121 results about "Glucocorticoid" patented technology

The invention discloses an application of ganoderma lucidum spore oil in preparation of a medicine or health food for improving sarcopenia. Ganoderma lucidum spore oil can effectively improve weight loss and muscle hypofunction induced by glucocorticoid, and improve the holding power and exercise tolerance level of the body; meanwhile, the skeletal muscle mass and the muscle fiber cross sectional area can be increased, and the skeletal muscle tissue morphological structure is improved; in addition, the ganoderma lucidum spore oil can improve the oxidation resistance of the body and skeletal muscle and reduce the oxidative stress level, so that the skeletal muscle injury related to aging is relieved on the whole. Therefore, the ganoderma lucidum spore oil has a definite application value in the aspect of improving the skeletal muscle function.

The present invention relates to a novel polymorph of (1R,2R,3aS,3bR,10aS,10bR,11S,12aS)-5,10b-difluoro-1-(((fluoromethyl)thio)carbonyl)-11-hydroxyl-2,10a,12a-trimethyl-7-phenyl-1,2,3,3a,3b,7,10,10a,10b,11,12,12a-dodecylhydrocyclapenta[5,6]napththo[1,2-F]indazole-1-furan-2-carboxylate ester as shown in formula (I), a preparation method therefor, and a use thereof. The crystal form of the present invention has characteristics such as a significant pharmaceutical effect, good stability, high yield, and high purity, and is beneficial for the selection and design of a drug administration route and the determination of a drug preparation process parameter, thereby improving drug production quality.

The invention discloses application of ginkgetin in treatment of chronic pulmonary obstruction, and relates to the field of medical technical methods of ginkgetin. According to the invention, by constructing a model of cigarette extract on airway epithelial cell injury, the biflavone compound is found to have a protective effect on epithelial cell injury caused by smoking; through transcriptomics research, biflavone compounds such as ginkgetin and the like are found to have pharmacological activity of inhibiting CEBP beta protein high expression caused by cigarette extracts, so that the effect of protecting airway inflammation caused by smoking is achieved. More importantly, the ginkgetin and the glucocorticoid are jointly used, so that the treatment effect on chronic pulmonary obstruction is remarkably improved compared with that of independently using the ginkgetin and the glucocorticoid, and the ginkgetin and the glucocorticoid have wide medical application.

The present disclosure relates to the technical field of medicinal chemistry, and particularly, to a novel glucocorticoid, a method for preparing same, and use thereof. The novel glucocorticoid comprises a compound represented by formula I, an optical isomer thereof, a pharmaceutically acceptable salt thereof, or a solvate thereof, wherein the structure of the compound represented by formula I is shown herein. The compound provided by the present disclosure exhibits a high plasma clearance rate, a short half-life, reduced systemic exposure, and enhanced glucocorticoid receptor (GR) selectivity, thereby significantly reducing the adverse effects associated with systemic absorption of the glucocorticoid drug. The present disclosure has significant anti-inflammatory activity in animals with asthma, uveitis, dry eye syndrome, inflammatory bowel disease, psoriasis, and the like. The compound provided by the present disclosure demonstrates good safety, with no abnormal intraocular pressure observed after continuous ocular administrations in guinea pigs and no significant changes in the thickness of the epidermal layer after continuous dermal administrations in rats.

Provided are methods and compositions, for treating prostate cancer by administering to a patient in need thereof a therapeutically effective amount of a PARP inhibitor, e.g., niraparib; a therapeutically effective amount of a CYP17 inhibitor, e.g., abiraterone acetate, and a therapeutically effective amount of a glucocorticoid, e.g., prednisone.

The disclosure provides a method of treatment for glucocorticoid excess in a patient in need thereof, comprising administering to the patient a pseudo-irreversible HSD-1 inhibitor.

The invention discloses multifunctional selenium nanoparticles for treating inflammatory bowel diseases as well as a preparation method and application of the multifunctional selenium nanoparticles, and relates to the technical field of biological medicines. The multifunctional selenium nanoparticle is of a core-shell structure and comprises an inner core and an outer layer coating the inner core, the inner core is selenium nanoparticles; and the outer layer is a polydopamine shell embedded with chitosan oligosaccharide. The multifunctional selenium nanoparticles provided by the invention have good stability and dispersibility, can target intestinal inflammation parts, prolong the in-vivo time of the nanoparticles, and show strong antioxidant and anti-inflammatory activity on cell and animal levels. The whole nanoparticle is based on low toxicity and colon targeting of a natural material, is higher in safety compared with a traditional glucocorticoid / biological preparation, relieves intestinal inflammation by adjusting a redox steady state, prolonging drug action time and the like, and is expected to become a novel colitis treatment strategy with high efficiency, targeting property and safety.

