116 results about "Damage liver" patented technology

A method for cultivating Antrodia Camphorata is provided. First, Antrodia Camphorata is pre-incubated on a sloped surface culture medium. A portion of the pre-incubated Antrodia Camphorata is transferred to a liquid culture medium for incubation. Then, Antrodia Camphorata incubated in the liquid culture medium is moved to a solid culture medium for incubation. The cultivated Antrodia Camphorata has similar efficacies for inhibiting cancel cell growth, reducing the occurrence of atherosclerosis or recovering the damaged liver functions, as the wild Antrodia Camphorata.

The invention relates to an alcoholism-relieving liver-protecting botanical nutritional beverage and a making method thereof. An antialcoholic medicine is a chemical and a Chinese medicinal preparation, and can cause metabolic burden to livers and kidneys to hurt the livers and the kidneys at different degrees while dispelling the effects of alcohol. A health-care product which is mutually complementary and beneficial, is low in cost, has good mouthfeel, and is suitable for both the old and the young, and of which the source of raw materials is wide is prepared from Hovenia dulcis Thunb, hawthorn, kudzuvine root, medlar, honeysuckle, chrysanthemum, liquorice and mulberries, does not have side effect, and can achieve the effects of repairing and nourishing damaged liver cells; and the invention provides the safe and reliable alcoholism-relieving liver-protecting botanical nutritional beverage and the making method thereof.

The invention provides an antrodia camphorate cultivation method; firstly, pre-cultivating the antrodia camphorate on a slant culture medium, taking out a part of pre-cultivated antrodia camphorate to inoculate a liquid culture medium, and then inoculating the antrodia camphorate cultivated in the liquid culture medium to a solid culture medium for the cultivation. The antrodia camphorate cultivated in the method has similar effects of wild antrodia camphorate, including effects of restraining growth activity of human cancer cells and cancer auxiliary treatment, also having abilities of restraining human low density lipoprotein oxidation for lowering incidence rates of artery hardening and restoring damaged liver functions.

The present invention belongs to the field of medicine technology. The compound coenzyme medicine contains CoA, NAD, GSH and ATP; and features that it contains also FMN, FAD, ADP, AMP and SAM. The present invention has improved compound coenzyme medicine preparing process. The compound coenzyme medicine can protect liver cell, myocardial cell and other cells, maintain or restore their normal metabolism, and may be used in heart and liver surgical operation, restoring of damaged liver, restoring damaged cell caused by radiotherapy and chemotherapy.

The present invention relates to methods for the treatment of hepatic disorders in a subject in need thereof. More specifically, the methods of the invention are based on the administration, preferably, systemic administration, of a therapeutically effective amount of at least one biocompatible alginate biomaterial, any modification thereof and any combination thereof. The invention further provides methods for sustaining serum albumin levels, and / or reducing serum AST and ALT, in subjects suffering from hepatic disorder. Still further, the invention provides methods for reducing apoptosis and inducing cell proliferation in a damaged liver tissue of a subject suffering of hepatic disorder, using the alginate biomaterial described by the invention.

The invention discloses an implanted artificial liver comprising a polyglycolic acid or polylactic-co-glycolic acid sleeve, more than one three-dimensional porous scaffold, and polyglycolic acid or polylactic-co-glycolic acid tube seals; the three-dimensional porous scaffolds are mounted inside the polyglycolic acid or polylactic-co-glycolic acid sleeve; and polyglycolic acid or polylactic-co-glycolic acid tubes are used for sealing two ends of the polyglycolic acid or polylactic-co-glycolic acid sleeve. The invention has the beneficial effects of maximally simulating the structure of a hepatic lobule, developing implanted stem cells into liver cells through directional differentiation, and inducing the regeneration of microvessels of a tissue engineering liver. Meanwhile, the exterior of the three-dimensional porous scaffolds is wrapped in the highly biocompatible biomaterial sleeve which serves to simulate the structure of a liver capsule; and small lacunas are formed between the sleeve and the scaffolds to allow blood to circulate through tissue engineering brackets, thereby facilitating the regeneration of vessels of the engineering liver in an envelope, and ultimately forming an artificial liver to replace the damaged liver of a parasitifer.

