49 results about "Florfenicol" patented technology

The invention discloses an iron-sulfur-carbon-based composite filler for removing florfenicol in tail water, and belongs to the technical field of water treatment materials. The composite filler is composed of charcoal, pyrite, a calcium base, a binder and zeolite in proportion, through the synergistic effect of all the components, an adsorption-reduction-degradation combined mechanism is achieved, and florfenicol in municipal tail water and aquaculture tail water is efficiently removed. The preparation method comprises the steps of ingredient mixing, roller granulation, maintenance forming and the like, is simple in process and low in cost, and can be used for recycling preparation of agricultural and mine wastes. The filler is suitable for constructed wetlands and other water treatment scenes, the removal rate of florfenicol reaches 80% or above, meanwhile, the filler has the removal effect on nitrate nitrogen and other pollutants, and wide application prospects are achieved.

The application discloses a high-water-solubility florfenicol powder and a preparation method thereof, and belongs to the technical field of veterinary drug preparations. The powder is prepared from florfenicol, a water-soluble polymer carrier, tetraethyl orthosilicate or a mixture of the tetraethyl orthosilicate and methyl triethoxysilane and a C2-C6 organic polyacid containing polyhydroxy and polycarboxyl groups as raw materials through in-situ sol-gel spray drying one-step method. In the preparation, the controllable hydrolysis and condensation of organosilane and the in-situ esterification cross-linking of the organic polyacid are used to synergistically assemble and build an organic-inorganic hybrid network skeleton, and the amorphous florfenicol is anchored in the network skeleton. The product has both instant and moisture-proof properties. The method is simple in process, and the raw and auxiliary materials are safe and easy to obtain, so the method is suitable for industrial production and solves the problem that traditional solid dispersions are easy to absorb moisture and form lumps.

The invention relates to a florfenicol preparation for reversing drug resistance, and every 100 kg of the florfenicol preparation is prepared from the following raw materials by weight: 30 to 50 kg of florfenicol, 5 to 10 kg of puerarin, 0.5 to 1 kg of magnesium stearate, and the balance of silicon dioxide. The florfenicol preparation is subjected to low-temperature crushing treatment, the crystal form of the medicine can be prevented from being converted, the dissolution rate of the medicine is prevented from being reduced, the florfenicol and the puerarin are reasonably proportioned according to the formula, the optimal reverse drug resistance effect is achieved, and meanwhile, the product process is particularly suitable for industrial production.

This invention relates to a chiral preparation method for florfenicol. Specifically, the method uses p-methylsulfonylbenzaldehyde and glycine ester as starting materials, and synthesizes the key chiral intermediate I through an asymmetric aldol reaction process under the action of a pyridinium salt carbonyl catalyst. Subsequently, through reduction, cyclization, fluorination, and hydrolysis ring-opening reactions, the chiral product florfenicol is obtained. Compared with existing technologies, this invention utilizes the strong catalytic ability of small-molecule pyridinium salt carbonyl catalysts, starting from inexpensive and readily available raw materials, to efficiently control the stereoselectivity of the aldol reaction process, highly selectively constructing the two chiral centers on the florfenicol structure, obtaining the desired chiral configuration, and finally synthesizing florfenicol. The preparation method of this invention is simple, rapid, and efficient.

The application discloses a small-molecule multi-connection detection kit based on a biochip, a preparation method and a detection method thereof. The kit comprises nano-gold particle labeled antibodies, a multi-connection detection chip plate and a detection buffer. The nano-gold particle labeled antibodies comprise nano-gold particle labeled florfenicol antibodies and enrofloxacin antibodies. The multi-connection detection chip plate is coated with florfenicol antigens and enrofloxacin antigens in detection holes. The detection buffer is composed of 10-40 mM phosphate buffer and 0.05-0.5 wt% surfactant S17. The application can simultaneously detect florfenicol and enrofloxacin small molecules by using one detection buffer, thereby saving time and labor.

