Medicinal composition

Abstract

The invention discloses a medicinal composition. The medicinal composition comprises piperacillin sodium and tazobactam sodium serving as raw material medicaments, and is characterized in that: the piperacillin sodium serving as the raw material medicament is prepared from piperacillin acid through ion exchange resin; and the tazobactam sodium serving as the raw material medicament is prepared from tazobactam acid through the ion exchange resin. Experiments prove that a preparation prepared from the medical composition has higher quality.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition made of piperacillin acid and tazobactam acid as raw materials. Background technique [0002] Bacterial drug resistance, also known as drug resistance, generally means that after repeated contact between bacteria and drugs, the sensitivity to drugs decreases or even disappears, resulting in reduced or ineffective efficacy of drugs against drug-resistant bacteria. Today, the problem of drug-resistant bacteria in my country has become very prominent. The number of nosocomial infections caused by drug-resistant bacteria has accounted for about 30% of the total number of hospitalized infected patients. Solving the problem of bacterial drug resistance has become a top priority. β-lactam antibiotics such as penicillins and cephalosporins are currently the most clinically used and most important class of antibiotics, accounting for more than 50% of the tota...

AI Technical Summary

Problems solved by technology

The Chinese patent application number 200680040942.6 discloses a method for preparing a piperacillin / tazobactam composition, which discloses the reaction of piperacillin acid / tazobactam acid with sodium bicarbonate or sodium carbonate, nitrogen or vacuum The method of excluding carbon dioxide prepares a stable composition. Although this method is technically feasible, it needs to control the amount of carbon dioxide in the water to ensure the amount of insoluble particles in the preparation. However, due to the limitation of the reaction raw materials of this method, carbon dioxide will always remain in the water , therefore, the stability of the preparation and the insoluble particles are always unsolvable. Therefore, it is imperative to research and develop a new piperacillin / tazobactam pharmaceutical composition to ensure the quality of the preparation and ensure the safety of patients.

Images