25 results about "Mulberry Root Bark" patented technology

The present application relates to the technical field of traditional Chinese medicine composition, and provides a traditional Chinese medicine composition for treating fire-evil type acne as well as a preparation method and application thereof.The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 18-22 parts of purple flower ground ivy, 12-14 parts of gotu kola, 12-14 parts of mulberry bark, 5-7 parts of white flower snake tongue grass, 2-3 parts of honeysuckle, 5-7 parts of loquat leaf, and 3-5 parts of coix seed.The traditional Chinese medicine composition of the present application uses pure natural medicinal materials as raw materials, has controllable cost, is convenient to popularize, has no obvious side effects, can effectively reduce the burden and pain of patients, reduces the influence on the body and psychology of people, and has wide application prospect.

This invention discloses a traditional Chinese medicine paste for clearing the lungs, resolving phlegm, relieving cough and asthma, and its preparation method, belonging to the field of traditional Chinese medicine technology. The traditional Chinese medicine paste of this invention is mainly prepared from the following raw materials in parts by weight: 5-15 parts mulberry bark, 3-10 parts mulberry leaves, 3-10 parts apricot kernels, 5-15 parts ophiopogon japonicus, 5-15 parts glehnia littoralis, 3-10 parts earthworm, 8-30 parts roasted black sesame seeds, 3-10 parts loquat leaves, 8-30 parts clam shells, 8-30 parts reed rhizome, 5-15 parts trichosanthes root, 5-15 parts isatis root, 11-40 parts dried tangerine peel, 5-15 parts atractylodes macrocephala, 1-6 parts gastrodia elata, 5-15 parts buckwheat, 9-25 parts licorice root, 100-200 parts jujube, and 5-15 parts venison powder. The herbal paste of this invention has the effects of clearing the lungs and resolving phlegm, relieving cough and asthma, and also nourishing yin and moistening dryness, strengthening the spleen and stomach. It is suitable for cough, expectoration, and asthma caused by lung heat and yin deficiency, and internal accumulation of phlegm and heat. Preliminary animal experiments have verified that the herbal paste of this invention can significantly prolong the latency period of cough and reduce the frequency of cough. The soaking and decompression concentration processes in the preparation are all carried out under strict conditions, which can reduce the loss of effective ingredients and ensure the stability of product efficacy.

The present application relates to the technical field of natural product extraction, and provides mulberry root bark extract and a preparation method thereof.The extract contains 3-8 characteristic components among eight characteristic components of mulberry flavone C, morusin, cyclo-morusin, cyclo-moracen, mulberroside G, morusin M, mulberroside C and mulberry flavone H.Further, the content relationship of four key components, the proportion of 300-800 Da components, the proportion of >1000 Da components, the content of fat-soluble resin impurities and the proportion of chromatographic peak area are coupled and limited by stability index S and synergy index T.The preparation method comprises the following steps: acid buffer infiltration, ethanol ultrasonic reflux extraction, concentration and adjustment of polarity, sedimentation separation, supercritical carbon dioxide impurity removal, resin column narrow window chromatographic separation, microfiltration-ultrafiltration-nanofiltration separation and drying.The obtained extract can regulate the expression of inflammation-related factors and promote the recovery of intracellular signal molecule level, thereby showing good soothing and skin barrier repair effects at the cell level.

This invention relates to the field of traditional Chinese medicine technology, and more particularly to the application of a traditional Chinese medicine composition in the preparation of drugs for the prevention and treatment of lung injury. The traditional Chinese medicine composition includes Astragalus membranaceus, Eupolyphaga sinensis, Morus alba root bark, Fritillaria cirrhosa, Perilla frutescens seed, Lepidium apetalum seed, Prunus armeniaca seed, Pheretima aspergillum, Ephedra sinica, and Clematis chinensis. Experiments show that this traditional Chinese medicine composition can significantly reduce the level of the inflammatory factor TNF-α, decrease the lung index, and alleviate pathological damage to lung tissue, and can be used for the prevention and treatment of lung injury.

