81 results about "Florfenicol" patented technology

The invention discloses an iron-sulfur-carbon-based composite filler for removing florfenicol in tail water, and belongs to the technical field of water treatment materials. The composite filler is composed of charcoal, pyrite, a calcium base, a binder and zeolite in proportion, through the synergistic effect of all the components, an adsorption-reduction-degradation combined mechanism is achieved, and florfenicol in municipal tail water and aquaculture tail water is efficiently removed. The preparation method comprises the steps of ingredient mixing, roller granulation, maintenance forming and the like, is simple in process and low in cost, and can be used for recycling preparation of agricultural and mine wastes. The filler is suitable for constructed wetlands and other water treatment scenes, the removal rate of florfenicol reaches 80% or above, meanwhile, the filler has the removal effect on nitrate nitrogen and other pollutants, and wide application prospects are achieved.

The application discloses a high-water-solubility florfenicol powder and a preparation method thereof, and belongs to the technical field of veterinary drug preparations. The powder is prepared from florfenicol, a water-soluble polymer carrier, tetraethyl orthosilicate or a mixture of the tetraethyl orthosilicate and methyl triethoxysilane and a C2-C6 organic polyacid containing polyhydroxy and polycarboxyl groups as raw materials through in-situ sol-gel spray drying one-step method. In the preparation, the controllable hydrolysis and condensation of organosilane and the in-situ esterification cross-linking of the organic polyacid are used to synergistically assemble and build an organic-inorganic hybrid network skeleton, and the amorphous florfenicol is anchored in the network skeleton. The product has both instant and moisture-proof properties. The method is simple in process, and the raw and auxiliary materials are safe and easy to obtain, so the method is suitable for industrial production and solves the problem that traditional solid dispersions are easy to absorb moisture and form lumps.

The invention provides a rapid detection method for florfenicol in a meat matrix. The rapid detection method comprises the steps of sample treatment, magnetic nano material enrichment, washing and elution and the like. According to the rapid detection method for florfenicol in the meat matrix, the meat is pretreated, florfenicol in the meat matrix is fully extracted, then the florfenicol is enriched through a magnetic nano material and finally removed to serve as a detection solution, and then detection is conducted through a rapid detection card, so that the sensitivity of rapid detection is fully improved.

The invention relates to a florfenicol preparation for reversing drug resistance, and every 100 kg of the florfenicol preparation is prepared from the following raw materials by weight: 30 to 50 kg of florfenicol, 5 to 10 kg of puerarin, 0.5 to 1 kg of magnesium stearate, and the balance of silicon dioxide. The florfenicol preparation is subjected to low-temperature crushing treatment, the crystal form of the medicine can be prevented from being converted, the dissolution rate of the medicine is prevented from being reduced, the florfenicol and the puerarin are reasonably proportioned according to the formula, the optimal reverse drug resistance effect is achieved, and meanwhile, the product process is particularly suitable for industrial production.

This invention relates to a chiral preparation method for florfenicol. Specifically, the method uses p-methylsulfonylbenzaldehyde and glycine ester as starting materials, and synthesizes the key chiral intermediate I through an asymmetric aldol reaction process under the action of a pyridinium salt carbonyl catalyst. Subsequently, through reduction, cyclization, fluorination, and hydrolysis ring-opening reactions, the chiral product florfenicol is obtained. Compared with existing technologies, this invention utilizes the strong catalytic ability of small-molecule pyridinium salt carbonyl catalysts, starting from inexpensive and readily available raw materials, to efficiently control the stereoselectivity of the aldol reaction process, highly selectively constructing the two chiral centers on the florfenicol structure, obtaining the desired chiral configuration, and finally synthesizing florfenicol. The preparation method of this invention is simple, rapid, and efficient.

The application discloses a small-molecule multi-connection detection kit based on a biochip, a preparation method and a detection method thereof. The kit comprises nano-gold particle labeled antibodies, a multi-connection detection chip plate and a detection buffer. The nano-gold particle labeled antibodies comprise nano-gold particle labeled florfenicol antibodies and enrofloxacin antibodies. The multi-connection detection chip plate is coated with florfenicol antigens and enrofloxacin antigens in detection holes. The detection buffer is composed of 10-40 mM phosphate buffer and 0.05-0.5 wt% surfactant S17. The application can simultaneously detect florfenicol and enrofloxacin small molecules by using one detection buffer, thereby saving time and labor.

