3 results about "Sulfadimidine" patented technology

The invention discloses an MOF (Metal Organic Framework) immunochromatography test strip for detecting sulfadimidine and a preparation method thereof. According to the invention, a mouse hybridoma cell 1B12 is screened, the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.46705, and the mouse hybridoma cell 1B12 is preserved in China General Microbiological Culture Collection Center on October 13, 2025. The mouse hybridoma cell 1B12 is secreted to obtain an anti-sulfadimidine monoclonal antibody, the anti-sulfadimidine monoclonal antibody is used for preparing an MOF immune probe, and finally the MOF immunochromatography test strip for detecting sulfadimidine is prepared. The prepared MOF immunochromatography test strip is short in determination time, easy to operate and low in cost, has excellent specificity and sensitivity, and can simply, conveniently and rapidly detect sulfadimidine.

This invention discloses the application of sulfadimidine in the preparation of drugs for treating osteoarthritis. This invention is the first to demonstrate the significant efficacy of intra-articular injection of sulfadimidine in the treatment of osteoarthritis (OA); the results show that sulfadimidine can not only significantly relieve the symptoms of osteoarthritis but also improve the metabolic function of chondrocytes, thereby slowing the progression of arthritis. Traditional treatment methods mainly include intra-articular injection of anesthetic drugs, joint lubricants (such as sodium hyaluronate), glucocorticoids, and platelet-rich plasma (PRP). However, these methods each have limitations, such as significant short-term effects but potential long-term side effects. Sulfamidine, as a novel treatment method, not only has good efficacy but also fewer side effects, providing a new approach to the drug treatment of osteoarthritis.

The application provides a thioxanthene quinone derivative carbon catalyst and a preparation method and application thereof, and belongs to the technical field of carbon materials. The derivative carbon catalyst is prepared by using sodium sulfide and 2,3-dichloro-1,4-naphthoquinone as raw materials, first synthesizing a purple solid organic matter precursor, and then adopting a pyrolysis method under anoxic conditions to prepare the derivative carbon catalyst with strong PMS catalytic capacity. The generation of key active sites quinone groups on the surface of the derivative carbon depends on the fact that the precursor contains 6 quinone groups, a large number of active sites are provided, and most of the quinone groups are retained in the pyrolysis process. With the advantage that the organic quinone groups synthesized by the precursor are rich in content, the abundance of the quinone groups on the surface of the derivative carbon catalyst obtained under the pyrolysis condition is increased. The derivative carbon catalyst can efficiently remove organic pollutants such as tetracycline, bisphenol A, sulfamethoxazole, sulfadimidine or ciprofloxacin in water.