with a certain size gradient, are beneficial for the uniformity of the mixed powder of cefoperazone sodium and sulbactam sodium, resulting in a longer-lasting efficacy, better stability, lower hygroscopicity, and also playing an antibacterial role.

The invention relates to a wrinkle fading repairing composition containing recombinant collagen as well as a preparation method and application of the wrinkle fading repairing composition. The wrinkle fading repairing composition comprises acetyl 6 peptide-8, dipeptide diaminobutyryl benzyl amide diacetate, arginine / lysine polypeptide and the recombinant collagen. All the components are matched with one another and have a synergistic effect, so that the generation of wrinkles can be effectively inhibited.

This invention provides a wireless bladder volume monitoring system based on inductive coupling, comprising a passive LC sensor unit attached close to the bladder, an external reading coil integrated into clothing or a belt, and a portable impedance measurement unit located in a clothing pocket. This system utilizes the strong penetrating power of low-to-medium frequency scanning signals to wirelessly monitor the state of the bladder through electromagnetic coupling between the passive LC sensor unit and the external reading coil, effectively overcoming the influence of relative pose changes between the passive LC sensor unit and the external reading coil on the measurement results. This invention obtains the system resonant frequency of the passive LC resonant unit by continuously detecting the impedance at the input terminal of the external reading coil, thereby realizing a wearable, wireless, passive, real-time bladder volume monitoring system. It features a simple structure, high reliability, and portability, making it suitable for long-term monitoring scenarios.

The invention provides an apatinib-loaded engineered exosome as well as a preparation method and application thereof, belongs to the technical field of ophthalmic preparations, and aims to solve the problem of low bioavailability of current eye drops. The preparation method comprises the following steps: step 1, preparing APA-loaded PLGA nanoparticles; step 2, separating the HCE-EXs; step 3, preparing the Apa nano particles wrapped by the HCE-EXs; step 4, preparing a phospholipid polymer modified by arginine; and 5, mixing the HCE-EXs coated APa nanoparticles prepared in the step 3 with the arginine modified phospholipid polymer prepared in the step 4, incubating the mixture at 37 DEG C for 30 minutes, and removing free impurities through volume exclusion chromatography to obtain the engineered exosome. The engineered exosome can release nitric oxide (NO) to effectively solve oxidative stress after corneal alkali burn. Secondly, compared with traditional medicine eye drops, the engineered exosome can be retained in cornea for a long time to continuously release apatinib for treatment.

The invention discloses a nuclide silk film as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The nuclide silk film provided by the invention is a silk film marked with radionuclide iodine 125. The preparation method comprises the following steps: labeling mulberry silk with iodine 125, and then spinning to form a film; or the mulberry silk is woven into a film and then labeled with iodine 125. The invention discloses an application of a nuclide silk film in preparation of a tumor local radiotherapy material. The nuclide silk film can cover wounds after various cancer resection operations, gamma rays released by radioactive isotope iodine 125 on the nuclide silk film are used for killing residual cancer cells in an operation area or remaining essence and cross sections of visceral organs and cancer cells possibly remaining in adjacent vascular nerve gaps, and therefore the cancer resection effect is achieved. Therefore, the purpose of brachytherapy is achieved, tumor recurrence after cancer operation can be effectively reduced, and external radiation therapy after operation can be partially replaced.

The invention relates to the technical field of biomedical engineering and implantable medical instruments, in particular to a biodegradable flexible wireless implantable intracerebral heating device and a preparation method thereof. The device is of a layered structure and sequentially comprises a porous bioprotein substrate layer and a silk protein nanofiber membrane prepared by adopting an electrostatic spinning process from bottom to top, and the crystallinity and degradation rate of the silk protein nanofiber membrane are adjusted through ethanol annealing treatment. And the lower hydrophobic encapsulation layer is positioned on the substrate layer, is made of a biodegradable hydrophobic polymer, preferably polylactic acid (PLA), and is used for isolating biological fluid. And the wireless heating layer is positioned on the lower hydrophobic packaging layer and is formed by depositing a biodegradable metal material, preferably zinc (Zn). And the upper hydrophobic packaging layer covers the wireless heating layer and forms a sealed package for the heating layer together with the lower layer, so that the metal layer is prevented from being corroded by the body fluid too early. The device aims at solving the problems that an existing intracerebral implantation device needs to be taken out through a secondary operation and mechanical mismatch is caused.

