Traditional Chinese medicine composition for treating chronic constipation and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating chronic constipation and a preparation method thereof.The traditional Chinese medicine composition is prepared from eucommia ulmoides, radix clematidis, aster, rhizoma atractylodis macrocephalae, mangnolia officinalis, poria cocos, codonopsis pilosula, immature bitter orange, cynomorium songaricum, cistanche deserticola, semen cassiae and glycyrrhiza uralensis. The traditional Chinese medicine composition has the functions of warming and tonifying liver and kidney, tonifying kidney and strengthening essence, diffusing and lowering lung qi, invigorating spleen and replenishing qi, eliminating dampness and promoting diuresis and the like, so that body fluid is generated, intestines are moistened and nourished, qi movement is smooth, large intestine conduction is recovered, and constipation, especially chronic constipation of old people or people with deficiency of qi and blood, is effectively treated.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine composition for treating chronic constipation. Background Art

[0002] Constipation refers to the condition in which feces are retained in the intestine for too long, resulting in constipation and prolonged defecation cycle, or the cycle is not long, but the feces are dry and hard, and it is difficult to defecate, or the feces are not hard, and although there is a desire to defecate, the defecation is not smooth, often accompanied by symptoms such as abdominal distension, abdominal pain, bad breath, poor appetite, fatigue, dizziness, palpitations, etc. In traditional Chinese medicine, functional constipation is "constipation", and its disease site is mainly located in the large intestine, and the intestinal conduction function is the mechanism of constipation. Although Western medicine treatment can achieve certain therapeutic effects, long-term use will affect the intestinal environment, interfere with intestinal function, and form dependence, and surgical treatment cannot solve the fundamental problem. Traditional Chinese medicine has its unique advantages in treating constipation. It can not only improve the patient's clinical symptoms, but also has fewer adverse reactions and complications. However, some Chinese medicines are currently complex in composition, high in cost, and easily cause certain irritation to the intestine, and the effects of some Chinese medicines are not ideal. Summary of the invention

[0003] Therefore, based on the above background, the present invention provides a Chinese medicine composition for treating chronic constipation and a preparation method thereof.

[0004] The technical solution of the present invention is:

[0005] A Chinese medicine composition for treating constipation, which is composed of the following raw materials in parts by weight:

[0006] 25-30 parts of Eucommia ulmoides, 10-15 parts of Clematis chinensis, 15-25 parts of Aster tataricus, 15-25 parts of Atractylodes macrocephala, 15-25 parts of Magnolia officinalis, 15-20 parts of Poria, 20-25 parts of Codonopsis pilosula, 10-25 parts of Citrus aurantium, 10-25 parts of Cynomorium songaricum, 15-25 parts of Cistanche deserticola, 20-30 parts of Cassia seed, and 10-20 parts of roasted liquorice.

[0007] Preferably, it is composed of the following raw materials in parts by weight:

[0008] 30 parts of Eucommia ulmoides, 10 parts of Clematis chinensis, 20 parts of Aster tataricus, 20 parts of Atractylodes macrocephala, 20 parts of Magnolia officinalis, 15 parts of Poria, 20 parts of Codonopsis pilosula, 15 parts of Citrus aurantium, 20 parts of Cynomorium songaricum, 15 parts of Cistanche deserticola, 20 parts of Cassia seed, and 15 parts of moxibustion liquorice.

[0009] Preferably, it is composed of the following raw materials in parts by weight:

[0010] 25 parts of Eucommia ulmoides, 10 parts of Clematis chinensis, 15 parts of Aster tataricus, 15 parts of Atractylodes macrocephala, 15 parts of Magnolia officinalis, 15 parts of Poria, 20 parts of Codonopsis pilosula, 10 parts of Citrus aurantium, 10 parts of Cynomorium songaricum, 15 parts of Cistanche deserticola, 20 parts of Cassia seed, and 10 parts of moxibustion liquorice.

