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Subcutaneous implant rod for long-acting blood pressure reduction and preparation method of subcutaneous implant rod

A blood pressure-lowering, long-acting technology, applied to non-active ingredient medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of inability to achieve long-term stable blood pressure and insignificant therapeutic effect of catgut embedding, etc. Achieve good biocompatibility and non-toxicity, improve mechanical properties and thermal properties, and simple production process

Pending Publication Date: 2021-10-08
吕汇川
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There is also a precedent for using catgut embedding therapy in traditional Chinese medicine to treat hypertension, but the therapeutic effect of catgut embedding is not significant, and the effect of long-term stable blood pressure cannot be achieved

Method used

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  • Subcutaneous implant rod for long-acting blood pressure reduction and preparation method of subcutaneous implant rod
  • Subcutaneous implant rod for long-acting blood pressure reduction and preparation method of subcutaneous implant rod
  • Subcutaneous implant rod for long-acting blood pressure reduction and preparation method of subcutaneous implant rod

Examples

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Effect test

preparation example Construction

[0043] The present invention uses micelles of diblock copolymers to prepare drug carriers for implant rods, specifically, the method for preparing subcutaneous implant rods for long-acting blood pressure reduction comprises the following steps:

[0044] Step 1: Preparation of polycaprolactone diblock copolymer micelles: ring-opening polymerization of polycaprolactone initiated by polyethylene glycol. The ring-opening polymerization of polycaprolactone, and considering the safety and compatibility of PCL-PEG copolymer as a biomedical material when it acts on the human body, our laboratory directly uses polyethylene glycol PEG as a macromolecular initiator, poly Caprolactone PCL is a monomer, because it is used in human body, avoiding the use of toxic metal catalysts, successfully prepared PCL-PEG-diblock copolymer. Preparation of PCL-PEG-diblock copolymer micelles: Add polycaprolactone and polyethylene glycol to the reaction kettle, close the reaction kettle, vacuumize, heat an...

Embodiment 1

[0047] The formula of this embodiment can produce the diameter of implant rod is 3mm, and length is 50mm, and the weight of each implant rod is 300mg, and each implant rod contains raw material medicine is 100mg.

[0048] Specifically, a subcutaneous implant stick for long-acting blood pressure lowering, its formula is: polycaprolactone 10g, polyethylene glycol 5g, polyvinylpyrrolidone 2g, perindopril 5g, amlodipine 5g, total The weight is 27g, each 300mg, about 90 pieces are made.

[0049] The preparation process of above-mentioned implant rod is:

[0050]Step 1: Preparation of polycaprolactone diblock copolymer micelles: ring-opening polymerization of polycaprolactone initiated by polyethylene glycol. The ring-opening polymerization of polycaprolactone, and considering the safety and compatibility of PCL-PEG copolymer as a biomedical material when it acts on the human body, our laboratory directly uses polyethylene glycol PEG as a macromolecular initiator, poly Caprolacton...

Embodiment 2

[0053] The formula of this embodiment can produce implanted rods with a diameter of 3 mm and a length of 25 mm, each implanted rod has a weight of 15 mg, and each implanted rod contains 50 mg of raw material.

[0054] Wherein, the specific formula of this embodiment is: polycaprolactone 10g, polyethylene glycol 7g, polyvinylpyrrolidone 3g, perindopril 10g, amlodipine 10g, total weight 40g, each 300mg, about 133 branch.

[0055] The preparation method of this embodiment is the same as that of Example 1.

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Abstract

The invention discloses a subcutaneous implant rod for long-acting blood pressure reduction and a preparation method of the subcutaneous implant rod. A diblock copolymer is adopted as a carrier, and the formula comprises the following substances in parts by weight: 10-20 parts of polycaprolactone, 5-10 parts of polyethylene glycol, 1-5 parts of polyvinylpyrrolidone and 5-20 parts of bulk drugs; and wherein the raw material medicine is prepared by combining two medicines, namely perindopril and amlodipine, and the mass ratio of the perindopril to the amlodipine in the raw material medicine is (1-20): 1. After the implant rod of the invention is implanted subcutaneously, direct long-term sustained-release administration is performed to treat and stabilize blood pressure, the diblock copolymer is adopted as a carrier, the problem that an existing implant rod is short in loading action time is solved, the preparation method is simple, materials are easy to obtain, and the production process is simple and easy to master; and the prepared implant rod is implanted under the skin of a human body, has complete degradability, good biocompatibility and no toxicity according to biological materials, and is good in comfort level when implanted under the skin of the human body.

Description

technical field [0001] The present invention relates to a long-acting blood pressure lowering subcutaneous implant rod and a preparation method thereof. The implant rod is implanted subcutaneously and is used to treat and stabilize corresponding diseases according to the pharmacological properties of drugs mixed into the implant rod. It is a long-acting antihypertensive subcutaneous implant rod for long-term stable normal blood pressure. Background technique [0002] At present, the treatment of essential hypertension at home and abroad mostly relies on oral antihypertensive drugs to maintain normal and balanced blood pressure. The drug has a short duration of action and needs to be taken orally three or two times a day. Oral doses of antihypertensive drugs have large side effects, cause systemic and gastrointestinal reactions, and greatly damage liver and kidney functions. [0003] There is also a precedent for adopting traditional Chinese medicine catgut embedding therap...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/32A61K47/10A61K47/34A61K31/4422A61K38/05C08G81/00A61P9/12
CPCA61K38/05A61K31/4422A61K9/0024A61K9/2027A61K9/204A61P9/12C08G81/00
Inventor 吕汇川
Owner 吕汇川
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