3 results about "Dexamethasone Sodium Phosphate" patented technology

This invention discloses a sodium alginate cross-linked matrix metalloproteinase-sensitive peptide-loaded dexamethasone sodium phosphate hydrogel and its preparation method. The dexamethasone-loaded hydrogel has good injectability. After injection, it is cleaved by MMPs at the site of inflammation in an inflammatory environment to release dexamethasone, exhibiting good sustained-release effect. It achieves targeted and long-acting treatment of inflammatory arthritis, osteoarthritis or other inflammatory diseases, and reduces the frequency of repeated intra-articular injections of glucocorticoids.

A dexamethasone sodium phosphate lyophilized composition suitable for administration to the eardrum and a preparation method therefor are provided. Provided is a lyophilized powder injection preparation, wherein the preparation is a dexamethasone medicament lyophilized powder injection omitting a lyophilization supporting agent or an excipient or a matrix agent, wherein the lyophilized powder injection preparation comprises pharmaceutically acceptable auxiliary material of glycerol, and the glycerol is added before the lyophilized powder injection preparation is lyophilized. The provided lyophilized preparation omits a lyophilized supporting agent or an excipient, achieving the effect of improving the stability of the drug by only adding a small amount of glycerol, and also allowing adjustment the osmotic pressure to be closer to the physiological osmotic pressure during the tympanogram administration and prolong the action time of local administration, thereby increasing the safety and effectiveness of the tympanogram administration.

The application provides a kind of for heart death after organ acquisition perfusion fluid and its application, belong to medical technical field.The application is used for heart death after organ acquisition perfusion fluid, including the following components: thrombolytic drug, vasodilator, albumin, dexamethasone sodium phosphate, low molecular weight heparin sodium and lactated Ringer's solution.The organ acquisition perfusion fluid of the application can effectively remove the thrombus formed by coagulation system activation, reduce vasospasm caused by warm ischemic injury and tissue cell edema in the process of perfusion, which can effectively improve the quality and function of the acquired organ, increase the utilization rate of the organ, and has clinical transformation application prospect.