The utility model relates to the technical field of florfenicol production, in particular to a spiral feeder for a florfenicol fluorination procedure, which comprises a base, a spiral conveyor body is arranged at the top of the base, a moving table is arranged above the spiral conveyor body, a storage barrel is embedded at the rear end of the top of the moving table, and a feed hopper is arranged at the rear end of the top of the moving table. A barrel cover is arranged at the top of the storage barrel, the top end of the left side of the spiral conveyor body communicates with a feeding hopper, and a beating mechanism for preventing materials on the inner wall of the storage barrel from being bonded is arranged in the moving table. According to the spiral feeder for the florfenicol fluorination process, through the arranged beating mechanism, when raw materials are fed, the storage barrel can be beaten to generate vibration, so that the raw materials attached to the inner wall are shaken off, manual cleaning is not needed, and the purpose of preventing the materials from being bonded is achieved.

The present invention provides a kind of L-threonine aldolase mutant and its application in catalytic synthesis of p-methylsulfonylphenylserine, the L-threonine aldolase mutant source Pseudomonas of the present invention, can use threonine and p-methylsulfonylbenzaldehyde as substrate, with pyridoxal phosphate and reduced nicotinamide adenine dinucleotide as coenzyme, catalysis obtains the synthesis of florfenicol intermediate p-methylsulfonylphenylserine, compared to wild-type L-threonine aldolase, mutant enzyme has higher activity, can effectively improve conversion efficiency, shorten conversion time. The enzyme and technical method reaction conditions of the present invention are mild, pollution is small, and there is good industrial prospect in the production of florfenicol synthetic intermediate.

The present application relates to the technical field of antibiotic pollution remediation, and particularly relates to a method for simultaneously degrading florfenicol and inhibiting drug resistance induced by florfenicol. On the basis of traditional microbial degradation, the method regulates the community structure of a biofilm by using nano zero-valent iron, and through detection of degradation products and microbial metagenome, the method achieves effective inhibition of the singleization of the biofilm community structure and the risk of drug resistance induced by florfenicol while maintaining the microbial degradation effect, overcomes the environmental risk and public health and safety problems caused by traditional biological degradation of antibiotics, and can achieve safe and efficient removal of antibiotic pollution in water bodies.

The utility model relates to the technical field of pharmaceutical equipment, in particular to a preparation stirrer for PLGA (poly (lactic-co-glycolic acid)) nano-particles containing florfenicol medicine, which comprises a stirring barrel, a mounting rack is arranged on the stirring barrel, connecting rotating rods are arranged at the tops of two sides of the mounting rack, one end of each connecting rotating rod is fixedly connected with the outer wall of the stirring barrel, and the other end of each connecting rotating rod is fixedly connected with the stirring barrel. A driving motor is provided with an encoder and a controller, the encoder provides an accurate rotating speed feedback signal to help the controller to adjust the speed of the driving motor in real time, and under the transmission that a driving gear drives a driven gear, two groups of screw rods synchronously rotate, so that the mixing uniformity in the stirring barrel can be improved, and the stirring efficiency is improved while stirring. And through cooperation of the double-shaft motor, the rotating rod, the rotating disc and the movable rod, the barrel body can be shaken, the effect of providing power for shaking of the barrel body is achieved, so that raw materials are shaken, the up-and-down fluidity of the raw materials in the stirring barrel is accelerated, the mixing effect and efficiency are improved, and the practicability is higher.

