Innovative formula of traditional Chinese medicine preparation for relieving cough and asthma and preparation method thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to an innovative formula and a preparation method of a traditional Chinese medicine preparation for relieving cough and asthma, and the traditional Chinese medicine preparation comprises the following medicinal materials in parts by weight: 10-20 parts of flos farfarae, 10-20 parts of radix asteris, 5-15 parts of ephedra, 5-15 parts of almond, 5-15 parts of scutellaria baicalensis, 5-15 parts of white mulberry root-bark, 5-15 parts of radix stemonae and 3-10 parts of liquorice. Through reasonable compatibility of various traditional Chinese medicines, the traditional Chinese medicine composition acts on the respiratory system in a multi-target manner, can moisten the lung to arrest cough, can release the lung to relieve asthma, can clear heat and reduce phlegm, and has a good treatment effect on cough and asthma caused by various reasons. Animal experiments and clinical preliminary verifications prove that compared with a traditional Chinese medicine preparation for relieving cough and asthma, the preparation disclosed by the invention can more remarkably prolong the cough latency period, reduce the cough frequency, relieve the asthma symptom and improve the lung function, and the links such as reduced pressure concentration and preparation forming in the preparation process are all carried out under strict condition control, so that the traditional Chinese medicine preparation is free of toxic and side effects. The loss and degradation of effective components are reduced, and the stability and consistency of the product quality are ensured.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine preparations, in particular to an innovative formula of a cough-relieving and asthma-relieving traditional Chinese medicine preparation and a preparation method thereof. Background Art

[0002] Coughing and wheezing are reflex protective responses triggered by irritation of the respiratory organs, manifested as rapid exhalation accompanied by sound, which can clear foreign objects or sputum from the respiratory tract. Traditional Chinese Medicine categorizes coughing and wheezing as cold-induced, heat-induced, and water-induced. Cold-induced coughing and wheezing are often caused by exogenous wind and cold, heat-induced coughing is more common in summer, and water-induced coughing and wheezing are accompanied by symptoms such as urinary retention and chest tightness. Western medicine associates coughing and wheezing with diseases such as asthma and chronic bronchitis, often caused by bronchial spasms or inflammation. Coughing and wheezing are common symptoms of respiratory diseases and seriously affect patients' quality of life. Currently, there are many types of cough and asthma suppressants on the market, including Western and traditional Chinese medicine preparations.

[0003] Although Western medicine works quickly, it often has side effects, and long-term use may have adverse effects on the body. Traditional Chinese medicine preparations, on the other hand, have unique advantages in relieving cough and asthma. Their multi-component, multi-target mechanism of action can regulate body functions holistically, and their side effects are relatively minor. However, some existing traditional Chinese medicine cough and asthma preparations use imprecisely selected herbs, resulting in insufficient levels of active ingredients; some traditional formulas fail to fully integrate modern medical understanding of the disease for optimization; and the extraction rate of active ingredients during the preparation process is low, affecting the quality and efficacy of the preparations. Summary of the Invention

[0004] In response to the deficiencies in the prior art, the present invention provides an innovative formula for a cough and asthma relieving Chinese herbal preparation and a preparation method thereof, which solves the problem that although Western medicine takes effect quickly, it often has side effects and may cause adverse effects on the body with long-term use. Chinese herbal preparations have unique advantages in relieving cough and asthma. Their multi-component and multi-target mechanism of action can regulate the body's functions as a whole, and the side effects are relatively small. However, the medicinal materials of some existing Chinese herbal cough and asthma preparations are not accurately selected, resulting in insufficient content of effective ingredients; some traditional formulas fail to fully combine modern medicine's understanding of the disease for optimization; the extraction rate of effective ingredients in the preparation process is low, affecting the quality and efficacy of the preparations.

[0005] To achieve the above purpose, the present invention provides the following technical solution: calculated by weight, it includes the following medicinal ingredients: 10-20 parts of coltsfoot flowers, 10-20 parts of aster, 5-15 parts of ephedra, 5-15 parts of apricot kernel, 5-15 parts of scutellaria, 5-15 parts of mulberry bark, 5-15 parts of stemona, and 3-10 parts of liquorice.

[0006] As a preferred technical solution of the present invention, the medicinal ingredients are specifically as follows, by weight: 15 parts of coltsfoot flowers, 15 parts of aster, 10 parts of ephedra, 10 parts of apricot kernel, 10 parts of scutellaria, 10 parts of mulberry bark, 10 parts of stemona, and 5 parts of liquorice.

[0007] S1: Select high-quality, authentic medicinal materials, remove impurities and non-medicinal parts, wash and dry; extract the active ingredients: use supercritical carbon dioxide extraction technology combined with water extraction and alcohol precipitation. First, mix the pretreated medicinal materials and perform supercritical carbon dioxide extraction. Extract at a temperature of 35-45°C and a pressure of 20-30 MPa for 2-3 hours, and collect the extract. Then, extract the extracted medicinal residue with water, add 8-10 times the amount of water, and boil 2-3 times, each time for 1-2 hours. Combine the decoctions, filter, and concentrate the filtrate to a clear paste with a relative density of 1.10-1.20 (60°C). Slowly add 95% ethanol to increase the alcohol content to 60%-70%. Stir evenly, let it stand for 12-24 hours, filter, collect the supernatant, and recover the ethanol.

