38 results about "Piperacillin Sodium/ Tazobactam Sodium" patented technology

The invention discloses a sterile filtration system for piperacillin sodium and tazobactam sodium for injection. The sterile filtration system comprises a filter tube, wherein an inner tube is fixedlydisposed inside the filter tube; a sterilization hole is formed in the side wall of the inner tube in a penetration manner; the outer side of the inner tube is fixedly covered with a rubber ring; a steam spraying nozzle is disposed in the rubber ring in a penetration manner; and one end of the steam spraying nozzle is movably located in the sterilization hole. According to the invention, when a filtration process of production is needed to be ensured in a sterile environment, a large amount of steam is injected into a steam sleeve from a steam generator, and the steam is injected into the inner tube from the front end of the steam spraying nozzle, so that the sterilization treatment is performed; a liquid to be filtered is injected into the inner tube from a water inlet during filtration,then a motor is driven, and a gear is driven by the motor to rotate, so that a threaded shaft is driven to rotate, and under the action of a threaded sleeve, the threaded shaft can be enabled to moveup and down while rotating, thereby changing a pre-filter plate and a sterile filter plate, and ensuring the sufficiency of the filtration of the liquid; and the filtered liquid is discharged from awater outlet.

The invention discloses a preparation method of piperacillin sodium and tazobactam sodium for injection. The preparation method comprises the following steps: adding water into a blending tank, cooling to 5-10 DEG C, adding citric acid, then slowly adding sodium bicarbonate, and after reacting, reading the pH value and adjusting the pH value to be 6.3-6.6; adding piperacillin acid into the blending tank, and then dropwise adding the sodium bicarbonate solution, wherein the pH value in the dropwise adding process is controlled to be less than or equal to 7.0; after dropwise adding, adding tazobactam acid, and then dropwise adding the sodium bicarbonate solution, wherein the pH value in the dropwise adding process is controlled to be less than or equal to 7.0; after dropwise adding, carrying out vacuum removal on carbon dioxide gas by suction, and after the feed liquid in the blending tank is stabilized, reading the pH value and adjusting the pH value to be 6.0-6.5; and carrying out aseptic filtration and freeze-drying to obtain raw powder of piperacillin sodium and tazobactam sodium for injection. According to the preparation method, by adding salified citric acid, the acidity stability of the product is increased, the decomposition of piperacillin sodium and tazobactam sodium is inhibited, and the storage stability of the product is increased.