The utility model relates to the technical field of florfenicol production, in particular to a spiral feeder for a florfenicol fluorination procedure, which comprises a base, a spiral conveyor body is arranged at the top of the base, a moving table is arranged above the spiral conveyor body, a storage barrel is embedded at the rear end of the top of the moving table, and a feed hopper is arranged at the rear end of the top of the moving table. A barrel cover is arranged at the top of the storage barrel, the top end of the left side of the spiral conveyor body communicates with a feeding hopper, and a beating mechanism for preventing materials on the inner wall of the storage barrel from being bonded is arranged in the moving table. According to the spiral feeder for the florfenicol fluorination process, through the arranged beating mechanism, when raw materials are fed, the storage barrel can be beaten to generate vibration, so that the raw materials attached to the inner wall are shaken off, manual cleaning is not needed, and the purpose of preventing the materials from being bonded is achieved.

The utility model relates to the technical field of pharmaceutical equipment, in particular to a preparation stirrer for PLGA (poly (lactic-co-glycolic acid)) nano-particles containing florfenicol medicine, which comprises a stirring barrel, a mounting rack is arranged on the stirring barrel, connecting rotating rods are arranged at the tops of two sides of the mounting rack, one end of each connecting rotating rod is fixedly connected with the outer wall of the stirring barrel, and the other end of each connecting rotating rod is fixedly connected with the stirring barrel. A driving motor is provided with an encoder and a controller, the encoder provides an accurate rotating speed feedback signal to help the controller to adjust the speed of the driving motor in real time, and under the transmission that a driving gear drives a driven gear, two groups of screw rods synchronously rotate, so that the mixing uniformity in the stirring barrel can be improved, and the stirring efficiency is improved while stirring. And through cooperation of the double-shaft motor, the rotating rod, the rotating disc and the movable rod, the barrel body can be shaken, the effect of providing power for shaking of the barrel body is achieved, so that raw materials are shaken, the up-and-down fluidity of the raw materials in the stirring barrel is accelerated, the mixing effect and efficiency are improved, and the practicability is higher.

The invention discloses a treatment method of a florfenicol by-product N, N-diethyl-2, 3, 3, 3-tetrafluoropropionamide, and belongs to the technical field of chemical engineering, the treatment method comprises a hydrolysis addition reaction and a cyclization reaction; the hydrolysis addition reaction comprises the following steps: mixing N, N-diethyl-2, 3, 3, 3-tetrafluoropropionamide with diethylamine and alkali liquor, and then carrying out hydrolysis reaction and addition reaction to obtain N, N, N ', N'-tetraethyl malonamide; the cyclization reaction comprises the following steps: mixing organic solvent solutions of N, N, N ', N'-tetraethyl malonamide and sodium methoxide, adding a mixed solution of formamidine and an organic solvent, carrying out reflux heat preservation reaction, evaporating materials to dryness, acidifying and filtering. According to the method, the malonamide intermediate is generated through fewer reaction steps, then the 4, 6-dihydroxypyrimidine is prepared, most of materials can be recycled, the atom economy is high, and the pollution to the environment and the post-treatment pressure are also reduced.

The present application relates to aquaculture wastewater treatment technical field, specifically to a kind of surface boric acid layer modified zero-valent iron material and its preparation and application.The present application provides a kind of surface boric acid layer modified zero-valent iron material preparation method, comprising: boric acid powder is mixed with zero-valent iron powder to obtain mixture, water is added, ball milling is carried out under inert atmosphere, to obtain surface boric acid layer modified zero-valent iron.This method is based on mechanical chemistry principle, uses mechanical shearing force, impact force and friction force and other forces, boric acid, water and zero-valent iron are mechanically ball-milled, and a layer of uniform coated surface boric acid layer is generated on the surface of zero-valent iron material, to improve the removal efficiency of fluorophenylc.

The invention discloses a method for efficiently synthesizing a florfenicol key intermediate I. The intermediate I is efficiently prepared by adopting a Lewis acid / BH3-NH3 reduction catalysis system. According to the reaction, (2S, 3R)-2-amino-3-hydroxy-3-(4-(methylsulfonyl) phenyl) propionic acid is used as a substrate, BF3-Et2O is used as a catalyst, BH3-NH3 is used as a reducing agent, Et2O is used as a solvent, and an intermediate I can be directly prepared at the temperature of 15-25 DEG C. According to the method, the process of firstly carrying out esterification and then carrying out reduction in the early-stage industrialization process is avoided, so that the reaction steps are simpler and more convenient, and the enantioselectivity and diastereoselectivity are not influenced in the reaction process. Meanwhile, the catalytic reduction strategy also avoids the requirement of a traditional strong reducing agent, so that the compatibility of the reaction is more excellent, and the reaction conditions are milder.