The invention discloses a treatment method of a florfenicol by-product N, N-diethyl-2, 3, 3, 3-tetrafluoropropionamide, and belongs to the technical field of chemical engineering, the treatment method comprises a hydrolysis addition reaction and a cyclization reaction; the hydrolysis addition reaction comprises the following steps: mixing N, N-diethyl-2, 3, 3, 3-tetrafluoropropionamide with diethylamine and alkali liquor, and then carrying out hydrolysis reaction and addition reaction to obtain N, N, N ', N'-tetraethyl malonamide; the cyclization reaction comprises the following steps: mixing organic solvent solutions of N, N, N ', N'-tetraethyl malonamide and sodium methoxide, adding a mixed solution of formamidine and an organic solvent, carrying out reflux heat preservation reaction, evaporating materials to dryness, acidifying and filtering. According to the method, the malonamide intermediate is generated through fewer reaction steps, then the 4, 6-dihydroxypyrimidine is prepared, most of materials can be recycled, the atom economy is high, and the pollution to the environment and the post-treatment pressure are also reduced.

The application discloses a compound enrofloxacin injection, which contains 10-25g of enrofloxacin, 2-10g of sulfadimoxine sodium, 5-12g of florfenicol, 0.5-2.5g of bromhexine hydrochloride, 1-20g of glacial acetic acid, 2-5g of Tween 80, 5-15g of alpha-pyrrolidone and 5-20g of N, N-dimethylformamide per 100ml of the injection, and the rest is water for injection. The compound enrofloxacin injection has advanced and reasonable prescription design, stable and reliable preparation process, good preparation stability and small irritation, and can achieve the effect of treating all samples for respiratory system diseases of livestock and poultry.

The present application relates to aquaculture wastewater treatment technical field, specifically to a kind of surface boric acid layer modified zero-valent iron material and its preparation and application.The present application provides a kind of surface boric acid layer modified zero-valent iron material preparation method, comprising: boric acid powder is mixed with zero-valent iron powder to obtain mixture, water is added, ball milling is carried out under inert atmosphere, to obtain surface boric acid layer modified zero-valent iron.This method is based on mechanical chemistry principle, uses mechanical shearing force, impact force and friction force and other forces, boric acid, water and zero-valent iron are mechanically ball-milled, and a layer of uniform coated surface boric acid layer is generated on the surface of zero-valent iron material, to improve the removal efficiency of fluorophenylc.

The invention discloses a method for efficiently synthesizing a florfenicol key intermediate I. The intermediate I is efficiently prepared by adopting a Lewis acid / BH3-NH3 reduction catalysis system. According to the reaction, (2S, 3R)-2-amino-3-hydroxy-3-(4-(methylsulfonyl) phenyl) propionic acid is used as a substrate, BF3-Et2O is used as a catalyst, BH3-NH3 is used as a reducing agent, Et2O is used as a solvent, and an intermediate I can be directly prepared at the temperature of 15-25 DEG C. According to the method, the process of firstly carrying out esterification and then carrying out reduction in the early-stage industrialization process is avoided, so that the reaction steps are simpler and more convenient, and the enantioselectivity and diastereoselectivity are not influenced in the reaction process. Meanwhile, the catalytic reduction strategy also avoids the requirement of a traditional strong reducing agent, so that the compatibility of the reaction is more excellent, and the reaction conditions are milder.

This utility model relates to the field of pharmaceutical processing technology and discloses a spray processing device for processing florfenicol soluble powder. The device body has a heating wire inside and a top cover at its top. This spray processing device for florfenicol soluble powder generates heat within the device body through the heating wire. Then, a first drive motor drives a connecting rod installed at its output end to agitate the stirring blades, thus stirring the florfenicol soluble powder within the device body. Since the first drive motor is mounted on a connecting plate, opening the electric telescopic rod causes the connecting plate to rise and fall, effectively agitating the florfenicol soluble powder within the device body and improving the stirring effect. Simultaneously, the heating wire helps to keep the florfenicol soluble powder dry, allowing moisture to escape from the powder.

The present invention discloses the use of cobalt-loaded nitrogen-doped hollow carbon spheres in the electrocatalytic hydrogenolysis and dechlorination of florfenicol. In the present invention, cobalt is loaded onto the nitrogen-doped hollow carbon spheres to obtain cobalt-loaded nitrogen-doped hollow carbon spheres (Co / N-HCS). Cobalt-loaded nitrogen-doped hollow carbon spheres (Co / N-HCS) can efficiently remove the carbon-chlorine bond in the antibiotic florfenicol molecule, demonstrating very high florfenicol degradation and dechlorination rates.

