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Glucocorticoid capsule type inhaling atomized powder and preparation method

A glucocorticoid, inhalation powder spray technology, applied in capsule delivery, aerosol delivery, pharmaceutical formulations, etc., to achieve the effects of no liver first-pass effect, fast onset of action, and rapid drug absorption

Active Publication Date: 2006-03-08
TIANJIN PHARMA GROUP CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently on the market, ciclesonide and other glucocorticoid preparations are all sprays, and there are no powder spray products

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Mix 1 gram of budesonide and 8 grams of lactose evenly, micronize them by mechanical pulverization to make the average particle size reach 5 μm, pass through a 200-mesh sieve for 3 times, mix well, and pack into No. 4 capsules.

Embodiment 2

[0019] Mix 1 g of R-type budesonide and 30 g of lactose evenly, micronize by spray drying method to make the average particle size reach 5 μm, pass through a 200-mesh sieve for 3 times, mix well, and pack into No. 4 capsules.

Embodiment 3

[0021] 1 g of ciclesonide and 75 g of lactose were uniformly mixed, micronized by mechanical pulverization to make the average particle size reach 4 μm, passed through a 200-mesh sieve for 3 times, mixed evenly, and packed into No. 4 capsules.

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Abstract

The present invention relates to a medicine for curing diseases of respiratory tract, specially for curing asthma. In particular, it relates to a glucocorticoid hormone capsule type inhalation powder aerosol preparation and its preparation method. It is made up by mixing glucocorticoid hormone and carrier, the described carrier is lactose, glycine and mannitol or their mixture, and the average grain size of powder is 0.1-10 micrometers.

Description

Technical field: [0001] The invention relates to a medicine for treating respiratory diseases, especially asthma, in particular to a capsule-type inhalation powder of glucocorticoid and a preparation method thereof. Background technique: [0002] Glucocorticoids are currently the most effective anti-inflammatory drugs in the treatment of asthma. Ciclesonide (CAS: 126544-47-6), a glucocorticoid compound shown in the following structural formula, is a drug for treating respiratory diseases and asthma, and has a good curative effect [Drugs2004: 64 (5): 511-519], In 2004, the aerosol was approved to go on the market in Australia and the United Kingdom. [0003] Chinese patent application discloses several compositions related to ciclesonide, ZL95196265.5 is a compound composed of ciclesonide and a pulmonary surfactant, especially a surfactant containing phospholipids, which is used to treat infant respiratory Distress Syndrome (IRDS) and Adult Respiratory Distress Syndrome (AR...

Claims

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Application Information

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IPC IPC(8): A61K31/57A61K31/58A61K38/22A61K9/12A61K9/48A61P11/06
Inventor 吕万良张强王桂玲王晓霞卢彦昌李金禄孙亮
Owner TIANJIN PHARMA GROUP CORP