Method for improving yield of injection piperacillin sodium and tazobactam sodium

Abstract

The invention provides a method for improving the yield of injection piperacillin sodium and tazobactam sodium. The method is characterized by comprising the following steps: (1) weighing piperacillin sodium and tazobactam sodium in a weight ratio of 2:1; (2) weighing ionic exchange resin and water in a weight ratio of 1:30, jointly or independently mixing with piperacillin sodium and tazobactam sodium, stirring at a speed of 1300-1500 revolutions / minute by adopting a double-section paddle type at an angle of 15 degrees formed by leading a paddle to be vertical to the liquid level, filtering by use of a 120-mesh filter screen, and preparing injections, infusion solutions, powder injections or lyophilized powder. According to the method, the yield of the injection piperacillin sodium and tazobactam sodium is 90.0 percent, the pH value is 6.3, the moisture is less than 0.7 percent, the content of piperacillin in 1mg of injection piperacillin sodium and tazobactam sodium is 882 mu g, and the content of tazobactam in 1mg of injection piperacillin sodium and tazobactam sodium is 112 mu g, so that the drug stability is further improved, and the quality of medicines in validity can be guaranteed.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a method for increasing the yield of piperacillin sodium and tazobactam sodium for injection. Background technique [0002] Piperacillin / tazobactam is a compound broad-spectrum antibiotic composed of piperacillin sodium and β-lactamase inhibitor tazobactam sodium. Piperacillin is a semi-synthetic broad-spectrum penicillin belonging to the ureide penicillin family. Its antibacterial mechanism is similar to that of penicillin. It plays an antibacterial effect by binding to the main penicillin-binding proteins (PBPs) of bacteria and interfering with the synthesis of bacterial cell walls. It is characterized by a broad spectrum, but not resistant to penicillinase. Tazobactam, also known as triazinemethyl penicillin sulfone, is a penicillin acid sulfone and an inhibitor of β-lactamase. It has almost no antibacterial activity itself, but has a strong broad-spectrum inhibitory effec...

AI Technical Summary

Problems solved by technology

2. The mixing method of the batching device should be reasonable, and the added Na + Quickly disperse and react with raw material acid to form a salt, which may cause local Na + If the concentration is too high, the main component will be degraded and the product yield will be affected

3. The temperature control of the batching reaction process will also affect the product yield. If the temperature is too low, it will affect the reaction speed. If the temperature is too high, the main components will be degraded and the product yield will be reduced.