Sterile filtration system for piperacillin sodium and tazobactam sodium for injection

Abstract

The invention discloses a sterile filtration system for piperacillin sodium and tazobactam sodium for injection. The sterile filtration system comprises a filter tube, wherein an inner tube is fixedlydisposed inside the filter tube; a sterilization hole is formed in the side wall of the inner tube in a penetration manner; the outer side of the inner tube is fixedly covered with a rubber ring; a steam spraying nozzle is disposed in the rubber ring in a penetration manner; and one end of the steam spraying nozzle is movably located in the sterilization hole. According to the invention, when a filtration process of production is needed to be ensured in a sterile environment, a large amount of steam is injected into a steam sleeve from a steam generator, and the steam is injected into the inner tube from the front end of the steam spraying nozzle, so that the sterilization treatment is performed; a liquid to be filtered is injected into the inner tube from a water inlet during filtration,then a motor is driven, and a gear is driven by the motor to rotate, so that a threaded shaft is driven to rotate, and under the action of a threaded sleeve, the threaded shaft can be enabled to moveup and down while rotating, thereby changing a pre-filter plate and a sterile filter plate, and ensuring the sufficiency of the filtration of the liquid; and the filtered liquid is discharged from awater outlet.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical production, in particular to a sterile filtration system for piperacillin sodium and tazobactam sodium for injection. Background technique [0002] Piperacillin Sodium-Tazobactam Sodium for Injection is a compound preparation, its components are piperacillin sodium and tazobactam sodium; excipients are: disodium ethylenediaminetetraacetic acid (EDTA), citric acid , sodium bicarbonate and water for injection, suitable for Staphylococcus, Escherichia coli, Citrobacter, Klebsiella, Enterobacter, Providence and Pseudomonas aeruginosa that are sensitive to this product Septicemia, complicated cystitis, and pyelonephritis caused by the genus. [0003] At present, piperacillin sodium and tazobactam sodium for injection are required to be produced and installed according to the prescription and process design requirements, and it is required to carry out aseptic production, and at the same time av...

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Problems solved by technology

[0003] At present, piperacillin sodium and tazobactam sodium for injection are required to be produced and installed according to the prescription and process design requirements, and it is required to carry out aseptic production, and at the same time avoid interference to the processing of the liquid medicine after aseptic treatment. At present, piperacillin sodium for injection is Most of the sterile filtration systems produced by tazobactam sodium have complex structures, high input costs, and difficult operations. Therefore, we propose a sterile filtration system for piperacillin sodium and tazobactam sodium for injection to solve the above problems. question

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