This invention provides therapeutic compositions and combinations for the protection, treatment and repair of liver tissue. The invention relates to novel compositions and combinations comprising two or more compounds selected from the group consisting of S-adenosylmethionine, L-ergothioneine, and a substance selected from the group consisting of constituents of Milk thistle (Silybum marianum), silymarin and active components of silymarin, whether naturally, synthetically, or semi-synthetically derived, and to methods of preventing and treating liver disease and of repairing damaged liver tissue. The invention also provides a method of administering these compositions and combinations to humans or animals in need thereof.

The invention relates to an enzymatically decomposed clam oligopeptide having a recovery effect on a non-alcoholic fatty liver disease (NAFLD) cell model. The clam oligopeptide is characterized by comprising an amino acid sequence of Gln Leu Asn Trp Asp. The invention also relates to a preparation method of the enzymatically decomposed clam oligopeptide having the recovery effect on the NAFLD cell model. Compared with the prior art, the following advantages can be achieved: the NAFLD cell model is established by virtue of induction of palmitic acid and the damaged liver cells in a body are simulated sufficiently, and the result indicates that the TG content of the in-vitro NAFLD cell model established 48 hours after induction by 15 micrograms / milliliter palmitic acid increased remarkably in comparison with that of normal liver cells; oil red O staining shows that the number of intracellular lipid droplets of the model group is increased in contrast with that of the cells of a normal group, and the cell mortality rate is low and the repeatability is good, and therefore, the modeling method is simple, convenient and feasible; meanwhile, the enzymatically decomposed clam oligopeptide having the obvious recovery effect on the NAFLD cell model can be separated out from clams.

The present invention relates to one kind of orally disintegrated silibinin-meglumine salt tablet for protecting liver cell, stimulating the biological synthesis of protein inside liver cell, promoting recovery of damaged liver cell, resisting fibrillation, capturing free oxygen radical and inhibiting the deposition and infiltration of fat in liver, and its preparation. The orally disintegrated silibinin-meglumine salt tablet is prepared with silibinin-meglumine salt as main material, and through adding stuffing, disintegrating agent, corrective, flow assistant and other supplementary material, pressing into tablet and other steps. The present invention has the features of low production cost, fast disintegration, good taste, etc.

Methods and compositions useful for preventing the disruption of thiol (sulfur) signaling which affects degenerative / age related disease and other disease states related to thiol redox signaling, such as S-glutathiolation. The compositions are capable of increasing the DNA transcription of Gamma-Glutamyl-cysteine synthase which is the rate limiting enzyme for the production of the thiol regulating enzyme Glutathione. The acid-stable compositions disclosed herein contain esterfied and free form cafestol and kahweol, and may be formed using ground roasted or unroasted coffee beans. The beans in combination with water are exposed to cavatonic energy sonic or mechanical. C&K typically increase cholesterol and damage the liver. The compositions disclosed are absorbed before or after the distal portion of the small intestines, eliminating liver toxicity and increases in cholesterol. Additional materials may be added to the compositions, such as additional hydrophobic compounds hydrophilic compounds, and may be added to the film or embedded in the compositions by the cavitation process. The process is also adapted for use in all standard methods of brewing coffee, causing the coffee to possess the disclosed compositions.

The invention discloses a traditional Chinese medicine oral liquid, in particular a traditional Chinese medicine oral liquid for treating cholecystitis and gallstones and a preparation method thereof. The traditional Chinese medicine oral liquid for treating cholecystitis and gallstones is characterized by comprising the following components: wine Coptis chinensis, wine Scutellaria baicalensis, wine rheum officinale, honeysuckle, desmodium, vinegar fried turmeric, elecampane, bran fried fructus aurantii, vinegary radix bupleuri, vinegary corydalis tuber, radix clematidis, fructus amomi, vinegar fried endothelium corneum gigeriae galli, burnt hawthorn, smoked plum, Lygodium japonicum, Codonopsis pilosula, bran fried Chinese yam, honey astragalus and pepper. The traditional Chinese medicine oral liquid is specially used for treating cholecystitis and gallstones, and properties of the material medicines are changed or alleviated by means of compatibility so that medicine with strong property are alleviated. The invention has obvious clinical efficacy, treats both principal and secondary aspect of disease and is safe and reliable and better exerts functions of medicines without damaging liver and kidney. The traditional Chinese medicine oral liquid has good taste, is convenient to take, beneficial to storage and can be taken by diabetics and hyperpietics safely. Totally 360 patients are treated and total effective rate reaches 98%.

