17 results about "Sulfadimidine" patented technology

The invention relates to the technical field of preparation of imprinted polymers, and particularly discloses a magnetic molecularly imprinted polymer for sulfonamides and a preparation method of the magnetic molecularly imprinted polymer for sulfonamides. Tetraethyl orthosilicate is used for silanization of the surface of Fe3O4, then 3-(trimethoxysilyl) propyl methacrylate and silicon hydroxyl of Fe3O4 (at) SiO2 are used for condensation, and the magnetic molecularly imprinted polymer for sulfonamides is obtained. The preparation method comprises the following steps: carrying out vinyl modification on the surface of Fe3O4 (at) SiO2-CH = CH2 particles to obtain Fe3O4 (at) SiO2-CH = CH2 particles, and carrying out copolymerization on the Fe3O4 (at) SiO2-CH = CH2 particles and Fe3O4 (at) SiO2-CH = CH2 by adopting a surface imprinting method and taking sulfadimidine as a template molecule, methyl methacrylate as a functional monomer and ethylene glycol dimethacrylate as a cross-linking agent so as to prepare the Fe3O4 (at) SiO2-CH = CH2 molecularly imprinted polymer. The magnetic molecularly imprinted polymer obtained by the invention can quickly identify sulfadimidine under the action of an external magnetic field, is simple to prepare, good in adsorbability, relatively low in cost and convenient to recycle, can be repeatedly utilized, and has a relatively good application prospect.

The invention discloses a method for synergistically treating hexavalent chromium and sulfadimidine composite wastewater, the hexavalent chromium and sulfadimidine composite wastewater is synergistically treated by using a bimetallic node coupled metal organic framework derivative electrode, and the electrode comprises a conductive substrate coupled with ZrO2 and ZnO. According to the invention, the bimetal node coupled metal organic framework derivative electrode is used as a working electrode, so that the constructed photoelectrocatalysis system has the advantages of strong light utilization capability, high electron transfer efficiency, strong conversion effect between complex free radical chemistry and different active substances and the like; according to the present invention, with the method, the synergistic degradation of the hexavalent chromium and the sulfamethazine in the wastewater can be achieved, the hexavalent chromium and the sulfamethazine in the wastewater can be efficiently removed at the same time, and the method has advantages of good recycling, high removal efficiency, good cycle performance, strong practical application and the like, and is the widely used photoelectrocatalysis method; the use value and the application prospect are very high.

The invention discloses an MOF (Metal Organic Framework) immunochromatography test strip for detecting sulfadimidine and a preparation method thereof. According to the invention, a mouse hybridoma cell 1B12 is screened, the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.46705, and the mouse hybridoma cell 1B12 is preserved in China General Microbiological Culture Collection Center on October 13, 2025. The mouse hybridoma cell 1B12 is secreted to obtain an anti-sulfadimidine monoclonal antibody, the anti-sulfadimidine monoclonal antibody is used for preparing an MOF immune probe, and finally the MOF immunochromatography test strip for detecting sulfadimidine is prepared. The prepared MOF immunochromatography test strip is short in determination time, easy to operate and low in cost, has excellent specificity and sensitivity, and can simply, conveniently and rapidly detect sulfadimidine.

The invention discloses an application of sulphaguanidine in preparation of a medicine for treating osteoarthritis. According to the invention, the obvious curative effect of the sulfadimidine (sulfadimidine) in the aspect of treating the osteoarthritis (OA) through intraarticular injection is confirmed for the first time; research results show that the sulphaguanidine not only can remarkably relieve the symptoms of osteoarthritis, but also can improve the metabolic function of cartilage cells, so that the progress of arthritis is slowed down. Traditional treatment methods mainly include intraarticular injection of anesthetic drugs, joint lubrication drugs (such as sodium hyaluronate), glucocorticoid and platelet rich plasma (PRP). However, these methods have limitations, such as significant effects in short periods but may cause side effects in long-term use. As a novel treatment means, sulphaguanidine not only has a good curative effect, but also has small side effects, and provides a new thought for drug treatment of osteoarthritis.

