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72 results about "Polypill" patented technology

A polypill is a medication that is a drug product in pill form (i.e., tablet or capsule) that combines multiple active pharmaceutical ingredients. The prefix "poly" means "multiple", referring to the multiplicity of distinct drugs in a given "pill". An occasional synonym is combopill. It is commonly manufactured as a fixed-dose combination (FDC) drug product targeting treatment or prevention of chronic disease. Polypills may be aimed to be consumed by healthy people as a means of preventive medicine, and/or treating actual pathophysiological condition(s), the former typically involving lower dosages than the latter. Polypills can reduce the number of tablets or capsules (generally orally administered) that need to be taken, which in turn may facilitate handling and administration of pharmaceuticals as well as alleviate patient pill-burden. Sometimes the multiple drugs in a given polypill might all be aimed at a single underlying condition (or, group of related conditions), partly because this expands the pool of potential patients for whom a given combination of drugs/dosages might be appropriate (particularly in the case of mass-produced polypills, i.e. FDCs). The term polypill was first coined in the context of cardiovascular disease prevention, but has since gained broader acceptance, including now for combinatorial drug products that existed before the term was actually coined (as the bare term without any modifiers is now quite generic).

Compound preparation containing curcumin nanoparticles as well as preparation method and application of compound preparation

The invention provides a compound preparation containing curcumin nano-particles as well as a preparation method and application of the compound preparation. Curcumin is wrapped by alcohol-soluble protein to form nano-particles, and the nano-particles are used as a Pickering milk solid emulsifier for emulsifying and dispersing vitamin D and olive oil into an oil phase to form a stable droplet structure; furthermore, polysaccharide with enteric characteristics is used as a water-phase carrier material, and the emulsion is encapsulated in the pellet by using a hole sharpening-solidification method, so that the solidification of the liquid medicine (the emulsion) is realized; the three natural components, namely the curcumin, the vitamin D and the olive oil, are ingeniously integrated into a whole; the targeting property of the medicine at the colon part is improved; meanwhile, the destructive effect of the gastrointestinal tract environment on the medicine carrying nanoparticles is reduced.
Owner:FUJIAN HEALTH COLLEGE

Quality control method of Beijing medicine compound preparation

The invention discloses a quality control method of a Beijing medicine compound preparation, and particularly relates to the field of quality control methods. Comprising the steps of comprehensive detection of medicinal materials, multi-component content determination, biological activity evaluation, quality consistency evaluation and the like. The quality stability of the medicinal materials is guaranteed from the source by determining the medicinal material producing area, the harvesting time and the processing technology preset standard; a biological activity detection model related to efficacy is established, and the quality standard and the efficacy are tightly combined; a compound preparation quality database is constructed, principal component analysis and clustering analysis are used for regular review analysis, and quality control standards and methods are dynamically adjusted and optimized; and a quality early warning mechanism is formulated, and quality problems are handled in time. According to the method, the quality is comprehensively controlled from multiple dimensions, the quality stability of preparations in different batches is ensured, the disjunction of the quality and the efficacy is effectively avoided, and the safety and the effectiveness of the Beijing medicine compound preparation are ensured.
Owner:FANGCHENGGANG TRADITIONAL CHINESE MEDICINE HOSPITAL

Use of antiviral agents, composition of matter, combination preparations / agents to treat chronic diseases associated with epstein-barr virus and other human herpes viruses

PendingUS20260191871A1MonocytosisFibromyalgia
The present invention is directed to the use of antiviral agents, in particular valomaciclovir stearate and its polymorph Form A, as well as H2G (omaciclovir) to treat multiple sclerosis in combination with other agents, as well as the use of these agents to treat diseases and conditions such as chronic mononucleosis, long COVID, chronic fatigue syndrome, fibromyalgia, Crohn's disease, ulcerative colitis, rheumatoid arthritis, systemic lupus erythematosus, Graves' disease, Alzheimer's disease, mesial temporal lobe seizures, Epstein-Barr-virus-linked autism, or an Epstein-Barr-virus-linked cancer.
Owner:EPIPHANY BIOSCIENCES INC

Combinations containing oxylanthanum carbonate for treating hyperphosphatemia

PendingCA3317758A1Serum phosphateNephrosis
Combinations of oxylanthanum carbonate and tenapanor for reducing serum phosphate levels in patients with end-stage renal disease (ESRD) and / or chronic kidney disease (CKD).
Owner:UNICYCIVE THERAPEUTICS INC