[0011] Preferably, it is composed of the following raw materials in parts by weight:

[0012] 30 parts of Eucommia ulmoides, 10 parts of Clematidis, 25 parts of Aster tataricus, 25 parts of Atractylodes macrocephala, 25 parts of Magnolia officinalis, 20 parts of Poria, 25 parts of Codonopsis pilosula, 25 parts of Citrus aurantium, 20 parts of Cynomorium songaricum, 15 parts of Cistanche deserticola, 25 parts of Cassia seed, and 20 parts of moxibustion liquorice.

[0013] Preferably, the Clematis chinensis is processed with rice wine.

[0014] Preferably, it is added with medically acceptable adjuvants to prepare an oral preparation.

[0015] Preferably, the Chinese medicine oral liquid is a decoction liquid, and its preparation comprises the following steps:

[0016] S1. Take the raw materials according to the amount, add 8 times of its own weight of water, boil over high heat, then simmer over low heat for 35-40 minutes;

[0017] S2. After filtering, take the filtrate, add 3 times the weight of water to the residue, boil it over high heat, then simmer it over low heat for 15-20 minutes, filter it, and take the filtrate;

[0018] S3. Combine the two filtrates and simmer over low heat until the liquid volume is reduced to 1 / 4 to 1 / 5 of the combined filtrate.

[0019] The pharmacology of the raw material medicine used in the present invention is as follows:

[0020] Eucommia ulmoides is sweet in taste and warm in nature, and it enters the liver and kidney meridians. It is sweet, warm and nourishing, and enters the liver and kidney meridians. It has a strong medicinal effect. It is good at warming and nourishing the liver and kidneys, strengthening tendons and bones, and calming the fetus. It also lowers blood pressure. It is not only an important medicine for treating kidney deficiency, sore waist and knees or weak tendons and bones, but also a good medicine for treating liver and kidney deficiency, fetal leakage or fetal movement; it nourishes the kidney and strengthens yang, promotes blood circulation and removes blood stasis, and strengthens tendons and bones.

[0021] Clematis is pungent, salty, warm, enters the bladder meridian (or the twelve meridians), is good at running, has strong effect and fast effect. It warms the liver and kidneys, strengthens the spleen and appetite, and activates blood circulation and dredges the meridians.

[0022] Ziyuan tastes pungent and bitter, and is warm in nature. Its pungent and bitter properties disperse and descend, and it is warm and moist without being dry. It specifically enters the lung meridian, is good at moistening the lungs and lowering qi, resolving phlegm and relieving cough, and can be used for any cough regardless of external or internal injuries.

[0023] Atractylodes macrocephala tastes bitter and sweet, and is warm in nature. Its sweet tonic effect is beneficial for infiltration, bitter, warm and dry, and enters the spleen and stomach meridians. It is mainly used to warm and strengthen the body, and can also remove dampness. It is good at replenishing qi and strengthening the spleen, drying dampness and promoting diuresis, stopping sweating, and calming the fetus. It can treat spleen and stomach qi deficiency, spleen deficiency edema, phlegm and fluid retention, spontaneous sweating due to superficial deficiency, and fetal movement disorder. The present invention is used raw.

[0024] Magnolia officinalis is bitter and pungent in taste and warm in nature. It is bitter, dry, purgative and warming. It enters the spleen, stomach and large intestine meridians, removing dampness and food accumulation in the gastrointestinal tract and regulating qi stagnation in the gastrointestinal tract. Therefore, it is an important medicine for treating abdominal distension caused by dampness, food accumulation and qi stagnation. It enters the lung meridian, can descend qi, remove phlegm and dampness and relieve asthma, and is commonly used to treat cough, asthma and excessive sputum.

[0025] Poria cocos tastes sweet and light, and is neutral in nature. Its sweetness and lightness can penetrate, benefit, and nourish, and it is neutral in nature. It enters the spleen and kidney meridians, is good at penetrating dampness and promoting water and eliminating water, strengthening the spleen and promoting the transportation of water and dampness; it also enters the heart meridian, is good at calming the heart and soothing the mind, and is suitable for those with water and dampness, stagnant fluid, and spleen deficiency, regardless of cold or heat or both. It is especially good for those with spleen deficiency edema or excessive dampness.

[0026] Codonopsis is sweet and neutral in nature. It is sweet and nourishing, not dry or greasy, and enters the spleen and lung meridians. It is mostly used for mild symptoms of spleen and lung qi deficiency. It also produces body fluid and nourishes blood, and can treat symptoms such as body fluid deficiency and blood deficiency.

