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Suspension powder injection of piperacillin sodium and tazobactam sodium pharmaceutical composition and new application thereof

A technology of tazobactam sodium and piperacillin sodium, which is applied in the field of suspension powder injection of piperacillin sodium-tazobactam sodium pharmaceutical composition, and can solve the problems of poor stability of piperacillin sodium-tazobactam sodium and the like , to achieve the effects of reducing drug side effects, improving stability, and simple production process

Inactive Publication Date: 2010-01-27
HAINAN MEILAN SMITH KLINE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] After a long period of earnest research, the inventors have found that the application of emulsification and suspension technology to make powder injections by freeze-drying not only solves the problem of poor stability of piperacillin sodium and tazobactam sodium, but also prevents the generation of particles to the greatest possible extent. For the treatment of lung abscess, it is far superior to the products of the prior art, thus completing the present invention

Method used

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  • Suspension powder injection of piperacillin sodium and tazobactam sodium pharmaceutical composition and new application thereof
  • Suspension powder injection of piperacillin sodium and tazobactam sodium pharmaceutical composition and new application thereof
  • Suspension powder injection of piperacillin sodium and tazobactam sodium pharmaceutical composition and new application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1 Preparation of Piperacillin Sodium-Tazobactam Sodium Suspension Powder Injection

[0048] Prescription (100 bottles):

[0049] Piperacillin Sodium 100g

[0050] Tazobactam Sodium 12.5g

[0051] Egg yolk lecithin 178.6g

[0052] Poloxamer 188 71.4g

[0053] Sodium Glycocholate 62.5g

[0054] Lactose 250g

[0055] Sorbitol 125g

[0056] Preparation Process

[0057] (1) Add 178.6g egg yolk lecithin, 71.4g poloxamer 188 and 62.5g sodium glycocholate to 2400ml water for injection, then add 100g piperacillin sodium and 12.5g tazobactam sodium and mix well, 90 ℃ water bath heating and stirring until molten state;

[0058] (2) Keeping the above liquid at 70-90°C for 10 minutes with a tissue masher to shear and stir at a speed of 12,000 r / min to obtain a primary emulsion, and then circulate and emulsify it through a high-pressure homogenizer for 5 times to obtain an emulsion;

[0059] (3) Add 250 g of lactose and 125 g of sorbitol to the emulsion, dissolve,...

Embodiment 2

[0081] The preparation of embodiment 2 piperalin sodium tazobactam sodium suspension powder injection

[0082] Prescription (100 bottles):

[0083] Piperacillin Sodium 100g

[0084] Tazobactam Sodium 25g

[0085] Egg yolk lecithin 321.4g

[0086] Poloxamer 188 128.6g

[0087] Sodium Glycocholate 200g

[0088] Lactose 166.7g

[0089] Sorbitol 83.3g

[0090] Preparation Process

[0091] (1) Add 321.4g of egg yolk lecithin, 128.6g of poloxamer 188 and 200g of sodium glycocholate into 4500ml of water for injection, then add 100g of piperacillin sodium and 25g of tazobactam sodium, mix well, and place in a 70°C water bath Heat and stir until molten state;

[0092] (2) Keeping the above liquid at 70-90°C for 20 minutes with a tissue masher to shear and stir at a speed of 10,000 r / min to obtain a primary emulsion, which is then circulated and emulsified by a high-pressure homogenizer for 5 times to obtain an emulsion;

[0093] (3) Add 166.7g of lactose and 83.3g of sorbitol ...

Embodiment 3

[0107] Example 3 Preparation of Piperacillin Sodium-Tazobactam Sodium Suspension Powder Injection

[0108] Prescription (100 bottles):

[0109] Piperacillin Sodium 300g

[0110] Tazobactam Sodium 37.5g

[0111] Egg yolk lecithin 401.8g

[0112] Poloxamer 188 160.7g

[0113] Sodium Glycocholate 450g

[0114] Lactose 333.3g

[0115] Sorbitol 166.7g

[0116] Preparation Process

[0117] (1) Add 401.8g of egg yolk lecithin, 160.7g of poloxamer 188 and 450g of sodium glycocholate to 9000ml of water for injection, then add 300g of piperacillin sodium and 37.5g of tazobactam sodium and mix well at 80°C Heat and stir in a water bath until molten;

[0118] (2) Keeping the above liquid at 70-90°C for 10 minutes with a tissue masher to shear and stir at a speed of 15,000 r / min to obtain a primary emulsion, and then circulate and emulsify it through a high-pressure homogenizer for 4 times to obtain an emulsion;

[0119] (3) Add 333.3g of lactose and 166.7g of sorbitol to the em...

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Abstract

The invention discloses a suspension powder injection of a piperacillin sodium and tazobactam sodium pharmaceutical composition, and further discloses an application thereof to preparing medicines for treating lung abscess.

Description

technical field [0001] The invention relates to piperacillin sodium-tazobactam sodium pharmaceutical composition suspension powder injection and its new therapeutic application. Background technique [0002] Lung abscess refers to the suppurative lesion of the lungs caused by various pathogenic bacteria infection. The early stage is purulent inflammation, followed by tissue necrosis and abscess. Since the use of antibiotics, the incidence of the disease has decreased significantly, but in recent years, due to the abuse of antibiotics, drug-resistant strains have increased, and because the abscess cavity of the lung abscess is surrounded by a layer of uneven thickness and fibrous tissue, general antibiotics are not suitable. Through this wall into the abscess cavity, conventional therapy is not good, resulting in poor curative effect and slow recovery of the disease course. In severe cases, pulmonary abscess drainage or even surgical lung abscess resection is required, which ...

Claims

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Application Information

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IPC IPC(8): A61K31/496A61K31/431A61K9/19A61P11/00
Inventor 王明
Owner HAINAN MEILAN SMITH KLINE PHARMA
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