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High-purity medicament and preparation thereof

A high-purity, pharmaceutical technology, applied in the direction of separation methods, pharmaceutical formulations, chemical instruments and methods, etc., can solve the problems of low purity of active ingredients, low purity, and large side effects, so as to facilitate industrial continuous production and reduce production Cost, the effect of improving stability

Inactive Publication Date: 2009-01-21
HAINAN LINGKANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This new technology allows for highly pure compounds like cefoxitaxel (CX) that are important drugs found naturally within bacteria called Actinosynnema spp., but they have other properties such as being less expensive compared to older methods involving complicated chemical processes. These technical benefits include improved efficiency when producing these materials through various techniques, reduced environmental impact during manufacturing, increased productivity due to fewer steps needed per unit time, and lower costs associated with disposal after use.

Problems solved by technology

This patented technical solution described involves combining different types of drugs together called ceforadilarsine hydrochlorides and tazarotricarbazones like tebuconazon sulfate monohydrate/tebacidecrocenanolate sodium hydride). These combinations result in improved efficacy compared to each individual component separately due to their complementary functions.

Method used

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  • High-purity medicament and preparation thereof
  • High-purity medicament and preparation thereof
  • High-purity medicament and preparation thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0034] Dissolve 500 g of cefoperazone sodium raw material for injection in 2000 ml of water, and the resulting solution is subjected to gel chromatography. The filler of the chromatographic column used is Sephadex LH-20, which is eluted with 1200 ml of 95% ethanol solution, and the cefoperazone sodium content is greater than 92%. off fraction. The resulting eluted fraction was chromatographed with BUCHI medium pressure preparative chromatography, and the filler of the reverse chromatography column used was C 18 Alkyl bonded phase silica gel. Carry out elution with 1500ml of 95% ethanol solution, collect the cefoperazone sodium content not less than 99% elution fraction, reclaim solvent, obtain high-purity cefoperazone sodium raw material 424.0g after freeze-drying, and purity is 99.5%, and yield is 84.8%.

[0035] Dissolve 500 g of tazobactam sodium raw material for injection in 1800 ml of water, and perform gel chromatography on the resulting solution. The packing of the chrom...

Embodiment 2

[0038] Dissolve 1000 g of cefoperazone sodium for injection in 3000 ml of water, and carry out gel chromatography on the resulting solution. The packing of the chromatographic column used is Sephadex LH-60, and elution is carried out with 1600 ml of 80% ethanol solution, and the cefoperazone sodium content is not less than 92%. Elution fractions. The resulting eluted fraction was chromatographed with BUCHI medium pressure preparative chromatography, and the filler of the reverse chromatography column used was C 4 Alkyl bonded phase silica gel. Carry out elution with 1800ml of 70% ethanol solution, collect the elution flow fraction that cefoperazone sodium content is not less than 99%, reclaim solvent, obtain high-purity cefoperazone sodium raw material 822.1g after freeze-drying, and purity is 99.6%, and yield is 82.2%.

[0039] Dissolve 600 g of tazobactam sodium raw material for injection in 1500 ml of water, and perform gel chromatography on the resulting solution. The pac...

Embodiment 3

[0042] Dissolve 800 g of cefoperazone sodium for injection in 2400 ml of water, and carry out gel chromatography on the resulting solution. The filler of the chromatographic column used is Sephadex LH-20, which is eluted with 1200 ml of 85% ethanol solution, and the cefoperazone sodium content is not less than 92%. Elution fractions. The resulting eluted fraction was chromatographed with BUCHI medium pressure preparative chromatography, and the filler of the reverse chromatography column used was C 4 Alkyl bonded phase silica gel. Carry out elution with 1000ml of 80% ethanol solution, collect the cefoperazone sodium content not less than 99% elution fraction, reclaim solvent, obtain high-purity cefoperazone sodium raw material 667.2g after freeze-drying, and purity is 99.5%, and yield is 83.4%.

[0043] Dissolve 500 g of tazobactam sodium raw material for injection in 1500 ml of water, and perform gel chromatography on the resulting solution. The packing of the chromatography...

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Abstract

The invention provides a method for preparing a high purity drug, particularly relating to a method for preparing high purity cefoperazone sodium or tazobactam sodium. The invention also provides a method for preparing a compound powder-injection of high purity cefoperazone sodium and high purity tazobactam sodium and the high purity drug or high purity drug compound prepared according to the methods.

Description

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Claims

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Application Information

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Owner HAINAN LINGKANG PHARMA CO LTD
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