Compound sulfamonomethoxine sodium injection and preparation method thereof

A technology of methoxine sodium and compound sulfa, which is applied to medical preparations, pharmaceutical formulations, organic active ingredients and other directions containing active ingredients, can solve the problems of incomplete curative effect and the like, achieves long action time, small local irritation, The effect of enhancing the body's resistance

Inactive Publication Date: 2009-03-18
陈建波
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The dosage of the injection is accurate and the effect is reliable, unlike the oral medicine that may ...

Method used

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  • Compound sulfamonomethoxine sodium injection and preparation method thereof
  • Compound sulfamonomethoxine sodium injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A compound sulfamethoxine sodium injection for veterinary use, the raw material comprises the following components:

[0032] Sulfamethoxine sodium 10g, trimethoprim 2g, dexamethasone sodium phosphate 0.05g, imidazolone 1.0g, astragalus polysaccharide 2.0g, α-pyrrolidone 25g, N,N-dimethylformamide 30g, propylene glycol 15g, water for injection 12g, pH regulator ethanolamine 2.5g.

[0033] The preparation method of the veterinary compound sulfamethoxine sodium injection, the steps are as follows:

[0034] 1) Mix and dissolve 2 g of trimethoprim, 25 g of α-pyrrolidone, 30 g of N, N-dimethylformamide, and 15 g of propylene glycol to obtain a trimethoprim solution; in pyridine solution;

[0035] 2) Mix and dissolve 0.05 g of dexamethasone sodium phosphate and 4 g of water for injection to obtain dexamethasone sodium phosphate solution;

[0036] 3) Mix and dissolve 1.0 g of imidazolium and 4 g of water for injection to obtain an imidazuron solution;

[0037]4) Mix and dis...

Embodiment 2

[0051] A compound sulfamethoxine sodium injection for veterinary use, the raw material comprises the following components:

[0052] Sulfamethoxine sodium 8g, trimethoprim 1.6g, dexamethasone sodium phosphate 0.03g, imidazolium 0.8g, astragalus polysaccharide 1.6g, α-pyrrolidone 20g, N,N-dimethylformamide 35g, Propylene glycol 15g, water for injection 13g, pH regulator ethanolamine 2g.

[0053] The preparation steps are the same as in Example 1.

Embodiment 3

[0055] A compound sulfamethoxine sodium injection for veterinary use, the raw material comprises the following components:

[0056] Sulfamethoxine sodium 12g, trimethoprim 2.4g, dexamethasone sodium phosphate 0.07g, imidazolium 1.2g, astragalus polysaccharide 2.4g, α-pyrrolidone 30g, N,N-dimethylformamide 30g, Propylene glycol 20g, water for injection 10g, pH regulator ethanolamine 3g.

[0057] The preparation steps are the same as in Example 1.

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Abstract

The invention relates to a compound sulfamonomethoxine sodium injection for veterinary use and a preparation method thereof, and belongs to the technical field of medicines for veterinary use. The raw material components of the compound sulfamonomethoxine sodium injection for veterinary use comprise sulfamonomethoxine sodium, dexamethasone sodium phosphate, trimethoprim, imidocarb, astragalus polysaccharide, organic solvent and water for injection. As a special compound preparation for veterinary use, the injection has remarkable efficacy on strengthening resistance of livestock and poultry, and treating mixed infection and severe diseases caused by a plurality of pathogenic bacteria and viruses. The injection has the advantages of convenient use, short treatment course, low drug resistance and the like.

Description

technical field [0001] The invention relates to a veterinary compound sulfamethoxine sodium injection, in particular to a compound preparation made of sulfamethoxine sodium, trimethoprim, imidazolamide, astragalus polysaccharide, etc., and a preparation method thereof . Background technique [0002] 1. At present, the mixed infection of livestock and poultry in the aquaculture industry has a high incidence and serious complications. The market is in urgent need of targeted new products, which can not only enhance the resistance of livestock and poultry, but also treat mixed infections and critical illnesses caused by various bacteria and viruses. [0003] 2. At present, in clinical use, the combination of sulfamethoxine sodium and synergistic factor trimethoprim can enhance the antibacterial effect dozens of times, adding dexamethasone sodium phosphate, midazolium, and astragalus polysaccharide can achieve antibacterial effect at the same time , anti-inflammation, deworming...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/715A61K31/661A61K31/505A61K31/4178A61P31/00A61P29/00A61P33/00
Inventor 陈建波
Owner 陈建波
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