[0008] S2: The extract obtained by supercritical carbon dioxide extraction and the extract obtained by water extraction and alcohol precipitation are mixed evenly, and concentrated under reduced pressure at a temperature of 50-60°C and a pressure of -0.06 to -0.08 MPa to a thick paste with a relative density of 1.30-1.35 (60°C);

[0009] S3: The thick paste is made into different dosage forms such as pills, granules, and tablets as needed. For pills, appropriate amounts of starch, dextrin, and other excipients are added to form a soft material, which is then made into pills using a pill making machine and coated after drying. For granules, appropriate amounts of sucrose, dextrin, and other excipients are added to form a soft material, which is then made into granules using a granulator. After drying, the granules are sized and packaged. For tablets, appropriate amounts of microcrystalline cellulose, sodium carboxymethyl starch, and other excipients are added, mixed evenly, pressed into tablets, and coated.

[0010] As a preferred technical solution of the present invention, the temperature of the supercritical carbon dioxide extraction is 40°C, the pressure is 25MPa, and the extraction time is 2.5 hours; when extracting with water, add 9 times the amount of water, boil 3 times, each time for 1.5 hours; the temperature of the reduced pressure concentration is 55°C and the pressure is -0.07MPa.

[0011] As a preferred technical solution of the present invention, when preparing pills, pills with a diameter of 3 mm are made and dried at 60°C for 2 hours; when preparing granules, they are dried at 65°C for 1.5 hours and packaged in 10g bags; when preparing tablets, each tablet weighs 0.5g.

[0012] Compared with the prior art, the present invention provides an innovative formula of a cough-relieving and asthma-relieving Chinese medicine preparation and its preparation method, which has the following beneficial effects:

[0013] 1. The innovative formula and preparation of this cough-relieving and asthma-relieving Chinese medicine preparation, through the rational combination of various Chinese herbs, acts on the respiratory system at multiple targets, moistening the lungs and relieving coughs, promoting lung function and relieving asthma, and clearing away heat and resolving phlegm, has a good therapeutic effect on coughs and asthma caused by various causes. Animal experiments and preliminary clinical verification have shown that compared with traditional cough-relieving and asthma-relieving Chinese medicine preparations, the preparation of the present invention can more significantly prolong the cough incubation period, reduce the number of coughs, relieve asthma symptoms, and improve lung function.

[0014] 2. The innovative formula and preparation of this cough and asthma-relieving traditional Chinese medicine preparation utilizes rigorously controlled processes throughout the preparation process, including vacuum concentration and formulation molding. This minimizes the loss and degradation of active ingredients and ensures the stability and consistency of product quality. Quality testing of multiple batches has confirmed that all indicators meet relevant standards, with minimal inter-batch variation. DETAILED DESCRIPTION

[0015] The following is a clear and complete description of the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative efforts are within the scope of protection of the present invention.

[0016] Example

[0017] Example 1: Preparation of cough-relieving and asthma-relieving pills

[0018] Preparation of medicinal materials: Weigh 15g of coltsfoot flower, 15g of aster root, 10g of ephedra, 10g of apricot kernel, 10g of scutellaria baicalensis, 10g of mulberry bark, 10g of stemona radix, and 5g of liquorice.

[0019] Pretreatment of medicinal materials: Wash and dry the medicinal materials according to the requirements of the above preparation method.

[0020] Extraction of active ingredients: Mix the pretreated medicinal materials and place them in a supercritical carbon dioxide extraction apparatus. Extract at 40°C and 25 MPa for 2.5 hours, then collect the extract. Extract the extracted medicinal residue with water, adding 9 times the amount of water. Decoction the mixture three times for 1.5 hours each. Combine the decoctions and filter. Concentrate the filtrate to a clear paste with a relative density of 1.15 (at 60°C). Slowly add 95% ethanol to a concentration of 65% alcohol. Stir thoroughly, let the mixture stand for 18 hours, filter, collect the supernatant, and recover the ethanol.

[0021] Mixing and concentration: The extract obtained by supercritical carbon dioxide extraction is mixed evenly with the extract obtained by water extraction and alcohol precipitation. Under the conditions of temperature 55°C and pressure -0.07MPa, the mixture is concentrated under reduced pressure to a thick paste with a relative density of 1.32 (60°C).

[0022] Preparation molding: Add appropriate amount of starch and dextrin to the thick paste to make a soft material, use a pill making machine to make pills with a diameter of 3mm, dry at 60℃ for 2 hours, and then coat to obtain cough and asthma relief pills.

[0023] Example 2: Preparation of cough-relieving and asthma-relieving granules

[0024] Preparation of medicinal materials: Weigh 12g of coltsfoot flower, 12g of aster root, 8g of ephedra, 8g of apricot kernel, 8g of scutellaria, 8g of mulberry bark, 8g of stemona, and 4g of liquorice.