The application belongs to the technical field of florfenicol medicine preparation, and specifically provides florfenicol nanoemulsion and a preparation method thereof. The florfenicol nanoemulsion is composed of an oil phase, an aqueous phase and a composite emulsification stabilizing solution. The composite emulsification stabilizing solution comprises a non-ionic surfactant, a co-surfactant and a polysaccharide stabilizing solution. The polysaccharide stabilizing solution is obtained after in-situ mineralization of a calcium source to generate amorphous calcium carbonate with a degradation product of kappa-carrageenan and sodium phytate as a synergistic mineralization regulator. The florfenicol nanoemulsion prepared by the application has the advantages of good stability, uniform particle size distribution and high bioavailability.

The invention discloses a production process of a florfenicol premix with the content of 2%, and belongs to the field of preparation of florfenicol with the content of 2%. Comprising the following steps: mixing florfenicol, maltodextrin, corn starch, hydroxypropyl methyl cellulose and defatted rice bran, and granulating by using a granulator; drying and finishing the granules prepared by the granulator to obtain 2% florfenicol mixed granules with uniform diameter; totally mixing the 2% florfenicol mixed particles to obtain 2% florfenicol premix mixed particles; and packaging the 2% florfenicol premix mixed particles. The florfenicol premix has the beneficial effects that the core problems of poor uniformity, low stability, poor flowability and the like existing in a low-concentration florfenicol premix for a long time are successfully solved through a specific auxiliary material formula and key process combination of granulation, drying and finishing and total mixing; the invention provides an ideal preparation method which is stable in quality, safe and convenient to use and high in production efficiency.

The invention relates to the technical field of nano drug loading, in particular to a florfenicol derivative long-acting sustained release preparation and a preparation process thereof. The invention discloses a florfenicol-PEG-PLGA (poly (lactic-co-glycolic acid)-polyethylene glycol-poly (lactic-co-glycolic acid))-PLGA (poly (lactic-co-glycolic acid)) copolymer with a specific proportion, magnetic targeting microspheres, an antioxidant compound containing various components, a pH-responsive coating material and enzyme-responsive nanogel, wherein the derivative is formed by connecting florfenicol and 2-mercaptobenzothiazole; all the components are synergistic, so that long-acting slow release, targeting and intelligent drug release are realized, and the stability of the preparation is guaranteed. The method has outstanding advantages; the innovative components have a synergistic effect, can accurately target a diseased region, and intelligently release drugs in different environments; the composition can improve the drug concentration of diseased regions, enhance the curative effect, reduce the dosage and toxic and side effects, reduce the breeding cost, and have wide application prospects.

The application relates to the technical field of pharmaceutical preparations, in particular to a florfenicol preparation with high water solubility and bacteriostatic effect and a preparation method thereof.The raw materials of the florfenicol preparation with high water solubility and bacteriostatic effect include, by mass fraction, florfenicol 20-30 parts, beta-cyclodextrin 30-50 parts, solid polyethylene glycol 30-50 parts, sodium dodecyl sulfate 2-5 parts, dopamine aqueous solution 100-200 parts and dextran sulfate aqueous solution 1-5 parts; wherein the concentration of the dopamine aqueous solution is 1-3 g / L, and the concentration of the dextran sulfate aqueous solution is 0.1-0.5 mol / L.The application has a wide application range, is commonly used for granulation of heat-sensitive materials and drugs which are easily decomposed in water, and is convenient for subsequent re-compression tabletting or encapsulation; and compared with a wet granulation method, the application has the advantages of simple process, low energy consumption, small filler consumption and the like.

