Antidepressant traditional Chinese medicine composition and application thereof

A composition and anti-depressant technology, applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of slow onset time, easy relapse, and unsatisfactory effective treatment methods , to achieve the effect of low cost and treatment of depression

Active Publication Date: 2010-11-24
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Because there are many causes of depression, and there are many factors that affect its pathogenesis, at present, there is no effective treatment method that can satisfy people's expectations in terms of curative effect, adverse reactions and recurrence prevention of depression.
Chemical drugs for the treatment of depression have obvious curative effects, but there are also many disadvantages such as slow onset time, narrow antidepressant spectrum, easy relapse, etc.

Method used

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  • Antidepressant traditional Chinese medicine composition and application thereof
  • Antidepressant traditional Chinese medicine composition and application thereof
  • Antidepressant traditional Chinese medicine composition and application thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1: antidepressant Chinese medicine composition

[0026]The dosage of a single prescription is as follows: 50 grams of raw gypsum, 10 grams of Anemarrhena, 30 grams of Uncaria, 10 grams of Radix Ophiopogon, 15 grams of Rehmannia, 15 grams of Inula, 10 grams of Magnolia officinalis, 10 grams of Achyranthes bidentata, 10 grams of raw ochre, 30 grams of reed rhizome, 10 grams of citrus aurantium, 12 grams of radish; according to the above composition, take 8 prescriptions of Chinese herbal pieces, add 10 times the quality of water and boil for 60 minutes, decoct three times, remove sediment, concentrate to density 1.20g / ml, add ethanol to precipitate at 60°C until the alcohol concentration is 50% (v / v), refrigerate for 48 hours, remove the precipitate to obtain the supernatant, evaporate the supernatant to an extract without ethanol smell, that is Antidepressant Chinese medicinal composition.

Embodiment 2

[0027] Embodiment 2: antidepressant Chinese medicine composition

[0028] The dosage of a single prescription is as follows: 17 grams of raw gypsum, 3 grams of Anemarrhena, 10 grams of Uncaria, 3 grams of Radix Radix, 5 grams of Inula, 3 grams of Magnolia officinalis, 3 grams of Achyranthes bidentata, 3 grams of raw ocher, 10 grams of reed rhizome, 3 grams of citrus aurantium, 4 grams of radish seeds; take 8 prescriptions of Chinese herbal pieces, add 8 times the quality of water and boil them for 60 minutes, decoct three times, remove the sediment, concentrate to a density of 1.20g / ml, add ethanol to precipitate at 60°C until the alcohol concentration is 50%, refrigerate for 48 hours, remove the precipitate to obtain the supernatant, evaporate the supernatant to 84.90 g of extract with no ethanol smell, and obtain the antidepressant Chinese medicine composition . Embodiment 3: antidepressant Chinese medicine composition

Embodiment 3

[0029] The dosage of a single prescription is as follows: 9 grams of raw gypsum, 2 grams of Anemarrhena, 5 grams of Uncaria, 2 grams of Radix Ophiopogon, 3 grams of Rehmannia, 3 grams of Inula, 2 grams of Magnolia officinalis, 2 grams of Achyranthes bidentata, 2 grams of raw ocher, 5 grams of reed rhizome, 2 grams of citrus aurantium, 2 grams of raisin seeds; take 8 prescriptions of Chinese herbal pieces, add 15 times the quality of water and boil for 60 minutes, decoct three times, remove sediment, concentrate to a density of 1.20g / ml, add ethanol to precipitate at 60°C until the alcohol concentration is 50%, refrigerate for 48 hours, remove the precipitate to obtain the supernatant, evaporate the supernatant to 42.45 grams of extract with no ethanol smell, and obtain the antidepressant Chinese medicine composition .

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Abstract

The invention provides an antidepressant traditional Chinese medicine composition, which is prepared from the following components in parts by weight: 15-50 parts of gypsum, 3-10 parts of rhizoma anemarrhenae, 10-30 parts of uncaria rhynchophylla, 3-10 parts of radix ophiopogonis, 5-15 parts of rehmanniae praeparatum, 5-15 parts of Inula japonica, 3-15 parts of officinal magnolia bark, 3-15 parts of medicinal cyathula root, 3-10 parts of raw hematite,10-30 parts of rhizoma phragmitis, 3-10 parts of immature bitter orange and 3-12 parts of semen raphani. The antidepressant traditional Chinese medicine composition in the invention has the following beneficial effects: (1) the composition can cure depression effectively; (2) as for curative effect, the composition is similar to or stronger than fluoxetine hydrochloride, and the composition has the functions of invigorating food stagnation and relaxing bowel; (3) as for price, the cost of the composition is lower than that of fluoxetine hydrochloride; and (4) in long-term clinic observation, side effects such as excitement, anxiety, thirsty, hydrosis, headache, drowsiness in day, insomnia at night, astriction and sexual dysfunction, damaged liver kidney function and the like do not occur.

Description

(1) Technical field [0001] The invention relates to an antidepressant traditional Chinese medicine composition and its application. (2) Background technology [0002] Depression is a common mental illness, mainly manifested as low mood, loss of interest, pessimism, slow thinking, lack of initiative, self-blame, poor diet and sleep, worry that you have various diseases, and feeling that you are suffering from various diseases in your body. Discomfort, and in severe cases, suicidal thoughts and behaviors may appear. Depression is a "mental disease closest to us". With the increasingly fierce social competition, people need to bear more and more physical and psychological pressure, and the incidence of depression continues to increase, and the incidence of depression accompanied by various diseases (coronary heart disease, diabetes, cancer) also increasing. Among the top ten diseases in the world (including developing countries), depression ranks fifth, and there are about 3...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K45/00A61P25/24A61K33/06A61K33/26
Inventor 单伟光唐岚李西秦杨絮侯晓蓉王建伟李成平占扎君于海宁王占黎
Owner ZHEJIANG UNIV OF TECH
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