The application discloses a preparation method of CCR2+ gamma delta T cells with anti-tumor activity and migration ability, and belongs to the technical field of cells; the method comprises the following steps: step (1), PBMC of peripheral blood of a healthy person is extracted, inoculated into complete culture medium, and added with zoledronic acid, IL-15 and metformin, and then is cultured in a T25 culture bottle; step (2), complete culture medium is supplemented, the cell concentration is adjusted, and then the cells are transferred into a T75 culture bottle for culture; step (3), complete culture medium is supplemented, the cell concentration is adjusted, glucocorticoid and nicotinamide are added, and then the cells are transferred into a T150 culture bottle for culture; step (4), cells are collected at D6, rinsed with normal saline, resuspended with complete culture medium, the cell concentration is adjusted, and then the cells are inoculated into a T300 culture bottle for culture; and step (5), complete culture medium is supplemented every two days from D8 to D16, the cell concentration is maintained, and then the cells are harvested at D16 to obtain CCR2+ gamma delta T cells.

The invention discloses a three-channel bionic bone organ chip and a method thereof.The three-channel bionic bone organ chip comprises a three-channel model and a carrier, the three-channel model comprises a blood vessel channel in the middle and bone channels located on the two sides of the blood vessel channel, the width of the blood vessel channel is 500 micrometers, the width of the bone channels is 1000 micrometers, and the width of the carrier is 100 micrometers. The two sides of the blood vessel channel are separated from the bone channels on the two sides through long barriers respectively. The carrier is used for bearing the three-channel model. According to the invention, a novel bone organ chip (Bone Orga-on-a-Chip, BOC) is constructed, which is convenient for simulating an OP microenvironment induced by glucocorticoid and the influence of mechanical mechanics on treatment of OP by MSCs. On the basis, a candidate gene TPD52L1 is further analyzed and screened through bioinformatics, the candidate gene TPD52L1 is remarkably up-regulated in MSCs induced osteogenic differentiation, and the effect of the gene in MSCs osteogenic adipogenic fate choice is discussed.

The invention discloses a biomarker, a kit, a system, a method and application for acute respiratory syndrome (ARDS) inflammation phenotype typing. The biomarker combination is selected from any two or a combination of more than two of PLAUR, BSG, TNFRSF14, DFFA, IFNGR1, ENAH, LAIR1, NUB1, AGRN, LTBR, BTN3A2 and F2R, and the biomarker combination is a combination of any two or more of PLAUR, BSG, TNFRSF14, DFFA, IFNGR1, ENAH, LAIR1, NUB1, AGRN, LTBR, BTN3A2 and F2R. By detecting the expression level of the marker in serum of a subject and utilizing a machine learning classification model (such as XGBoost) for analysis, ARDS patients can be divided into three phenotypes of C1 (high inflammation and high injury), C2 (low inflammation repair) and C3 (intermediate). The typing method can accurately predict clinical outcomes such as the 90-day death rate of the patient and guide individualized application of glucocorticoid and PEEP ventilation strategies, and has important significance for achieving accurate treatment of ARDS.

Compositions and methods are provided for the prevention of osteonecrosis or osteoporosis associated with corticosteroid administration in an individual. The methods of the disclosure comprise administration of an effective dose of a metformin agent, or a derivative, mimetic or analog thereof in combination with administration of a corticosteroid. The effective dose of metformin agent decreases oxidative stress and restores osteogenic capacity of mesenchymal stem cells exposed to a glucocorticoid.

The present disclosure is directed to methods of treatment, including treatment of a myopathy by administering to a subject in need thereof an elastase inhibitor in combination with a glucocorticoid. The present disclosure is also directed to pharmaceutical compositions that include an elastase inhibitor that can be used in such treatment.

The invention discloses a sterone compound derived from achyranthes bidentata as well as a preparation method and application of the sterone compound. Belongs to the technical field of biological medicine. The invention aims to solve various side effects and defects of the existing medicine for treating glucocorticoid-induced osteoporosis in long-term use. The molecular formula of the compound (SSA) is C33H48O9, the compound (SSA) has a beta-ecdysterone skeleton, and acetal type 5-hydroxymethylfurfural groups are introduced at the positions of side chains C20 and C22. SSA has a remarkable protection effect in a DEX-induced osteoblast injury model, can improve cell viability decline and G1 phase retardation caused by glucocorticoid, and recovers osteogenic differentiation and mineralization ability. The SSA effectively reverses the inhibition effect of DEX on osteoblasts by activating a Wnt / beta-catenin signal channel and up-regulating the expression of RUNX2. SSA has a remarkable anti-osteoporosis function potential.

