10 results about "Cefoperazone Sodium" patented technology

The invention discloses a preparation method of cefoperazone sodium, which comprises the following steps: S1, adding cefoperazone acid into a first solvent system, and dropwise adding a sodium salt-forming agent aqueous solution for reaction to obtain a first reaction solution; s2, adding the first reaction solution into a second solvent system, and filtering to obtain an amorphous cefoperazone sodium wet product; s3, the amorphous cefoperazone sodium wet product is added into a third solvent system for suspension pulping, the crystal transformation temperature is controlled, and crystalline cefoperazone sodium is obtained; the high-purity cefoperazone sodium is obtained by salifying and crystallizing cefoperazone acid and then carrying out suspension crystal transformation, so that the molecular space structure of the cefoperazone sodium can be changed, and N-nitrosamine genotoxic impurities such as NDMA embedded into the crystal can be effectively separated.

The invention relates to the field of chemical medicine impurities, and particularly discloses a cefoperazone sodium polymer degradation impurity and a preparation process thereof.The preparation process comprises the steps that cefoperazone sodium serves as a raw material and is subjected to an acylation reaction with pivaloyl chloride, then a product obtained after the acylation reaction reacts with 7-TMCA, and the cefoperazone sodium polymer degradation impurity is obtained. According to the method, cefoperazone sodium is taken as a raw material, cefoperazone sodium polymer degradation impurities are prepared through a synthesis method, the content of the cefoperazone sodium polymer degradation impurities is higher, synthesized components are purer, crystallization and purification are facilitated, a target product with higher purity is prepared, the purity reaches 95.21-99.88%, the yield is 45-50%, the process is simplified, the period is short, operation is easier, and large-scale preparation is easy.

This invention discloses a cefoperazone sodium and sulbactam sodium composition and its preparation method, comprising the following steps: preparing a chitosan-β-glycerophosphate sodium colloidal solution; mixing dry ice and sorbitol evenly, then adding the mixture to the colloidal solution, freezing, heating, and drying under reduced pressure to obtain chitosan-β-glycerophosphate sodium nanospheres; slowly adding cefoperazone sodium, sulbactam sodium, and chitosan-β-glycerophosphate sodium nanospheres to water for injection, stirring to dissolve; adjusting the pH to 7.1-7.5, adding an adsorbent for adsorption and filtration, adding dry ice; freeze-drying to obtain a cefoperazone sodium and sulbactam sodium mixed powder. The nanospheres of this invention, with a certain size gradient, are beneficial for the uniformity of the mixed powder of cefoperazone sodium and sulbactam sodium, resulting in a longer-lasting efficacy, better stability, lower hygroscopicity, and also playing an antibacterial role.

This invention discloses a pharmaceutical composition containing cefoperazone sodium and tazobactam sodium for the treatment of renal insufficiency complicated with bacterial infection. The weight ratio of cefoperazone sodium to tazobactam sodium is 6:1. In the treatment of renal insufficiency complicated with bacterial infection, this composition effectively improves clinical efficacy while significantly reducing the incidence of adverse reactions, achieving a good balance between efficacy and safety. This invention also provides a pharmaceutical composition that effectively reduces the production of related substances, significantly improving the product quality of the 6:1 cefoperazone sodium and tazobactam sodium mixture, and further ensuring the stability of the drug during use, storage, and transportation.

The application provides a preparation method of cefoperazone, which comprises the following steps: providing a 7-TMCA solution; providing a HO-EPCP acyl chloride solution; adding the HO-EPCP acyl chloride solution into the 7-TMCA solution drop by drop under the condition of-30 to-20 DEG C, and continuing to react under the condition of-30 to-20 DEG C after the addition is completed to obtain a reaction solution containing cefoperazone. The preparation method of cefoperazone can effectively reduce the content of impurity H in cefoperazone. Experiments prove that the content of impurity H in cefoperazone can be reduced to less than 0.15%, the yield of cefoperazone reaches more than 90%, the purity of cefoperazone reaches more than 99.6%, and the content of other impurities is less than 0.15%, so that the cefoperazone prepared by the method can be used to prepare cefoperazone sodium which completely meets the quality standard of cefoperazone sodium raw medicine.