The invention relates to a drink containing ornithine aspartate and a preparation method thereof. The drink comprises the following components by weight: 0.1-30% of ornithine aspartate, 0.013% of tartaric acid, 0.1-10% of white granulated sugar, 0.1-10% of glucose, 0.01-3% of citric acid, 0.01-10% of lactic acid, 0.01-10% of honey, and the balance of purified water. The invention further discloses a preparation method of the drink. The drink provided by the invention with good taste is suitable for everyday drinking, has the efficacies of repairing damaged liver cells and protecting the liver, and can protect the liver, detoxify and alleviate drunkenness.

A traditional Chinese medicine decocted tea or a particle tea bag preparation for treating fatty liver comprises gynostemma pentaphyllum, the astragalus, largehead atractylodes rhizome, dried tangerine or orange peel, bupleurum, fructus aurantii immaturus, angelica, salvia miltiorrhiza, turmeric root-tuber, giant knotweed, notoginseng, amomum, folium microcotis, membrane of chicken gizzard, hawthorn fruit, dry bamboo shoot, lotus leaf, rhizoma alismatis, dry parrot stem leaf, Serissa serissoides, gardenia root or gardenia, Japanese ardisia, abrus herb, barberry, costustoot, rhubarb, green tea, malt sugar juice adhesive and bag material. Industrialization of particle tea bag preparation is easy. The particle tea bag preparation is convenient to take and fine in curative effect, and has no side effect, has promising market prospect, high total effective rate in clinical symptomatic treatment, can lower blood fat and blood viscosity stably, can eliminate excessive blood fat and toxic substances in the liver effectively, can restore organs such as damaged liver tissues, can prevent embolism and expand liver blood vessels, can improve blood flow of liver tissues, and can prevent fatty liver, hyperlipemia, viscous blood, syndrome of fat not turning sugar and the like.

The present invention relates to one kind of orally disintegrated silibinin tablet for protecting liver cell, stimulating the biological synthesis of protein inside liver cell, promoting recovery of damaged liver cell, resisting fibrillation, capturing free oxygen radical and inhibiting the deposition and infiltration of fat in liver, and its preparation. The orally disintegrated silibinin tablet is prepared with silibinin as main material, and through adding stuffing, disintegrating agent, corrective, flow assistant and other supplementary material, pressing into tablet and other steps. The present invention has the features of low production cost, fast disintegration, good taste, etc.

The invention provides a traditional Chinese medicine composition alleviating chemical liver injury. The composition is composed of, by weight, 2-6 parts of kudzu vine roots, 2-6 parts of lucid ganoderma, 1-5 parts of cat's-foot, 1-5 parts of rhodiola rosea, 1-3 parts of liquorice and 0.1-1 part of turmeric extractive, wherein the kudzu vine roots clear away heat and toxic materials, the lucid ganoderma enhances the immunity, the cat's-foot promotes blood circulation to remove blood stasis, the rhodiola rosea replenishes qi to invigorate the spleen, turmeric cooperates to promote the circulation of qi and disperse blood stasis, and the liquorice coordinates the drug actions of a prescription, so that the effects of clearing damp and heat, dispelling alcohol effects, unchoking the liver and gall and dissolving the indigestion are jointly achieved. Therefore, after the substances are compounded, interaction occurs, a good effect of alleviating the chemical liver injury is achieved, so that the effect of protecting the liver is achieved. A preparation method of the composition, Chinese materia medica preparation prepared with the compositions and auxiliary materials and application of the composition in preparing health care products which have protective functions for chemically damaged livers are further provided.

The invention belongs to the field of Chinese medicaments, and in particular relates to an external Chinese medicinal composition for treating knee osteoarthritis. The external Chinese medicinal composition is prepared from cassia twig, divaricate saposhnikovia root, dragon blood, caulis sinomenii, kadsura pepper stem, oriental variegated coralbean bark, ephedra and liquorice. The external Chinese medicinal composition is low in cost, simple in prescription, reasonable and effective in component compatibility and convenient to use, prevents the medicament from stimulating stomach and intestinal tracts and damaging liver and kidney, does not have toxic or side effect to a human body, and has remarkable curative effect in treating knee osteoarthritis.