[0027] Zhishi tastes bitter, pungent, and sour, and is slightly cold in nature. Its bitterness descends, its pungentness dissipates, it is slightly cold but not warm, and its medicinal power is strong, entering the spleen, stomach, and large intestine meridians. It is good at breaking up qi and eliminating stagnation to eliminate fullness, and is also good at promoting qi and eliminating phlegm to clear stagnation, so it is an important medicine for treating gastrointestinal stagnation and phlegm stagnation in the chest. In addition, it can also treat organ prolapse.

[0028] Cynomorium songaricum is sweet and warm in nature. It enters the liver, kidney and large intestine meridians. Its sweet, warm and nourishing properties enter the liver, kidney and large intestine meridians. Its function is similar to that of roucongrong, and it is also good at nourishing kidney yang, benefiting essence and blood, and moistening dry intestines. It can treat impotence caused by kidney deficiency, deficiency of essence and blood, and dry intestines and constipation.

[0029] Cistanche deserticola is sweet, salty and warm in nature. Its salty taste enters the kidney, and it is sweet, warm and moistening. The medicinal effect is relatively slow and not very hot. It enters the kidney meridian and can replenish kidney yang and benefit essence and blood; it enters the large intestine meridian and can moisten the intestines and relieve constipation.

[0030] Cassia seed tastes sweet, bitter, and salty, and is slightly cold in nature. Its bitter and slightly cold taste clears and drains, while its sweet taste is beneficial and lubricating. It enters the liver and kidney meridians, can clear liver fire, benefit kidney yin and improve eyesight, and is an essential medicine for red, swollen and painful eyes and dark eyes. It enters the large intestine meridian, can clear heat, moisten the intestines and promote bowel movements, and is a good product for treating constipation caused by heat and dryness of the colon.

[0031] Licorice is sweet and neutral in nature, and it enters the heart, lung, spleen, and stomach meridians. It is sweet, nourishing, moistening, and slow-acting. It is cool when raw, and warm when roasted. It mainly enters the spleen and lung meridians, and also enters the stomach and heart meridians. It can replenish qi and nourish the middle, relieve pain, moderate the properties of the medicine, and also eliminate phlegm, relieve cough, and detoxify. Honey roasting has a strong effect of replenishing qi and relieving urgency.

[0032] The basic pathogenesis of constipation is "dysfunction of large intestine conduction". For the weak elderly or postoperative patients, those with qi and blood deficiency or long-term constipation will have blocked blood vessels, slow blood circulation, stagnation in the blood vessels, and easy formation of blood stasis. Qi is the commander of blood, and if qi is deficient, blood circulation has no power to push blood, and blood stasis may form. The formation of blood stasis affects the rise and fall of qi and causes dysfunction of the visceral transmission and transformation. Blood stasis blocks the intestines, which affects the intestinal qi and leads to constipation. Long-term constipation will inevitably affect the circulation of qi and blood in the intestines, aggravate blood stasis, or lead to the formation of blood stasis, causing constipation due to blood stasis. Blood stasis and constipation are mutually harmful. Long-term constipation can produce blood stasis, and blood stasis also leads to long-term constipation.

[0033] Therefore, the treatment of chronic constipation caused by deficiency of Qi and blood should focus on removing blood stasis. Therefore, this application uses Eucommia ulmoides and Clematis chinensis to promote blood circulation and remove blood stasis, promote smooth movement of Qi, smooth transportation of fine substances (body fluid) in the intestines, nourish the intestines and restore the balance of large intestine conduction.