The invention provides in-situ polymerization hydrogel with pH responsiveness and a preparation method and application thereof, and belongs to the technical field of hydrogel, the in-situ polymerization hydrogel is obtained by in-situ polymerization of a component A and a component B. The component A comprises a block copolymer, a polypropylene glycol acrylate monomer and a reducing agent, the block copolymer is prepared from the following raw materials: sulfadimidine containing hydroxyl, polypropylene glycol and isocyanate; the component B is prepared from a contrast agent and an oxidizing agent; the specific component A and the specific component B are selected for matching, so that the obtained in-situ polymerization hydrogel has the pH response characteristic, secondary pH response gelling can be carried out in weak acid blood vessels around tumors, deeper and more complete embolism of the blood vessels is further achieved, meanwhile, the in-situ polymerization hydrogel is not prone to hydrolysis, and the in-situ polymerization hydrogel can be used for in-situ embolism of the blood vessels. The blood vessel embolism time length under different embolism requirements can be better met, operation is convenient and time-saving, and important research significance is achieved.

The invention discloses a multi-antibody immunomagnetic bead as well as a preparation method and application thereof, and relates to the technical field of immunomagnetic beads and chemical pollutant detection. The multiple antibody immunomagnetic beads comprise a sulfadimidine immunomagnetic bead, an enrofloxacin immunomagnetic bead, an aflatoxin M1 immunomagnetic bead, a tetracycline immunomagnetic bead and a melamine immunomagnetic bead, and each immunomagnetic bead is obtained by coupling a sulfadimidine antibody, an enrofloxacin antibody, an aflatoxin M1 antibody, a tetracycline antibody and a melamine antibody with magnetic microspheres; the invention also provides application of the multi-antibody immunomagnetic beads in simultaneous detection of multiple chemical pollutants in animal-derived food, and a kit and a detection method for simultaneous detection of multiple chemical pollutants in animal-derived food. The method has the beneficial effects that the method can be used for simultaneously detecting various chemical pollutants in the animal-derived food, and is high in detection efficiency and good in specificity.

The invention relates to the technical field of fine chemical engineering, in particular to a sulfadimidine sodium production method and a microchannel reactor thereof. The method comprises the following steps: 1, reacting sulfanilamide with acetic anhydride under the action of a catalyst at the reaction temperature of 50-60 DEG C for 1-3 hours to generate acesulfamide; step 2, adding acesulfamide into chloroform, contacting with halogen, and reacting under the action of illumination or an initiator at the reaction temperature of 30-60 DEG C for 2-6 hours to generate p-halogenated acesulfamide; and step 3, adding halogenated acesulfamide and 2, 4-dimethyl pyrimidine into an organic solvent, then adding an alkaline substance, and carrying out condensation reaction under an alkaline condition at the reaction temperature of 80-120 DEG C for 4-8 hours to obtain a condensation product. Through the mode, the sulfadimidine sodium is high in yield, good in quality and good in stability.

The present invention relates to the technical field of water body antibiotic degradation, and specifically relates to a method for degrading antibiotics in wastewater by activating PMS using Fe-C-N(M) materials, comprising the following steps: S1, preparation of a gel solution; S2, preparation of Fe-C-N(M); S3, detection of wastewater; S4, determination of wastewater treatment system parameters: S4-1, primary correction of wastewater treatment system parameters; S4-2, secondary correction of wastewater treatment system parameters; S4-3, tertiary correction of wastewater treatment system parameters; S5, wastewater treatment. The method of the present invention prepares a gel solution by the gel method and pyrolyzes with melamine as a nitrogen source to prepare a nitrogen-doped derivative carbon material Fe-C-N(M), which has CNTs on its surface, has pores on the surface and the pore sizes are relatively concentrated, facilitating electron transfer, and has the best catalytic activity. It has a 100% removal rate for 5 mg / L of sulfamethazine SMZ within 15 minutes, indicating that N doping can improve the catalytic activity of the carbon material and can achieve a good removal effect on sulfamethazine SMZ after activating PMS.