This invention discloses a herbal compound-based hair growth and anti-hair loss conditioning cream and its low-temperature preparation process, relating to the fields of cosmetics and scalp care technology. Specifically, it is a herbal compound-based hair growth and anti-hair loss conditioning cream and its low-temperature preparation process. The conditioning cream contains, by weight, herbal active ingredients such as ginseng, arborvitae leaf, duckweed, soapberry, angelica, chuanxiong, rosemary, ginger, asarum, and mulberry bark, as well as functional and matrix excipients such as sodium hyaluronate, cocoyl glucoside, carbomer 940, phenoxyethanol, and ethylhexylglycerin. Its preparation process employs low-temperature treatment throughout, including low-temperature extraction at room temperature to 50℃ and ultrasonic extraction at 200-800W, as well as low-temperature blending with low-speed stirring at 25-40℃, effectively preserving the active herbal ingredients. This product can improve scalp microcirculation, repair hair follicles, and regulate sebum secretion, suitable for various types of hair loss, while also relieving scalp itching and repairing damaged hair.

This invention discloses a blood-nourishing and kidney-tonifying pill for treating lower back pain due to kidney yin deficiency, prepared from the following Chinese medicinal herbs in parts by weight: 25-35 parts Rehmannia glutinosa, 20-30 parts Cornus officinalis, 18-22 parts Eucommia ulmoides, 15-25 parts Achyranthes bidentata, 20-30 parts Angelica sinensis, 22-30 parts Ligusticum chuanxiong, 20-28 parts Salvia miltiorrhiza, 15-25 parts Curcuma zedoaria, 20-30 parts Citrus reticulata peel, 10-20 parts Cyperus rotundus, 15-25 parts Bupleurum chinense, and 20-30 parts Atractylodes macrocephala. The formula contains 0 parts of Rehmannia glutinosa, 15-25 parts of Citrus aurantium, 18-22 parts of Amomum villosum, 20-30 parts of Scutellaria baicalensis, 15-25 parts of Morus alba root bark, 10-20 parts of bitter apricot kernel, and 15-25 parts of Eriobotrya japonica leaf. The whole formula contains Rehmannia glutinosa, Cornus officinalis, Eucommia ulmoides, Achyranthes bidentata, Angelica sinensis, Ligusticum chuanxiong, Salvia miltiorrhiza, Curcuma zedoaria, Citrus reticulata peel, Cyperus rotundus, Bupleurum chinense, Atractylodes macrocephala, Citrus aurantium, Amomum villosum, Scutellaria baicalensis, Morus alba root bark, bitter apricot kernel, and Eriobotrya japonica leaf. It nourishes blood and tonifies the kidneys to treat kidney yin deficiency and lower back pain, and its preparation method is disclosed.

Application of mulberry bark effective part in whitening and anti-UVA damage and preparation method thereof, the effective part is that mulberry bark is extracted with ethanol, the obtained extract is concentrated under reduced pressure, then dissolved with ethanol, then adsorbed with macroporous resin, eluted with different concentrations of ethanol, different concentrations of ethanol eluate is collected respectively, then concentrated under reduced pressure to obtain the effective part. α The protective effect of the effective part on UVA damaged human dermal fibroblasts (HDF- α ) is equivalent to that of the positive control vitamin C (100 μM). The effective part (0.3% emulsion) shows significant whitening effect in ultraviolet irradiation test population, which is equivalent to that of the positive control vitamin C (7% emulsion). The effective part of the application has good application prospect in developing whitening, anti-photo damage or double effect cosmetics.

This invention discloses a traditional Chinese medicine composition for pulmonary nodules and its preparation method. The composition is prepared from the following components in parts by weight: 6-30 parts raw oyster shell, 3-15 parts Scrophularia ningpoensis, 3-15 parts Fritillaria thunbergii, 2-10 parts Uncaria rhynchophylla, 3-15 parts vinegar-processed turtle shell, 3-15 parts stir-fried Bombyx mori, 2-10 parts stir-fried mustard seed, 2-10 parts processed Pinellia ternata, 3-15 parts Codonopsis pilosula, 2-10 parts vinegar-processed Curcuma zedoaria, 3-15 parts Rhodiola rosea, 2-10 parts bee honeycomb, 6-30 parts lily bulb, 3-15 parts dried plum, 3-15 parts Ganoderma lucidum, 2-10 parts stir-fried bitter almond, 3-15 parts honey-processed mulberry bark, and 2-10 parts Scutellaria baicalensis. This invention has the functions of resolving phlegm and removing blood stasis, attacking toxins and dispersing nodules, invigorating qi and promoting qi circulation, and nourishing yin and moistening the lungs. It is used in medicines and health products for pulmonary nodules.

