Pharmaceutical composition used for preventing and treating colibacillosis in livestock and poultry

A technology of colibacillosis and composition, which is applied in the field of veterinary drugs, can solve problems such as poor stability and threat of infectious diseases, and achieve the effects of strong antibacterial activity, high blood drug concentration, and strong antibacterial activity

Inactive Publication Date: 2012-05-23
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because it is insoluble in water and has poor stability, it is often made into ceftiofur sodium salt and ceftiofur hydrochloride to improve its stability and water solubility
With the wide application of ceftiofur in clinical practice, Escherichia coli has gradually developed serious drug resistance to ceftiofur. The main reason for bacterial resistance to ceftiofur is

Method used

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  • Pharmaceutical composition used for preventing and treating colibacillosis in livestock and poultry
  • Pharmaceutical composition used for preventing and treating colibacillosis in livestock and poultry

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] After pulverizing and sieving (80 mesh), ceftiofur hydrochloride 2g, tazobactam sodium 0.25g, probenecid sodium 5g, dexamethasone sodium phosphate 0.1g, β-cyclodextrin 2g, add sucrose to 100g, mix evenly, promptly make a kind of medicine that is mainly used in the prevention and treatment of livestock and poultry Escherichia coli disease.

Embodiment 2

[0022] Ceftiofur hydrochloride 5g, tazobactam sodium 1g, probenecid sodium 6g, dexamethasone sodium phosphate 0.2g, β-cyclodextrin 5g after crushing and sieving (80 mesh), add oral glucose to 100g, mix evenly, promptly make a kind of medicine that is mainly used in the prevention and treatment of livestock and poultry Escherichia coli disease.

Embodiment 3

[0024] After crushing and sieving (80 mesh), ceftiofur hydrochloride 8g, tazobactam sodium 2g, probenecid sodium 8g, dexamethasone sodium phosphate 0.3g, β-cyclodextrin 10g, add anhydrous sulfuric acid Sodium up to 100g, mixed evenly, promptly made a kind of medicine that is mainly used in the prevention and treatment of Escherichia coli disease of livestock and poultry.

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Abstract

The invention relates to a pharmaceutical composition used for preventing and treating colibacillosis in livestock and poultry. Every 100 g of the pharmaceutical composition comprises 2 to 10 g of ceftiofur hydrochloride, 0.25 to 10 g of tazobactam sodium, 5 to 10 g of probenecid sodium, 0.1 to 0.5 g of dexamethasone sodium phosphate and 2 to 15 g of beta-cyclodextrin, with the balance being pharmaceutically acceptable accessories. The pharmaceutical composition has the advantages of reasonable composition, low cost, a remarkable curative effect on clinical pathogenic escherichia coli, especially on drug-resistant intractable escherichia coli, a simple preparation method, stable properties and convenience in large scale intensive production.

Description

technical field [0001] The invention belongs to the field of veterinary drugs, in particular to a pharmaceutical composition for preventing and treating Escherichia coli diseases in livestock and poultry. Background technique [0002] Colibacillosis is a general term for a class of livestock and poultry diseases caused by some pathogenic strains of Escherichia coli. Escherichia coli is a conditional pathogenic bacterium that parasitizes almost all animals and forms a balance with the body most of the time. When the physiological functions of the body are out of balance, pathogenic E. coli can have a reproductive advantage. and lead to disease. The disease can occur all year round, and it is more likely to occur in winter and spring when the air humidity is relatively high or the climate is changeable. It mainly causes the disease of young livestock and poultry. Peritonitis, perihepatitis, air sacitis and diarrhea are the main symptoms. In recent years, with the developmen...

Claims

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Application Information

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IPC IPC(8): A61K31/661A61K31/546A61K31/431A61K31/195A61P31/04
Inventor 昌莉丽魏德宝刘桂兰
Owner TIANJIN RINGPU BIO TECH
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