A method of inducing liver regeneration in a damaged liver tissue region of an individual is provided. The method including the step of providing at least two distinct growth factors to the damaged liver tissue region of the individual, at least one of the at least two distinct growth factors being an angiogenic factor.

The invention provides medical application of small molecule peptide of black food in liver damage repair. Methionine is obtained by fermentation of an AtD-SAT transgenic yeast strain; the small molecule peptide of the black food has good anti-inflammatory and repairing effects on damaged liver cells caused by liver fibrosis and alcoholic hepatitis; drugs prepared from the small molecule peptide of the black food have the advantages of remarkable clinical effect and few toxic and side effects; a preparation method of the small molecule peptide of the black food is simple and practical.

The invention discloses a feed additive for protecting liver health of special aquatic fish. The feed additive for protecting liver health of special aquatic fish consists of the following raw materials by mass percentages: 8-15% of bile acid, 2-8% of glutamine, 20-28% of salvia miltiorrhiza, 15-20% turmeric, 20-25% of Gynostemma pentaphyllum, 10-15% Polygonum cuspidatum, 5-8% of Astragalus polysaccharide, and the balance of a filler. The invention also discloses a preparation method of the feed additive. The feed additive is used in a feed to promote liver health of the special aquatic fish,reduces liver fat deposition, and promotes damaged liver cell restoration and hepatocyte proliferation.

The invention relates to a traditional Chinese medicine health-care preparation, and aims to provide the traditional Chinese medicine health-care preparation with cistanche and acanthopanax as main medicines by means of conventional traditional Chinese principle of compatibility of medicines. The medicines are matched with other Chinese herbal medicines for scientific extraction. The preparation comprises cistanche, acanthopanax, raspberry, Semen Cuscutae, Schisandra chinensis and the fruit of Chinese wolfberry and can be prepared as capsules, troches, particles, medicinal tea, oral liquids or medicated liquors. The preparation obtained by the invention has the effects of cultivating the five internal organs and tonifying the vital essence, supporting the healthy energy, nourishing yin and tonifying yang, strengthening tendons and bones, prolonging life, preventing aging and the like, and can be used for preventing and treating hypoimmunity, essence deficiency and weakness, fatigue syndrome, anxiety and irritability, hypomnesis, damaged liver, arthralgia in waist and legs, impotence and premature ejaculation of man, persistent failure to conceive of women and the like.

The invention discloses a flos chrysanthemi indici effective ingredient, which is extracted by a method comprising the following steps of: 1) taking flos chrysanthemi indici, adding 60-90% ethanol which is 5-10 times of the weight of the flos chrysanthemi indici to extract, filtering the extracting solution, and concentrating the filtrate into extract; and 2) adding water into the extract to prepare suspension, adding extract liquor to extract, and recovering the extract liquor to obtain the flos chrysanthemi indici effective ingredient. Experiments show that the flos chrysanthemi indici effective ingredient can more obviously inhibit hepatitis B virus, can also inhibit the glutamic-oxalacetic transaminease (AST) and glutamic-pyruvic transaminease (ALT) indexes of liver serum of the damaged liver, can reduce the tumor necrosis factor (TNF) content, liver indexes and malondialdehyde content of the liver serum of the damaged liver, and has good liver protection function. The flos chrysanthemi indici effective ingredient can be used as the active ingredient, and can be prepared into anti-hepatitis B virus medicaments or compositions with the liver protection function, such as food, drinks, health care products, drugs and the like, and the medicaments or compositions can be prepared into tablet, capsule, powder, injections and any other medically acceptable formulations.

The present invention belongs to the field of natural medicine technology and is especially one kind of antiviral drug containing silverweed cinquefoil essence, Pharmacodynamics research shows that the drug of the present invention has inhibition effect to HbsAg and HbeAg, obvious inhibiting effect on hepatitis B virus and the function of protecting liver cell and promoting repair of damaged liver cell and may become one prospective hepatitis B virus resisting medicine.

