2 results about "TAZOBACTAM SODIUM" patented technology

The utility model relates to filling device technical field especially for automatic filling device based on piperacillin sodium and tazobactam sodium medicine powder for injection, including conveying line and support drive package, support drive package one end installs the storage component, the inboard of storage component is installed and is smashed and is unloaded component, and the storage component includes storage shell, and the upper end fixed connection of storage shell has the unloading cylinder, and the upper end of storage shell is opened and has the discharge hole, and the lower end fixed connection of storage shell has the guide plate, and the smashed and unloaded component includes drive motor, and the drive motor main shaft end fixed connection has first extension shaft, and first extension shaft outside fixed connection has eccentric wheel and crushing knife, and the second extension shaft is installed to the crushing knife through the clutch, and second extension shaft outside fixed connection has spiral blade, in the utility model, the device can effectively solve the caking problem of medicine powder because of hygroscopicity, ensure the uniformity of medicine powder to realize the high accuracy ration filling, guarantee the consistency of medicine quality.

The invention discloses a piperacillin sodium and tazobactam sodium preparation and a preparation method thereof, and the preparation method comprises the following steps: mixing piperacillin sodium with chitosan and a surfactant 1, mixing tazobactam sodium with a surfactant 2, and respectively carrying out low-temperature mechanical ball milling activation; respectively adding the activated piperacillin sodium and tazobactam sodium into low-temperature water for injection, and dissolving to obtain a piperacillin sodium solution and a tazobactam sodium solution; the method comprises the following steps: under the protection of nitrogen, carrying out liquid co-dissolution mixing on a piperacillin sodium solution and a tazobactam sodium solution; and uniformly mixing, carrying out multi-stage filtration to remove impurities, and freeze-drying to obtain the piperacillin sodium and tazobactam sodium preparation. Before the piperacillin sodium and the tazobactam sodium are dissolved, the chitosan and the surfactant are respectively adopted for low-temperature ball-milling activation, so that the mixing uniformity of the raw materials can be improved, impurities embedded in raw material crystals can be adsorbed, captured and flocculated to form a compound, and the internal impurities are efficiently removed.