12 results about "Sulfadimidine" patented technology

The invention relates to the technical field of preparation of imprinted polymers, and particularly discloses a magnetic molecularly imprinted polymer for sulfonamides and a preparation method of the magnetic molecularly imprinted polymer for sulfonamides. Tetraethyl orthosilicate is used for silanization of the surface of Fe3O4, then 3-(trimethoxysilyl) propyl methacrylate and silicon hydroxyl of Fe3O4 (at) SiO2 are used for condensation, and the magnetic molecularly imprinted polymer for sulfonamides is obtained. The preparation method comprises the following steps: carrying out vinyl modification on the surface of Fe3O4 (at) SiO2-CH = CH2 particles to obtain Fe3O4 (at) SiO2-CH = CH2 particles, and carrying out copolymerization on the Fe3O4 (at) SiO2-CH = CH2 particles and Fe3O4 (at) SiO2-CH = CH2 by adopting a surface imprinting method and taking sulfadimidine as a template molecule, methyl methacrylate as a functional monomer and ethylene glycol dimethacrylate as a cross-linking agent so as to prepare the Fe3O4 (at) SiO2-CH = CH2 molecularly imprinted polymer. The magnetic molecularly imprinted polymer obtained by the invention can quickly identify sulfadimidine under the action of an external magnetic field, is simple to prepare, good in adsorbability, relatively low in cost and convenient to recycle, can be repeatedly utilized, and has a relatively good application prospect.

The invention discloses a method for synergistically treating hexavalent chromium and sulfadimidine composite wastewater, the hexavalent chromium and sulfadimidine composite wastewater is synergistically treated by using a bimetallic node coupled metal organic framework derivative electrode, and the electrode comprises a conductive substrate coupled with ZrO2 and ZnO. According to the invention, the bimetal node coupled metal organic framework derivative electrode is used as a working electrode, so that the constructed photoelectrocatalysis system has the advantages of strong light utilization capability, high electron transfer efficiency, strong conversion effect between complex free radical chemistry and different active substances and the like; according to the present invention, with the method, the synergistic degradation of the hexavalent chromium and the sulfamethazine in the wastewater can be achieved, the hexavalent chromium and the sulfamethazine in the wastewater can be efficiently removed at the same time, and the method has advantages of good recycling, high removal efficiency, good cycle performance, strong practical application and the like, and is the widely used photoelectrocatalysis method; the use value and the application prospect are very high.

The invention discloses an MOF (Metal Organic Framework) immunochromatography test strip for detecting sulfadimidine and a preparation method thereof. According to the invention, a mouse hybridoma cell 1B12 is screened, the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.46705, and the mouse hybridoma cell 1B12 is preserved in China General Microbiological Culture Collection Center on October 13, 2025. The mouse hybridoma cell 1B12 is secreted to obtain an anti-sulfadimidine monoclonal antibody, the anti-sulfadimidine monoclonal antibody is used for preparing an MOF immune probe, and finally the MOF immunochromatography test strip for detecting sulfadimidine is prepared. The prepared MOF immunochromatography test strip is short in determination time, easy to operate and low in cost, has excellent specificity and sensitivity, and can simply, conveniently and rapidly detect sulfadimidine.

The invention discloses a multi-antibody immunomagnetic bead as well as a preparation method and application thereof, and relates to the technical field of immunomagnetic beads and chemical pollutant detection. The multiple antibody immunomagnetic beads comprise a sulfadimidine immunomagnetic bead, an enrofloxacin immunomagnetic bead, an aflatoxin M1 immunomagnetic bead, a tetracycline immunomagnetic bead and a melamine immunomagnetic bead, and each immunomagnetic bead is obtained by coupling a sulfadimidine antibody, an enrofloxacin antibody, an aflatoxin M1 antibody, a tetracycline antibody and a melamine antibody with magnetic microspheres; the invention also provides application of the multi-antibody immunomagnetic beads in simultaneous detection of multiple chemical pollutants in animal-derived food, and a kit and a detection method for simultaneous detection of multiple chemical pollutants in animal-derived food. The method has the beneficial effects that the method can be used for simultaneously detecting various chemical pollutants in the animal-derived food, and is high in detection efficiency and good in specificity.

The invention relates to the technical field of fine chemical engineering, in particular to a sulfadimidine sodium production method and a microchannel reactor thereof. The method comprises the following steps: 1, reacting sulfanilamide with acetic anhydride under the action of a catalyst at the reaction temperature of 50-60 DEG C for 1-3 hours to generate acesulfamide; step 2, adding acesulfamide into chloroform, contacting with halogen, and reacting under the action of illumination or an initiator at the reaction temperature of 30-60 DEG C for 2-6 hours to generate p-halogenated acesulfamide; and step 3, adding halogenated acesulfamide and 2, 4-dimethyl pyrimidine into an organic solvent, then adding an alkaline substance, and carrying out condensation reaction under an alkaline condition at the reaction temperature of 80-120 DEG C for 4-8 hours to obtain a condensation product. Through the mode, the sulfadimidine sodium is high in yield, good in quality and good in stability.

The present invention relates to the technical field of water body antibiotic degradation, and specifically relates to a method for degrading antibiotics in wastewater by activating PMS using Fe-C-N(M) materials, comprising the following steps: S1, preparation of a gel solution; S2, preparation of Fe-C-N(M); S3, detection of wastewater; S4, determination of wastewater treatment system parameters: S4-1, primary correction of wastewater treatment system parameters; S4-2, secondary correction of wastewater treatment system parameters; S4-3, tertiary correction of wastewater treatment system parameters; S5, wastewater treatment. The method of the present invention prepares a gel solution by the gel method and pyrolyzes with melamine as a nitrogen source to prepare a nitrogen-doped derivative carbon material Fe-C-N(M), which has CNTs on its surface, has pores on the surface and the pore sizes are relatively concentrated, facilitating electron transfer, and has the best catalytic activity. It has a 100% removal rate for 5 mg / L of sulfamethazine SMZ within 15 minutes, indicating that N doping can improve the catalytic activity of the carbon material and can achieve a good removal effect on sulfamethazine SMZ after activating PMS.