This utility model relates to the field of pharmaceutical processing technology and discloses a spray processing device for processing florfenicol soluble powder. The device body has a heating wire inside and a top cover at its top. This spray processing device for florfenicol soluble powder generates heat within the device body through the heating wire. Then, a first drive motor drives a connecting rod installed at its output end to agitate the stirring blades, thus stirring the florfenicol soluble powder within the device body. Since the first drive motor is mounted on a connecting plate, opening the electric telescopic rod causes the connecting plate to rise and fall, effectively agitating the florfenicol soluble powder within the device body and improving the stirring effect. Simultaneously, the heating wire helps to keep the florfenicol soluble powder dry, allowing moisture to escape from the powder.

The application belongs to the technical field of florfenicol medicine preparation, and specifically provides florfenicol nanoemulsion and a preparation method thereof. The florfenicol nanoemulsion is composed of an oil phase, an aqueous phase and a composite emulsification stabilizing solution. The composite emulsification stabilizing solution comprises a non-ionic surfactant, a co-surfactant and a polysaccharide stabilizing solution. The polysaccharide stabilizing solution is obtained after in-situ mineralization of a calcium source to generate amorphous calcium carbonate with a degradation product of kappa-carrageenan and sodium phytate as a synergistic mineralization regulator. The florfenicol nanoemulsion prepared by the application has the advantages of good stability, uniform particle size distribution and high bioavailability.

The invention discloses a production process of a florfenicol premix with the content of 2%, and belongs to the field of preparation of florfenicol with the content of 2%. Comprising the following steps: mixing florfenicol, maltodextrin, corn starch, hydroxypropyl methyl cellulose and defatted rice bran, and granulating by using a granulator; drying and finishing the granules prepared by the granulator to obtain 2% florfenicol mixed granules with uniform diameter; totally mixing the 2% florfenicol mixed particles to obtain 2% florfenicol premix mixed particles; and packaging the 2% florfenicol premix mixed particles. The florfenicol premix has the beneficial effects that the core problems of poor uniformity, low stability, poor flowability and the like existing in a low-concentration florfenicol premix for a long time are successfully solved through a specific auxiliary material formula and key process combination of granulation, drying and finishing and total mixing; the invention provides an ideal preparation method which is stable in quality, safe and convenient to use and high in production efficiency.

The application relates to the technical field of pharmaceutical preparations, in particular to a florfenicol preparation with high water solubility and bacteriostatic effect and a preparation method thereof.The raw materials of the florfenicol preparation with high water solubility and bacteriostatic effect include, by mass fraction, florfenicol 20-30 parts, beta-cyclodextrin 30-50 parts, solid polyethylene glycol 30-50 parts, sodium dodecyl sulfate 2-5 parts, dopamine aqueous solution 100-200 parts and dextran sulfate aqueous solution 1-5 parts; wherein the concentration of the dopamine aqueous solution is 1-3 g / L, and the concentration of the dextran sulfate aqueous solution is 0.1-0.5 mol / L.The application has a wide application range, is commonly used for granulation of heat-sensitive materials and drugs which are easily decomposed in water, and is convenient for subsequent re-compression tabletting or encapsulation; and compared with a wet granulation method, the application has the advantages of simple process, low energy consumption, small filler consumption and the like.

The application belongs to the technical field of veterinary drug preparation, and particularly relates to a water-soluble florfenicol powder and a preparation method thereof. The water-soluble florfenicol powder is prepared from the following components by weight: florfenicol 20-25 parts, folium isatidis flavones 3-8 parts, a composite dispersion carrier 30-35 parts, hydroxypropyl-beta-cyclodextrin 10-15 parts, a surfactant 6-8 parts, and lactitol 3-5 parts. The water-soluble florfenicol powder prepared by adopting florfenicol and folium isatidis flavones as the effective components and cooperating with specific excipients has high in-vitro dissolution rate, can effectively improve the bioavailability and treatment effect, and has excellent storage stability, and can maintain the drug efficacy and chemical integrity even under long-time storage or specific conditions, and is not prone to degradation or deterioration.

The application discloses an asymmetric synthesis method of florfenicol intermediate, which comprises the following steps: adding an organic solvent and a substrate I into a dry reaction bottle, adding a catalyst III, then adding a substrate II, controlling temperature, and carrying out post-treatment to obtain a product IV. Through the suitable chiral catalyst, the target product is obtained, the method has mild conditions, high hand type selectivity, the molar yield is more than 80%, the chiral purity can reach more than 99% ee, and the cis-trans selectivity is more than 90% dr.

