10 results about "Perindopril" patented technology

The invention discloses a preparation method of perindopril amlodipine tablets, and belongs to the field of pharmacy. The perindopril amlodipine tablet is prepared from the following raw material medicines: arginine perindopril and amlodipine besylate and auxiliary materials: lactose, microcrystalline cellulose, hydrophobic colloidal silicon dioxide and magnesium stearate. The preparation method of the perindopril amlodipine tablet comprises the following steps: weighing according to the prescription amount, crushing and sieving the raw materials for pretreatment, sieving the whole particles of the auxiliary materials for pretreatment, premixing, feeding and total mixing, tabletting and the like. The prepared perindopril amlodipine tablet is relatively good in quality, high in stability and relatively few in waste products.

The invention relates to the technical field of pharmaceutical preparations, in particular to a stable perindopril amlodipine tablet and a preparation method thereof, and the tablet comprises the following components in percentage by weight: 5.0% of arginine perindopril; 3.5% of amlodipine besylate; 20%-40% of pregelatinized starch; 40%-68% of a microcrystalline cellulose colloidal silicon dioxide compound; 2.5%-6% of a disintegrating agent, wherein the disintegrating agent is selected from one or more of ion exchange resin, sodium alginate and croscarmellose sodium; the pregelatinized starch and the microcrystalline cellulose colloidal silicon dioxide compound are selected as main diluents, so that the Maillard reaction possibly occurring between the lactose and the active pharmaceutical ingredients is completely avoided, the problem of increase of related substances is fundamentally solved, and the stability and the safety of the product are remarkably improved.

The invention belongs to the field of medicines, and relates to a perindopril amlodipine solid preparation as well as a preparation method and application thereof. In the prior art, when an in-vitro dissolution behavior of an imitated medicine of perindopril and amlodipine tablets is investigated, it is found that the release behaviors of the perindopril and amlodipine tablets are difficult to keep consistent with those of an original developed preparation at the same time, so that the safety and effectiveness of the imitated medicine are not guaranteed. A large number of experiments find that the particle size distribution and the water content of the microcrystalline cellulose are controlled, so that the in-vitro dissolution curve of the perindopril amlodipine solid preparation is similar to that of an imported original development agent produced by an original research company, the possibility of bioequivalence with the original development agent is improved, and the drug consistency evaluation requirement is met.

The invention relates to the technical field of compound preparation, in particular to a preparation method of a compound N-nitrosoperindopril. The method specifically comprises the following steps: S1, selecting a first chemical which is prepared from an initial raw material and has the HPLC detection purity of more than or equal to 99.0%, dissolving the first chemical in water, stirring, dissolving, and cooling to obtain a first mixture; s2, adding acid into the first solution to obtain a second mixture; s3, nitrite is added into the second mixture in batches and stirred, white solids are separated out after dissolving clarification, and a third mixture is obtained; s4, after the interior of the third mixture is completely reacted, multiple times of extraction is conducted through dichloromethane, drying and concentration are conducted, and the off-white solid N-nitrosoperindopril is obtained.According to the preparation method of the compound N-nitrosoperindopril, the blank that no standard substance is sold in the market and no literature is used for synthesis report is filled, and the preparation method is suitable for large-scale popularization and application of the compound N-nitrosoperindopril. And help is provided for ensuring that the safety and the quality of medicine products are not influenced.

The invention discloses a positive ion saliva marker related to brain glioma and meningioma and application of the positive ion saliva marker, and relates to the field of biological medicine. The positive ion saliva marker is prepared from one or more of N1, N12-diacetyl spermine, N-capryloyl dihydrosphingosine and perindopril. The invention provides a kit which is used for detecting positive ion saliva markers related to brain glioma and meningioma and comprises a specific detection reagent. Besides, the invention further provides a computer program product which can judge whether the patient to be detected is a glioma patient or a meningioma patient, so that a solid foundation is laid for subsequent treatment. The method has good feasibility and accuracy, is safe and noninvasive, can effectively distinguish brain glioma and meningioma, and provides a brand new powerful tool for clinical diagnosis.

The invention discloses a pharmaceutical composition for treating cardiovascular diseases as well as a preparation method and application thereof, and the composition comprises perindopril or pharmaceutically acceptable salt thereof, amlodipine or pharmaceutically acceptable salt thereof and amino-modified silicon dioxide, the amino modified silicon dioxide is prepared by modifying the surface of silicon dioxide by using 3-aminopropyltriethoxysilane as a coupling agent. The composition provided by the invention can keep stable storage under the condition of not adding an antioxidant, especially can avoid or reduce impurities generated by oxidative degradation of perindopril and amlodipine, and improves the safety of the medicine.

According to the tablet containing the arginine perindopril and the levamlodipine besylate and the preparation method of the tablet, the pregelatinized starch and microcrystalline cellulose colloidal silicon dioxide co-treated substance is used as a filling agent, and the proportion of the pregelatinized starch and the microcrystalline cellulose colloidal silicon dioxide co-treated substance is controlled, so that the tablet containing the arginine perindopril and the levamlodipine besylate is prepared. The problem that the fluidity of the tablet is poor in preparation is solved, the stability is remarkably improved, the tablet has the advantages of being simple in preparation method, low in cost, good in fluidity, good in compressibility and the like, meanwhile, the tablet shows rapid disintegration, dissolution and stability, and the tablet is suitable for large-scale industrial production.

The invention discloses an arginine perindopril solid dispersion and a compound preparation thereof, and belongs to the technical field of pharmaceutical preparations. The arginine perindopril solid dispersion provided by the invention is prepared from the following components in parts by mass: 1 part of arginine perindopril, 0.1 to 0.3 part of calcium acetate and 5.2 to 5.4 parts of microcrystalline cellulose. The arginine perindopril solid dispersion and the compound perindopril amlodipine tablet prepared from the arginine perindopril solid dispersion have excellent stability, the preparation methods of the arginine perindopril solid dispersion and the compound perindopril amlodipine tablet are simple to operate, actual production is facilitated, and a drying agent can be prevented from being used during preparation packaging.

1. The name of the design product: medicine packaging box (Doxazosin Mesylate Sustained Release Tablets, Perindopril Amlodipine Tablets (I), Perindopril Amlodipine Tablets (III), Indapamid Sustained Release Tablets). 2. The use of the design product: used for packaging medicine. 3. The design points of the design product: the combination of shape, pattern and color. 4. The picture or photo that best shows the design points: design 1 perspective view. 5. The design protected contains color. 6. The specified basic design: design 1.

The invention belongs to the field of medicaments, and provides a perindopril amlodipine tablet and a preparation method thereof, and the perindopril amlodipine tablet comprises perindopril arginine, amlodipine besylate, lactose monohydrate, microcrystalline cellulose and a lubricant. According to the perindopril amlodipine tablet disclosed by the invention, good uniformity, stability and dissolution performance are realized by adjusting the lubricant and the formula.