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Meropenem sodium/tazobactam sodium medicinal composition

A technology of tazobactam sodium and meropenem, applied in the field of medicine, can solve the problems of multidrug-resistant Acinetobacter baumannii invasion and other problems

Active Publication Date: 2012-02-15
深圳市新泰医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Carbapenems are the drug of choice for the treatment of severe Acinetobacter baumannii infections, but carbapenem-multidrug-resistant strains have emerged around the world in recent years, with worrying multi-drug resistance emerging from Spain to Norway The "invasion" phenomenon of Acinetobacter baumannii is prevalent among traumatized soldiers of the U.S. and British troops stationed in Afghanistan and Iraq, causing serious public health problems. Acinetobacter baumannii brought back by the U.S. military in Iraq is prevalent in the United States

Method used

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  • Meropenem sodium/tazobactam sodium medicinal composition
  • Meropenem sodium/tazobactam sodium medicinal composition
  • Meropenem sodium/tazobactam sodium medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1: Study on antibacterial effect of meropenem / tazobactam sodium in vitro

[0031] 1. Materials and methods

[0032] 1. Test drugs:

[0033] (1) Meropenem (Meropenem, chemical structure is C17H25N3O5S 3H2O), chemical name 3-[[5-[(dimethylamino)carbonyl]-3-pyrrolidinyl]thio]-6-(1-hydroxyethyl Base)-4-methyl-7-oxo-1-azabicyclo[3,2,0]hept-2-ene-2-carboxylic acid provided by Shenzhen Xintai Pharmaceutical Co., Ltd. Place. Lot No. 130506-200702, Potency: 93.7%

[0034] (2) Tazobactam Sodium (Tazobactam Sodium): batch number 0481-9801, potency: 93.7%. , purchased from China Institute for the Control of Pharmaceutical and Biological Products.

[0035] The following proportions are calculated by weight, where the weight of meropenem is calculated based on the dry conversion of meropenem, and the weight of tazobactam is calculated based on the dry conversion of tazobactam sodium.

[0036] 2. Test ratio:

[0037] (1) Meropenem

[0038] (2) Tazobactam sodium

[003...

Embodiment 2

[0075] Example 2: In vivo antibacterial effect of meropenem / tazobactam sodium for injection

[0076] Compositions of meropenem and tazobactam sodium in weight ratio (3:1), (2:1), (1:1), (1:2), (1:4) have certain effects on infected mice Significant antibacterial therapeutic effect.

[0077] 1. Test drug

[0078] Meropenem (Meropenem, molecular formula C17H25N3O5S 3H2O) batch number: 081212; provided by Shenzhen Xintai Pharmaceutical Co., Ltd., purchased from China Institute for the Control of Pharmaceutical and Biological Products; tazobactam sodium: batch number 0481-9801, potency: 93.7%, purchased from From the National Institute for the Control of Pharmaceutical and Biological Products.

[0079] 2 Drug preparation

[0080] Use 0.9% sodium chloride injection solution to prepare different proportions to the required concentration.

[0081] (1), meropenem (single dose)

[0082] (2), tazobactam sodium (single dose)

[0083] (3), meropenem / tazobactam sodium (3:1)

[0084]...

Embodiment 3

[0100] Example 3: Comparative study on the antibacterial effect of meropenem / tazobactam and cefoperazone / tazobactam on Acinetobacter baumannii

[0101] The combination of meropenem and tazobactam sodium in weight ratio (2:1, 1:1, 1:2, 1:4) has significant antibacterial therapeutic effect on infected mice.

[0102] 1. Test drug

[0103]Meropenem (Meropenem, chemical structure C17H25N3O5S 3H2O) was provided by Shenzhen Xintai Pharmaceutical Co., Ltd. and purchased from China National Institute for the Control of Pharmaceutical and Biological Products.

[0104] Cefoperazone / sulbactam sodium (1:1), produced by Pfizer Pharmaceutical Co., Ltd., batch number, 058354030. Provided by Shenzhen Xintai Pharmaceutical Co., Ltd.

[0105] Tazobactam sodium: batch number 0481-9801, potency: 93.7%. purchased from China National Institute for the Control of Pharmaceutical and Biological Products.

[0106] Small white mice, Kunming species, weighing 18-22g, half male and half male. Provided ...

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Abstract

The invention provides a combined medicament, in particular a meropenem tazobactam sodium combined medicament for treating infectious diseases caused by acinetobacter baumannii. The meropenem and tazobactam sodium combined medicament has a synergistic effect and an accumulative antibacterial effect on the infectious diseases caused by the acinetobacter baumannii and particularly has a good synergistic effect and a good accumulative antibacterial effect on multiple medicine-tolerant acinetobacter baumannii strains, and can be used for curing clinical infection caused by the multiple medicine-tolerant acinetobacter baumannii strains in clinic.

Description

technical field [0001] The present invention provides a combined drug, in particular, a combined drug of meropenem / tazobactam sodium for treating infectious diseases caused by Acinetobacter baumannii. It belongs to the field of medical technology. Background technique [0002] Antibiotic resistance is not a new problem, but its threat to humanity is growing. While countries are taking action, efforts are needed to avoid a return to a pre-antibiotic era, leaving the future without medicines. Therefore, the theme of World Health Day 2011 is to fight against drug resistance. [0003] Carbapenem antibiotics are a class of antibiotics with the broadest antibacterial spectrum and strong antibacterial activity so far. However, with the widespread use of carbapenems, the resistance rate of Acinetobacter baumannii to carbapenems has increased year by year. increased. And once it is resistant to carbapenems, it means that most of the commonly used broad-spectrum antibacterial drug...

Claims

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Application Information

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IPC IPC(8): A61K31/431A61K31/407A61P31/04A61P11/00A61P7/00A61P13/00
Inventor 廖文广
Owner 深圳市新泰医药有限公司
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