38 results about "Piperacillin Sodium/ Tazobactam Sodium" patented technology

The invention discloses a sterile filtration system for piperacillin sodium and tazobactam sodium for injection. The sterile filtration system comprises a filter tube, wherein an inner tube is fixedlydisposed inside the filter tube; a sterilization hole is formed in the side wall of the inner tube in a penetration manner; the outer side of the inner tube is fixedly covered with a rubber ring; a steam spraying nozzle is disposed in the rubber ring in a penetration manner; and one end of the steam spraying nozzle is movably located in the sterilization hole. According to the invention, when a filtration process of production is needed to be ensured in a sterile environment, a large amount of steam is injected into a steam sleeve from a steam generator, and the steam is injected into the inner tube from the front end of the steam spraying nozzle, so that the sterilization treatment is performed; a liquid to be filtered is injected into the inner tube from a water inlet during filtration,then a motor is driven, and a gear is driven by the motor to rotate, so that a threaded shaft is driven to rotate, and under the action of a threaded sleeve, the threaded shaft can be enabled to moveup and down while rotating, thereby changing a pre-filter plate and a sterile filter plate, and ensuring the sufficiency of the filtration of the liquid; and the filtered liquid is discharged from awater outlet.

The invention belongs to the technical field of medicine, and in particular relates to a piperacillin sodium-tazobactam sodium medicine composition and a preparation method of the medicine composition. The medicine composition is a sterile powder injection; the mass ratio of the piperacillin sodium to the tazobactam sodium in the medicine composition is 4-20:1; the X-ray powder diffraction pattern of the piperacillin sodium measured by means of powder X-ray diffraction measurement method is shown in Figure 1; the chemical structural formula of the piperacillin sodium is shown in Formula (I); and the content of the piperacillin sodium polymer in the medicine composition provided by the invention is quite low and is not changed obviously in an accelerated test condition and in a long-term test condition. The medicine composition prepared from the piperacillin sodium and the tazobactam sodium provided by the invention also has the advantages of low polymer content and good stability.

The invention discloses a compound pharmaceutical composition containing piperacillin sodium and tazobactam sodium. The compound pharmaceutical composition contains piperacillin sodium, tazobactam sodium, an excipient and a pH regulator, wherein the ratio of piperacillin sodium to tazobactam sodium is 4:1. Moreover, the invention also discloses a preparation method of the pharmaceutical composition. Compared with the prior art, the pharmaceutical composition disclosed by the invention not only is good in stability, low in impurity content and high in safety, but also is improved in dissolution rate and is more suitable for industrialization.

The invention discloses a preparation method of piperacillin sodium and tazobactam sodium for injection. The preparation method comprises the following steps: adding water into a blending tank, cooling to 5-10 DEG C, adding citric acid, then slowly adding sodium bicarbonate, and after reacting, reading the pH value and adjusting the pH value to be 6.3-6.6; adding piperacillin acid into the blending tank, and then dropwise adding the sodium bicarbonate solution, wherein the pH value in the dropwise adding process is controlled to be less than or equal to 7.0; after dropwise adding, adding tazobactam acid, and then dropwise adding the sodium bicarbonate solution, wherein the pH value in the dropwise adding process is controlled to be less than or equal to 7.0; after dropwise adding, carrying out vacuum removal on carbon dioxide gas by suction, and after the feed liquid in the blending tank is stabilized, reading the pH value and adjusting the pH value to be 6.0-6.5; and carrying out aseptic filtration and freeze-drying to obtain raw powder of piperacillin sodium and tazobactam sodium for injection. According to the preparation method, by adding salified citric acid, the acidity stability of the product is increased, the decomposition of piperacillin sodium and tazobactam sodium is inhibited, and the storage stability of the product is increased.