The invention provides an immunochromatography test strip for detecting clobetasol propionate in cosmetics and a method for quantitatively detecting clobetasol propionate in cosmetics. According to the invention, a hollow gold nano-labeled material is applied to immunodetection of glucocorticoid clobetasol propionate for the first time, and an immunochromatography test strip with high sensitivity, quantitative function and strong specificity is constructed. The test strip can complete detection within 15 minutes, has high detection sensitivity, and realizes accurate quantification in a range of 0.01-25 ng / mL; meanwhile, the method is high in anti-interference capacity, the detection recovery rate of actual cosmetic samples reaches up to 89%-107%, the false positive rate and the false negative rate are both 0, reliability is good, and a powerful screening analysis tool is provided for rapid screening and quantitative detection of clobetasol propionate addition in cosmetics.

This invention discloses a sodium alginate cross-linked matrix metalloproteinase-sensitive peptide-loaded dexamethasone sodium phosphate hydrogel and its preparation method. The dexamethasone-loaded hydrogel has good injectability. After injection, it is cleaved by MMPs at the site of inflammation in an inflammatory environment to release dexamethasone, exhibiting good sustained-release effect. It achieves targeted and long-acting treatment of inflammatory arthritis, osteoarthritis or other inflammatory diseases, and reduces the frequency of repeated intra-articular injections of glucocorticoids.

The present invention relates to methods, kits, and compositions for testing a sample from a subject with asthma to determine: i) if the subject is A / A or A / C at position 1245 in the HSD3B1 gene, and / or if the subject expresses a 367N version of the 3β-HSD1 protein (e.g., and should be administered a non-corticosteroid for their asthma), or ii) if the subject is C / C at position 1245 in the HSD3B1 gene, and / or if the subject expresses only the 367T version of the 3β-HSD1 protein (e.g., and should be administered a corticosteroid for their asthma). In certain embodiments, the corticosteroid is a glucocorticoid.

Therapeutic combinations of an AKT inhibitor and a BCL-2 inhibitor; an AKT inhibitor and a glucocorticoid; and an AKT inhibitor, a BCL-2 inhibitor and a glucocorticoid are described. The combinations can be useful in the treatment of acute lymphoblastic leukemia (ALL).

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for preventing or treating progressive hearing loss of large vestibular aqueduct syndrome as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from fructus psoraleae, herba cistanche, rhizoma drynariae, poria peel, polyporus umbellatus, cortex mori radicis, plantain herb, radix salviae miltiorrhizae, ligusticum wallichii, caulis spatholobi and honey-fried licorice root. The traditional Chinese medicine composition disclosed by the invention has the effects of tonifying kidney and strengthening primordial qi, and tonifying spleen and promoting urination, and is mainly used for preventing or treating patients with progressive hearing loss caused by large vestibular aqueduct syndrome. Compared with western medicine glucocorticoid, the traditional Chinese medicine composition has no adverse reaction, the health risk is reduced, and the treatment tolerance and compliance of patients are improved. A standardized scheme for preventing or treating progressive hearing loss of large vestibular aqueduct syndrome by traditional Chinese medicine is formed, clinical popularization is facilitated, more patients are benefited, a reference basis is provided for subsequent research, and related medical research is promoted.

To provide a new method for treating lupus nephritis (LN), which improves renal response, reduces recurrence, prevents eventual end-stage renal disease (ESRD), and reduces the need for glucocorticoids.SOLUTION: WHAT IS CLAIMED IS: 1. A method of reducing lupus nephritis (LN) disease activity in a subject in need thereof, comprising administering to the subject a type I IFN receptor (IFNAR1) inhibiting agent. Preferably, the IFNAR1 inhibitors are human monoclonal antibodies specific for IFNAR1, such as anifrolumab.SELECTED DRAWING: None