[0034] Although the location of constipation is in the large intestine, it is closely related to the lungs, kidneys, spleen, stomach and other internal organs. The kidney is the innate foundation and the source of water. The kidney qi has the function of regulating water metabolism. The function of other internal organs to transport and distribute body fluids depends on the kidney. If the kidney's function of regulating water is abnormal, the internal organs are deficient in yin and fluid or the body fluid is unevenly distributed, it will also lead to large intestine fluid deficiency and constipation. The above-mentioned main drugs Eucommia ulmoides and Clematis chinensis can also warm and nourish the liver and kidney, return the water to its normal position, moisten and nourish the intestines, and thus help defecation. One drug has two uses;

[0035] The present invention uses aster, atractylodes, codonopsis and poria as the assistant drugs, wherein aster is used to promote and descend lung qi to help the large intestine to conduct dregs, just like "lifting the lid of a pot, the pot water pours out smoothly after the lid is opened, atractylodes, codonopsis and poria complement each other, strengthen the spleen and replenish qi, dry dampness and promote diuresis, and help to transform qi, when qi is transformed, body fluids can be produced, blood circulation is strong, intestinal stagnation can be relieved, and the stomach and intestines are effectively moistened;

[0036] Magnolia officinalis, Citrus aurantium, Cistanche deserticola, Cynomorium songaricum and Cassia seed are used as adjuvant drugs. Among them, Magnolia officinalis and Citrus aurantium are necessary for promoting qi and relieving bloating, Cistanche deserticola and Cynomorium songaricum assist the main drug in replenishing kidney yang, benefiting essence and blood, and helping to moisten the intestines, while Cassia seed is used to guide catharsis and moisten the intestines; Licorice root is used as the guiding drug to harmonize the various drugs and replenish the spleen and stomach.

[0037] The present invention rationally groups drugs according to the principle of monarch, minister, assistant and envoy in traditional Chinese medicine for the etiology and pathogenesis of patients with both qi and blood deficiency or chronic constipation, and achieves the functions of promoting blood circulation and removing blood stasis, warming and nourishing the liver and kidney, nourishing the kidney and replenishing essence, promoting descending lung qi, strengthening the spleen and replenishing qi, drying dampness and promoting diuresis, so as to produce body fluids, nourish the intestines and viscera, and promote smooth movement of qi, so as to restore the conduction of the large intestine, so as to effectively treat constipation, especially chronic constipation of the elderly or patients with qi and blood deficiency. DETAILED DESCRIPTION

[0038] In order to make the objectives, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with its embodiments; it should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0039] Example 1: A Chinese medicine composition for treating chronic constipation, which is composed of the following raw materials in parts by weight:

[0040] 30 parts of Eucommia ulmoides, 10 parts of Clematis chinensis, 20 parts of Aster tataricus, 20 parts of Atractylodes macrocephala, 20 parts of Magnolia officinalis, 15 parts of Poria, 20 parts of Codonopsis pilosula, 15 parts of Citrus aurantium, 20 parts of Cynomorium songaricum, 15 parts of Cistanche deserticola, 20 parts of Cassia seed, and 15 parts of moxibustion liquorice.

[0041] During specific implementation, one dose is composed of the following raw materials in parts by weight:

[0042] Eucommia ulmoides 30g, Clematidis 10g, Aster 20g, Atractylodes macrocephala 20g, Magnolia officinalis 20g, Poria 15g, Codonopsis pilosula 20g, Citrus aurantium 15g, Cynomorium songaricum 20g, Cistanche deserticola 15g, Cassia seed 20g, and roasted liquorice 15g.

[0043] Example 2: A Chinese medicine composition for treating chronic constipation, which is composed of the following raw materials in parts by weight:

[0044] It is composed of the following raw materials in parts by weight:

[0045] 30 parts of Eucommia ulmoides, 10 parts of Clematidis, 25 parts of Aster tataricus, 25 parts of Atractylodes macrocephala, 25 parts of Magnolia officinalis, 20 parts of Poria, 25 parts of Codonopsis pilosula, 25 parts of Citrus aurantium, 20 parts of Cynomorium songaricum, 15 parts of Cistanche deserticola, 25 parts of Cassia seed, and 20 parts of moxibustion liquorice.

[0046] During specific implementation, one dose is composed of the following raw materials in parts by weight:

[0047] Eucommia ulmoides 30g, Clematidis 10g, Aster 25g, Atractylodes 25g, Magnolia officinalis 25g, Poria 20g, Codonopsis pilosula 25g, Citrus aurantium 25g, Cynomorium songaricum 20g, Cistanche 15g, Cassia seed 25g, and roasted liquorice 20g.