The application discloses a preparation method of mulberry bark lung-targeting microcapsules, the product and application of the mulberry bark lung-targeting microcapsules, and the mulberry bark lung-targeting microcapsules are prepared by the following steps: dissolving mulberry bark powder in water, mixing the mulberry bark powder with a PLGA solution dissolved in dichloromethane, adding a PVA solution and stirring, centrifuging and collecting the solid after the organic solvent is volatilized, washing with water and drying to obtain a microcapsule powder. The prepared microcapsules have a particle size controlled in a range of 1-10 microns, can be efficiently deposited in the lung, improve the concentration of a drug at a lesion site, and reduce systemic side effects. The preparation method is simple in process, controllable in conditions, suitable for industrial production, and the obtained drug has high drug loading capacity and process stability.

This invention discloses a fermented traditional Chinese medicine product, its preparation method, and its application, belonging to the field of traditional Chinese medicine fermentation technology. The product uses peppermint, astragalus, wolfberry, mulberry bark, anemarrhena, arborvitae leaf, scrophularia, cimicifuga, elsholtzia, angelica, lily, ginkgo, licorice, schisandra, eleutherococcus senticosus, ophiopogon japonicus, and dried ginger as raw materials, sorghum as a co-fermentation raw material, and brewing liquid as a fermentation enhancer. The process involves pretreatment of the traditional Chinese medicine, co-cooking with sorghum, saccharification with small-grain starter, segmented fermentation, extraction and purification, and post-treatment. This invention utilizes a "compound traditional Chinese medicine ~ sorghum" co-fermentation system, combined with the microbial community and active substances rich in brewing liquid, to increase the dissolution rate of active ingredients such as astragaloside A, lily polysaccharide, and wolfberry polysaccharide in the traditional Chinese medicine by more than 50%, while simultaneously converting them into easily absorbed small molecule derivatives. The finished product has an alcohol content controlled at 6-8 degrees, which not only promotes the absorption of active ingredients but also possesses synergistic effects of clearing the lungs and regulating qi, tonifying qi and benefiting the lungs, moistening the lungs and relieving cough, and clearing heat and resolving phlegm. The process enables the resource utilization of yellow water from brewing, reducing costs by 35%, and the product exhibits excellent stability, making it suitable for industrial production. It also has significant value in the field of lung function regulation and health care.

This invention discloses a traditional Chinese medicine shampoo for androgenetic alopecia caused by liver and kidney deficiency, its preparation method, and its application. Belonging to the field of traditional Chinese medicine technology, the shampoo uses processed Polygonum multiflorum, wine-processed Ligustrum lucidum, Eclipta prostrata, ginseng, Angelica sinensis, safflower, Salvia miltiorrhiza, Platycladus orientalis leaves, mulberry leaves, honey-processed mulberry bark, Sophora flavescens, Cnidium monnieri, Paeonia suffruticosa, Cercis chinensis bark, ginger, Sapindus mukorossi, Gleditsia sinensis, and Clematis chinensis as raw materials, prepared through water extraction and concentration. This invention achieves both symptomatic and root-cause treatment, addressing both the underlying cause and symptoms. It intervenes in androgenetic alopecia through the HIF-1 / VEGE and IL-17 pathways, promoting angiogenesis and improving microcirculation in the scalp, inhibiting follicular immune inflammation, and creating a favorable environment for hair follicle growth. Compared with existing technologies, this invention has irreplaceable advantages in improving local symptoms such as oily scalp, itching, and dandruff.

The present application relates to plaster preparation technical field, disclose a kind of traditional Chinese medicine combination formula of dissolving blood stasis and reducing swelling and preparation process thereof, including dragon's blood 60 parts, xiaoshang 60 parts, chuanqiong 60 parts, red shao 60 parts, baizhi 60 parts, sea scallop 60 parts, raw dahuang 60 parts, purple jingpi 60 parts, gusuibu 60 parts, safflower 30 parts, xiaocin 30 parts, angelica 90 parts, prepared frankincense 90 parts, prepared myrrh 90 parts, mulberry bark 120 parts, artificial musk 10 parts, sesame oil 1200 parts, yellow wax 300 parts.The plaster provided by the present application can promote blood circulation to remove blood stasis and relieve pain, is suitable for long-term use for joint sprain without open wound and purplish swelling and pain, and the action time is up to 48 hours, can kill bacteria and relieve itching when being pasted on the skin of patient, prevent allergic reaction and bacterial infection caused by too long pasting time.

