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Suspension powder injection of cefoperazone sodium and tazobactam sodium pharmaceutical composition and new application thereof

A technology of tazobactam sodium and cefoperazone sodium, which is applied in the field of cefoperazone sodium tazobactam sodium pharmaceutical composition suspension powder injection, can solve the problems of poor stability of cefoperazone sodium and tazobactam sodium, and reduce drug side effects and drug toxicity , the effect of preventing the generation of particles

Inactive Publication Date: 2010-01-27
HAINAN YONGTIAN PHARMA INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] After a long period of serious research, the inventor has applied emulsified suspension technology to make powder injection by freeze-drying, which not only solves the problem of poor stability of cefoperazone sodium and tazobactam sodium, but also facilitates the good use of its freeze-dried preparation after reconstitution, and Helps to treat cystitis, has thus completed the present invention

Method used

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  • Suspension powder injection of cefoperazone sodium and tazobactam sodium pharmaceutical composition and new application thereof
  • Suspension powder injection of cefoperazone sodium and tazobactam sodium pharmaceutical composition and new application thereof
  • Suspension powder injection of cefoperazone sodium and tazobactam sodium pharmaceutical composition and new application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1 Preparation of cefoperazone sodium tazobactam sodium suspension powder injection

[0041] Prescription (100 bottles):

[0042] Cefoperazone Sodium 160g

[0043] Tazobactam Sodium 40g

[0044] Soy Lecithin 450g

[0045] Poloxamer 188 150g

[0046] Sodium Deoxycholate 200g

[0047] Mannitol 240g

[0048] Trehalose 240g

[0049] Preparation Process

[0050] (1) Add 450g soybean lecithin, 150g poloxamer 188 and 200g sodium deoxycholate to 4500ml water for injection, then add 160g cefoperazone sodium and 40g tazobactam sodium and mix well, heat and stir in a water bath at 70°C until it melts ;

[0051] (2) adopting tissue masher to shear and stir for 20min under the condition of thermal insulation 70-90℃, rotating speed 10000r / min to obtain primary emulsion, and then circulate emulsification by high pressure homogenizer for 4 times to obtain emulsion;

[0052] (3) 240g of mannitol and 240g of trehalose were added to the emulsion, dissolved and then filt...

Embodiment 2

[0064] Example 2 Preparation of cefoperazone sodium tazobactam sodium suspension powder injection

[0065] Prescription (100 bottles):

[0066] Cefoperazone Sodium 80g

[0067] Tazobactam Sodium 20g

[0068] Soy Lecithin 150g

[0069] Poloxamer 188 50g

[0070] Sodium Deoxycholate 60g

[0071] Mannitol 50g

[0072] Trehalose 50g

[0073] Preparation Process

[0074] (1) Add 150g soybean lecithin, 50g poloxamer 188 and 60g sodium deoxycholate to 2000ml water for injection, then add 80g cefoperazone sodium and 20g tazobactam sodium and mix well, heat and stir in a water bath at 80°C until it is molten ;

[0075] (2) adopting the tissue masher to shear and stir for 10min under the condition of keeping the above-mentioned liquid at 70-90°C, the rotating speed is 15000r / min, to obtain the primary emulsion, and then circulate emulsification through a high-pressure homogenizer for 5 times to obtain an emulsion;

[0076] (3) 50g of mannitol and 50g of trehalose were added...

Embodiment 3

[0087] Example 3 Preparation of cefoperazone sodium tazobactam sodium suspension powder injection

[0088] Prescription (100 bottles):

[0089] Cefoperazone Sodium 400g

[0090] Tazobactam Sodium 50g

[0091] Soy Lecithin 750g

[0092] Poloxamer 188 250g

[0093] Sodium Deoxycholate 400g

[0094] Mannitol 500g

[0095] Trehalose 500g

[0096] Preparation Process

[0097] (1) Add 750g soybean lecithin, 250g poloxamer 188 and 400g sodium deoxycholate to 11000ml water for injection, then add 400g cefoperazone sodium and 50g tazobactam sodium and mix well, heat and stir in a 90°C water bath until it melts ;

[0098] (2) adopting the tissue masher to shear and stir for 10 minutes under the condition of keeping the above-mentioned liquid at 70-90 ℃, the rotating speed is 13000r / min, to obtain the primary emulsion, and then circulate emulsification through the high-pressure homogenizer for 5 times to obtain the emulsion;

[0099] (3) adding 500g mannitol and 500g trehalo...

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Abstract

The invention discloses a suspension powder injection with a cefoperazone sodium and tazobactam sodium pharmaceutical composition as an active ingredient, and comprises the following components: 4 parts of the cefoperazone sodium, 1 part of the tazobactam sodium, 5-30 parts of an emulsifier, 1-15 parts of an auxiliary emulsifier and 1-40 parts of a freeze-drying support agent. The invention further discloses an application thereof in preparing medicines for treating cystitis.

Description

technical field [0001] The invention relates to cefoperazone sodium tazobactam sodium pharmaceutical composition suspension powder injection, and further relates to its new application in the preparation of medicines for treating cystitis. Background technique [0002] Cystitis is a common and frequently-occurring infectious disease in clinical practice. It is intractable and protracted. It takes a long time to treat and has a high recurrence rate. There are two clinical manifestations of cystitis, acute and chronic. Chronic cystitis has a slow onset, a burning sensation during urination, and pain in the urethral area. Sometimes there is urgency and frequency of urination. The symptoms can last for several weeks or intermittently, making the patient weak. ,thin. The onset of acute cystitis is sudden, and the symptoms are similar to those of chronic cystitis. It is common in women. The patient feels weak and weak, with low or high fever, discomfort on the phalanges and low b...

Claims

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Application Information

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IPC IPC(8): A61K31/546A61K31/431A61K9/19A61P13/10
Inventor 王明
Owner HAINAN YONGTIAN PHARMA INST
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