[0048] Example 3: A Chinese medicine composition for treating chronic constipation, which is composed of the following raw materials in parts by weight:

[0049] 25 parts of Eucommia ulmoides, 10 parts of Clematis chinensis, 15 parts of Aster tataricus, 15 parts of Atractylodes macrocephala, 15 parts of Magnolia officinalis, 15 parts of Poria, 20 parts of Codonopsis pilosula, 10 parts of Citrus aurantium, 10 parts of Cynomorium songaricum, 15 parts of Cistanche deserticola, 20 parts of Cassia seed, and 10 parts of moxibustion liquorice.

[0050] During specific implementation, one dose is composed of the following raw materials in parts by weight:

[0051] Eucommia ulmoides 25g, Clematidis 10g, Aster 15g, Atractylodes 15g, Magnolia officinalis 15g, Poria 15g, Codonopsis pilosula 20g, Citrus aurantium 10g, Cynomorium songaricum 10g, Cistanche 15g, Cassia seed 20g, and roasted liquorice 10g.

[0052] The Clematis chinensis used in Examples 1 to 3 was processed with rice wine by conventional means.

[0053] When the Chinese medicine compositions of Examples 1 to 3 are taken in the form of decoctions, the preparation method thereof comprises the following steps:

[0054] S1. Take the raw materials according to the amount, add 8 times of its own weight of water, boil over high heat, then simmer over low heat for 35-40 minutes;

[0055] S2. After filtering, take the filtrate, add 3 times the weight of water to the residue, boil it over high heat, then simmer it over low heat for 15-20 minutes, filter it, and take the filtrate;

[0056] S3. Combine the two filtrates and simmer over low heat until the liquid volume is reduced to 1 / 4 to 1 / 5 of the combined filtrate.

[0057] Example 4: Retrospective clinical data

[0058] For the patients diagnosed with chronic constipation who came to our hospital for treatment from June to October 2019, there were 9 males and 11 females, including 5 patients under 20 years old, 10 patients aged 20-60 years, 5 patients over 60 years old, 6 patients with a disease course of less than 3 years, 10 patients with a disease course of 3-10 years, and 4 patients with a disease course of more than 10 years. All the patients were confirmed to have both Qi and blood deficiency through Chinese medicine differentiation, and none of them had real heat in the intestines.

[0059] Western medicine diagnosis refers to the diagnostic criteria for chronic constipation in the "Functional Gastrointestinal Disorders (FGIDS-Rome III International Standards)" (2006) and the "Guidelines for the Diagnosis and Treatment of Chronic Constipation in China" (2019).

[0060] Exclusion criteria: Use of antibiotics, microbial preparations, and drugs that affect intestinal motility in the past 6 months.

[0061] The above patients were all treated with the decoction liquid prepared in Example 1, one dose per day, taken once in the morning and once in the evening, and a follow-up visit was conducted after 1 month of continuous treatment. The efficacy was statistically analyzed based on the follow-up visit of the patients after 1 month of treatment.

[0062] Efficacy criteria:

[0063] Significant effect: The patient has one bowel movement per day, the stool is formed, and all symptoms disappear;

[0064] Effective: defecation once every 3 days, the process is relatively smooth, and abdominal distension and abdominal pain are effectively improved;

[0065] Ineffective: The patient's bowel movements did not change and tended to worsen.

[0066] Effective rate = (markedly effective + effective) * 100% / total number of people;

[0067] Treatment is as follows:

[0068] There were 7 patients with marked effect, 11 patients with effect, and 2 patients with ineffectiveness, with an effective rate of 90%.

[0069] Example 5: Typical Case

[0070] Patient 1, female, 26 years old, visited the hospital on June 11, 2019;

[0071] Main complaint: difficulty in defecation, which has reached half a year, difficulty in defecation, once every 5 days, dry, like sheep dung, poor defecation, few gas discharges, conscious fatigue, and fear of cold; symptoms worsened one month ago, and when he went to the doctor, he could see that he was thin, his limbs were not warm, and his waist was sore and cold; pulse diagnosis: pale tongue, white fur, slow pulse, insufficient qi and blood in pulse diagnosis, flat abdomen, and hard strips could be touched in the left lower abdomen without tenderness; the decoction of Example 1 was used for treatment, and one dose was taken in the morning and evening. On July 11, 2019, he went to the doctor again, and reported that he had bowel movements once a day, and his fear of cold symptoms was alleviated, so he continued to take it for half a month, and then followed up, and his bowel movements were normal, soft, and maintained at once a day. He was in a good mental state and had been working normally.