This invention relates to a screening method and application of traditional Chinese medicine inhibitors against carbapenem-resistant Klebsiella pneumoniae, belonging to the field of biomedical technology. Based on a high-throughput screening system for carbapenem-resistant Klebsiella pneumoniae inhibitors constructed using a fluorescent probe for carbapenemase activity detection, the invention successfully screened out mulberry bark as a carbapenemase inhibitor, sanghorn ketone G. When used in combination with meropenem, this inhibitor significantly inhibits the metabolism of meropenem by carbapenem-resistant Klebsiella pneumoniae, greatly enhancing the inhibitory efficiency of meropenem against the strain, providing a highly effective and valuable combination therapy for clinical treatment of carbapenem-resistant Klebsiella pneumoniae infection.

The application belongs to the field of medicine, and particularly relates to application of a compound traditional Chinese medicine extract and active ingredients thereof to treatment of respiratory diseases. A preparation method of the compound traditional Chinese medicine extract comprises the following steps: (1) according to weight parts, 1 part of dried mulberry bark is taken, 2 parts of Huangqi are added, 15-20 times of 60%-75% ethanol solution is added, and after 20-30 min of soaking, heating is performed to a reflux temperature, reflux extraction is performed for 2 h, and then extraction liquid is collected by filtration, and after concentration, an extract is obtained; (2) the extract obtained in step (1) is subjected to normal phase silica gel column chromatography, the stationary phase is 200-300 mesh silica gel, the mobile phase is a 20%-25% ethyl acetate / petroleum ether mixed solvent, 3-4 column volumes are eluted, and the obtained fraction is concentrated, dried, and the compound traditional Chinese medicine extract is obtained.

The invention discloses a traditional Chinese medicine composition for relieving cough and a preparation method thereof. The composition is prepared from ephedra, almond, gypsum, perillaseed, thunberg fritillary bulb, white mulberry root-bark, cicada slough, radix stemonae, inula flower, clam shell, cynanchum glaucescens, tussilago farfara, schisandra chinensis, loquat leaf, perilla stem, tetrapanax papyriferus, indigo naturalis, semen raphani and liquorice according to a specific ratio. Aiming at the current situation that an existing cough-relieving traditional Chinese medicine prescription is insufficient in consideration of complex syndrome type cough and limited in curative effect, a synergistic compound is formed through combination of multiple methods such as lung freeing, heat clearing, phlegm reducing, qi depressing, spasmolysis and lung astringing, and the traditional Chinese medicine prescription is especially suitable for cough with phlegm-heat stagnating lung, lung dysfunction and descending and airway spasm syndrome.

This invention provides a topical composition and its preparation method for reversing gray hair to black and repairing the scalp. The topical composition comprises the following raw materials in parts by weight: 10-30 parts of Polygonum multiflorum, 10-25 parts of Platycladus orientalis leaves, 8-20 parts of Artemisia argyi, 5-15 parts of ginger, 5-15 parts of Morus alba root bark, 5-12 parts of Leonurus japonicus, 5-12 parts of Lycium chinense root bark, 3-10 parts of Angelica dahurica, 5-15 parts of Morus alba leaves, 5-12 parts of Citrus reticulata peel, 3-10 parts of tea leaves, 3-10 parts of Auricularia auricula-judae, and 2-8 parts of Glycyrrhiza uralensis. The topical composition also contains a compound plant extract, which is obtained by alcohol extraction from Acer palmatum, Paederia scandens, and Areca catechu flowers in a mass ratio of (2.8-3.2):(0.9-1.1):(1.5-2.5). The composition of this invention can activate scalp tyrosinase activity and promote melanin production; improve scalp microcirculation and hair follicle nutrient supply; repair damaged hair and delay gray hair growth; achieve root-cause promotion of gray hair turning black, and also has scalp care function to restore black and shiny hair.

