5 results about "Perindopril" patented technology

The invention relates to the technical field of compound preparation, in particular to a preparation method of a compound N-nitrosoperindopril. The method specifically comprises the following steps: S1, selecting a first chemical which is prepared from an initial raw material and has the HPLC detection purity of more than or equal to 99.0%, dissolving the first chemical in water, stirring, dissolving, and cooling to obtain a first mixture; s2, adding acid into the first solution to obtain a second mixture; s3, nitrite is added into the second mixture in batches and stirred, white solids are separated out after dissolving clarification, and a third mixture is obtained; s4, after the interior of the third mixture is completely reacted, multiple times of extraction is conducted through dichloromethane, drying and concentration are conducted, and the off-white solid N-nitrosoperindopril is obtained.According to the preparation method of the compound N-nitrosoperindopril, the blank that no standard substance is sold in the market and no literature is used for synthesis report is filled, and the preparation method is suitable for large-scale popularization and application of the compound N-nitrosoperindopril. And help is provided for ensuring that the safety and the quality of medicine products are not influenced.

According to the tablet containing the arginine perindopril and the levamlodipine besylate and the preparation method of the tablet, the pregelatinized starch and microcrystalline cellulose colloidal silicon dioxide co-treated substance is used as a filling agent, and the proportion of the pregelatinized starch and the microcrystalline cellulose colloidal silicon dioxide co-treated substance is controlled, so that the tablet containing the arginine perindopril and the levamlodipine besylate is prepared. The problem that the fluidity of the tablet is poor in preparation is solved, the stability is remarkably improved, the tablet has the advantages of being simple in preparation method, low in cost, good in fluidity, good in compressibility and the like, meanwhile, the tablet shows rapid disintegration, dissolution and stability, and the tablet is suitable for large-scale industrial production.

The invention discloses an arginine perindopril solid dispersion and a compound preparation thereof, and belongs to the technical field of pharmaceutical preparations. The arginine perindopril solid dispersion provided by the invention is prepared from the following components in parts by mass: 1 part of arginine perindopril, 0.1 to 0.3 part of calcium acetate and 5.2 to 5.4 parts of microcrystalline cellulose. The arginine perindopril solid dispersion and the compound perindopril amlodipine tablet prepared from the arginine perindopril solid dispersion have excellent stability, the preparation methods of the arginine perindopril solid dispersion and the compound perindopril amlodipine tablet are simple to operate, actual production is facilitated, and a drying agent can be prevented from being used during preparation packaging.

1. The name of the design product: medicine packaging box (Doxazosin Mesylate Sustained Release Tablets, Perindopril Amlodipine Tablets (I), Perindopril Amlodipine Tablets (III), Indapamid Sustained Release Tablets). 2. The use of the design product: used for packaging medicine. 3. The design points of the design product: the combination of shape, pattern and color. 4. The picture or photo that best shows the design points: design 1 perspective view. 5. The design protected contains color. 6. The specified basic design: design 1.