The present invention relates to a biodegradable polymer, a preparation method and a sustained-release microneedle patch, and belongs to the field of biomaterial technology. The polymer is polyethylene glycol-polysulfadimethoxine carbonate carbamate, and the polymer has good biocompatibility and biosafety. Through a series of simple synthesis methods, including acrylic acid reaction, Michael addition reaction, ring-opening reaction, and addition polymerization reaction, a PEG-PSCU polymer is finally obtained, which can be used to prepare a new sustained-release microneedle. Compared with traditional biodegradable microneedles, this new microneedle can not only efficiently load protein vaccines, but also further prolong the release time of these vaccines in different environments, including normal ground environment and simulated microgravity environment, and further enhance the mechanical strength of the microneedle itself.

The present application relates to a kind of sulfadimidine neuraminidase inhibitors and its preparation and application, the preparation method of the inhibitor is specifically (1a) sulfadimidine, monoethyl ester acyl chloride and anhydrous potassium carbonate are reacted, and after treatment, the intermediate of formula (II) is obtained;(2a) the intermediate of formula (II) is dissolved in organic solvent, after adding potassium hydroxide, the intermediate of formula (III) is obtained;(3a) the intermediate of formula (III) is dissolved in organic solvent, after adding substituted aniline, HOBT and EDCI, the inhibitor is obtained after treatment;(1b) sulfadimidine, chloroacetyl chloride and anhydrous potassium carbonate are reacted, and the intermediate of formula (IV) is obtained;(2b) the intermediate of formula (IV) is dissolved in organic solvent, after adding substituted mercaptan or thiophenol and anhydrous potassium carbonate, the inhibitor is obtained after treatment.Compared with prior art, the structure of the inhibitor of the present application is novel, has good neuraminidase inhibitory activity, and can be used for preparing the drug for inhibiting neuraminidase activity.

The utility model relates to a reactor for producing sulfadimidine sodium, which comprises a reactor main body, a first driving motor, a rotating rod, a disturbance rod, a first fluid flowing appliance, a second fluid flowing appliance, a nozzle and a first communicating pipeline, the reactor main body is provided with an internal chamber and a bottom opening, and the bottom opening is communicated with fluid in the internal chamber; the first driving motor is fixedly connected with the rotating rod, and the disturbance rod is fixedly mounted on the rotating rod; at least one part of the rotating rod and the disturbance rod are arranged in the inner cavity of the reactor main body; the first fluid flowing device, the second fluid flowing device, the nozzle and the first communicating pipeline are all arranged in an inner cavity of the reactor main body; the first fluid flowing device and the second fluid flowing device are in fluid communication through a first communication pipeline, the nozzle is arranged on the first fluid flowing device, and the nozzle and the first fluid flowing device are in fluid communication; the bottom opening is in fluid communication with the second fluid flow appliance.

This invention discloses the application of sulfadimidine in the preparation of drugs for treating osteoarthritis. This invention is the first to demonstrate the significant efficacy of intra-articular injection of sulfadimidine in the treatment of osteoarthritis (OA); the results show that sulfadimidine can not only significantly relieve the symptoms of osteoarthritis but also improve the metabolic function of chondrocytes, thereby slowing the progression of arthritis. Traditional treatment methods mainly include intra-articular injection of anesthetic drugs, joint lubricants (such as sodium hyaluronate), glucocorticoids, and platelet-rich plasma (PRP). However, these methods each have limitations, such as significant short-term effects but potential long-term side effects. Sulfamidine, as a novel treatment method, not only has good efficacy but also fewer side effects, providing a new approach to the drug treatment of osteoarthritis.

The present invention relates to the technical fields of solid-phase microextraction probes and veterinary drug detection, and specifically relates to a surface coating material, a solid-phase microextraction probe, a preparation method and an application thereof. The surface coating material is prepared on the surface of a substrate by an electrospinning method after 2D-Ni-MOF material, polyacrylonitrile and N,N-dimethylformamide are mixed and stirred; the solid-phase microextraction probe comprises a substrate and a coating, and the coating is formed on the surface of the substrate by an electrospinning method. The solid-phase microextraction probe prepared by the present invention can perform quantitative analysis on sulfamethazine, thiabendazole and clenbuterol, and solves the problem in the prior art that different types of veterinary drugs cannot be detected at one time.

The application provides a thioxanthene quinone derivative carbon catalyst and a preparation method and application thereof, and belongs to the technical field of carbon materials. The derivative carbon catalyst is prepared by using sodium sulfide and 2,3-dichloro-1,4-naphthoquinone as raw materials, first synthesizing a purple solid organic matter precursor, and then adopting a pyrolysis method under anoxic conditions to prepare the derivative carbon catalyst with strong PMS catalytic capacity. The generation of key active sites quinone groups on the surface of the derivative carbon depends on the fact that the precursor contains 6 quinone groups, a large number of active sites are provided, and most of the quinone groups are retained in the pyrolysis process. With the advantage that the organic quinone groups synthesized by the precursor are rich in content, the abundance of the quinone groups on the surface of the derivative carbon catalyst obtained under the pyrolysis condition is increased. The derivative carbon catalyst can efficiently remove organic pollutants such as tetracycline, bisphenol A, sulfamethoxazole, sulfadimidine or ciprofloxacin in water.