[0072] Patient 2, female, 60 years old, visited the hospital on October 1, 2019;

[0073] Main complaint: difficult defecation, weak defecation, general fatigue after defecation, sweating, good diet, normal sleep, pulse diagnosis: pale tongue, white fur, slow pulse. The decoction of Example 1 of the present invention was used for treatment, one dose was taken in the morning and evening, and the patient was re-examined on November 1, 2019, and the patient reported that he could defecate once a day.

[0074] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating chronic constipation, characterized in that: It is composed of the following raw materials in parts by weight: 25-30 parts of Eucommia ulmoides, 10-15 parts of Clematis chinensis, 15-25 parts of Aster tataricus, 15-25 parts of Atractylodes macrocephala, 15-25 parts of Magnolia officinalis, 15-20 parts of Poria, 20-25 parts of Codonopsis pilosula, 10-25 parts of Citrus aurantium, 10-25 parts of Cynomorium songaricum, 15-25 parts of Cistanche deserticola, 20-30 parts of Cassia seed, and 10-20 parts of roasted liquorice.

2. A Chinese medicine composition for treating chronic constipation according to claim 1, characterized in that: It is composed of the following raw materials in parts by weight: 30 parts of Eucommia ulmoides, 10 parts of Clematis chinensis, 20 parts of Aster tataricus, 20 parts of Atractylodes macrocephala, 20 parts of Magnolia officinalis, 15 parts of Poria, 20 parts of Codonopsis pilosula, 15 parts of Citrus aurantium, 20 parts of Cynomorium songaricum, 15 parts of Cistanche deserticola, 20 parts of Cassia seed, and 15 parts of moxibustion liquorice.

3. A Chinese medicine composition for treating chronic constipation according to claim 1, characterized in that: It is composed of the following raw materials in parts by weight: 25 parts of Eucommia ulmoides, 10 parts of Clematis chinensis, 15 parts of Aster tataricus, 15 parts of Atractylodes macrocephala, 15 parts of Magnolia officinalis, 15 parts of Poria, 20 parts of Codonopsis pilosula, 10 parts of Citrus aurantium, 10 parts of Cynomorium songaricum, 15 parts of Cistanche deserticola, 20 parts of Cassia seed, and 10 parts of moxibustion liquorice.

4. A Chinese medicine composition for treating chronic constipation according to claim 1, characterized in that: It is composed of the following raw materials in parts by weight: 30 parts of Eucommia ulmoides, 10 parts of Clematidis, 25 parts of Aster tataricus, 25 parts of Atractylodes macrocephala, 25 parts of Magnolia officinalis, 20 parts of Poria, 25 parts of Codonopsis pilosula, 25 parts of Citrus aurantium, 20 parts of Cynomorium songaricum, 15 parts of Cistanche deserticola, 25 parts of Cassia seed, and 20 parts of moxibustion liquorice.

5. A Chinese medicine composition for treating chronic constipation according to any one of claims 1 to 4, characterized in that: The Clematis chinensis is prepared with rice wine.

6. A Chinese medicine composition for treating chronic constipation according to claim 5, characterized in that: The pharmaceutical composition is added with medically acceptable adjuvants to prepare an oral preparation.

7. A Chinese medicine composition for treating chronic constipation according to claim 5, characterized in that: The Chinese medicine oral liquid is a decoction liquid, and its preparation comprises the following steps: S1. Take the raw materials according to the amount, add 8 times of its own weight of water, boil over high heat, then simmer over low heat for 35-40 minutes; S2. After filtering, take the filtrate, add 3 times the weight of water to the residue, boil it over high heat, then simmer it over low heat for 15-20 minutes, filter it, and take the filtrate; S3. Combine the two filtrates and simmer over low heat until the liquid volume is reduced to 1 / 4 to 1 / 5 of the combined filtrate.