Small molecule therapy for ocular conditions

Provided are pharmaceutical compositions comprising a combination therapy having therapeutically effective amounts of sodium 4-phenyIbutylate and tauroursodeoxycholic acid for the treatment of an ocular condition in a subject. Also provided herein are methods using the combination therapy, and a pharmaceutical composition thereof, for preventing or treating an ocular condition in a subject.
Owner:RGT UNIV OF CALIFORNIA

Tripterine-loaded nanoparticles as well as preparation method and application thereof

The invention belongs to the technical field of medicines, and particularly relates to tripterine-loaded nano-particles as well as a preparation method and application thereof, and the tripterine-loaded nano-particles (Cel-GDNPs) comprise ginger exosome (GDNPs) and tripterine (Cel) encapsulated in the ginger exosome. According to the invention, the Cel is used as a therapeutic drug, and the adopted carrier GDNPs has anti-inflammatory activity, so that when the Cel and the GDNPs are used for treating inflammatory diseases such as colitis and the like, the Cel and the GDNPs can play a multi-component synergistic therapeutic effect, and compared with the single use of the Cel or the GDNPs, the expression of proinflammatory factors (such as TNF-alpha, IL-1beta and IL-6) can be more effectively inhibited, so that the synergistic therapeutic effect is realized; a new strategy is provided for developing a novel natural compound preparation.
Owner:YANTAI UNIV

A compound preparation for treating vascular dementia and a preparation method thereof

This invention discloses a compound preparation for treating vascular dementia and its preparation method. The active pharmaceutical ingredient consists of protopanaxadiol and gallic acid in a 1:1 mass ratio, and the dosage form is liposomes. The preparation method includes extraction, mixing, liposome preparation, and optional freeze-drying steps: protopanaxadiol and gallic acid are extracted and purified from ginseng rhizome and Terminalia chebula fruit, respectively. After mixing, they are combined with phospholipids and cholesterol to prepare a lipid membrane. The membrane is then homogenized by hydration, low-temperature ultrasound, and high-pressure microfluidic jet to obtain a homogeneous liposome suspension, which can be further freeze-dried into a freeze-dried powder. The 1:1 composition of protopanaxadiol and gallic acid targets multiple points on the pathological mechanism of vascular dementia, showing significant therapeutic effects and broad application prospects. This preparation uses a liposome dosage form to improve the bioavailability of the active ingredient, the preparation process parameters are controllable, the active ingredient has high purity, the liposomes have uniform particle size, high encapsulation efficiency, and good stability.
Owner:GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE

Method for characterizing volatile components in compound pseudo-ginseng and salvia miltiorrhiza capsules based on gas chromatography-mass spectrometry

ActiveCN121805482AEnrich qualitative identification informationImprove detection efficiencyComponent separationChemical compoundPhysical chemistry
The invention discloses a method for characterizing volatile components in a compound pseudo-ginseng and salvia miltiorrhiza capsule based on gas chromatography-mass spectrometry, and relates to the technical field of compound pseudo-ginseng and salvia miltiorrhiza capsule detection, and the method comprises the following steps: (1) preparing a compound pseudo-ginseng and salvia miltiorrhiza capsule test solution; and (2) detecting the volatile components in the traditional Chinese medicine compound test solution by adopting a triple quadrupole gas chromatograph-mass spectrometer. According to the method, volatile oil of a trace component of rhizoma cyperi in a compound preparation is fully retained and extracted by pre-treating the compound pseudo-ginseng and salvia miltiorrhiza capsule, and after detection by the method, a quasi-molecular ion peak can be obtained, and a fragment ion peak containing rich structure information can be obtained, so that the structure information of the compound can be quickly and accurately obtained.
Owner:THE AFFILIATED HOSPITAL OF YUNNAN UNIVERSITY

Combinations comprising lanifibranor and a GLP-1 / GIP / glucagon triple receptor agonist for use in the treatment of liver diseases

The present disclosure relates to a drug combination and a method for the prevention and / or the treatment of a liver disease, the combination comprising lanifibranor or a deuterated form thereof and a GLP-1 / GIP / glucagon triple receptor agonist.
Owner:INVENTIVA

Novel compound preparation for resisting mycobacterium tuberculosis and preparation method thereof

