4 results about "Cefoperazone Sodium" patented technology

This invention discloses a cefoperazone sodium and sulbactam sodium composition and its preparation method, comprising the following steps: preparing a chitosan-β-glycerophosphate sodium colloidal solution; mixing dry ice and sorbitol evenly, then adding the mixture to the colloidal solution, freezing, heating, and drying under reduced pressure to obtain chitosan-β-glycerophosphate sodium nanospheres; slowly adding cefoperazone sodium, sulbactam sodium, and chitosan-β-glycerophosphate sodium nanospheres to water for injection, stirring to dissolve; adjusting the pH to 7.1-7.5, adding an adsorbent for adsorption and filtration, adding dry ice; freeze-drying to obtain a cefoperazone sodium and sulbactam sodium mixed powder. The nanospheres of this invention, with a certain size gradient, are beneficial for the uniformity of the mixed powder of cefoperazone sodium and sulbactam sodium, resulting in a longer-lasting efficacy, better stability, lower hygroscopicity, and also playing an antibacterial role.

This invention discloses a pharmaceutical composition containing cefoperazone sodium and tazobactam sodium for the treatment of renal insufficiency complicated with bacterial infection. The weight ratio of cefoperazone sodium to tazobactam sodium is 6:1. In the treatment of renal insufficiency complicated with bacterial infection, this composition effectively improves clinical efficacy while significantly reducing the incidence of adverse reactions, achieving a good balance between efficacy and safety. This invention also provides a pharmaceutical composition that effectively reduces the production of related substances, significantly improving the product quality of the 6:1 cefoperazone sodium and tazobactam sodium mixture, and further ensuring the stability of the drug during use, storage, and transportation.

The utility model discloses a filling device for cefoperazone sodium and sulbactam sodium, and relates to the technical field of medicine filling equipment. A filling device for cefoperazone sodium and sulbactam sodium comprises a rotating disc set used for bearing and transporting medicine bottles; the supporting frame is arranged on the side edge of the rotating disc set; the lifting assembly is mounted on the supporting frame; the filling assembly is connected with the bottom of the lifting assembly and used for filling the medicine bottles with cefoperazone sodium and sulbactam sodium; the anti-overflow assembly is fixed to the filling assembly and arranged around the medicine bottle by a circle. The problems that mixed powder flies and is wasted, and the filling weight is insufficient are solved.

The invention relates to the technical field of cefoperazone sodium, and particularly discloses a preparation method of a cefoperazone sodium impurity H. The preparation method of the cefoperazone sodium impurity H provided by the invention comprises the following steps: carrying out carboxyl protection reaction on a compound shown in a formula 2 and a compound shown in a formula 3 to obtain a compound shown in a formula 4; carrying out condensation reaction on the compound shown in the formula 4 and a compound shown in a formula 5 to obtain a compound shown in a formula 6; and carrying out carboxyl deprotection reaction on the compound shown in the formula 6 to obtain the cefoperazone sodium impurity H. According to the method, a strategy of precisely controlling a synthesis path is adopted, the limitation of a traditional process is broken through, and efficient directional generation of impurity products is realized. The synthesis method provides an impurity H reference substance for quality control of a cefoperazone sodium preparation, and is beneficial to accurate identification and quantitative analysis of related impurities, so that controllable drug quality is ensured, and clinical medication safety is guaranteed.