98 results about "Indapamide" patented technology

The invention discloses a method for preparing indapamide from chloro-1,3-dimethyl-2-climiqualine as a condensing agent, comprising the following concrete steps of: under the action of a condensing agent of chloro-1,3-dimethyl-2-climiqualine and organic base, reacting 4-chloro-3-sulfamoylbenzoic acid with N-amido-2-methylene indoline or corresponding salts thereof in inert solvent at room temperature and carrying out purification treatment to obtain a target product of the indapamide, wherein the corresponding salts of the 4-chloro-3-sulfamoylbenzoic acid and the N-amido-2-methylene indoline are hydrochloride, hydrobromide, mesylate or paraaminomethyl benzene sulfonate. The invention has the advantages of high yield in the technological process, low cost and simple and convenient operation, and can meet the requirement of large-scale production.

The invention relates to a indapamide retard tablet and its preparation process, said retard tablet comprising indapamide, bone material, filler and lubricant, in each said tablet containing controllable 0.5-1.5mg( each tablet containing 0.15 g. or 150g/1000 tablet ).

The invention discloses an indapamide sustained-release drug composite and a preparation method thereof. The indapamide sustained-release drug composite comprises the following ingredients: indapamide serving as an active ingredient and a proper amount of filler, framework material, lubricant and copovidone (VA64). The indapamide sustained-release tablet disclosed by the invention is used for treating primary hypertension and is characterized in that the VA64 is added in the prescription so that the burst release of the drug is prevented, the stable release of the drug is guaranteed and the hypokalemia caused by overhigh blood concentration is avoided; in the process, the indapamide is micronized to below 50 micrometers so that the release of the drug is improved and the delayed release of the drug is avoided; and the direct powder compression process is adopted so that the problems that the framework material coheres to form sticky balls due to adhesive and the homogeneity of drug releasing rate is influenced are avoided. The prepared indapamide sustained-release tablet has the advantages that the drug releasing rate is stable; the homogeneity of the releasing rate is good; the drug bioavailability is increased; and the drug quality is guaranteed.

The slow-released Indapamide capsule consists of Indapamide, slow-releasing material and supplementary material in the ratio of 0.5-3.0 to 5-20 to 131-165. The slow-releasing material is one to four of polyacrylic resin, hydroxypropyl methyl cellulose, ethyl cellulose, acetyl phthalate cellulose and PVP, and each capsule contains Indapamide in 0.5-3.0 mg. The slow-released Indapamide capsule may be prepared via rolling process. The preparation form of the present invention has lasting effective time, less side effect and high biological utilization, and through the different combination of the micro pellet, ideal release rate may be reached.

The invention discloses an indapamide tablet and a preparation method thereof. The indapamide tablet comprises a tablet core using indapamide as an active component and a coating layer, wherein the coating layer is formed at 36-45 DEG C; the tablet core is prepared from the following components in parts by weight: 1 part of the indapamide, 20-30 parts of a filling agent, 1-5 parts of an adhesive and 5-10 parts of a lubricating agent. Through control on the temperature of the coating, the impurity content of the indapamide tablet is obviously controlled, so that the quality of the preparation is guaranteed.

The invention provides an indapamide tablet. The indapamide tablet comprises the following components in parts by weight: 1% to 5% of indapamide, 50% to 75% of milk sugar, 10% to 35% of starch, 4% to8% of povidone, 2% to 5% of talcum powder and 0.2% to 1.5% of magnesium stearate, and the adhesive is a mixed solution of starch slurry and PVP-K30. The dissolution of the indapamide tablet is slower.The invention further provides a preparation method of the indapamide tablet. According to the preparation method, the indapamide tablet is palletized and prepared by adopting a one-step method, andthe preparation method is cleaner and more efficient.

The invention discloses an indapamide monolayer osmotic pump sustained-release tablet, which comprises a tablet core and a controlled-release film coating layer, wherein the tablet core contains 0.5-2% of indapamide as a monarch drug, 1-20% of filling agent, 50-90% of penetration enhancer, 1-15% of adhesive, 1-20% of release regulator and 0.5-3% of lubricant; the controlled-release film coating layer comprises a controlled-release film forming material, a plasticizer and/or a pore-forming agent; and the filling agent comprises agar powder.

The invention discloses a stable storage indapamide sustained release tablet. The sustained release tablet comprises indapamide used as the active ingredient, an appropriate amount of filling agent, asustained-release material and a lubricating agent, and direct powder compression process is adopted. The stable storage indapamide sustained release tablet is characterized in that the ingredients of suitable kinds and the preparation process are selected, so that the genotoxicity impurity (2RS)-2-methyl-1-nitroso-2,3-dihydro-1H-indol is controlled at 20 ppm or below. The stable storage indapamide sustained release tablet can be produced in the mode of saving time and production cost.

