The invention discloses a production method of a
piperacillin sodium tazobactam sodium freeze-
drying preparation for injection and belongs to the technical field of medicines. The production method comprises the steps of reacting, prefreezing, sublimation
drying,
drying again and taking out of a box. According to the production method, in the step of reacting,
sodium hydroxide is adopted for substituting
sodium bicarbonate, so that no bubble is produced in a reaction process; and a
sodium hydroxide solution is dropwise added into a turbid liquid containing
piperacillin acid and
tazobactam acid, reaction is carried out in a manner of adding
nitrogen to the bottom of a reaction tank, and
reaction speed of feed liquid can be increased while time that local concentration of
sodium hydroxide is overhigh can be shortened, so that degradation effect of a high-concentration
sodium hydroxide solution on
piperacillin sodium
tazobactam sodium is effectively avoided. According to the production method, mutual combination between
quick freezing and
slow cooling is realized on prefreezing of the
piperacillin sodium tazobactam sodium freeze-drying preparation, so that a
crystal form of the obtained
piperacillin sodium tazobactam sodium freeze-drying preparation product, insoluble particles and
related impurities of freeze-drying products are at the best level. The product
piperacillin sodium tazobactam sodium freeze-drying preparation for injection prepared by using the production method disclosed by the invention is good in quality and low in
impurity content.