This invention belongs to the field of traditional Chinese medicine compositions, specifically relating to a traditional Chinese medicine composition for treating lung heat, its preparation method, and its application. The Xiebai Powder provided by this invention is composed of the following ingredients: Lycium chinense root bark, stir-fried mulberry bark, stir-fried licorice root, japonica rice, pickled apricot kernels, and Pinellia ternata. The formula provided by this invention is both clearing and moistening, purging while also tonifying, and tonifying while dispersing. The addition of pickled apricot kernels and Pinellia ternata makes it more suitable for the immature Yin and Yang constitution of children, addressing both cough and diarrhea symptoms, thus balancing the root cause and the symptoms. It aligns with the characteristics of the lungs being a delicate organ, intolerant to cold and heat, and children's weak spleen and stomach, making them prone to diarrhea and cough, thereby shortening the course of the disease and improving efficacy.

The present application provides a kind of multi-target synergistic whitening and freckle lightening plant composition and its preparation method and application, belong to medical, dental or cosmetic preparation field.The active ingredient is composed of Radix Glycyrrhizae, Radix Scutellariae, Coix Seed, Centella asiatica and mulberry root-bark extract according to specific proportion.The composition realizes signal pathway inhibition, tyrosinase activity blocking, melanin transport interference, keratin metabolism acceleration and skin barrier repair by constructing multi-target synergistic network.The present application overcomes the limitations of single whitening target, such as repeated color spots and slow effect, realizes whole-cycle and systematic whitening and freckle lightening effect under the premise of ensuring safety, and is suitable for cosmetic field.

The application provides a microbial limit test method of mulberry bark formula granules, adopts a membrane filtration method, takes pH 7.0 sodium chloride proteose peptone buffer solution as a basic diluent, adds Tween 80 and soybean lecithin, is sterilized by high pressure, is cooled, and then sterile bovine serum albumin freeze-dried powder is added before use, is shaken to prepare a diluent; and the pancreas tyrosine soybean peptone agar medium and the sand sugar glucose agar medium both are previously added with Tween 80 and soybean lecithin, are sterilized by high pressure and cooled, and then the sterile bovine serum albumin freeze-dried powder is added, so that the two kinds of culture media become two kinds of improved novel culture media with neutralizing activity. The microbial limit test method of the mulberry bark formula granules is stable, can realize qualified recovery rate of test bacteria, smooth filtration without membrane blockage, completely eliminates bacteriostatic interference, the result is accurate and reliable, and has good repeatability and practicability.

This invention relates to the field of traditional Chinese medicine (TCM) technology, and particularly to the application of TCM compositions in the preparation of drugs for the prevention and treatment of asthma. The TCM composition includes Astragalus membranaceus, Eupolyphaga sinensis, Morus alba root bark, Fritillaria cirrhosa, Perilla frutescens seed, Lepidium apetalum seed, Prunus armeniaca seed, Pheretima aspergillum, Ephedra sinica, and Clematis chinensis. Experiments show that the TCM composition provided by this invention can effectively improve airway hyperresponsiveness, reduce lung resistance, and enhance dynamic lung compliance in asthma model animals. Simultaneously, it can significantly reduce the content of pro-inflammatory factors IL-4 and IL-13 in the bronchoalveolar lavage fluid of asthma models, alleviate airway inflammation, and relieve asthma pathological symptoms. It can stably exert its effect in preventing and treating asthma, and its efficacy is stable and its safety is good. It can be further developed into a drug for the prevention and treatment of asthma and has good clinical application prospects.

This invention discloses a Qingjin Huatan Decoction and its application in regulating the serum inflammatory factor protein network of patients with AECOPD and phlegm-heat accumulation in the lungs, belonging to the field of biomedical technology. The Qingjin Huatan Decoction of this invention is composed of the following raw materials in parts by weight: Scutellaria baicalensis 10-20 parts, Gardenia jasminoides 6-12 parts, Morus alba root bark 6-12 parts, Trichosanthes kirilowii 10-14 parts, Fritillaria thunbergii 6-12 parts, Ophiopogon japonicus 6-12 parts, Platycodon grandiflorus 10-20 parts, Anemarrhena asphodeloides 6-12 parts, Citrus reticulata peel 10-20 parts, Poria cocos 10-20 parts, and Glycyrrhiza uralensis (processed) 4-8 parts. This formula is consistent with the core pathogenesis of AECOPD and phlegm-heat accumulation in the lungs, with appropriate warming and cooling properties, and a combination of tonifying and purging effects. It can inhibit the proliferation of pathogenic bacteria in the intestines, correct intestinal flora imbalance, achieve intestinal-lung harmony through the intestinal-lung axis, comprehensively improve patients' clinical symptoms, and enhance clinical suitability.