The present invention relates to a biodegradable polymer, a preparation method and a sustained-release microneedle patch, and belongs to the field of biomaterial technology. The polymer is polyethylene glycol-polysulfadimethoxine carbonate carbamate, and the polymer has good biocompatibility and biosafety. Through a series of simple synthesis methods, including acrylic acid reaction, Michael addition reaction, ring-opening reaction, and addition polymerization reaction, a PEG-PSCU polymer is finally obtained, which can be used to prepare a new sustained-release microneedle. Compared with traditional biodegradable microneedles, this new microneedle can not only efficiently load protein vaccines, but also further prolong the release time of these vaccines in different environments, including normal ground environment and simulated microgravity environment, and further enhance the mechanical strength of the microneedle itself.

The invention relates to the technical field of preparation of activated carbon, in particular to modified activated carbon as well as a preparation method and application thereof. The method comprises the following steps: mixing activated carbon with acid, and performing activation reaction to obtain pretreated activated carbon; dipping the pretreated activated carbon in a copper salt solution to obtain activated carbon loaded with copper ions; mixing the active carbon loaded with the copper ions with water, and performing microwave treatment to obtain the modified active carbon. According to the prepared modified activated carbon, the doping amount of copper metal is only about 0.7%, and the problem that residual heavy metal ions cause secondary pollution to the environment is solved while the excellent sulfadimidine removal capacity is achieved.

The invention discloses a multi-type veterinary drug mixed standard substance as well as a preparation method and application thereof, and the preparation method comprises the following steps: (1) screening veterinary drug candidates: selecting representative veterinary drugs which are wide in application range, diversified in detection method and easy to cause harm to human bodies, comprising difloxacin, florfenicol, sulfadimidine, trimethoprim, thiamphenicol and fenvalerate. And (2) mixing the selected veterinary drugs in proportion: mixing the difloxacin, the florfenicol, the sulfadimidine, the trimethoprim, the thiamphenicol and the fenvalerate in proportion. The multi-type veterinary drug mixed standard substance developed by the invention has a certain quantity value, can be used for simultaneously measuring multiple veterinary drugs, and can be stably stored at-20 DEG C for 6 months. According to the multi-type veterinary drug mixed standard substance, the detection accuracy of various veterinary drugs under different platforms can be improved; the method can be applied to the detection process of various veterinary drugs, and the accuracy and efficiency of veterinary drug residue detection are improved.

The present application relates to a kind of sulfadimidine neuraminidase inhibitors and its preparation and application, the preparation method of the inhibitor is specifically (1a) sulfadimidine, monoethyl ester acyl chloride and anhydrous potassium carbonate are reacted, and after treatment, the intermediate of formula (II) is obtained;(2a) the intermediate of formula (II) is dissolved in organic solvent, after adding potassium hydroxide, the intermediate of formula (III) is obtained;(3a) the intermediate of formula (III) is dissolved in organic solvent, after adding substituted aniline, HOBT and EDCI, the inhibitor is obtained after treatment;(1b) sulfadimidine, chloroacetyl chloride and anhydrous potassium carbonate are reacted, and the intermediate of formula (IV) is obtained;(2b) the intermediate of formula (IV) is dissolved in organic solvent, after adding substituted mercaptan or thiophenol and anhydrous potassium carbonate, the inhibitor is obtained after treatment.Compared with prior art, the structure of the inhibitor of the present application is novel, has good neuraminidase inhibitory activity, and can be used for preparing the drug for inhibiting neuraminidase activity.