The application belongs to the technical field of veterinary drug preparation, and particularly relates to a water-soluble florfenicol powder and a preparation method thereof. The water-soluble florfenicol powder is prepared from the following components by weight: florfenicol 20-25 parts, folium isatidis flavones 3-8 parts, a composite dispersion carrier 30-35 parts, hydroxypropyl-beta-cyclodextrin 10-15 parts, a surfactant 6-8 parts, and lactitol 3-5 parts. The water-soluble florfenicol powder prepared by adopting florfenicol and folium isatidis flavones as the effective components and cooperating with specific excipients has high in-vitro dissolution rate, can effectively improve the bioavailability and treatment effect, and has excellent storage stability, and can maintain the drug efficacy and chemical integrity even under long-time storage or specific conditions, and is not prone to degradation or deterioration.

The application discloses an asymmetric synthesis method of florfenicol intermediate, which comprises the following steps: adding an organic solvent and a substrate I into a dry reaction bottle, adding a catalyst III, then adding a substrate II, controlling temperature, and carrying out post-treatment to obtain a product IV. Through the suitable chiral catalyst, the target product is obtained, the method has mild conditions, high hand type selectivity, the molar yield is more than 80%, the chiral purity can reach more than 99% ee, and the cis-trans selectivity is more than 90% dr.

The utility model provides a florfenicol intermediate (1R, 2R)-p-methylsulfonyl phenyl serinol synthesizer, which comprises a reduction reaction kettle, the top of the reduction reaction kettle is respectively connected with a configuration kettle, a dripping tank, a first feeder, a feeding bin, a water source and an N2 source through pipelines, the water source and the N2 source are further connected to the configuration kettle through pipelines, and the dripping tank is connected with the first feeder through a pipeline. The configuration kettle is connected with a second feeder through a pipeline, and a discharge hole in the bottom of the reduction reaction kettle is sequentially connected with a concentration crystallization kettle and a centrifugal machine. The florfenicol intermediate synthesis device has the beneficial effects that the florfenicol intermediate can be quickly and effectively synthesized, and the production efficiency and the production quality of the florfenicol intermediate are greatly improved.

The utility model discloses a water-soluble florfenicol powder preparation device, which comprises a spray dryer and a material receiving tank, the bottom of the material receiving tank is provided with a supporting piece, the inner side of the supporting piece is provided with a moving plate, the top of the moving plate is provided with a limiting lantern ring, the left side and the right side of the inner side of the supporting piece are both provided with limiting columns, and the limiting lantern ring is provided with a limiting sleeve ring. A supporting shell is arranged on the rear side of the supporting piece, and a control device used in cooperation with the moving plate is arranged at the bottom of the supporting shell. The movable plate, the limiting lantern ring, the control device, the clamping device and the driving assembly are used in cooperation, and the problems that when an existing spray dryer is used, a material collecting tank is mostly fixed to the position of a discharging opening of the spray dryer in a hoop mode, and when the material collecting tank is installed, the material collecting tank cannot be fixed to the discharging opening of the spray dryer are solved. The problems that in the prior art, a user usually needs to manually align a bottle opening with a discharging opening of the spray dryer and fixedly connect the bottle opening with the discharging opening through a clamp, and the operation process is tedious are solved.

The application discloses application of florfenicol in prevention and treatment of plant bacterial diseases and an inhibitor. The application provides a new application of florfenicol, which can be used for preventing and treating Xanthomonas oryzae pv. oryzae, Xanthomonas campestris pv. oryzae, Xanthomonas axonopodis pv. citri, Pseudomonas syringae pv. tabaci, Pseudomonas syringae pv. lachrymans, Pseudomonas syringae pv. tomato, Pseudomonas syringae pv. lactucae, Pseudomonas syringae pv. actinidiae, Pseudomonas syringae pv. angulata and the like, and provides a new idea for preventing and treating the above-mentioned plant bacterial diseases. Experiments prove that florfenicol has high bactericidal activity on the above-mentioned plant bacterial diseases.