The invention relates to the field of biological medicine, and discloses a protein degradation targeting chimera (PROTAC) compound targeting 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) and medical application of the protein degradation targeting chimera (PROTAC) compound. The compound comprises a structural unit shown as a formula I, X is a 11 beta-HSD1 binding ligand, Y is a connecting chain, Z is an E3 ubiquitin ligase ligand, ubiquitination degradation of 11 beta-HSD1 can be induced, and therefore the function of the compound can be regulated and controlled at the protein level. Different from a traditional small-molecule inhibitor, the degradation agent can significantly reduce expression of 11 beta-HSD1 in cells and improve glucocorticoid signal abnormality, and shows a novel action mode at molecular and cellular levels. In diabetes, obesity, lipid metabolism disorder and related complication models, the compound can reduce blood sugar, improve insulin sensitivity, regulate blood fat and relieve inflammation, and shows a good treatment prospect. The half degradation concentration of a representative compound in vitro is about 1000 nM, and feasible degradation efficiency is achieved. The compound can be synthesized by Click chemistry and other methods, and can be prepared into a pharmaceutical composition for prevention and treatment of type II diabetes, metabolic syndrome, polycystic ovarian syndrome and other diseases, and a new strategy is provided for research and development of related drugs.

Provided is a product containing lysozyme that helps improve oral mucosa-related fibrosis. Lysozyme is found for the first time to have a significant improvement effect on oral mucosa-related fibrosis. Compared with anti-inflammatory drugs such as glucocorticoids commonly used at present, the product has a better improvement effect. Meanwhile, lysozyme is highly safe and can be used as both a drug and food, and has a good application prospect in improving oral mucosa-related fibrosis.

The disclosure provides a method of treatment for glucocorticoid excess in a patient in need thereof, comprising administering to the patient a pseudo-irreversible HSD-1 inhibitor.

The invention relates to biological adhesive powder for preventing stenosis after endoscopic mucosal dissection of esophageal premature cancer. The biological adhesive powder comprises a silk fibroin-polyphenol cross-linked network and an adhesive layer, wherein the silk fibroin-polyphenol cross-linked network is formed by cross-linking a silk fibroin solution and a polyphenol solution through phenolic hydroxyl groups; the mass ratio of the glucocorticoid carried in the cross-linked network to the adhesive powder is (1: 40)-(1: 50); the structural characteristic is that the content of beta-sheet conformation in Fourier infrared spectroscopy is greater than or equal to 20%. The preparation method comprises the following steps: mixing the silk fibroin-polyphenol basic powder with the therapeutic drug, activating the mixture into gel by using a 20-50% ethanol aqueous solution, and then performing secondary freeze drying. In a miniature pig esophageal ESD operation model, after being sprayed to a wound surface and activated into hydrogel, the powder can be stably attached to the wound surface for more than 14 days, is gradually degraded and releases glucocorticoid, and can continuously release more than or equal to 80% of medicine within 72 hours, so that esophageal stenosis is effectively inhibited.

The application provides a paper-based molecular imprinting sensor for detecting glucocorticoids and a preparation method thereof, wherein the preparation method of the paper-based molecular imprinting sensor for detecting glucocorticoids comprises the following steps: using nitrogen-doped carbon / carbon nanotube composite material with a hierarchical structure as electrode modification material, and coating the electrode modification material on a screen-printed electrode; and assembling the obtained screen-printed electrode with a paper-based microfluidic device. The nitrogen-doped carbon and the carbon nanotube form a hierarchical porous structure, and high specific surface area and high conductivity make the sensor performance more excellent. The paper-based microfluidic process enables the sensor to simultaneously detect multiple glucocorticoids, and shows the application value of the sensor in the inspection field.

The embodiment of the invention provides a preparation method and application of composite drug-loaded nanoparticles targeting a blood brain barrier, and the composite drug-loaded nanoparticles are prepared by taking mesoporous polydopamine (MPDA) as a carrier and covalently coupling a blood brain barrier targeting peptide RPP-12, a microglial cell targeting peptide MG-1 and an MMP-2 responsive connecting peptide Pep (Ac-CSSSGPLGIAGQSSS). The multi-stage precise delivery of blood brain barrier penetration-inflammatory cell targeting-microenvironment response release is realized. In-vivo animal experiments show that the nanoparticles can significantly reduce the level of pro-inflammatory factors (IL-1, IL-6 and TNF-alpha) of craniocerebral trauma model mice, promote polarization of pro-inflammatory microglial cells to anti-inflammatory phenotypes, promote survival of nerve cells and improve neurological functions (sucrose preference experiments, forced swimming experiments and the like). According to the application, by integrating a multi-stage targeting strategy and a microenvironment response release mechanism, the bottleneck that glucocorticoid is low in intracerebral delivery efficiency and large in systemic side effect is broken through, and an efficient and safe new treatment strategy is provided for central nervous system diseases such as traumatic brain injury.