The invention discloses a novel compound preparation for resisting mycobacterium tuberculosis and a preparation method thereof.The compound preparation comprises glutathione active part and pyrazinamide, the weight ratio of glutathione to pyrazinamide is (2-4): 5, the glutathione active part comprises glutathione, an isolation stabilizer, a plasticizer, an anti-sticking agent and a first stabilizer, and the first stabilizer comprises glutathione, an isolation stabilizer, a plasticizer, an anti-sticking agent and a second stabilizer. According to the glutathione active part, firstly, a fluidized powder coating technology is adopted, and the relatively unstable active ingredient glutathione is subjected to powder coating; and preparing the coated components, pyrazinamide, a filler, a second stabilizer, an adhesive, a disintegrating agent and a lubricant into a specific preparation. According to the preparation, the hepatotoxicity during pyrazinamide medication is reduced, the compliance is increased, and meanwhile, the technical problem that a pyrazinamide glutathione preparation is unstable is solved.
Owner:ZHUOHE PHARM GRP CO LTD

Citicoline dextrophan derivatives, process for their preparation and use

The present application relates to a kind of cytidine choline dextrohydrotalcid derivatives and its preparation method and application, belong to biological medicine technical field.The present application is aimed at solving the technical problems of low blood-brain barrier penetration rate and limited treatment effect of existing edaravone dextrohydrotalcid compound preparation.The present application prepares a dextrohydrotalcid derivative (C-B) with boronic acid structure, then it is compounded with cytidine choline in specific pH buffer system, and forms cytidine choline dextrohydrotalcid derivative (C-D-B).The present application can effectively improve the efficiency of drug crossing blood-brain barrier by using the dynamic covalent characteristics of boronic ester bond and free radical responsiveness.The experimental results show that, compared with existing combination drug, the derivative of the present application can significantly reduce the infarction area of cerebral ischemia model animal, reduce cell damage and active oxygen level, and promote vascular regeneration, and show better treatment effect on ischemic brain injury.
Owner:CHONGQING UNIV

Olmesartan medoxomil pharmaceutical co-crystal as well as preparation, preparation method and application thereof

The invention discloses an olmesartan medoxomil pharmaceutical co-crystal as well as a preparation, a preparation method and application thereof. The co-crystal is formed by olmesartan medoxomil and a specific co-crystal forming agent through intermolecular force. The invention also particularly provides a compound preparation containing the olmesartan medoxomil pharmaceutical co-crystal and hydrochlorothiazide. Through the eutectic technology, the invention fundamentally overcomes the inherent defects of low solubility and slow dissolution of olmesartan medoxomil as a BCS II drug. Experiments show that the preparation disclosed by the invention can realize rapid and complete drug release in vitro (the dissolution rate within 30 minutes is greater than or equal to 98%), the relative bioavailability of olmesartan in vivo can be improved by at least 180% compared with that of a reference preparation, and meanwhile, the eutectic structure ensures that the preparation has excellent chemical stability under an accelerated test condition. The invention provides an innovative solution for the development of an efficient and stable olmesartan medoxomil preparation.
Owner:ZHEJIANG NUODE PHARM CO LTD

Traditional Chinese medicine compound preparation component identification method, quality marker screening method and quality marker

The invention relates to the technical field of traditional Chinese medicine quality control, and particularly discloses a traditional Chinese medicine compound preparation component identification method which comprises the following steps: taking a traditional Chinese medicine compound preparation, grinding and uniformly mixing to obtain powder; adding the powder into an extraction solvent, performing ultrasonic extraction and centrifugation, and taking supernate; component analysis is carried out on the supernate by adopting chromatography and mass spectrometry detection, and the chromatographic conditions are as follows: the chromatographic column is Thermo Hypersil gold C18 (1.9 [mu] m, 2.1 mm * 100 mm); the flow velocity is 0.3 mL / min, and the sample size is 10 [mu] L; mobile phases are as follows: a phase A is a 0.1% formic acid aqueous solution, a phase B is a 0.1% formic acid acetonitrile solution, and gradient elution is 0-1 min, 90% of A; in 1-15 min, 90%-10% of A is obtained; 15-17 min, 10% of A is taken; in 17-17.1 min, 10% to 90% of A is obtained; according to the component identification method of the traditional Chinese medicine compound preparation, qualitative analysis is conducted on the traditional Chinese medicine compound preparation through an LC-MS method, a basis and support are provided for quality control of the traditional Chinese medicine compound preparation, and a good foundation is provided for network pharmacology research.
Owner:GUANGXI INST OF CHINESE MEDICINE & PHARMA SCI

