The invention discloses muscle and bone cream which is prepared from the following raw material components in parts by weight: 3 to 8 parts of radix aconiti, 3 to 8 parts of radix aconiti kusnezoffii, 3 to 8 parts of fructus chaenomelis, 10 to 20 parts of zaocys, 10 to 20 parts of bungarus parvus, 3 to 8 parts of semen strychni, 3 to 8 parts of radix angelicae dahuricae, 3 to 8 parts of resina ferulae, 5 to 10 parts of radix achyranthis bidentatae, 5 to 10 parts of olibanum, 5 to 10 parts of myrrh, 3 to 8 parts of dragon's blood, 3 to 8 parts of radix et rhizoma rhei, 1 to 10 parts of radix astragali seu hedysari, 3 to 8 parts of radix dipsaci, 3 to 8 parts of tuberculate speranskia herb, 2 to 6 parts of Chinese angelica, 3 to 8 parts of poria cocos, 3 to 8 parts of rhizoma chuanxiong, 5 to 10 parts of dried body of ground beetle, 4 to 10 parts of flos carthami, 3 to 8 parts of cortex eucommiae, 4 to 10 parts of Chinese viscum herb, 3 to 8 parts of rhizoma sparganii, 3 to 8 parts of radix linderae, 3 to 8 parts of semen momordicae, 5 to 10 parts of radix notoginseng, 3 to 8 parts of bighead atractylodes rhizome, 300 to 400 parts of minium and 500 to 800 parts of sesame oil. The prepared muscle and bone cream has effects of dispelling wind, eliminating dampness, dredging meridians and collaterals and relieving pain and has obvious treating effects on joint pain and inconvenient movement which are caused by acute and chronic rheumatism and traumatic injury, cervical spondylosis, prolapse of lumbar intervertebral disc, spur, scapulohumeral periarthritis, waist and knee osteoarthritis, light fracture and the like. The muscle and bone cream provided by the invention is convenient to prepare, convenient to apply, quick in effect and definite in treating effect and has a good application prospect.