4 results about "TAZOBACTAM SODIUM" patented technology

This invention discloses a pharmaceutical composition containing cefoperazone sodium and tazobactam sodium for the treatment of renal insufficiency complicated with bacterial infection. The weight ratio of cefoperazone sodium to tazobactam sodium is 6:1. In the treatment of renal insufficiency complicated with bacterial infection, this composition effectively improves clinical efficacy while significantly reducing the incidence of adverse reactions, achieving a good balance between efficacy and safety. This invention also provides a pharmaceutical composition that effectively reduces the production of related substances, significantly improving the product quality of the 6:1 cefoperazone sodium and tazobactam sodium mixture, and further ensuring the stability of the drug during use, storage, and transportation.

The application discloses a method for preparing tazobactam from tazobactam diphenylmethyl ester, which comprises the following steps: firstly, micronizing tazobactam diphenylmethyl ester, then adding the micronized tazobactam diphenylmethyl ester into water, and then adding enzymes and a phase transfer catalyst; under a proper temperature, the reaction is carried out in batches by adding alkali to control the pH value; tazobactam is obtained by hydrolysis and removal of the diphenylmethyl group; during the reaction, the liquid is filtered through a nanofiltration system to intercept tazobactam sodium, and the permeate returns to the reaction system; the reaction is completely promoted by removing the product, so that the water-phase reaction is obviously realized. The reaction condition of the application is mild, the water is used as the solvent, and the environment is friendly; the post-treatment is simplified; the continuous automatic operation is realized; the yield is improved; the product quality is improved; and the production cost is reduced.

The utility model relates to filling device technical field especially for automatic filling device based on piperacillin sodium and tazobactam sodium medicine powder for injection, including conveying line and support drive package, support drive package one end installs the storage component, the inboard of storage component is installed and is smashed and is unloaded component, and the storage component includes storage shell, and the upper end fixed connection of storage shell has the unloading cylinder, and the upper end of storage shell is opened and has the discharge hole, and the lower end fixed connection of storage shell has the guide plate, and the smashed and unloaded component includes drive motor, and the drive motor main shaft end fixed connection has first extension shaft, and first extension shaft outside fixed connection has eccentric wheel and crushing knife, and the second extension shaft is installed to the crushing knife through the clutch, and second extension shaft outside fixed connection has spiral blade, in the utility model, the device can effectively solve the caking problem of medicine powder because of hygroscopicity, ensure the uniformity of medicine powder to realize the high accuracy ration filling, guarantee the consistency of medicine quality.

The invention discloses a piperacillin sodium and tazobactam sodium preparation and a preparation method thereof, and the preparation method comprises the following steps: mixing piperacillin sodium with chitosan and a surfactant 1, mixing tazobactam sodium with a surfactant 2, and respectively carrying out low-temperature mechanical ball milling activation; respectively adding the activated piperacillin sodium and tazobactam sodium into low-temperature water for injection, and dissolving to obtain a piperacillin sodium solution and a tazobactam sodium solution; the method comprises the following steps: under the protection of nitrogen, carrying out liquid co-dissolution mixing on a piperacillin sodium solution and a tazobactam sodium solution; and uniformly mixing, carrying out multi-stage filtration to remove impurities, and freeze-drying to obtain the piperacillin sodium and tazobactam sodium preparation. Before the piperacillin sodium and the tazobactam sodium are dissolved, the chitosan and the surfactant are respectively adopted for low-temperature ball-milling activation, so that the mixing uniformity of the raw materials can be improved, impurities embedded in raw material crystals can be adsorbed, captured and flocculated to form a compound, and the internal impurities are efficiently removed.