Compound preparation containing macloxvir, preparation method of compound preparation and application of compound preparation in anti-influenza treatment

The invention provides a compound preparation containing macarovir, a preparation method and application of the compound preparation in anti-influenza treatment, the multi-layer pellet compound preparation sequentially comprises a pellet core layer containing macarovir, an isolating layer, an active layer and an enteric layer from inside to outside, the pellet core layer containing macarovir and a sustained-release material, the isolating layer comprises an adhesive and an anti-sticking agent, the active layer comprises a hydrophobic layer and a hydrophobic layer, and the enteric layer comprises a hydrophobic layer and a hydrophobic layer. The active layer comprises oseltamivir phosphate and an adhesive, and the enteric-coated layer is made of synthetic polymer materials. The multi-layer pellet provided by the invention has good compressibility, disintegrability and lubricity. The compound preparation solves the problems of drug resistance, drug interaction and children medication compliance. The preparation is suitable for single-drug or combined treatment of influenza A / B viruses, and is especially suitable for children and drug-resistant influenza patients.
Owner:CHANGZHOU PHARMA FACTORY

Formula and preparation method of cream capable of regulating menstruation and beautifying skin

The invention relates to the technical field of menstruation regulating and beauty maintaining, and discloses a menstruation regulating and beauty maintaining paste formula and a preparation method thereof.The preparation method comprises the steps that S1, raw materials are prepared, specifically, the raw materials comprise main materials including reed-removed ginseng, American ginseng, cynanchum otophyllum, rubia yunnanensis, pearl powder, raw pseudo-ginseng, cooked pseudo-ginseng and the like; the formula of the cream for regulating menstruation and beautifying is a compound preparation cream formula which is formed according to the traditional Chinese medicine theory and clinical practice in combination with modern medicine science and technology knowledge, 63 traditional Chinese medicinal materials, three auxiliary materials and genuine Dongai water are used as medicines in the form of water, and the formula of the cream for regulating menstruation and beautifying is prepared on the basis of the traditional Chinese medicine theory and literature literature. A traditional preparation process and modern research results are combined, a cream preparation is prepared through careful decoction, the formula is clinically used, the effects of regulating menstruation and enriching blood, reinforcing qi and nourishing blood, expelling toxins and promoting qi circulation, tonifying kidney and spleen, promoting blood circulation to remove meridian obstruction, soothing liver and regulating qi, helping sleep and beautifying, removing freckles and beautifying and the like are positive, and no obvious toxic or side effect or adverse reaction exists.
Owner:SICHUAN QISEDANG HEALTH MANAGEMENT CO LTD

PqsR inverse agonists

The present invention relates to a compounds according to general formula (I), which acts as an inverse agonist of PqsR (the currently only known receptor for the Pseudomonas Quinolone Signal (PQS), sometimes also referred to as MvfR); to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to uses of said compound(s), including the use as a medicament, e.g. the use in the treatment or prophylaxis of a bacterial infection, especially a Pseudomonas aeruginosa or Burkholderia infection.
Owner:HELMHOLTZ ZENTRUM FUER INFEKTIONSFORSCHUNG GMBH

A compound formulation of active ingredients of Zhuang and Yao medicines and its preparation method

This invention discloses a compound Zhuang-Yao medicine active ingredient synergistic formulation and preparation method, relating to the field of ethnic medicine compound preparations and extraction and preparation technology. The invention uses a scientific ratio of each medicinal ingredient, particularly strictly controlling the molar ratio of *Qianjinba* flavonoids from the Zhuang medicine *Qianjinba* to *Lingxiangcao* lactones from the Yao medicine *Lingxiangcao* at 3:2. This precise ratio helps maximize the synergistic effect between the active ingredients. Through this synergistic effect, the compound Zhuang-Yao medicine formulation can more effectively exert its medicinal effects, showing superior efficacy in treating specific diseases or improving health conditions. Furthermore, the addition of other medicinal materials such as *Niudali* and *Zoumatai* further enriches the variety of active ingredients and enhances the overall pharmacological effect.
Owner:GUANGXI HEALTH VOCATIONAL & TECH COLLEGE +1

Inhibitors of 17β-HSD7 and uses thereof

Novel chemical agents are described herein. More specifically, a novel inhibitor of 17β-HSD7 for decreasing estradiol concentrations while restoring dihydrotestosterone (DHT) concentrations in breast cancer cells is disclosed herein. In a particular embodiment, the inhibitor of 17β-HSD7 has the following structure: (Formula I) A process for producing the novel inhibitors of 17β-HSD7 and their use in the manufacture of pharmaceutical formulations and / or combinations is also disclosed.
Owner:LIN SHENGXIANG