The invention relates to a kind of the lecithin milky beverage. It contains (Wt.% per ton): fresh milk 200-400kg, sugar 40-60kg, asparteme 0.8-1.2kg, dairy stabilizer 4-6kg, citric acid monohydration 2-4kg, llactic acid 1-2Kg,sodium citrate 0.1-0.5Kg,lecithin 0.5-1.5Kg,milk flavor 0.1-0.4Kg,Citrus garadis flavor 0.2-0.4Kg,grapefruit flavor 0.1-0.3Kg,Garcinia mangostana L. flavor 0.1-0.3Kg,remaining water. Such product has the merit both of the nutrition from the milk and the lecithin function. It mainly works on dissolving the cholesterin,antiatherogenic;activation of the cells;activation of the brain enginery,prevention of the senile dementia;being young and long live, protecting your liver function. Alcohol and high cholesterin are two mainly factors to hepar adiposum and hepatocirrhosis, on the contrary, the lecithin can restore the damaged liver cells.

The invention relates a traditional Chinese medicine compound curing tuberculosis, in particular to a Chinese medicine for curing tuberculosis, in particular to the traditional Chinese medicine used for curing tuberculosis such as phthisis, skin tuberculosis, etc. According to weight mixture ratio, the compound adopts a raw material formula that is 3 to 4 portions of fritillaria, 5 to 10 portions of tuber of common bletilla, 3 to 5 portions of fructus arctii, 3 to 5 portions of platycodon root, 3 to 10 portions of sticky rice and 3 to 5 portions of heartleaf houttuynia herb. The traditional Chinese medicine compound curing tuberculosis of the invention has the advantages that the Chinese medicine masters the basic remedy of many Chinese medicines for curing tuberculosis, only uses the basic remedy for compatibility and has small digit number of the medicine and small dose, which causes dose for one time to be only 20 to 40 grams of powder; course of treatment is short (average curing period is 90 to 120 days and the curing period of severe case is 180 to 200 days); the medicine has low cost and is convenient for taking. Through being clinically proven for sixteen years by an inventor, the medicine curing various tuberculosis of thousands of cases and no recurrence cases happen for two follow-up years; the Chinese medicine is especially applicable to being taken by tuberculosis patients who are sensitive to antibiotics, have damaged liver or kidney functions and is extremely for drug-resistant.

The invention relates to a pure natural alcohol-relieving and liver-protecting product and a preparation method thereof. The alcohol-relieving and liver-protecting product is prepared from rosemary liposoluble extract containing 20 to 40 percent of carnosic acid and effective ingredients extracted from root of kudzu vine and lily, and by ultralow-temperature extraction by a modern biological technique and by mixing. The product uses the antioxidant, antihepatitis, liver-protecting and alcohol-relieving capacities of rosemary liposoluble extract, the body fluid secretion promoting and thirsty-quenching effects of root of root of kudzu vine, and the yin-tonifying, lung-nourishing, hearfire-clearing and nerve-soothing effects of lily and can improve the activity of enzyme in liver; and thus, the product can conduct the functions of reliving alcohol, protecting liver, soothing the liver, regulating qi, promoting secretion of body fluid, quenching thirsty, clearing heat and fire, clearing hearfire and soothing nerves to quickly eliminate the symptoms of dizziness, headache, drowsiness, fatigue and the like, to effectively repair damaged liver cells and to inhibit the damage of alcohol to the liver. The product is made by the active ingredients extracted from pure natural plants and therefore is free from toxic and side effects and is an alcohol-relieving and liver-protecting product with remarkable effect.

