Nucleic acid constructs, cells transformed therewith and methods utilizing same for inducing liver regeneration and alleviation of portal hypertension

a technology of nucleic acid and constructs, which is applied in the field of nucleic acid constructs, can solve the problems of high blood vessel pressure, patients subject to inborn metabolic abnormalities, and inability of diseased organs to perform vital functions, etc., and achieve the effects of reducing the risk of liver cirrhosis
US20020164310A1Inactive Publication Date: 2002-11-07MULTI GENE VASCULAR SYST
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Patent Information

Authority / Receiving Office
US Β· United States
Patent Type
Applications(United States)
Current Assignee / Owner
MULTI GENE VASCULAR SYST
Publication Date
2002-11-07
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

A method of inducing liver regeneration in a damaged liver tissue region of an individual is provided. The method including the step of providing at least two distinct growth factors to the damaged liver tissue region of the individual, at least one of the at least two distinct growth factors being an angiogenic factor.
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Description

FIELD AND BACKGROUND OF THE INVENTION

[0001] The present invention relates to nucleic acid constructs, cells transformed therewith and methods of utilizing such constructs and transformed cells for inducing hepatocytes proliferation and liver regeneration.

[0002] Liver Cirrhosis

[0003] Cirrhosis, is a disease of the liver, which results from injury to liver tissue. Cirrhosis is characterized by scar tissue formation throughout the organ; groups of cells termed regenerative nodules, surrounded by sheets of scar tissue, replace the normal spongy tissue of the liver. The diseased organ may be unable to perform vital functions such as manufacturing proteins and removing harmful substances from the blood. The affected liver tissue may block the flow of blood, causing high pressure in blood vessels, which serve the liver (portal hypertension). This blockage can lead to gastro-esophageal bleeding and ascites and in addition can contribute to the development of encephalopathy.

[0004] Liver inju...

Claims

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