External compound preparation for treating skin diseases as well as preparation method and application of external compound preparation

The invention discloses an external compound preparation for treating skin diseases as well as a preparation method and application thereof, and belongs to the technical field of medicines. The preparation is prepared from the following raw materials in specific parts by weight: borneol, dipterex tablets, cantharides, huechys sanguinea, ephedra, calculus bovis, dragon's blood, centipedes and garter snakes. The preparation method comprises raw material pretreatment, mixing and blending, and sub-packaging and storage, and is simple in process and easy to operate; the ointment is externally applied to skin lesions every morning and evening, and is suitable for diseases such as eczema, psoriasis, neurodermatitis and the like. Through the synergistic effect of multiple components, the comprehensive curative effects of clearing heat, detoxifying, dredging collaterals, relieving itching and promoting tissue regeneration are achieved, the traditional Chinese medicine composition has the advantages of being rapid in effect taking, convenient to externally use and small in side effect, the problems that an existing skin disease treatment medicine is large in side effect and slow in effect taking are solved, and a new effective scheme is provided for clinical treatment of skin diseases.
Owner:朱红立

Use of myostatin antagonists, combinations containing them, and their use

This invention relates to myostatin antagonists for the treatment of cancer cachexia and cancer cachexia resulting from chemotherapy. In particular, bimaglumab, a myostatin antagonist, has been found to be beneficial in treating cancer cachexia by reducing weight loss. This invention also relates to combinations of myostatin antagonists and mTOR inhibitors and their use for treating cancer cachexia by reducing, maintaining or increasing weight loss, or for use in treating age-related conditions.
Owner:NOVARTIS AG

A traditional Chinese medicine compound preparation and its application in the preparation of drugs for treating cardiovascular and cerebrovascular diseases

PendingCN122297609APlatelet aggregation ratioAntithrombotic
This invention provides a traditional Chinese medicine compound preparation and its application in the preparation of drugs for treating cardiovascular and cerebrovascular diseases, belonging to the field of traditional Chinese medicine technology. The traditional Chinese medicine compound preparation comprises the following raw materials in parts by weight: 10-20 parts bee pollen, 8-15 parts curcumin, 5-10 parts γ-aminobutyric acid, 5-12 parts Litsea cubeba leaf, 10-20 parts hawthorn, 5-10 parts Lindera strychnifolia leaf, 10-20 parts kudzu root, 5-12 parts ginseng, 8-15 parts Polygonatum sibiricum, 6-12 parts Sophora japonica flower bud, 3-8 parts tangerine peel, and 1-5 parts L-cysteine. This invention significantly improves the water solubility, stability, and bioavailability of curcumin by constructing a chlorophyll zinc / LDH nanosheet composite carrier to load curcumin. A compound preparation of traditional Chinese medicine was prepared by combining a complex loaded with curcumin with various food and medicine homologous ingredients. This traditional Chinese medicine compound preparation can significantly reduce whole blood viscosity, plasma viscosity and platelet aggregation rate in rats with acute blood stasis model, has anti-thrombotic effect, and significantly promotes the recovery of neurological function in rats with focal cerebral ischemia and reduces the volume of cerebral infarction.
Owner:SHANGHAI DUNPANG IND DEVELOPMENT CO LTD +1

A compound preparation for improving osteoporosis and osteoarthritis, and a preparation method and application thereof

PendingCN122624629AAdjuvantIncreased Bone Density
The application provides a compound preparation for improving osteoporosis and osteoarthritis, a preparation method and application thereof, and belongs to the technical field of biological medicines. The compound preparation contains the following raw materials: glutathione, curcumin, calcium carbonate, vitamin D3, hydrolyzed collagen, and glucosamine sulfate; wherein the glutathione exists in the form of a cyclodextrin inclusion compound. The preparation method comprises the following steps: mixing the calcium carbonate, the hydrolyzed collagen, the glucosamine sulfate and excipients, then adding an equal amount of a premix of the glutathione cyclodextrin inclusion compound, the curcumin and the vitamin D3 in a stepwise manner, and performing dry granulation and tabletting to obtain the compound preparation. The compound preparation can simultaneously increase bone density, protect articular cartilage, reduce the levels of oxidative stress and inflammation, and can be used for preparing medicines or health foods for preventing or adjuvant treating osteoporosis and osteoarthritis. The application has a scientific formula, a stable process and a good application prospect.
Owner:SHAANXI FUTURE FOOD AGRICULTURAL TECHNOLOGY CO LTD