[0025] Medicinal material pretreatment, extraction of active ingredients, mixing and concentration: The operation steps are the same as those in Example 1.

[0026] Preparation molding: Add appropriate amount of sucrose and dextrin to the thick paste to make a soft material, use a granulator to make granules, dry at 65℃ for 1.5 hours, and package after granulation, 10g per bag to obtain cough and asthma relieving granules.

[0027] Example 3: Preparation of cough and asthma relieving tablets

[0028] Preparation of medicinal materials: Weigh 18g of coltsfoot flower, 18g of aster root, 12g of ephedra, 12g of apricot kernel, 12g of scutellaria baicalensis, 12g of mulberry bark, 12g of stemona radix, and 6g of liquorice.

[0029] Medicinal material pretreatment, extraction of active ingredients, mixing and concentration: The operation steps are the same as those in Example 1.

[0030] Preparation molding: Add appropriate amount of microcrystalline cellulose and sodium carboxymethyl starch to the thick paste, mix well and press into tablets, each weighing 0.5g, and coat to obtain cough and asthma relieving tablets.

[0031] The cough-relieving and asthma-relieving Chinese medicine preparation prepared by the above embodiment meets the relevant standards through quality inspection and preliminary efficacy verification, and has good cough-relieving and asthma-relieving effects. In practical applications, a suitable dosage form can be selected for use according to the specific conditions of the patient.

[0032] Finally, it should be noted that the above descriptions are merely preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art will be able to modify the technical solutions described in the aforementioned embodiments or substitute equivalents for some of the technical features. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention shall be included within the scope of protection of the present invention.

Claims

1. An innovative formula of a cough-relieving and asthma-relieving Chinese medicine preparation and its preparation method, characterized by: The medicinal ingredients are as follows: 10-20 parts of coltsfoot flowers, 10-20 parts of aster, 5-15 parts of ephedra, 5-15 parts of apricot kernel, 5-15 parts of scutellaria, 5-15 parts of mulberry bark, 5-15 parts of stemona, and 3-10 parts of liquorice.

2. The innovative formula of the cough-relieving and asthma-relieving Chinese medicine preparation according to claim 1 and its preparation method are characterized in that: The medicinal ingredients are specifically as follows by weight: 15 parts of coltsfoot flowers, 15 parts of aster, 10 parts of ephedra, 10 parts of apricot kernel, 10 parts of scutellaria, 10 parts of mulberry bark, 10 parts of stemona, and 5 parts of liquorice.

3. The innovative formula of the cough-relieving and asthma-relieving Chinese medicine preparation according to claim 1 and its preparation method are characterized in that: The following steps are involved: 。 S1: Select high-quality, authentic medicinal materials, remove impurities and non-medicinal parts, wash and dry; extract the active ingredients: use supercritical carbon dioxide extraction technology combined with water extraction and alcohol precipitation. First, mix the pretreated medicinal materials and perform supercritical carbon dioxide extraction. Extract at a temperature of 35-45°C and a pressure of 20-30 MPa for 2-3 hours, and collect the extract. Then, extract the extracted medicinal residue with water, add 8-10 times the amount of water, and boil 2-3 times, each time for 1-2 hours. Combine the decoctions, filter, and concentrate the filtrate to a clear paste with a relative density of 1.10-1.20 (60°C). Slowly add 95% ethanol to increase the alcohol content to 60%-70%. Stir evenly, let it stand for 12-24 hours, filter, collect the supernatant, and recover the ethanol. S2: The extract obtained by supercritical carbon dioxide extraction and the extract obtained by water extraction and alcohol precipitation are mixed evenly, and concentrated under reduced pressure at a temperature of 50-60°C and a pressure of -0.06 to -0.08 MPa to a thick paste with a relative density of 1.30-1.35 (60°C); S3: The thick paste is made into different dosage forms such as pills, granules, and tablets as needed. For pills, appropriate amounts of starch, dextrin, and other excipients are added to form a soft material, which is then made into pills using a pill making machine and coated after drying. For granules, appropriate amounts of sucrose, dextrin, and other excipients are added to form a soft material, which is then made into granules using a granulator. After drying, the granules are sized and packaged. For tablets, appropriate amounts of microcrystalline cellulose, sodium carboxymethyl starch, and other excipients are added, mixed evenly, pressed into tablets, and coated.

4. The method for preparing the cough-relieving and asthma-relieving Chinese medicine preparation according to claim 3, characterized in that: The supercritical carbon dioxide extraction temperature is 40°C, the pressure is 25MPa, and the extraction time is 2.5 hours; when extracting with water, add 9 times the amount of water and boil for 3 times, each time for 1.5 hours; the temperature of the reduced pressure concentration is 55°C and the pressure is -0.07MPa.

5. The method for preparing the cough-relieving and asthma-relieving Chinese medicine preparation according to claim 3, characterized in that: When preparing pills, make pills with a diameter of 3mm and dry them at 60℃ for 2 hours; when preparing granules, dry them at 65℃ for 1.5 hours and pack them into 10g bags; when preparing tablets, each tablet weighs 0.5g.