7 results about "Sulfadimidine" patented technology

The invention relates to the technical field of preparation of imprinted polymers, and particularly discloses a magnetic molecularly imprinted polymer for sulfonamides and a preparation method of the magnetic molecularly imprinted polymer for sulfonamides. Tetraethyl orthosilicate is used for silanization of the surface of Fe3O4, then 3-(trimethoxysilyl) propyl methacrylate and silicon hydroxyl of Fe3O4 (at) SiO2 are used for condensation, and the magnetic molecularly imprinted polymer for sulfonamides is obtained. The preparation method comprises the following steps: carrying out vinyl modification on the surface of Fe3O4 (at) SiO2-CH = CH2 particles to obtain Fe3O4 (at) SiO2-CH = CH2 particles, and carrying out copolymerization on the Fe3O4 (at) SiO2-CH = CH2 particles and Fe3O4 (at) SiO2-CH = CH2 by adopting a surface imprinting method and taking sulfadimidine as a template molecule, methyl methacrylate as a functional monomer and ethylene glycol dimethacrylate as a cross-linking agent so as to prepare the Fe3O4 (at) SiO2-CH = CH2 molecularly imprinted polymer. The magnetic molecularly imprinted polymer obtained by the invention can quickly identify sulfadimidine under the action of an external magnetic field, is simple to prepare, good in adsorbability, relatively low in cost and convenient to recycle, can be repeatedly utilized, and has a relatively good application prospect.

The invention discloses an MOF (Metal Organic Framework) immunochromatography test strip for detecting sulfadimidine and a preparation method thereof. According to the invention, a mouse hybridoma cell 1B12 is screened, the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.46705, and the mouse hybridoma cell 1B12 is preserved in China General Microbiological Culture Collection Center on October 13, 2025. The mouse hybridoma cell 1B12 is secreted to obtain an anti-sulfadimidine monoclonal antibody, the anti-sulfadimidine monoclonal antibody is used for preparing an MOF immune probe, and finally the MOF immunochromatography test strip for detecting sulfadimidine is prepared. The prepared MOF immunochromatography test strip is short in determination time, easy to operate and low in cost, has excellent specificity and sensitivity, and can simply, conveniently and rapidly detect sulfadimidine.

The invention discloses a multi-antibody immunomagnetic bead as well as a preparation method and application thereof, and relates to the technical field of immunomagnetic beads and chemical pollutant detection. The multiple antibody immunomagnetic beads comprise a sulfadimidine immunomagnetic bead, an enrofloxacin immunomagnetic bead, an aflatoxin M1 immunomagnetic bead, a tetracycline immunomagnetic bead and a melamine immunomagnetic bead, and each immunomagnetic bead is obtained by coupling a sulfadimidine antibody, an enrofloxacin antibody, an aflatoxin M1 antibody, a tetracycline antibody and a melamine antibody with magnetic microspheres; the invention also provides application of the multi-antibody immunomagnetic beads in simultaneous detection of multiple chemical pollutants in animal-derived food, and a kit and a detection method for simultaneous detection of multiple chemical pollutants in animal-derived food. The method has the beneficial effects that the method can be used for simultaneously detecting various chemical pollutants in the animal-derived food, and is high in detection efficiency and good in specificity.

The present application relates to a kind of sulfadimidine neuraminidase inhibitors and its preparation and application, the preparation method of the inhibitor is specifically (1a) sulfadimidine, monoethyl ester acyl chloride and anhydrous potassium carbonate are reacted, and after treatment, the intermediate of formula (II) is obtained;(2a) the intermediate of formula (II) is dissolved in organic solvent, after adding potassium hydroxide, the intermediate of formula (III) is obtained;(3a) the intermediate of formula (III) is dissolved in organic solvent, after adding substituted aniline, HOBT and EDCI, the inhibitor is obtained after treatment;(1b) sulfadimidine, chloroacetyl chloride and anhydrous potassium carbonate are reacted, and the intermediate of formula (IV) is obtained;(2b) the intermediate of formula (IV) is dissolved in organic solvent, after adding substituted mercaptan or thiophenol and anhydrous potassium carbonate, the inhibitor is obtained after treatment.Compared with prior art, the structure of the inhibitor of the present application is novel, has good neuraminidase inhibitory activity, and can be used for preparing the drug for inhibiting neuraminidase activity.

The utility model relates to a reactor for producing sulfadimidine sodium, which comprises a reactor main body, a first driving motor, a rotating rod, a disturbance rod, a first fluid flowing appliance, a second fluid flowing appliance, a nozzle and a first communicating pipeline, the reactor main body is provided with an internal chamber and a bottom opening, and the bottom opening is communicated with fluid in the internal chamber; the first driving motor is fixedly connected with the rotating rod, and the disturbance rod is fixedly mounted on the rotating rod; at least one part of the rotating rod and the disturbance rod are arranged in the inner cavity of the reactor main body; the first fluid flowing device, the second fluid flowing device, the nozzle and the first communicating pipeline are all arranged in an inner cavity of the reactor main body; the first fluid flowing device and the second fluid flowing device are in fluid communication through a first communication pipeline, the nozzle is arranged on the first fluid flowing device, and the nozzle and the first fluid flowing device are in fluid communication; the bottom opening is in fluid communication with the second fluid flow appliance.

This invention discloses the application of sulfadimidine in the preparation of drugs for treating osteoarthritis. This invention is the first to demonstrate the significant efficacy of intra-articular injection of sulfadimidine in the treatment of osteoarthritis (OA); the results show that sulfadimidine can not only significantly relieve the symptoms of osteoarthritis but also improve the metabolic function of chondrocytes, thereby slowing the progression of arthritis. Traditional treatment methods mainly include intra-articular injection of anesthetic drugs, joint lubricants (such as sodium hyaluronate), glucocorticoids, and platelet-rich plasma (PRP). However, these methods each have limitations, such as significant short-term effects but potential long-term side effects. Sulfamidine, as a novel treatment method, not only has good efficacy but also fewer side effects, providing a new approach to the drug treatment of osteoarthritis.

The application provides a thioxanthene quinone derivative carbon catalyst and a preparation method and application thereof, and belongs to the technical field of carbon materials. The derivative carbon catalyst is prepared by using sodium sulfide and 2,3-dichloro-1,4-naphthoquinone as raw materials, first synthesizing a purple solid organic matter precursor, and then adopting a pyrolysis method under anoxic conditions to prepare the derivative carbon catalyst with strong PMS catalytic capacity. The generation of key active sites quinone groups on the surface of the derivative carbon depends on the fact that the precursor contains 6 quinone groups, a large number of active sites are provided, and most of the quinone groups are retained in the pyrolysis process. With the advantage that the organic quinone groups synthesized by the precursor are rich in content, the abundance of the quinone groups on the surface of the derivative carbon catalyst obtained under the pyrolysis condition is increased. The derivative carbon catalyst can efficiently remove organic pollutants such as tetracycline, bisphenol A, sulfamethoxazole, sulfadimidine or ciprofloxacin in water.