Cephalosporin compounds and their use in the preparation of antibacterial medicaments

The application belongs to the field of pharmaceutical chemistry and medicine, and relates to a cephalosporin compound and its use in preparing antibacterial drugs. Specifically disclosed are the use of a cephalosporin compound, or a pharmaceutically acceptable salt thereof, or a medicine composition taking the cephalosporin compound as an effective active ingredient in preparing a medicine for preventing and treating gram-negative drug-resistant bacterial infections. The compound can irreversibly covalently bind to metal beta-lactamase, inhibit the hydrolysis of beta-lactam antibiotics, effectively reduce the minimum inhibitory concentration (MIC) value and the blood bacterial load of gram-negative drug-resistant bacteria in a mouse with abdominal infection, and can be combined with beta-lactam antibiotics such as meropenem to prepare a compound preparation for treating diseases such as infections caused by gram-negative drug-resistant bacteria.
Owner:FUDAN UNIVERSITY

INOSITOL PHOSPHATE COMPOUNDS FOR USE IN THE TREATMENT, INHIBITION OF PROGRESSION, OR PREVENTION OF CARDIOVASCULAR CALCIFICATION

ActiveMX435043BAortic calcificationPharmaceutical Substances
The present invention relates to compounds, pharmaceutical compositions, combination preparations, and dosage guidelines for the treatment, inhibition of progression, and prevention of cardiovascular calcification, and in particular, coronary calcification, aortic artery calcification, and aortic valve calcification, comprising inositol phosphates. In one particular aspect, the disclosure provides a dosage guideline for the treatment, inhibition of progression, or prevention of cardiovascular calcification comprising the administration of approximately 200 mg to approximately 700 mg of myo-inositol hexaphosphate per dose.
Owner:VIFOR (INT) AG

Compound preparation for improving amnesia type mild cognitive impairment

The invention belongs to the field of medical application, and particularly relates to application of a compound preparation, namely a pharmaceutical composition or a medicine box for improving early menopausal forgetting type mild cognitive impairment, and the compound preparation is selected from Hankun decoction, fenmorpton or a combination thereof.
Owner:LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE

Construction method of characteristic chromatogram of traditional Chinese medicine compound preparation for treating chronic pelvic inflammation and application thereof

The application relates to the technical field of traditional Chinese medicine detection, in particular to a construction method of a characteristic chromatogram of a traditional Chinese medicine compound preparation and application thereof. The traditional Chinese medicine compound preparation is Taohong Siwu decoction or a freeze-dried agent thereof or other preparations prepared from pharmaceutically acceptable adjuvants; the construction method of the characteristic chromatogram comprises the following steps: dissolving the traditional Chinese medicine compound preparation in a solvent to prepare a test sample solution; performing liquid chromatography detection on the test sample solution to prepare a characteristic chromatogram of the test sample; and the liquid chromatography detection conditions comprise: using methanol as mobile phase A, using acetonitrile as mobile phase B, and using 0.1%-0.3% phosphoric acid aqueous solution as mobile phase C. The characteristic chromatogram constructed by the application has a smooth baseline, suitable peak height, good peak shape, small interference peak influence, 16 common peaks are obtained through detection, 12 index components are identified, and the content determination is accurate, and the result is reliable, scientific and objective.
Owner:GUANGZHOU BAIYUNSHAN ZHONGYI PHARMACEUTICAL CO LTD

Pharmaceutical composition comprising azilsartan medoxomil potassium and calcium channel blocker, method for preparing same, and use thereof

PendingUS20260191830A1TolerabilityAzilsartan Medoxomil
A pharmaceutical composition comprising azilsartan medoxomil potassium and a calcium channel blocker, a method for preparing same, and use thereof are provided. Azilsartan medoxomil potassium and the calcium channel blocker are formulated into a compound formulation, thus improving the blood pressure lowering efficacy, improving safety and tolerability, and reducing adverse effects. Azilsartan medoxomil potassium can ameliorate peripheral edema caused by amlodipine by means of expanding peripheral venous vessels, while amlodipine can ameliorate adverse effects such as vasogenic edema, dry cough, and the like caused by azilsartan medoxomil potassium.
Owner:SHANGHAI BOCIMED PHARMA CO LTD