The utility model provides a florfenicol intermediate (1R, 2R)-p-methylsulfonyl phenyl serinol synthesizer, which comprises a reduction reaction kettle, the top of the reduction reaction kettle is respectively connected with a configuration kettle, a dripping tank, a first feeder, a feeding bin, a water source and an N2 source through pipelines, the water source and the N2 source are further connected to the configuration kettle through pipelines, and the dripping tank is connected with the first feeder through a pipeline. The configuration kettle is connected with a second feeder through a pipeline, and a discharge hole in the bottom of the reduction reaction kettle is sequentially connected with a concentration crystallization kettle and a centrifugal machine. The florfenicol intermediate synthesis device has the beneficial effects that the florfenicol intermediate can be quickly and effectively synthesized, and the production efficiency and the production quality of the florfenicol intermediate are greatly improved.

The application discloses application of florfenicol in prevention and treatment of plant bacterial diseases and an inhibitor. The application provides a new application of florfenicol, which can be used for preventing and treating Xanthomonas oryzae pv. oryzae, Xanthomonas campestris pv. oryzae, Xanthomonas axonopodis pv. citri, Pseudomonas syringae pv. tabaci, Pseudomonas syringae pv. lachrymans, Pseudomonas syringae pv. tomato, Pseudomonas syringae pv. lactucae, Pseudomonas syringae pv. actinidiae, Pseudomonas syringae pv. angulata and the like, and provides a new idea for preventing and treating the above-mentioned plant bacterial diseases. Experiments prove that florfenicol has high bactericidal activity on the above-mentioned plant bacterial diseases.

The application discloses a florfenicol intermediate and belongs to the technical field of chemical synthesis. By adding aluminum magnesium hydrotalcite composite potassium carbonate as an alkaline catalyst in the preparation process of the florfenicol intermediate, the phenomenon that traditional pure potassium carbonate is easily dissolved and lost in glycerol solvent can be avoided, the prepared florfenicol intermediate has high purity and high yield; the aluminum magnesium hydrotalcite composite potassium carbonate is successively subjected to dimethyl sulfoxide stripping, methanol hydrothermal treatment and hexadecyl trimethyl ammonium bromide intercalation treatment, and modified aluminum magnesium hydrotalcite with a large specific surface area and interlayer spacing is obtained; and the modified aluminum magnesium hydrotalcite is used as a carrier to load potassium carbonate; the modified aluminum magnesium hydrotalcite is a layered structure, and the potassium carbonate is uniformly loaded in the interlayer space and the surface of the hydrotalcite; and the interlayer confinement effect can fix the potassium carbonate, thereby avoiding loss.

This utility model discloses a drying device for producing florfenicol powder, comprising a tank body. Inside the tank body, a first conical plate, a second conical plate, and a third conical plate are arranged sequentially from top to bottom, each conical in shape with a smaller upper end and a larger lower end. A circular clearance hole is provided in the middle of the first and second conical plates, with the diameter of the clearance hole in the first conical plate being larger than that in the second conical plate. The top of the third conical plate is sealed. The outer diameters of the first, second, and third conical plates increase sequentially. A hopper is located at the top of the tank body, with its lower end directly opposite the first conical plate. This utility model allows the powder to fall in a fully dispersed manner during feeding, greatly enhancing the drying effect, and the dried powder is automatically discharged.

The invention discloses a carbonyl reductase mutant which comprises mutations at three positions and is obtained by mutating alanine at the 138 position of an amino acid sequence shown in SEQ ID NO.2 into valine, mutating serine at the 193 position into alanine and mutating alanine at the 190 position into one of valine, leucine or methionine. The mutant can be used for preparing a florfenicol key intermediate 1b through biological catalysis, compared with a wild type enzyme, the catalytic activity is obviously improved, the efficiency of a catalytic substrate 1a is high, the reaction time is short, the stereoselectivity is high, the enzyme expression quantity of recombinant engineering bacteria is high, fermentation preparation is easy, the unit enzyme activity of wet thalli is high, and the yield is high. Compared with a chemical method for preparing the florfenicol key intermediate, the method has the advantages that the high-purity product 1b can be produced, and the whole reaction is efficient, green, economical and environment-friendly.