The application discloses a florfenicol intermediate and belongs to the technical field of chemical synthesis. By adding aluminum magnesium hydrotalcite composite potassium carbonate as an alkaline catalyst in the preparation process of the florfenicol intermediate, the phenomenon that traditional pure potassium carbonate is easily dissolved and lost in glycerol solvent can be avoided, the prepared florfenicol intermediate has high purity and high yield; the aluminum magnesium hydrotalcite composite potassium carbonate is successively subjected to dimethyl sulfoxide stripping, methanol hydrothermal treatment and hexadecyl trimethyl ammonium bromide intercalation treatment, and modified aluminum magnesium hydrotalcite with a large specific surface area and interlayer spacing is obtained; and the modified aluminum magnesium hydrotalcite is used as a carrier to load potassium carbonate; the modified aluminum magnesium hydrotalcite is a layered structure, and the potassium carbonate is uniformly loaded in the interlayer space and the surface of the hydrotalcite; and the interlayer confinement effect can fix the potassium carbonate, thereby avoiding loss.

The invention relates to the technical field of aquaculture wastewater treatment, in particular to a surface boric acid layer modified zero-valent iron material and preparation and application thereof. The invention provides a preparation method of a surface boric acid layer modified zero-valent iron material, which comprises the following steps: mixing boric acid powder and zero-valent iron powder to obtain a mixture, adding water, and carrying out ball milling in an inert atmosphere to obtain surface boric acid layer modified zero-valent iron. According to the method, boric acid, water and zero-valent iron are subjected to mechanical ball milling modification on the basis of the mechanochemical principle by utilizing acting forces such as mechanical shearing force, impact force and friction force, and a uniformly coated surface boric acid layer is generated on the surface of the zero-valent iron material, so that the removal efficiency of florfenicol is improved.

The application provides copper and sulfur co-lattice doped nano zero-valent iron and a preparation method and application thereof, and is based on the ironophilic and sulfurophilic properties of elements, successfully improves the copper content in the nano zero-valent iron lattice, changes the physicochemical properties, improves the stability and the removal capacity of trichloroethylene and florfenicol. When the material is synthesized, copper chloride is used as the copper source (sulfurophilic), iron trichloride is used as the iron source, and a sulfur source (sodium hydrosulfite) with ironophilic and sulfurophilic properties is added as a "bridge". Through a simple one-step method, the copper and sulfur co-lattice doped nano zero-valent iron material is synthesized by means of dissolution, mixing, stirring, drying and grinding. The crystal structure of the copper and sulfur co-lattice doped nano zero-valent iron material prepared by the application is complete, the copper and sulfur co-lattice are doped in the nano zero-valent iron, rather than forming copper elements on the surface of the iron. The sulfur content and electron transfer capacity of the copper and sulfur co-lattice doped nano zero-valent iron material are improved, and the material has superhydrophobicity. The stability of the material is significantly improved, that is, the life in water can reach more than 2 years, and after being exposed to air for 30 days, the material can maintain 80% of the zero-valent iron content and hydrophobicity. The material can also enhance the removal capacity of organic pollutants trichloroethylene and florfenicol in groundwater. The synthesis method provided by the application is simple and easy to operate, the material performance is significantly improved, can provide a new design idea for co-lattice doped iron-based nano materials, and can be applied to the remediation of contaminated groundwater.

The application discloses an antibody against thiamphenicol and / or florfenicol, a detection product and a method for detecting thiamphenicol and / or florfenicol, and relates to the technical field of thiamphenicol / florfenicol detection. The thiamphenicol or florfenicol monoclonal antibody provided by the application has high specificity for thiamphenicol or florfenicol, and has high detection sensitivity and a wide linear detection range for thiamphenicol or florfenicol. The application is helpful for rapidly detecting thiamphenicol and florfenicol antibiotic residues in livestock and poultry products and aquatic products.

The invention provides a preparation method of a florfenicol preparation with high oral bioavailability, and belongs to the technical field of biological medicine, the preparation is composed of florfenicol, a grinding aid, a surface stabilizer and a skeleton agent, and the florfenicol preparation is prepared by adding a florfenicol nano suspension into the skeleton agent for granulation and drying. The preparation has the advantages of high efficiency, time saving, easiness in industrialization, low cost and the like, can be mixed with materials or drunk water for administration, can quickly release florfenicol nanoparticles after meeting water, improves oral absorption of florfenicol, and reduces the dosage of florfenicol.