The invention discloses a preparation method and application of cefoperazone sodium and sulbactam sodium for injection, and relates to the field of preparation methods of cefoperazone sodium and sulbactam sodium, and the preparation method comprises preparation of cefoperazone sodium and preparation of a mixed solution. The preparation of the mixed solution comprises the following steps: weighing sulbactam sodium and the prepared cefoperazone sodium, adding the sulbactam sodium and the prepared cefoperazone sodium into a sodium chloride injection, dissolving, adding a phosphate buffer solution, filtering, adding valine into the solution, dispersing, and filtering to obtain the mixed solution. Sequentially carrying out freeze-drying treatment, drying, crushing, screening and re-drying on the dispersed mixed solution to obtain the cefoperazone sodium sulbactam sodium for injection. The mass ratio of the cefoperazone sodium to the sulbactam sodium is (1-5): 1. The valine is added into the mixed solution and the process is optimized, so that the valine and the cefoperazone sodium can form hydrogen bonds and electrostatic interaction, and the purpose of improving the stability of the cefoperazone sodium sulbactam sodium for injection with high cefoperazone sodium content is achieved.

The invention relates to a crystal form of cefoperazone sodium as well as a preparation method and application of the crystal form. The X-ray powder diffraction pattern of the crystal form has characteristic peaks when the 2theta value is 15.5 degrees + / -0.2 degrees, 18.4 degrees + / -0.2 degrees and 19.6 degrees + / -0.2 degrees. The crystal form of the cefoperazone sodium is a crystal structure with specific characteristic peaks, and compared with a crystal form A of the cefoperazone sodium, the novel crystal form of the cefoperazone sodium has lower residual solvents and water residues, higher content and better stability, and is beneficial to storage and preparation of pharmaceutical compositions. And during subsequent use, the pharmaceutical safety of the cefoperazone sodium and the composition thereof can be improved.

The utility model relates to the technical field of filling and feeding devices, in particular to a filling and feeding device suitable for cefoperazone sodium and sulbactam sodium for injection. Comprising a bottom plate, a baffle is arranged above the periphery of the bottom plate, and a runner pipe is arranged below the right side of the bottom plate; through the structure of an abutting plate, a fixing column and a sealing ring, a circulation pipe is blocked, under the elastic action of a spring, the circulation pipe is always kept in a closed state without external force under the use mode that the abutting plate is matched with a lifting frame, after a filling bottle is upwards connected with the circulation pipe, the fixing column slides out of the circulation pipe, and liquid medicine can flow out of the filling bottle; through the sliding structure of the sliding frame on the connecting frame, different filling bottles can be adjusted to move and be placed below the runner pipe, through the multi-station switching design of the sliding frame, continuous filling is achieved, manual intervention is reduced, and through clamping connection of a clamping groove and an elastic piece, the situation that in the filling process, the sliding frame slides, liquid medicine overflows, and waste is caused is avoided.

The utility model discloses a filling device for cefoperazone sodium and sulbactam sodium, and relates to the technical field of medicine filling equipment. A filling device for cefoperazone sodium and sulbactam sodium comprises a rotating disc set used for bearing and transporting medicine bottles; the supporting frame is arranged on the side edge of the rotating disc set; the lifting assembly is mounted on the supporting frame; the filling assembly is connected with the bottom of the lifting assembly and used for filling the medicine bottles with cefoperazone sodium and sulbactam sodium; the anti-overflow assembly is fixed to the filling assembly and arranged around the medicine bottle by a circle. The problems that mixed powder flies and is wasted, and the filling weight is insufficient are solved.

The invention relates to the technical field of cefoperazone sodium, and particularly discloses a preparation method of a cefoperazone sodium impurity H. The preparation method of the cefoperazone sodium impurity H provided by the invention comprises the following steps: carrying out carboxyl protection reaction on a compound shown in a formula 2 and a compound shown in a formula 3 to obtain a compound shown in a formula 4; carrying out condensation reaction on the compound shown in the formula 4 and a compound shown in a formula 5 to obtain a compound shown in a formula 6; and carrying out carboxyl deprotection reaction on the compound shown in the formula 6 to obtain the cefoperazone sodium impurity H. According to the method, a strategy of precisely controlling a synthesis path is adopted, the limitation of a traditional process is broken through, and efficient directional generation of impurity products is realized. The synthesis method provides an impurity H reference substance for quality control of a cefoperazone sodium preparation, and is beneficial to accurate identification and quantitative analysis of related impurities, so that controllable drug quality is ensured, and clinical medication safety is guaranteed.