This invention discloses a traditional Chinese medicine oral liquid for treating infectious airsacculitis in chickens and its preparation method, belonging to the field of traditional Chinese veterinary medicine preparation technology. The oral liquid is composed of thirteen traditional Chinese medicines: buckwheat, houttuynia cordata, isatis root, honeysuckle, forsythia, scutellaria baicalensis, gypsum, ephedra, apricot kernel, platycodon grandiflorus, fritillaria cirrhosa, mulberry bark, and licorice. This formula has the effects of clearing heat and detoxifying, relieving lung congestion and asthma, and resolving phlegm and relieving cough. This invention uses modern traditional Chinese medicine extraction technology, extracting volatile oils from some medicinal materials through steam distillation and extracting others through ethanol reflux extraction. The extracts are combined, and suitable excipients are added to prepare an oral liquid preparation. This invention overcomes the drawbacks of traditional powders, such as low bioavailability and slow onset of action. Clinical trials have proven that it achieves a cure rate of over 92% and an effective rate of over 96% for infectious airsacculitis in chickens, with rapid onset of action. Respiratory symptoms are significantly improved within 24 hours after administration, with no drug residue and no drug resistance.

The application discloses a traditional Chinese medicine composition for treating chronic obstructive pulmonary disease (COPD), which is composed of the following components in parts of mass: reed stem 10-20 parts, wax gourd seed 15-30 parts, caulis sargentodoxae 20-40 parts, luffa 10-20 parts, salvia miltiorrhiza 10-20 parts, rhodiola 6-15 parts, belamcanda 8-15 parts, ephedra 3-9 parts, radix pini 6-15 parts, forsythia suspensa 6-15 parts, mulberry bark 10-20 parts, rehmannia 10-20 parts, astragalus 15-30 parts, and licorice 3-9 parts. The application further discloses a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is capable of clearing heat, activating blood and promoting lung, and at the same time, the astragalus and rehmannia are used to tonify the lung and kidney, support the healthy qi and eliminate the pathogenic factors, so that the traditional Chinese medicine composition is suitable for long-term treatment of COPD.

The application provides application of a monascus composition in preparation of a medicine for preventing and / or treating coronary microcirculation disorder, wherein the monascus composition comprises one or more of mulberry bark, mulberry branch and mulberry leaf, monascus and pueraria. When the monascus composition is applied in preparation of the medicine for preventing and / or treating coronary microcirculation disorder, the following effects can be achieved: 1) improving microvascular structure abnormality (increasing myocardial microvascular density MVD, reducing perivascular edema of microvessels, improving lumen stenosis phenomenon, and good endothelial cell condition); 2) improving microvascular obstruction (pathological results show that the content of microvessels is reduced); 3) improving abnormal microvascular vasomotor function (increasing NO); 4) improving blood lipid metabolism disorder; and 5) improving heart function (increasing left ventricular ejection fraction LVEF and left ventricular short axis shortening rate LVFS, increasing left ventricular internal pressure maximum rising rate LV+dp / dtmax and left ventricular internal pressure maximum falling rate LV‑dp / dtmax).

The present application relates to a kind of macroelement water-soluble fertilizer and its preparation method, belong to water-soluble fertilizer field, according to percentage by weight, including urea 25~30%, potassium nitrate 30.0~35.0%, polyphosphate 15~20%, compound chelated state trace metal element 18~20%, potassium phosphite 1.0~2.0%, sodium octaborate 0.1~0.3%;The compound chelated state trace metal element includes calcium nitrate tetrahydrate, magnesium sulfate heptahydrate, ferrous sulfate heptahydrate, zinc sulfate heptahydrate, citric acid monohydrate, tartaric acid, poly-p-glutamic acid, glycine, potassium fulvic acid, mulberry bark extract and radix scrophulariae extract.The trace metal element of the present application is treated by step chelation, and the content of initial chelated state trace element is significantly higher than all the comparative examples, and the macroelement water-soluble fertilizer of the present application can effectively improve crop yield, and reduce the stress resistance of crop.