The utility model discloses an in-vitro tooth scraping device special for intentional tooth replantation, a handle is connected with a first scraper and a second scraper, the blade of the first scraper is of an inward concave structure, the blade of the second scraper is of a hook-shaped structure, the inward concave structure can be attached to the peripheral contour of the neck of a tooth, and the hook-shaped structure can be attached to the root contour of the tooth. According to the tooth curettage device, the scrapers for curettage of the tooth roots and the tooth peripheries are combined into a whole, the tooth neck periphery and root integrated curettage device is formed, and the tooth curettage device is small in size and convenient to take and use. A worker can select the first scraper and the second scraper of different models and / or sizes to perform subgingival scaling operation of the teeth of a patient, the first scraper is used for scaling the surfaces of the peripheries of the teeth, the second scraper is used for scaling the surfaces of the roots of the teeth, scaling operation of the peripheries of the teeth in multiple directions can be met, and the scaling efficiency is improved. And a smooth and flat surface with good histocompatibility is more easily formed under teeth and gingiva.

The application belongs to the technical field of medical materials and relates to a bacteriostatic suture for surgical suturing and a preparation method thereof. The preparation method comprises the following steps: 2-amino-5-acetylpyridine is dissolved in a hydrobromic acid glacial acetic acid solution, an acetic acid solution containing bromine is added, and an intermediate 1 is obtained through reaction; the intermediate 1 is added to tetrahydrofuran, triethylamine and acetic anhydride are added, and an intermediate 2 is obtained through reaction; the intermediate 2 and thiourea are added to anhydrous ethanol, and an intermediate 3 is obtained through reaction; the intermediate 3 and p-nitrobenzaldehyde are added to anhydrous methanol, and an intermediate 4 is obtained through reaction; phosphorus oxychloride is added to N,N-dimethylformamide, and the intermediate 4 is added to obtain an intermediate 5 through reaction; the intermediate 5 is dissolved in a mixed solvent, and cystamine is added to obtain an antibacterial agent; and the medical silk suture is immersed in dimethyl sulfoxide containing the antibacterial agent, and is subjected to ultrasonic treatment, soaking, rinsing and drying to obtain the bacteriostatic suture. The bacteriostatic suture has the advantages of multi-mechanism synergistic enhanced bacteriostatic performance, an environment-responsive active release mechanism and excellent interface affinity.

The present application relates to the technical field of pulling apparatus, in particular to a tissue adsorption type pulling apparatus for thoracoscope surgery. The apparatus comprises a main rod body, the bottom of the main rod body is connected with a mounting rod through welding, the diameter of the mounting rod is smaller than that of the main rod body, the mounting rod is used for mounting an adsorption sleeve, the bottom of the mounting rod is fixedly connected with an auxiliary support hook through integral forming, the end of the auxiliary support hook is in arc structure, and the outer wall is polished, the top of the main rod body is fixedly connected with a handle, the outer wall of the handle is provided with anti-skid lines to increase the friction between the hand and the handle, which is convenient for doctors to stably hold during surgery, through the setting of the adsorption sleeve and the control assembly, the stable pulling of soft tissue is realized, the uniform adsorption force of the plane suction cup can be realized, the pulling pressure of the auxiliary support hook is dispersed, the adsorption sleeve can be individually or synchronously controlled to rotate through the control assembly, and the soft tissue in the target area is removed, thereby solving the problem that the traditional hook type pulling apparatus is easy to damage soft tissue.