The utility model relates to a reactor for producing sulfadimidine sodium, which comprises a reactor main body, a first driving motor, a rotating rod, a disturbance rod, a first fluid flowing appliance, a second fluid flowing appliance, a nozzle and a first communicating pipeline, the reactor main body is provided with an internal chamber and a bottom opening, and the bottom opening is communicated with fluid in the internal chamber; the first driving motor is fixedly connected with the rotating rod, and the disturbance rod is fixedly mounted on the rotating rod; at least one part of the rotating rod and the disturbance rod are arranged in the inner cavity of the reactor main body; the first fluid flowing device, the second fluid flowing device, the nozzle and the first communicating pipeline are all arranged in an inner cavity of the reactor main body; the first fluid flowing device and the second fluid flowing device are in fluid communication through a first communication pipeline, the nozzle is arranged on the first fluid flowing device, and the nozzle and the first fluid flowing device are in fluid communication; the bottom opening is in fluid communication with the second fluid flow appliance.

This invention discloses the application of sulfadimidine in the preparation of drugs for treating osteoarthritis. This invention is the first to demonstrate the significant efficacy of intra-articular injection of sulfadimidine in the treatment of osteoarthritis (OA); the results show that sulfadimidine can not only significantly relieve the symptoms of osteoarthritis but also improve the metabolic function of chondrocytes, thereby slowing the progression of arthritis. Traditional treatment methods mainly include intra-articular injection of anesthetic drugs, joint lubricants (such as sodium hyaluronate), glucocorticoids, and platelet-rich plasma (PRP). However, these methods each have limitations, such as significant short-term effects but potential long-term side effects. Sulfamidine, as a novel treatment method, not only has good efficacy but also fewer side effects, providing a new approach to the drug treatment of osteoarthritis.

The invention provides a method for detecting sulfadimidine in meat products. The method comprises the following steps: pretreating an object to be detected; specifically, the method comprises the following steps: dissolving a to-be-detected object to obtain a dissolved solution, adding a PSA adsorbent into the dissolved solution for adsorption to obtain an adsorption solution, carrying out nitrogen blowing volatilization on the adsorption solution, and redissolving with a methanol aqueous solution to obtain a sample test solution; sampling the sample test solution to obtain an on-machine test solution; and detecting the loading test solution through a liquid chromatograph-tandem mass spectrometer, and determining the content of the sulfadimidine bromide. According to the method, the sample is pretreated and detected through liquid chromatography-tandem mass spectrometry, so that the market blank is filled, the content of sulfadimidine in the meat product can be detected, and the method has the advantages of excellent repeatability and reproducibility, simplicity and convenience in operation, high speed, easiness in obtaining used equipment and high generalizability.

The present invention relates to the technical fields of solid-phase microextraction probes and veterinary drug detection, and specifically relates to a surface coating material, a solid-phase microextraction probe, a preparation method and an application thereof. The surface coating material is prepared on the surface of a substrate by an electrospinning method after 2D-Ni-MOF material, polyacrylonitrile and N,N-dimethylformamide are mixed and stirred; the solid-phase microextraction probe comprises a substrate and a coating, and the coating is formed on the surface of the substrate by an electrospinning method. The solid-phase microextraction probe prepared by the present invention can perform quantitative analysis on sulfamethazine, thiabendazole and clenbuterol, and solves the problem in the prior art that different types of veterinary drugs cannot be detected at one time.

The application provides a thioxanthene quinone derivative carbon catalyst and a preparation method and application thereof, and belongs to the technical field of carbon materials. The derivative carbon catalyst is prepared by using sodium sulfide and 2,3-dichloro-1,4-naphthoquinone as raw materials, first synthesizing a purple solid organic matter precursor, and then adopting a pyrolysis method under anoxic conditions to prepare the derivative carbon catalyst with strong PMS catalytic capacity. The generation of key active sites quinone groups on the surface of the derivative carbon depends on the fact that the precursor contains 6 quinone groups, a large number of active sites are provided, and most of the quinone groups are retained in the pyrolysis process. With the advantage that the organic quinone groups synthesized by the precursor are rich in content, the abundance of the quinone groups on the surface of the derivative carbon catalyst obtained under the pyrolysis condition is increased. The derivative carbon catalyst can efficiently remove organic pollutants such as tetracycline, bisphenol A, sulfamethoxazole, sulfadimidine or ciprofloxacin in water.