The invention relates to a method for preparing an indapamide sustained-release agent, and aims to enable the prepared indapamide sustained-release agent to have a better performance. The preparation process comprises the following steps: a, preparing the following materials in proportion: 0.5-2 percent of indapamide, 30-50 percent of a frame material, 14-28 percent of 100-mesh lactose, 20-35 percent of 200-mesh lactose, 10-20 percent of povidone K30 and 0.2-2 percent of lubricant; b, mixing the indapamide raw material and the lactose with two finenesses according to a gradient increasing method; c, mixing with the frame material and the povidone K30; d, adding the lubricant, and uniformly mixing; and e, tabletting. According to the method, a process of directly tabletting powder is adopted, so that the method has the advantages that the main drug is uniformly distributed in the tablet, the tablet has good uniformity (the uniformity index of a tablet with small content is needed to be controlled), influence of water and heating dryness caused by a traditional manufacture process on the quality of the main drug can be avoided in the manufacturing process, the production energy consumption can be reduced, and the production efficiency can be improved.

A release-controllable percutaneous paster of indopamide for stable releasing within 24 hr is composed of substrate, layer, medicine bearing layer, and antisticking layer. Said medicine bearing layer contains indapamide, pressure sensitive adhesive, composite percutaneous absorption promoter, plasticizer, tackiness agent and antioxidant. Its preparing process is also disclosed.

The invention relates to a preparation method of an indapamide slow release medicine in order to improve the slow release performance of the medicine. The medicine comprises 0.5-2wt% of indapamide, 30-50wt% of a skeletal material, 14-28wt% of 100 mesh lactose, 20-35wt% of 200 mesh lactose, 10-20wt% of polyvinylpyrrolidone K30 and 0.2-2wt% of a lubricant. The medicine is prepared by adopting a powder direct pressing technology, and has the advantages of uniform distribution of a main medicine in a tablet, god tablet uniformity (uniformity index control needed by low content tablets), avoiding of the influences of water, heating and drying brought by traditional preparation technologies on the quality of the main medicine in the preparation process, production energy consumption reduction, and production efficiency increase.

The invention discloses an indapamide slow-release hypertension pill and a preparation method thereof. The indapamide slow-release hypertension pill comprises the following components in parts by weight: 0.75 part of indapamide, 40-55 parts of a framework material, 5-10 parts of a disintegration material, 40-50 parts of a diluent and 0.5 part of a lubricant. The indapamide slow-release hypertension pill is prepared by using a direct powder tabletting method which comprises the following steps: pretreating main materials and assistant materials, premixing the assistant materials, performing equivalent progressive increase mixing on the materials, tabletting, and coating. By adopting the indapamide slow-release hypertension pill disclosed by the invention, burst release can be relatively well inhibited, thorough later release can be ensured, the hypertension effect can be relatively stable and long-lasting, the production cost is reduced as a domestic framework material is adopted, and due to the adoption of a direct dry powder tabletting process, the phenomenon of too intense burst release caused by gelatinization of functional groups and water when a wet granulation method is adopted can be prevented, the pill can be prepared according to the formula ratio, the product quality can be relatively stable, and the in-batch product difference can be reduced.

The invention relates to a drug composition containing indapamide and B vitamins and an application thereof in preparing drugs for treating the HHCY-hyperhomocysteinemia and the elevated homocysteine. The composition of the indapamide and B vitamins can further reduce the Hcy level, and the effect is superior to that of single drug, so that the composition of the indapamide and the B vitamins can not only lower the Hcy level, but also has synergetic effect on reducing Hcy damages. The composition of the invention is a selection for treating Hcy, which provides a more effective treatment protocol for treating high homocysteine. The invention belongs to the pharmaceutical field.

The invention discloses a compound preparation for curing hypertension. The invention contains ingredients with following day doses: 0.5-2.5mg of indapamide and 1.25-5mg of piaster. The pressure relief effect is excellent than one single medicine with a large dose, and it can eliminate the bad reaction caused by one single medicine, prevents the compensation reaction caused by using one single medicine to relief blood pressure, upgrades the patience of sufferer, upgrades the compliance.

An antihypertensive slow-releasing indapamide tablet is prepared through mixing indapamide with slow-releasing material, pore-forming agent and filler, adding water, granulating, mixing with lubricant, tabletting to obtain tablet cores, preparing solution A fron distilled water, filming agent, antisticking agent and masking agent, preparing solution B from alcohol and polyethanediol 400, mixing A with B, diluting, coating on tablet cores, and drying.

The invention belongs to the technical field of medicine and particularly relates to an indapamide-containing medicine composition for treating hypertension and a preparation method thereof.The indapamide-containing medicine composition for treating hypertension is prepared from, by weight, 1.5-3.5 parts of indapamide, 2,000-4,000 parts of musa basjoo sieb et zucc., 2,000-4,000 parts of uncaria sessilifructus, 2,000-4,000 parts of fokienia hodginsii and 2,000-4,000 parts of herb of largeserrate mosla.The traditional Chinese medicine and indapamide are combined, the common gastrointestinal tract adverse reactions to indapamide can be avoided, and the treatment effect on hypertension can be improved.