Liposome injection prepared from ceftriaxone sodium tazobactam sodium medicinal composition

A technology of tazobactam sodium and ceftriaxone sodium, which is applied in the direction of liposome delivery, active ingredients of heterocyclic compounds, antibacterial drugs, etc., can solve problems such as the limitation of preparation technology means, achieve simple and effective preparation process, improve Curative effect, effect of prolonging action time

Inactive Publication Date: 2011-05-11
HAINAN YONGTIAN PHARMA INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] The present invention aims to face the limitations of the existing marketed products due to preparation techniques. After referring to numerous relevant materials and a large number of experimental summaries, it is found that ...

Method used

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  • Liposome injection prepared from ceftriaxone sodium tazobactam sodium medicinal composition
  • Liposome injection prepared from ceftriaxone sodium tazobactam sodium medicinal composition
  • Liposome injection prepared from ceftriaxone sodium tazobactam sodium medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Example 1 Preparation of ceftriaxone sodium tazobactam sodium drug mixture liposome

[0068] Prescription (100 bottles):

[0069] Ceftriaxone Sodium 75g

[0070] Tazobactam Sodium 25g

[0071] Dimyristoylphosphatidylcholine 66.7g

[0072] Soy Phosphatidylinositol 33.3g

[0073] Phosphatidylserine 32.5g

[0074] Octadecylamine 32.5g

[0075] Mannitol 50g

[0076] Trehalose 100g

[0077] Sodium metabisulfite 3.33g

[0078] Vitamin C 1.67g

[0079] making process:

[0080] (1) Dissolving 66.7g of dimyristoylphosphatidylcholine, 33.3g of soybean phosphatidylinositol, 32.5g of phosphatidylserine, and 32.5g of octadecylamine in 1200ml of isopropanol and tris In the mixed solvent of methyl chloride, the organic solvent was removed under reduced pressure on a rotary film evaporator to obtain a phospholipid film;

[0081] (2) Add 600ml of sodium dihydrogen phosphate-disodium hydrogen ph...

Embodiment

[0104] Embodiment and comparative example comparison Comparison of the preferred auxiliary material proportioning and freeze-drying process of the present invention

[0105] In the following table, the following examples and comparative examples are designed as experimental factors with the selected auxiliary materials and consumption and preparation technology of the present invention, wherein Examples 1-4 are carried out by the preparation technology of the present invention, and the auxiliary materials and consumption used are in the present invention Within the preferred range of comparative examples 1-4, the adjuvant or the amount of adjuvant used is outside the preferred range of the present invention, or some adopt the common freeze-drying process to carry out, and the results of investigation in the test example are compared and illustrated to the advantages of the present invention.

[0106] The comparison of table 1 embodiment and comparative example

[0107]

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PUM

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Abstract

The invention discloses a liposome injection prepared from ceftriaxone sodium tazobactam sodium medicinal composition, comprising the following components in parts by weight: 3 parts of ceftriaxone sodium, 1 part of azobactam sodium, 3-18 parts of liposome film material, 1.2-10 parts of addictive, 6-25 parts of frozen-dried support agent and 0.1-4 parts of antioxidant. By preparing the ceftriaxone sodium tazobactam sodium medicinal composition into liposome, the stability of a preparation can be greatly improved, the quality of medicines is improved, the toxic or side effects are reduced, the target property can be acquired and the curative effect can be improved.

Description

technical field [0001] The invention relates to a ceftriaxone sodium tazobactam sodium pharmaceutical composition liposome injection and a preparation method thereof, belonging to the field of pharmaceutical preparations. Background technique [0002] Ceftriaxone Sodium (Ceftriaxone, Junbizhi), is a semi-synthetic third-generation cephalosporin, which is effective against G + Bacteria have moderate antibacterial effect on G - The main sensitive bacteria are Staphylococcus aureus, Streptococcus, Streptococcus pneumoniae, Haemophilus, Neisseria, Escherichia coli, Klebsiella pneumoniae, Serratia, various types of Proteus, citrate Citrobacter, Salmonella typhi, Shigella, Peptococcus, Peptostreptococcus, Clostridium, etc. [0003] Clinically, the curative effect of ceftriaxone sodium on lower respiratory tract infection is relatively satisfactory, the clinical effective rate is 75%-100%, and the bacterial clearance rate is generally above 90%. The primary lesion is different, ...

Claims

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Application Information

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IPC IPC(8): A61K31/546A61K31/431A61K9/127A61P31/04
Inventor 郝志艳
Owner HAINAN YONGTIAN PHARMA INST
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