The utility model relates to water -soluble florfenicol powder processing technical field, and disclose a kind of for water -soluble florfenicol powder processing ration component, including stirring tank, the outer wall of stirring tank is fixedly equipped with feeding bin, the inner chamber of stirring tank is rotatably connected with stirring rod, the outer wall of stirring tank is fixedly equipped with driving motor, the outer wall of stirring tank is fixedly equipped with discharging bin, the outer wall of discharging bin is fixedly equipped with control panel.The ration component for water -soluble florfenicol powder processing, by setting the discharging bin, and the rotating roller in the inner chamber of discharging bin is set, the ration bin is opened on the outer wall of rotating roller, with the rotation of rotating roller, after its rotation a circle, can release twice additive in ration bin to the inner chamber of stirring tank, under the action of ration bin, the ration of additive can be realized, to facilitate better realization of the proportioning of water -soluble florfenicol powder processing.

The invention relates to the field of veterinary drugs, in particular to veterinary water-soluble florfenicol powder and a preparation method thereof. Comprising florfenicol, an inclusion agent and a dispersing agent, the inclusion agent is selected from beta-cyclodextrin, hydroxypropyl beta-cyclodextrin and a water-soluble cyclodextrin polymer, the water-soluble cyclodextrin polymer is water-soluble epoxypropane cross-linked cyclodextrin, and the molecular weight of the water-soluble cyclodextrin polymer is 1t; 100,000, 20,000, 20,000, 20,000; the dispersing agent is selected from povidone K30, polyethylene glycol, poloxamer 188 or sodium carboxymethyl cellulose. The preparation process is simplified, and the preparation method is suitable for large-scale industrial production; the production cost is greatly reduced; meanwhile, the water solubility of florfenicol is improved, the water solubility reaches up to 10000 ppm, and the prepared product is good in water solubility, safe and reliable and does not affect the health of animals.

The invention discloses nucleic acid aptamers for specifically recognizing florfenicol, thiamphenicol and chloramphenicol, and the nucleic acid aptamers are base sequences shown as SEQ ID NO.1 or SEQ ID NO.3 in a sequence table, or base sequences with the homology of more than 70% with the SEQ ID NO.1, or base sequences with the homology of more than 40% with the SEQ ID NO.3. The invention further discloses a preparation method of the nucleic acid aptamers for specifically recognizing florfenicol, thiamphenicol and chloramphenicol. Experiments prove that the nucleic acid aptamer can specifically recognize all amide alcohol antibiotics clinically used by veterinarians, and is not interfered by ampicillin and other antibiotics. The compound has wide application in the fields of food safety, environmental safety and the like, can be used for preparing a sensor or a detection kit for specifically recognizing florfenicol, thiamphenicol and chloramphenicol, and has important significance in preliminary screening of amido alcohol antibiotic residues and pollution in large-batch food and environmental samples; and a new recognition element is provided for establishing a rapid, simple, cheap and sensitive florfenicol, thiamphenicol and chloramphenicol detection method at the same time.

The invention relates to suspension type florfenicol powder which is mainly prepared from the following raw materials in parts by weight: 10-30 parts of florfenicol, 0.5-2 parts of a chelating agent, 5-10 parts of a stabilizer, 2-8 parts of an absorption enhancer and 50-80 parts of a solubilizer. According to the formula, the defects that florfenicol is poor in solubility, prone to being influenced by external factors, poor in suspension capacity, capable of blocking a doser, inaccurate in medication and the like are effectively overcome. According to the invention, the florfenicol powder with high solubility is produced by optimizing spray or freeze drying parameters; by adding the chelating agent, the stabilizer and other auxiliary materials in the formula, the solubility of the product under different water qualities and different temperatures is solved, and through process optimization, the drug solubility is increased, the drug can be suspended for a long time without layering and precipitation phenomena, and the composition can be suitable for farms in various regions, can ensure the drug use accuracy, and meets the use of the farms.

