6 results about "Dexamethasone Sodium Phosphate" patented technology

This invention discloses a sodium alginate cross-linked matrix metalloproteinase-sensitive peptide-loaded dexamethasone sodium phosphate hydrogel and its preparation method. The dexamethasone-loaded hydrogel has good injectability. After injection, it is cleaved by MMPs at the site of inflammation in an inflammatory environment to release dexamethasone, exhibiting good sustained-release effect. It achieves targeted and long-acting treatment of inflammatory arthritis, osteoarthritis or other inflammatory diseases, and reduces the frequency of repeated intra-articular injections of glucocorticoids.

A dexamethasone sodium phosphate lyophilized composition suitable for administration to the eardrum and a preparation method therefor are provided. Provided is a lyophilized powder injection preparation, wherein the preparation is a dexamethasone medicament lyophilized powder injection omitting a lyophilization supporting agent or an excipient or a matrix agent, wherein the lyophilized powder injection preparation comprises pharmaceutically acceptable auxiliary material of glycerol, and the glycerol is added before the lyophilized powder injection preparation is lyophilized. The provided lyophilized preparation omits a lyophilized supporting agent or an excipient, achieving the effect of improving the stability of the drug by only adding a small amount of glycerol, and also allowing adjustment the osmotic pressure to be closer to the physiological osmotic pressure during the tympanogram administration and prolong the action time of local administration, thereby increasing the safety and effectiveness of the tympanogram administration.

The invention relates to the field of medical application of biological hydrogel, in particular to dexamethasone loaded hydrogel delivered across tympanic membranes and a preparation method of the dexamethasone loaded hydrogel, the hydrogel takes gelatin Gel and dopamine modified hyaluronic acid HADA as base materials, a three-dimensional network structure is formed through enzymatic crosslinking of transglutaminase mTGase, dexamethasone sodium phosphate Dex is loaded, and the hydrogel can be used for preparing the dexamethasone loaded hydrogel. Furthermore, local trans-tympanic membrane middle ear drug delivery and release are realized; specifically, a solution A composed of Gel, HADA and Dex and a solution B composed of mTGase are evenly mixed according to the volume ratio of 4: 1 and dropwise added to the surface of the tympanic membrane through an external auditory canal, and finally Gel-HADA-Dex hydrogel is formed on the surface of the tympanic membrane. Local precise high-concentration drug delivery can be achieved, systemic drug toxicity is avoided, materials are safe, ear toxicity is avoided, meanwhile, adhesion performance is high, drug release is continuous, gradual self-degradation is achieved, manual taking out is not needed, and use convenience is remarkably improved.

The invention discloses a dexamethasone sodium phosphate freeze-dried composition suitable for ear drum administration and a preparation method of the dexamethasone sodium phosphate freeze-dried composition. The invention provides a freeze-dried powder injection preparation, the preparation is a dexamethasone drug freeze-dried powder injection, does not contain a freeze-drying supporting agent or an excipient or a support agent, the freeze-dried powder injection preparation contains a pharmaceutically acceptable auxiliary material glycerol, and the glycerol is added before the freeze-dried powder injection preparation is freeze-dried. The provided freeze-drying preparation does not contain a freeze-drying supporting agent or an excipient, the effect of improving the stability of the medicine can be achieved only by adding a small amount of glycerol before the preparation is freeze-dried, meanwhile, the osmotic pressure can be adjusted, so that the osmotic pressure is closer to physiological osmotic pressure during tympanic administration, and the action time of local administration is prolonged; and the safety and effectiveness of tympanic administration are improved.

The present application belongs to the field of biological medicine, and relates to a dexamethasone sodium phosphate lyophilized composition suitable for tympanic administration and a preparation method thereof. The present application provides a lyophilized powder injection preparation, which is a dexamethasone lyophilized powder injection, does not contain a lyophilized support agent or an excipient or a support agent, and contains a pharmaceutically acceptable auxiliary material glycerol, wherein the glycerol is added before lyophilization of the lyophilized powder injection preparation. The lyophilized preparation provided by the present application does not contain a lyophilized support agent or an excipient, and only a small amount of glycerol is added before lyophilization of the preparation to achieve the effect of improving the stability of the drug. Meanwhile, the osmotic pressure can be adjusted to be closer to the physiological osmotic pressure during tympanic administration, the local administration time is prolonged, the safety and effectiveness of tympanic administration are increased.