This invention belongs to the field of biomedical technology, specifically relating to the application of TLR1 receptor inhibitors in the preparation of products for treating hypertension. Existing drugs used clinically for hypertension have varying mechanisms of action. This study discovers a novel mechanism for treating hypertension: by inhibiting TLR1 receptors in juxtaglomerular cells of the kidney and hepatocytes of the liver, sympathetic nerve excitation-induced renin synthesis and glucocorticoid-induced angiotensinogen synthesis are suppressed, thereby inhibiting angiotensin II levels. This mechanism and method provide a new treatment option for hypertension, particularly neurogenic hypertension, and can also exhibit synergistic effects with existing therapeutic drugs. This invention identifies the TLR1 receptor as a novel target for treating hypertension. Currently, there are no developed and applied hypertension treatment drugs mediated by TLR1 receptors. This invention provides sufficient theoretical and experimental basis for the development of novel antihypertensive drugs.

The invention relates to clinical medicine, and more particularly to lymphology, surgery, plastic surgery and oncology, for treating lymphatic swelling in the case of primary or secondary lymphoedema in adults and children, inter alia accompanied by infectious complications, and even more particularly relates to methods for treating lymphoedema and to the use of accessible drugs in the treatment of lymphatic swelling at any stage and in any location. The claimed method for the lymphotropic treatment of lymphoedema involves consecutively preparing an injectable drug composition A containing an adrenergic alpha-1 receptor agonist and a glucocorticoid, administering same by lymphotropic interstitial injection by puncturing the interstitial tissue of the lymphatic region of interest and introducing the drug composition, preparing an injectable drug composition B containing a cholinesterase inhibitor, administering same by lymphotropic interstitial injection by puncturing the interstitial tissue of the lymphatic region of interest and introducing the drug composition, and also, if necessary, preparing an injectable drug composition C containing bovhyaluronidase azoximer, and administering same by interstitial injection by puncturing the interstitial tissue of the lymphatic region of interest. The technical result consists in improving the drainage of free fluid from the tissues and reducing limb swelling in the case of lymphoedema.

A nanoliposome suspension for soft aerosol spray and its preparation method are disclosed. The active ingredient of the nanoliposome suspension is selected from the following combinations: inhaled glucocorticoids, long / short-acting β2 receptor agonists and long / short-acting anticholinergic drugs (LAMA / SAMA), inhaled glucocorticoids, long / short-acting β2 receptor agonists and long / short-acting anticholinergic drugs, inhaled glucocorticoids and long / short-acting β2 receptor agonists, inhaled glucocorticoids and long / short-acting anticholinergic drugs; the active ingredient is encapsulated in nanoliposomes, which are prepared using cholesterol and phospholipids.

The invention relates to the technical field of nano-drugs, in particular to a glucocorticoid nano-emulsion, a liposome, a freeze-drying preparation and application of the glucocorticoid nano-emulsion, the liposome and the freeze-drying preparation in treatment of acute lung injury. According to the glucocorticoid nano-emulsion and lipidosome, accumulation of a nano-preparation in an inflammation part can be effectively increased through SA modification, selective targeting of the nano-preparation on the inflammation part is achieved, acute lung inflammation of ALI mice is remarkably relieved through pulmonary drug delivery, and under the same dosage, compared with lipidosome, the dosage of the nano-emulsion and lipidosome is reduced, and the dosage of the nano-emulsion and lipidosome is reduced. The nano-emulsion shows the best anti-inflammatory treatment effect. The nano preparation provided by the invention is good in biological safety and has a wide development prospect.

The application discloses a pea peptide mixture with calcium binding and osteogenesis promoting effects and application thereof, wherein the pea peptide mixture is derived from protein components in a by-product of pea starch extraction, is obtained through alkaline protease and papain enzymolysis and separation and purification, and is rich in aspartic acid and glutamic acid residues. The pea peptide mixture can effectively bind with calcium ions, the pea peptide mixture can promote calcium ion delivery in osteoblasts, improve alkaline phosphatase activity, and promote osteoblast differentiation, the osteogenesis promoting effect of the pea peptide mixture is related to epidermal growth factor receptor EGFR and downstream PI3K-Akt signal pathway regulation. The pea peptide mixture can improve glucocorticoid-induced zebrafish bone mass reduction, and up-regulate mRNA expression levels of ALP, EGFR, PI3K and Akt and other genes related to osteogenesis. The pea peptide mixture has both functions and nutrition, can be used for preparing products for promoting osteogenesis, improving bone mass, improving bone mass reduction and assisting in improving osteoporosis, and has a wide application prospect in the field of bone health.