The application discloses nanocrystal florfenicol particles and a preparation method thereof, and belongs to the technical field of veterinary medicine preparation and nanomedicine. The method comprises the following steps: dissolving florfenicol in edible ethanol to obtain an organic phase; cooling water for injection, adding polyethylene glycol-1000 vitamin E succinate and phytic acid into the water for injection to obtain an aqueous phase; pumping the two phase liquid into a high-pressure microjet collision reactor for continuous mixing crystallization; and performing vacuum dealcoholization, concentration and drying on the product to obtain spherical nanocrystal florfenicol particles. The application discloses a method for preparing nanocrystal with a particle size of 80-150 nm in one step by using the micro-turbulence of high-pressure microjet and the hydrogen bond crystal face regulation effect of phytic acid, and discarding traditional toxic solvents and ultrasonic crushing process. The obtained particles have good fluidity, no toxic solvent residue, a water phase solubility greatly improved at 25 DEG C, and a suspension stability of more than 120 hours.

The invention discloses a method for removing florfenicol by using an iron-doped biochar reinforced microbial electrolysis cell, which is characterized in that florfenicol in a water body is removed by using the microbial electrolysis cell, and a carbon-based material loaded with iron-doped biochar is used as a cathode in the microbial electrolysis cell. In the invention, the carbon-based material loaded with the iron-doped biochar is used as the cathode, so that the specific surface area and roughness of the electrode can be remarkably increased, florfenicol can be degraded by utilizing different functional microorganisms, and the carbon-based material can be used as an electron mediator to promote extracellular electron transfer between the cathode and the microorganisms, so that the efficient removal of florfenicol is facilitated; the method is used for reducing and degrading florfenicol in a water body, can quickly reduce florfenicol into low-toxicity products, can realize quick removal of florfenicol, has the advantages of simple process, low cost, low energy consumption, high treatment efficiency, good removal effect and the like, is a green technology capable of efficiently treating florfenicol-polluted wastewater, is high in use value and has wide application prospects. The application prospect is good.

The invention relates to the technical field of veterinary drugs, in particular to a high-stability progesterone injection and a preparation method thereof. The progesterone injection is prepared from the following components: 8 to 12 mg / ml of progesterone, 0.8 to 1.2 mg / ml of vitamin E and oil for injection. The progesterone injection is prepared by the following steps: taking oil for injection, adding vitamin E, heating in a water bath, stirring for 10-15 minutes, then adding progesterone, supplementing the oil for injection, stirring for 15-20 minutes, and introducing nitrogen for protection in the whole process to obtain the high-water-solubility florfenicol powder and a semi-finished product of the progesterone injection. And filtering, filling, sealing and sterilizing the semi-finished product progesterone injection to obtain the high-stability progesterone injection. Through the antioxidant design of solvent-antioxidant-inert gas, oxidation and hydrolysis paths are remarkably inhibited, high stability of the injection is achieved, safety and compliance are both achieved, and the progesterone injection is superior to a traditional progesterone injection which is not added with an antioxidant or only depends on single protection.

The application discloses a preparation method of florfenicol composite medicine and belongs to the technical field of pharmaceutical preparations. First, florfenicol is added into a chitosan solution, and the florfenicol is attached to the chitosan to form a precursor composite. Then, a Spirulina platensis sulfated polysaccharide extract is added into the precursor composite. Due to the binding force between the Spirulina platensis sulfated polysaccharide extract and the chitosan, the composite particles coated with the florfenicol are formed. The Spirulina platensis sulfated polysaccharide extract is located at the periphery of the composite particles, so that the composite particles are hydrophilic and have negative charges. The composite particles coated with the florfenicol are the florfenicol composite medicine. The method reduces the types of medicines used, integrates multiple treatment functions in one medicine, reduces the types of medicines that need to be taken by patients at the same time, and simplifies the treatment scheme. The method has the characteristics of biocompatibility and degradability, improves the water solubility of the florfenicol, and has a very simple reaction process and is suitable for industrial production.

The present application provides printing and dyeing alkali reduction white mud derived titanium-based MOF porous carbon and its preparation method and application, the inherent BDC in the white mud is extracted for resourceization, and the titanium-based MOF structure porous derived carbon is prepared for the electrocatalytic reduction degradation of florfenicol. The MOF material has the characteristics of high porosity, adjustable pore size structure size, high specific surface area, which enhances the enrichment of pollutants, is also beneficial to the activation of active sites and catalytic conversion of substances. In summary, the catalytic performance of the electrode material is improved, the efficient reduction degradation of florfenicol is realized, and the electrode material used in the present application is a non-noble metal material, which is low in price and simple in preparation, and meets the green economy and sustainable development concept.