The present invention provides a composition, a composite cytokine hydrogel, and a preparation method and application thereof, and belongs to the field of biomedical technology. The present invention adds insulin-like growth factor-1, epidermal growth factor, basic fibroblast growth factor-2, human platelet-derived growth factor, vascular endothelial cell growth factor C, and transforming growth factor-β2 in a specific ratio, which can promote fibroblast proliferation, be beneficial to the appearance and function recovery of new skin, and make wounds heal quickly. The composite cytokine hydrogel of the present invention has a strong repair effect and good tissue compatibility, and can form a solid gel after being placed at 37°C for 16 to 17 seconds. The preparation method of the composite cytokine hydrogel of the present invention is simple and can be widely used clinically.

The invention discloses a biodegradable large-diameter intravascular stent and a preparation method thereof.The stent comprises a soft stent body and a hard stent body, the hard stent body comprises a woven fixing ring and a hard net pipe, and the soft stent body is connected with the hard stent body through the woven fixing ring; the other end of the woven fixing ring is fixedly connected with the hard net pipe; the large-diameter biodegradable stent has supporting force, prevents blood flow from being affected by vascular adhesion, has flexibility, adapts to the environment of blood vessel bending, and improves the treatment effect of the stent; the invention discloses a preparation method of a stent. The preparation method comprises the following steps: blow molding a hard stent pipe; performing laser cutting on the hard stent tube; weaving a soft bracket net body; the soft bracket is welded with a sealing end; spraying medicine on the surface of the stent; pressing, holding and forming the bracket; according to the stent packaging and the preparation method of the stent, the problem that the biodegradable large-diameter intravascular stent is difficult to prepare is solved, the stent can be used for large-scale production, and guidance is provided for manufacturing of other related products.

The application discloses a self-derived protein anticoagulant coating and a preparation method and application thereof. The coating utilizes the oxidation of hydrogen peroxide generated by the reaction of an oxidizing agent or a reducing agent with oxygen in the air, is based on the endogenous active center (such as hematin) removal mechanism of self-extracted proteins (such as hemoglobin), induces the oxidative self-assembly of the proteins, and loads an anticoagulant in the assembly process to form a protein-anticoagulant composite nanofilm. The application utilizes the self-proteins to avoid the transmission risk of pathogens such as HIV, PERVs and prions from the source; the preparation method is simple and rapid, and the obtained coating has excellent adhesion stability, good biocompatibility and anti-biofouling capacity on the surface of various substrates. In-vitro and in-vivo experiments prove that the coating has superior anticoagulant performance, reduces the risk of bleeding and liver and kidney toxicity, and can be used for the surface modification of blood-contacting medical devices such as a heart stent, an artificial blood vessel, a central venous catheter and an extracorporeal oxygenator.

The invention relates to a bone defect repair material for simulating a complete hierarchical structure of bone units and a preparation method of the bone defect repair material, and belongs to the technical field of biomedical materials. The method comprises the following steps: firstly, preparing single-layer collagenous fibers by utilizing animal decellularized collagen tissue slices; sequentially rotating and stacking the single-layer collagenous fibers to prepare a collagenous fiber composite plate; the method comprises the following steps: mineralizing a collagenous fiber composite plate by using a mineralizing solution, curling into a three-dimensional body, preparing a bionic bone unit material, arranging the bionic bone unit material into a shape required for repairing defects, pouring a collagen solution, freeze-drying, self-assembling, and then cross-linking and mineralizing to obtain the bone defect repairing material. According to the invention, by selecting the specific rotary stacking angle of the single-layer collagenous fiber, the bone defect repair material prepared from the obtained collagenous fiber composite plate has better mechanical properties. A collagenous fiber composite plate prepared by utilizing a slicing technology is combined with mineralization treatment, so that a complete hierarchical structure of a bone unit can be accurately simulated, and the biomimetic material for efficiently repairing a large-range bone defect is prepared.