The invention discloses a Chinese medicinal composition for smoking cessation. The Chinese medicinal composition is prepared from the following raw materials by weight part: 10-15 of codonopsis pilosula, 5-10 of Rosa laevigata, 15-20 of Semen Raphani, 12-16 of cushaw stems, 18-24 of houttuynia cordata, 10-15 of persimmon leaves, 5-10 of polygala tenuifolia, 10-15 of Agastache rugosus, 5-10 of mint, 10-15 of licorice, 5-10 of perilla leaves, 10-15 of Tussilago farfara, 7-14 of Aster tataricus, 8-12 of Peucedanum praeruptorum, 10-15 of Tilia Europaea, 14-18 of Fritillaria cirrhosa, 11-17 of psoralea corylifolia, 10-15 of Siraitia grosvenorii, 5-10 of Zizyphus jujube roots, 12-16 of Platycodon grandiflorum, 7-14 of poria, 10-15 of Sterculia lychnophora, and 5-10 of Gynostemma pentaphyllum. The Chinese medicinal composition provided by the invention has good drug absorption effect, obvious curative effect, quick effect, and high cure rate, and can effectively quit smoking addiction of smokers, and eliminate various physical discomfort, dysphoria and the like generated by smoking cessation. Without toxic or side effect, the Chinese medicinal composition for smoking cessation has no irritation to the digestive tract and mouth mucosa, avoids damaging liver, kidney and other organs, is convenient to take and low in smoking cessation, and is safe and economical.

The invention discloses a traditional Chinese medicine composition for treating arthrolithiasis. The composition is prepared from, by weight, 25-40 parts of the extract of sunflower alkali, 15-25 parts of the extract of chicory, 15-30 parts of the extract of the seed of Job's tears, 10-15 parts of the extract of poria cocos, 3-5 parts of the extract of Chinese angelica, 1-5 parts of the extract ofpallas pit viper, 5-12 parts of hawthorn fruit powder and 5-12 parts of pawpaw powder; the preference weight parts of raw materials are 30 parts of the extract of the sunflower alkali, 20 parts of the extract of the chicory, 20 parts of the extract of the seed of Job's tears, 11 parts of the extract of the poria cocos, 4 parts of the extract of the Chinese angelica, 3 parts of the extract of thepallas pit viper, 7 parts of the hawthorn fruit powder and 7 parts of the pawpaw powder. The composition has the advantages of inhibiting the synthesis of purine, reducing purine trione, dissolving calculus uric acid, repairing damaged liver and kidney cells, increasing human body immunity and has significant meaning on the health of a arthrolithiasis patient.

The invention provides an antidepressant traditional Chinese medicine composition, which is prepared from the following components in parts by weight: 15-50 parts of gypsum, 3-10 parts of rhizoma anemarrhenae, 10-30 parts of uncaria rhynchophylla, 3-10 parts of radix ophiopogonis, 5-15 parts of rehmanniae praeparatum, 5-15 parts of Inula japonica, 3-15 parts of officinal magnolia bark, 3-15 parts of medicinal cyathula root, 3-10 parts of raw hematite,10-30 parts of rhizoma phragmitis, 3-10 parts of immature bitter orange and 3-12 parts of semen raphani. The antidepressant traditional Chinese medicine composition in the invention has the following beneficial effects: (1) the composition can cure depression effectively; (2) as for curative effect, the composition is similar to or stronger than fluoxetine hydrochloride, and the composition has the functions of invigorating food stagnation and relaxing bowel; (3) as for price, the cost of the composition is lower than that of fluoxetine hydrochloride; and (4) in long-term clinic observation, side effects such as excitement, anxiety, thirsty, hydrosis, headache, drowsiness in day, insomnia at night, astriction and sexual dysfunction, damaged liver kidney function and the like do not occur.

The invention relates to an oligopeptide functional food and a preparation method thereof. The oligopeptide functional food is prepared from, by weight, 15-21 parts of skipjack oligopeptide, 12-20 parts of whey oligopeptide, 8-17 parts of corn oligopeptide, 6-12 parts of sipunculid oligopeptide, 3-15 parts of a cistanche deserticola extract, 4-12 parts of an astragalus extract, 2-10 parts of a poria cocos extract, 2-8 parts of a cornus extract and 0.01-0.1 part of decavitamin. The oligopeptide functional food is safe, has no toxic and side effects, neither can generate dependency and drug resistance, nor can be accumulated in the body, has a synergistic effect on cells, tissue and metaboilic level while ensuring low purine ingestion, inhibits synthesis of uric acid, promotes excretion of the uric acid, also repairs the damaged liver and kidney tissue, ensures the smooth circulation of the uric acid in the body, and achieves the effect of addressing both symptoms and root causes. The preparation method has the advantages that the main active ingredients can be retained to the utmost extent, the yield is increased, the extraction and preparation time can also be effectively reduced,and the energy consumption is reduced.