Preparation technology of indapamide sustained-release tablets

Abstract

The invention relates to the technical field of chemical pharmaceutical, in particular to a preparation technology of indapamide sustained-release tablets. According to the specific technical scheme,the preparation technology of the indapamide sustained-release tablets comprises steps as follows: a sustained-release material, a filling agent, a lubricating agent and indapamide are sequentially added to a medicinal powder stirrer to be stirred and mixed; air is blown into the medicinal powder stirrer from the bottom and / or the top of the medicinal powder stirrer in a stirring and mixing process; mixed medicinal powder is added to a tabletting device for tabletting; and finally, the tablets obtained after tabletting are coated. According to the specific technology and equipment, the prepared indapamide sustained-release tablets have uniform and stable release rate, bioavailability of drugs is improved, little drug loss is produced in the tabletting process, and drug quality is uniform.

Description

technical field [0001] The invention relates to the technical field of chemical pharmacy, in particular to a preparation process of indapamide sustained-release tablets. Background technique [0002] Indapamide is a non-thiazide indole derivative with dual effects of antihypertensive and diuretic, and its antihypertensive effect is obvious in small doses. Oral administration is quickly absorbed, combined with plasma proteins, and selectively concentrated in vascular smooth muscle, which inhibits the inward flow of calcium ions in cells, reduces vasoconstriction, and the reactivity of blood vessels to boosting substances, thereby reducing vascular resistance, resulting in Antihypertensive activity. Indapamide has been widely used in the treatment of hypertension. [0003] The currently used indapamide sustained-release tablets are usually small-dose sustained-release preparations containing 1.5 mg of indapamide. The 1.5mg sustained-release indapamide has greatly improved t...

AI Technical Summary

Problems solved by technology

The preparation method described in this patent, first of all, its process is relatively complicated, which is not conducive to large-scale industrial production. Secondly, HPMC is granulated and then mixed with indapamide to form a tablet. Since the drug is not wrapped in the skeleton material, it is difficult to achieve the effect of sustained release.

[0005] The invention patent with the patent application number 200810240504.5 discloses an indapamide sustained-release tablet and its preparation method. It uses a wide range of skeleton materials. In the actual preparation process, it is difficult to achieve a sustained-release effect. Delayed release phenomenon, unable to guarantee the normal release of the drug in the body

[0006] When preparing indapamide sustained-release tablets, a tablet press is often used to make tablets. The existing patent application number is 201822256907.0, which discloses a drug tablet press, which includes a tablet press mechanism and a feeding mechanism arranged on a delivery mechanism. Mechanism, the feeding mechanism controls the speed of feeding through its control valve, and the tablet pressing mechanism realizes the tableting operation of powdered medicine through the cooperation between its pressing block and the model block. However, the tablet pressing machine has the following problems : In the process of controlling the blanking of the feeding mechanism, due to the small particle size of the powdered medicine, a part of the medicine will generate dust during the falling process; The impact force of the pressing down of the block will also cause a part of the powder to be ejected from the gap between the briquetting block and the inner wall of the model block, which will not only cause the problem of dust, but also lead to the waste of medicine, so that the weight of the finished tablet is lower than that of the tablet. The weight of each feeding of the conveying mechanism

In addition, after the feeding mechanism is unloaded, the thickness of the powdered medicine in the model block is inconsistent, and the thickness of the tablet pressed in this way is not uniform, which reduces the quality of the tablet.

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